K Nishida

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. ncbi Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Am J Pathol 154:331-6. 1999
  2. ncbi Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Am J Hum Genet 61:1268-75. 1997
  3. ncbi Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 126:535-42. 1998
  4. ncbi Gelatino-lattice corneal dystrophy: clinical features and mutational analysis
    T Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Ophthalmol 129:665-6. 2000
  5. ncbi Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease
    T Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan
    Invest Ophthalmol Vis Sci 42:549-56. 2001
  6. ncbi Differential expression of MUC16 in human oral mucosal epithelium and cultivated epithelial sheets
    Y Hori
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Exp Eye Res 87:191-6. 2008
  7. ncbi Apolipoprotein J expression in human ocular surface epithelium
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Invest Ophthalmol Vis Sci 37:2285-92. 1996
  8. ncbi Characteristics of the human ocular surface epithelium
    S Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 645 Kajii cho, Hirokoji Kawaramachi, Kamigyo ku, Kyoto 602 0841, Japan
    Prog Retin Eye Res 20:639-73. 2001
  9. ncbi Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Am J Ophthalmol 126:169-76. 1998
  10. ncbi Utility of Etest in choosing appropriate agents to treat fungal keratitis
    T Inoue
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Cornea 20:607-9. 2001

Collaborators

Detail Information

Publications43

  1. ncbi Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Am J Pathol 154:331-6. 1999
    ..We speculate that in Stevens-Johnson syndrome, epithelial hyperproliferation, and transglutaminase 1 gene expression lead to the pathological keratinization of ocular surface mucosal epithelia...
  2. ncbi Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Am J Hum Genet 61:1268-75. 1997
    ..Of particular interest, one of these mutations (Tyr429Asp), detected in both affected individuals in one of our pedigrees, is the first mutation to be identified within the alpha-helix-termination motif in type I keratin...
  3. ncbi Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 126:535-42. 1998
    ..To see whether there was a genetic basis for these phenotypic variations, we analyzed beta ig-h3, the gene that codes for kerato-epithelin and that contains a mutation (Arg555Gln) that causes RBCD...
  4. ncbi Gelatino-lattice corneal dystrophy: clinical features and mutational analysis
    T Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Ophthalmol 129:665-6. 2000
    ..To report five unrelated Japanese individuals with "gelatino-lattice corneal dystrophy that clinically resembled, to some extent, gelatinous drop-like corneal dystrophy and lattice corneal dystrophy type 1...
  5. ncbi Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease
    T Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan
    Invest Ophthalmol Vis Sci 42:549-56. 2001
    ..CONCLUSIONS. Various keratinization-related proteins, transglutaminase 1 included, are most likely involved in the pathogenesis of cicatrizing ocular surface diseases...
  6. ncbi Differential expression of MUC16 in human oral mucosal epithelium and cultivated epithelial sheets
    Y Hori
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Exp Eye Res 87:191-6. 2008
    ..MUC16 expressed in the oral mucosal sheets may contribute to ocular surface reconstruction after oral mucosal sheet transplantation...
  7. ncbi Apolipoprotein J expression in human ocular surface epithelium
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Invest Ophthalmol Vis Sci 37:2285-92. 1996
    ..The purpose of this study was to determine the expression and localization pattern of apoJ mRNA transcripts and protein in the human ocular surface epithelium...
  8. ncbi Characteristics of the human ocular surface epithelium
    S Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 645 Kajii cho, Hirokoji Kawaramachi, Kamigyo ku, Kyoto 602 0841, Japan
    Prog Retin Eye Res 20:639-73. 2001
    ....
  9. ncbi Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Am J Ophthalmol 126:169-76. 1998
    ..Three members of the family were affected with a severe placoid type of corneal dystrophy. To determine the relationship between gene mutations and phenotypic variations of the disease, we analyzed the kerato-epithelin gene...
  10. ncbi Utility of Etest in choosing appropriate agents to treat fungal keratitis
    T Inoue
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Cornea 20:607-9. 2001
    ..To evaluate the utility of Etest in choosing the appropriate treatment of fungal keratitis...
  11. ncbi Factors that influence the surgical effects of astigmatic keratotomy after cataract surgery
    T Inoue
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Ophthalmology 108:1269-74. 2001
    ..Adding the amount of preoperative astigmatism to the nomogram and improvement of surgical procedures will be required to obtain better surgical predictability of AK following cataract surgery...
  12. ncbi The effect of TGF-beta1 on differential gene expression profiles in human corneal epithelium studied by cDNA expression array
    S Hayashida-Hibino
    Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Invest Ophthalmol Vis Sci 42:1691-7. 2001
    ..These results strongly suggest that TGF-beta1 is critically involved in the maintenance of the corneal epithelium through the control of a network of various signal-transduction pathways...
