Toshio Nishikimi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites
    Toshio Nishikimi
    Department of Cardiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Japan
    Am J Physiol Regul Integr Comp Physiol 309:R639-49. 2015
  2. ncbi request reprint Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Protein Pept Sci 14:256-67. 2013
  3. pmc Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e53233. 2013
  4. doi request reprint Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Cardiol 57:131-40. 2011
  5. doi request reprint Diverse molecular forms of plasma B-type natriuretic peptide in heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Heart Fail Rep 8:140-6. 2011
  6. doi request reprint The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Sakyo ku, Kyoto, Japan
    Heart 98:152-61. 2012
  7. ncbi request reprint Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321 0293, Japan
    J Hypertens 25:1053-63. 2007
  8. ncbi request reprint Chronic effect of combined treatment with omapatrilat and adrenomedullin on the progression of heart failure in rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 19:1039-48. 2006
  9. ncbi request reprint Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 66:104-13. 2005
  10. doi request reprint Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats
    Shogo Koshikawa
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    J Hypertens 26:1837-48. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites
    Toshio Nishikimi
    Department of Cardiology, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Japan
    Am J Physiol Regul Integr Comp Physiol 309:R639-49. 2015
    ..The level of proBNP processing is lower in humans than rats, most likely due to the smaller distance between the O-glycosylation and cleavage sites in humans. ..
  2. ncbi request reprint Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Protein Pept Sci 14:256-67. 2013
    ..We also describe the clinical application of AM in cardiovascular disease from the viewpoints of diagnosis and treatment. ..
  3. pmc Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e53233. 2013
    ..It is important to know the exact levels of proBNP in heart failure, because elevation of the low-activity proBNP may be associated with the development of heart failure...
  4. doi request reprint Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Cardiol 57:131-40. 2011
    ..In this review we discuss recent progress in our understanding of the biochemistry, molecular biology and clinical relevance of the natriuretic peptide system...
  5. doi request reprint Diverse molecular forms of plasma B-type natriuretic peptide in heart failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Heart Fail Rep 8:140-6. 2011
    ..A new hypothesis that O-glycosylation at Thr71 in a region close to the cleavage site impairs proBNP-108 processing was proposed. In the future, the precise mechanism of increased proBNP-108 in HF should be elucidated...
  6. doi request reprint The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Sakyo ku, Kyoto, Japan
    Heart 98:152-61. 2012
    ..The pathophysiological significance of cardiac and plasma levels of non-glycosylated (nonglyNT-BNP) and glycosylated NT-BNP (glyNT-BNP) in heart failure (HF) and chronic renal failure (CRF) was investigated...
  7. ncbi request reprint Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321 0293, Japan
    J Hypertens 25:1053-63. 2007
    ..We also attempted to elucidate the mechanisms involved...
  8. ncbi request reprint Chronic effect of combined treatment with omapatrilat and adrenomedullin on the progression of heart failure in rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 19:1039-48. 2006
    ..This study examined the effects of long-term treatment with a vasopeptidase inhibitor plus adrenomedullin in a model of heart failure in rats and assessed potential mechanisms of action...
  9. ncbi request reprint Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 66:104-13. 2005
    ..We studied the effects of interleukin 1-beta (IL-1beta) on the adrenomedullin system in cardiac fibroblasts and also examined the pathophysiological significance of such effects...
  10. doi request reprint Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats
    Shogo Koshikawa
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    J Hypertens 26:1837-48. 2008
    ..In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved...
  11. ncbi request reprint Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Regul Pept 124:89-98. 2005
    ..We investigated the pathophysiological role of the renal adrenomedullin (AM) system, including the ligand, receptor, and amidating activity, in severe hypertensive rats...
  12. ncbi request reprint Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertension 42:1034-41. 2003
    ....
  13. ncbi request reprint Upregulation of ligand, receptor system, and amidating activity of adrenomedullin in left ventricular hypertrophy of severely hypertensive rats: effects of angiotensin-converting enzyme inhibitors and diuretic
    Xin Wang
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    J Hypertens 21:1171-81. 2003
    ..We investigated the pathophysiological role of the cardiac adrenomedullin (AM) system, including the ligand, receptor and amidating activity in the hypertrophied heart in severe hypertension...
  14. ncbi request reprint Different secretion patterns of two molecular forms of cardiac adrenomedullin in pressure- and volume-overloaded human heart failure
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine and Department of Thoracic Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Card Fail 10:321-7. 2004
    ..In this study, we investigated the differences of the concentrations of cardiac AM between pressure-overloaded (PO) heart failure (HF) and volume-overloaded (VO)-HF in humans...
  15. ncbi request reprint Altered gene expression of adrenomedullin and its receptor system and molecular forms of tissue adrenomedullin in left ventricular hypertrophy induced by malignant hypertension
    Kazuyoshi Tadokoro
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Regul Pept 112:71-8. 2003
    ..Considering that AM serves as a local antihypertrophic autocrine and/or paracrine factor, the induction of AM system observed here may modulate the pathophysiology of LV hypertrophy in certain forms of malignant hypertension...
