Toshio Nishikimi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Protein Pept Sci 14:256-67. 2013
  2. pmc Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e53233. 2013
  3. doi request reprint Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Cardiol 57:131-40. 2011
  4. doi request reprint Diverse molecular forms of plasma B-type natriuretic peptide in heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Heart Fail Rep 8:140-6. 2011
  5. doi request reprint The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Sakyo ku, Kyoto, Japan
    Heart 98:152-61. 2012
  6. pmc Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
    Takeya Minami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    EMBO J 31:4428-40. 2012
  7. pmc Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
    Shinji Yasuno
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Br J Pharmacol 170:1384-95. 2013
  8. pmc Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts
    Yoshihiro Kuwabara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Heart Assoc 2:e000150. 2013
  9. doi request reprint Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
    Leo Hata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 50:972-81. 2011
  10. ncbi request reprint Transcriptional regulation of the fetal cardiac gene program
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Pharmacol Sci 119:198-203. 2012

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Protein Pept Sci 14:256-67. 2013
    ..We also describe the clinical application of AM in cardiovascular disease from the viewpoints of diagnosis and treatment. ..
  2. pmc Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e53233. 2013
    ..It is important to know the exact levels of proBNP in heart failure, because elevation of the low-activity proBNP may be associated with the development of heart failure...
  3. doi request reprint Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Cardiol 57:131-40. 2011
    ..In this review we discuss recent progress in our understanding of the biochemistry, molecular biology and clinical relevance of the natriuretic peptide system...
  4. doi request reprint Diverse molecular forms of plasma B-type natriuretic peptide in heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Heart Fail Rep 8:140-6. 2011
    ..A new hypothesis that O-glycosylation at Thr71 in a region close to the cleavage site impairs proBNP-108 processing was proposed. In the future, the precise mechanism of increased proBNP-108 in HF should be elucidated...
  5. doi request reprint The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Sakyo ku, Kyoto, Japan
    Heart 98:152-61. 2012
    ..The pathophysiological significance of cardiac and plasma levels of non-glycosylated (nonglyNT-BNP) and glycosylated NT-BNP (glyNT-BNP) in heart failure (HF) and chronic renal failure (CRF) was investigated...
  6. pmc Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
    Takeya Minami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    EMBO J 31:4428-40. 2012
    ..Moreover, the MRTF-A inhibitor CCG1423 significantly reduced neointima formation following wire injury in mice. MRTF-A could thus be a novel therapeutic target for the treatment of vascular diseases...
  7. pmc Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
    Shinji Yasuno
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Br J Pharmacol 170:1384-95. 2013
    ....
  8. pmc Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts
    Yoshihiro Kuwabara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Heart Assoc 2:e000150. 2013
    ..Still, the role of induced HCN channel expression in the enhanced arrhythmicity associated with heart failure and the capacity of HCN channel blockade to prevent lethal arrhythmias remains undetermined...
  9. doi request reprint Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
    Leo Hata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 50:972-81. 2011
    ..Collectively, these results suggest that Zfp90 functions as a negative regulator of NRSF and contributes to genetic remodeling during the development of cardiac dysfunction...
  10. ncbi request reprint Transcriptional regulation of the fetal cardiac gene program
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Pharmacol Sci 119:198-203. 2012
    ..In this review we will summarize what is currently known about the transcriptional regulation of the fetal cardiac gene program...