  13. ncbi A gene expression profile of human corneal epithelium and the isolation of human keratin 12 cDNA
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Invest Ophthalmol Vis Sci 37:1800-9. 1996
    ..To describe the quantitative and qualitative aspects of gene expression in human corneal epithelium and to discover novel cornea-specific genes...
  14. ncbi Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)
    A Shimizu-Matsumoto
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Genomics 32:121-4. 1996
    ..From these results, we concluded that this clone (HGMW-approved symbol PDE6H) encodes for the gamma subunit of human cone-specific cGMP phosphodiesterase, and it was assigned to chromosome 12p13 by fluorescence in situ hybridization...
  15. ncbi Abnormal keratocytes and stromal inflammation in chronic phase of severe ocular surface diseases with stem cell deficiency
    T Saito
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Br J Ophthalmol 92:404-10. 2008
    ..The purpose of this study was to determine whether the keratocytes in the stroma were normal and whether the stroma remained inflamed in the chronic phase of these diseases...
  16. ncbi Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy
    S Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Cornea 19:551-5. 2000
    ..This investigation attempted to determine the effect of the abnormal M1S1 gene product by assessing epithelial barrier function and epithelial ultrastructure in GDLD corneas...
  17. ncbi Immunohistological study of infiltrated cells and cytokines in murine herpetic keratitis
    T Inoue
    Department of Ophthalmology, Osaka University Medical School, Suita Osaka, Japan
    Acta Ophthalmol Scand 79:484-7. 2001
    ..Together with neutrophils in the early phase of infection, gamma delta positive T cells may play an additional role in protecting the cornea against incoming pathogens...
  18. ncbi Transforming growth factor-beta 1, -beta 2 and -beta 3 mRNA expression in human cornea
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Curr Eye Res 14:235-41. 1995
    ....
  19. ncbi Rationale and design of the KYOTO HEART study: effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high risk of cardiovascular events
    T Sawada
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto, Japan
    J Hum Hypertens 23:188-95. 2009
    ..The KHS will provide new evidence for the management of blood pressure in hypertensive patients with high risk...
  20. ncbi Embolisation of proximal anastomotic pseudoaneurysm developing after surgical repair of abdominal aortic aneurysm with a bifurcated graft with n-butyl cyanoacrylate
    T Yamagami
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chyo, Kawaramachi Hirokoji, Kamigyo, Kyoto, 602 8566, Japan
    Br J Radiol 79:e193-5. 2006
    ....
  21. ncbi Peripheral lamellar keratoplasty for corneoscleral cyst: three case reports
    Y Sano
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto City, Japan
    Cornea 18:233-6. 1999
    ..To examine whether peripheral lamellar keratoplasty (LKP) using preserved cornea was effective for the treatment of corneoscleral cysts...
  22. ncbi Multiple bone lesions after allogeneic bone marrow transplantation in a patient with relapsed adult acute lymphoblastic leukemia: minimal residual disease analysis may predict extramedullary relapse
    K Nomura
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Leuk Lymphoma 42:1305-8. 2001
    ..The patient died of cardiac tamponade on day 236 after Allo-BMT. MRD assessed by PCR assay for TCRdelta gene in the bone marrow is useful for the prediction of extramedullary as well as medullary relapse after BMT...
  23. ncbi Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma
    A Tamura
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirikoji, Kamigyo-ku, Kyoto 602-0841, Japan
    Cancer Genet Cytogenet 129:1-9. 2001
    ..Interphase FISH using specific IGH-translocation probes is valuable for defining clinically meaningful subgroups of B-cell lymphoma...
  24. ncbi Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium
    W Adachi
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan
    Invest Ophthalmol Vis Sci 39:1789-96. 1998
    ..To isolate and characterize a novel cathepsin gene, as part of the systematic isolation of genes uniquely active in corneal epithelium...
  25. ncbi Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene
    T O Akama
    Glycobiology Program, The Burnham Institute, La Jolla, California, USA
    Nat Genet 26:237-41. 2000
    ..In situ hybridization analysis did not detect CHST6 transcripts in corneal epithelium in an MCD type II patient, suggesting that the mutations found in type II lead to loss of cornea-specific expression of CHST6...
  26. ncbi Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer
    Y Sagara
    Department of Breast Oncology, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Br J Cancer 91:959-65. 2004
    ..Therefore, CAV1 and CAV2 play an important role in tumour progression in breast cancer patients...
  27. ncbi Identification of Fabry's disease by the screening of alpha-galactosidase A activity in male and female hemodialysis patients
    M Tanaka
    Department of Nephrology, Akebono Clinic, 5 1 1 Shirafuji, Kumamoto 861 4112, Japan
    Clin Nephrol 64:281-7. 2005
    ..Here we determined the prevalence of Fabry's disease not only in male but also in female HD patients by measuring alpha-Gal A...
  28. ncbi Sulfation patterns of keratan sulfate in different macular corneal dystrophy immunophenotypes using three different probes