  16. ncbi request reprint Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats
    Yayoi Ishikawa
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 47:1075-83. 2006
    ..These renoprotective effects are associated with inhibition of extracellular matrix gene expression, monocyte/macrophage infiltration, oxidative stress, and upregulation of eNOS gene expression...
  17. ncbi request reprint Renoprotective effect of long-term combined treatment with adrenomedullin and omapatrilat in hypertensive rats
    Kimihiko Ishimura
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Hypertens 23:2287-96. 2005
    ..We have recently shown that the long-term administration of AM has renoprotective effects...
  18. ncbi request reprint Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Japan
    Circ J 73:892-8. 2009
    ..The present study was designed to examine whether long-term AM + human atrial natriuretic peptide (hANP) administration can be used as a therapeutic drug in patients with acute decompensated heart failure (ADHF) in clinical setting...
  19. ncbi request reprint Ventricular adrenomedullin system in the transition from LVH to heart failure in rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertension 41:512-8. 2003
    ..These results suggest that induction of the cardiac AM system, including the ligand, receptor, and amidating activity, may modulate pathophysiology during the transition from LVH to HF in this model...
  20. doi request reprint Role of adrenomedullin system in lipid metabolism and its signaling mechanism in cultured adipocytes
    Chikako Iemura-Inaba
    Dept of Hypertension and Cardiorenal Medicine, Dokkyo Univ School of Medicine, Mibu, Tochigi 321 0293, Japan
    Am J Physiol Regul Integr Comp Physiol 295:R1376-84. 2008
    ..These results indicate that AM and its receptor component are highly expressed in cultured adipocytes and may play a role in lipid metabolism via a different signaling pathway...
  21. doi request reprint Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Regul Pept 154:44-53. 2009
    ..This study was designed to examine whether natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system attenuates renal fibrosis in a unilateral ureteral obstruction (UUO) model and also examined the mechanism involved...
  22. ncbi request reprint Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Hypertens 22:1787-96. 2004
    ..The present study was designed to clarify whether the Rho-Rho-kinase pathway is involved in the process of hypertensive glomerulosclerosis and to assess the therapeutic effect of fasudil, a specific Rho-kinase inhibitor...
  23. doi request reprint Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Yosuke Takeda
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Hypertens Res 33:965-73. 2010
    ....
  24. ncbi request reprint Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Pharmacol Sci 100:22-8. 2006
    ....
  25. ncbi request reprint Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts
    Yoshiyuki Hattori
    Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Diabetes 56:804-8. 2007
    ..Thus, rather than having an antihypertrophic effect, gAd might contribute to the activation of myocardium signaling, leading to myocardial hypertrophy...
  26. ncbi request reprint Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Eur J Pharmacol 453:175-81. 2002
    ..These results suggest that cerivastatin directly attenuates cardiac hypertrophy induced by endothelin in cultured rat myocytes partly by inhibition of the Rho pathway...
  27. doi request reprint Stimulatory and Inhibitory regulation of lipolysis by the NPR-A/cGMP/PKG and NPR-C/G(i) pathways in rat cultured adipocytes
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Regul Pept 153:56-63. 2009
    ..This study was designed to investigate the levels of natriuretic receptor-A (NPR-A) and NPR-C gene expression during the process of preadipocyte differentiation and its role in adipogenesis and lipid metabolism...
  28. pmc The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis
    Yasuaki Nakagawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 9:e92314. 2014
    ..We therefore investigated the effects of high performance dialysis on measured levels of glycosylated proBNP, glycosylated NT-proBNP and other BNP-related peptides in end-stage renal disease (ESRD) patients on hemodialysis...
  29. ncbi request reprint Source of plasma adrenomedullin in patients with pheochromocytoma
    Junichi Minami
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Am J Hypertens 15:994-7. 2002
    ..The present results appear to be consistent with the hypothesis that the source of circulating AM is systemic vasculature...
  30. doi request reprint The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy
    Chinatsu Yamada
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Cardiovasc Res 109:162-73. 2016
    ..This mouse model exhibits progressive cardiac dysfunction leading to lethal arrhythmias...
  31. ncbi request reprint Association of plasma atrial natriuretic peptide, N-terminal proatrial natriuretic peptide, and brain natriuretic peptide levels with coronary artery stenosis in patients with normal left ventricular systolic function
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Med 116:517-23. 2004
    ....
  32. ncbi request reprint Activation of AMP-activated protein kinase enhances angiotensin ii-induced proliferation in cardiac fibroblasts
    Yoshiyuki Hattori
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertension 47:265-70. 2006
    ..Our findings indicate that AMPK works as a stimulator of the Ang II-induced proliferative pathway in cardiac fibroblasts. Inhibition of AMPK signaling might serve as a new therapeutic target of remodeling of the hypertrophic myocardium...
  33. ncbi request reprint Long-term adrenomedullin infusion improves survival in malignant hypertensive rats
    Yosuke Mori
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 40:107-13. 2002
    ..These results suggest that subdepressor dose of chronic adrenomedullin infusion has renoprotective effects in this malignant hypertension model, at least in part, via inhibition of the circulating and intrarenal renin-angiotensin system...
  34. doi request reprint Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure
    Yuko Yamada
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan Department of Peptide Research, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Cardiovasc Res 104:183-93. 2014
    ..We have investigated the ability of NCC blockade to prevent lethal arrhythmias associated with heart failure...
  35. pmc Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
    Takeya Minami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    EMBO J 31:4428-40. 2012
    ..Moreover, the MRTF-A inhibitor CCG1423 significantly reduced neointima formation following wire injury in mice. MRTF-A could thus be a novel therapeutic target for the treatment of vascular diseases...
  36. ncbi request reprint Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Hypertens 20:2475-85. 2002
    ..Thus, we evaluated whether aminoguanidine (AG), a selective iNOS inhibitor, protects against cardiac dysfunction and vascular remodeling in DS rats receiving a high-salt diet...
  37. pmc Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts
    Yoshihiro Kuwabara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Heart Assoc 2:e000150. 2013
    ..Still, the role of induced HCN channel expression in the enhanced arrhythmicity associated with heart failure and the capacity of HCN channel blockade to prevent lethal arrhythmias remains undetermined...
  38. ncbi request reprint The role of natriuretic peptides in cardioprotection
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 69:318-28. 2006
    ..In a clinical setting, human recombinant ANP and BNP may be used for a therapy of heart failure; however, further evaluation is required in the future...
  39. pmc Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
    Shinji Yasuno
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Br J Pharmacol 170:1384-95. 2013
    ....
  40. doi request reprint Greater expression of inflammatory cytokines, adrenomedullin, and natriuretic peptide receptor-C in epicardial adipose tissue in coronary artery disease
    Ikuko Shibasaki
    Department of Cardiothoracic Surgery and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Regul Pept 165:210-7. 2010
    ....
  41. ncbi request reprint Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Curr Med Chem Cardiovasc Hematol Agents 3:231-42. 2005
    ..We observed profound and sustained cardiovascular, hormonal and renal effects. These effects may incorporate many of the therapeutic goals of heart failure management...
  42. ncbi request reprint Transcriptional regulation of the fetal cardiac gene program
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Pharmacol Sci 119:198-203. 2012
    ..In this review we will summarize what is currently known about the transcriptional regulation of the fetal cardiac gene program...
  43. ncbi request reprint Multiple left ventricular diverticula detected by second harmonic imaging: a case report
    Masaki Takahashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Circ J 67:972-4. 2003
    ..Enhancement of the left ventricular endocardial borders by second harmonic imaging is useful for the diagnosis of left ventricular diverticula...
  44. ncbi request reprint Effects of smoking cessation or alcohol restriction on metabolic and fibrinolytic variables in Japanese men
    Junichi Minami
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Clin Sci (Lond) 103:117-22. 2002
    ....
  45. ncbi request reprint [Molecular target drug for hypertension and cardiovascular disease]
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 68:1911-6. 2010
    ....
  46. ncbi request reprint Adrenomedullin in the kidney-renal physiological and pathophysiological roles
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, 321 0293 Japan
    Curr Med Chem 14:1689-99. 2007
    ..This review describes the biochemistry, physiology, and circulating levels of AM and also discusses what is known about the pathophysiological role of AM in renal disease...
  47. doi request reprint Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
    Leo Hata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 50:972-81. 2011
    ..Collectively, these results suggest that Zfp90 functions as a negative regulator of NRSF and contributes to genetic remodeling during the development of cardiac dysfunction...
  48. ncbi request reprint Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 39:1077-82. 2002
    ....
  49. ncbi request reprint Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Clin Sci (Lond) 102:669-77. 2002
    ..Considering that AM has positive inotropic, coronary vasodilatory and anti-remodelling actions, increased cardiac AM may play a compensatory role in the ischaemic and failing myocardium...
  50. doi request reprint Right atrial abnormalities in a patient with arrhythmogenic right ventricular cardiomyopathy without ventricular tachycardia
    Naoki Takemura
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    J Cardiol 51:205-9. 2008
    ..Microscopic examination of the RV indicated fibrofatty myocardium. Atrial arrhythmias associated with SSS may be the cause of symptoms in some cases of ARVC...
  51. ncbi request reprint [Clinical significance of BNP as a biomarker for cardiac disease--from a viewpoint of basic science and clinical aspect]
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 70:774-84. 2012
    ..Although more than twenty years have passed since its discovery, recent studies have shown the new findings in BNP research. I describe here the recent advance of BNP research...