    T Saito
    Br J Ophthalmol 92:1434-6. 2008
  29. ncbi Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA
    Y Chinen
    Department of Molecular Laboratory Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kamigyo ku, Kyoto, Japan
    Oncogene 27:2249-56. 2008
    ..Furthermore, we successfully applied bubble PCR to clone the novel AML1-LAF4 fusion transcript. Bubble PCR is a powerful tool for detecting unknown fusion transcripts as well as genomic fusion points...
  30. ncbi Radiculopathy due to microfibrillar collagen hemostat mimicking recurrence of disc herniation
    M Doita
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, 650 0017 Kobe, Japan
    Skeletal Radiol 35:953-5. 2006
    ..When considering a mass lesion arising after spine surgery, the differential diagnosis should include foreign body granuloma along with recurrent disc herniation and peridural scar formation...
  31. ncbi Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors
    K Murayama
    Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Oncogene 26:4882-8. 2007
    ..The progenitor cell population increased consistently in 4OHT-treated transgenic mice. Our results show that PI3K/Akt signaling induces epidermal hyperplasia and proliferation of epidermal progenitors...
  32. ncbi Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat
    K Yamada
    Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science, Sapporo, Japan
    Cytogenet Cell Genet 94:39-42. 2001
    ..4-->q13.5 in human, 7E2 in mouse and 1q33.2-->q33.3 in rat. All human, mouse and rat Gab1 and Gab2 genes were localized to chromosome regions where conserved homology has been identified among the three species...
  33. ncbi Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules
    S Yamasaki
    Molecular Genetics, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Biol Chem 276:45175-83. 2001
    ..These results suggest that Gab2 is a substrate of ZAP-70 and functions as a switch molecule toward inhibition of TCR signal transduction by mediating the recruitment of inhibitory molecules to the TCR signaling complex...
  34. ncbi A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIA
    S Yamamoto
    Am J Hum Genet 62:719-22. 1998
  35. ncbi Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17
    S Osada
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Cytogenet Cell Genet 47:8-10. 1988
    ..Karyotype analysis showed that human chromosome 17 was essential for the expression of CD7 antigen. The presence of this chromosome was confirmed by enzyme analysis of galactokinase, which is coded by a gene on human chromosome 17...
  36. ncbi Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
    K Nishida
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Osaka, Japan
    Blood 93:1809-16. 1999
    ..Overexpression of Gab2 enhanced the gp130 or Src-related kinases-mediated ERK2 activation as that of Gab1 did. These data indicate that Gab-family molecules act as adapters for transmitting various signals...
  37. ncbi Identification of the gene responsible for gelatinous drop-like corneal dystrophy
    M Tsujikawa
    Department of Medical Genetics, Biomedical Research Center, Osaka University Medical School, Japan
    Nat Genet 21:420-3. 1999
    ..Our successful identification of the gene that is defective in GDLD should facilitate genetic diagnosis and potentially treatment of the disease, and enhance general understanding of the mechanisms of amyloidosis...
  38. ncbi Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
    M Itoh
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Cell Biol 20:3695-704. 2000
    ..These results indicate that Gab1 is a common player in a broad range of growth factor and cytokine signaling pathways linking ERK MAP kinase activation...
  39. ncbi Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate
    T O Akama
    Glycobiology Program, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:16271-8. 2001
    ..This observation suggests that mouse intestinal GlcNAc 6-O-sulfotransferase is the orthologue of hCGn6ST and functions as a sulfotransferase to produce keratan sulfate in the cornea...
  40. ncbi Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma
    S Kimura
    Division of Hematology, Kyoto Second Red Cross Hospital, Japan
    Ann Hematol 80:228-31. 2001
    ..The karyotype was described as 45, XY, der(1)t(1;20)(p32;q11.2), der(6) (1pter-->1p32:: 6p21.1-->6q13:: 7q11.2-->7qter), der(7) t(7;20)(q11.2;q11.2), t(13;14)(q14;q32), der(13)t(6;13) (p21.1; q14), -20...
  41. ncbi Transabdominal approach for intrapelvic migration of a total hip prosthesis component
    A Tazawa
    Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
    J Orthop Sci 6:362-5. 2001
    ..We concluded that the transabdominal approach was a useful approach for removing a severely migrated acetabular component...
  42. ncbi Isolation of chlamydia psittaci from domestic cats with oculonasal discharge in Japan
    K Iwamoto
    Kyoto Biken Laboratories, Inc, Uji, Japan
    J Vet Med Sci 63:937-8. 2001
    ..Comparison of nucleotide sequences of the ompA gene amplified from the three isolates with the published sequence of feline FEPN strain of C. psittaci showed almost 100% homology...
  43. ncbi The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia
    K Otsu
    First Department of Medicine, Osaka University Medical School, Japan
    J Biol Chem 269:9413-5. 1994
    ..These results provide definite evidence that a single amino acid mutation, Arg615-->Cys, in the ryanodine receptor is causative of MH...