Shuh Narumiya

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
    Tomoko Moriyama
    Dept of Cellular and Molecular Physiology, Mie University School of Medicine, Mie 514 8507, Japan
    Mol Pain 1:3. 2005
  2. pmc The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke
    Muzamil Ahmad
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, 21205, USA
    Exp Transl Stroke Med 2:12. 2010
  3. ncbi request reprint Rho effectors and reorganization of actin cytoskeleton
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo, Japan
    FEBS Lett 410:68-72. 1997
  4. ncbi request reprint Prostanoids in immunity: roles revealed by mice deficient in their receptors
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, 606 8501, Kyoto, Japan
    Life Sci 74:391-5. 2003
  5. ncbi request reprint Rho GTPases in animal cell mitosis
    Shuh Narumiya
    Department of Pharmacology and Horizontal Medical Research Organization, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Curr Opin Cell Biol 18:199-205. 2006
  6. doi request reprint Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, 606 8501, Japan
    Cancer Metastasis Rev 28:65-76. 2009
  7. doi request reprint Prostanoids and inflammation: a new concept arising from receptor knockout mice
    Shuh Narumiya
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Mol Med (Berl) 87:1015-22. 2009
  8. ncbi request reprint A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Cell Cycle 3:855-7. 2004
  9. ncbi request reprint Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia
    Koji Takayama
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Nat Med 11:562-6. 2005
  10. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010

Detail Information

Publications115 found, 100 shown here

  1. pmc Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
    Tomoko Moriyama
    Dept of Cellular and Molecular Physiology, Mie University School of Medicine, Mie 514 8507, Japan
    Mol Pain 1:3. 2005
    ..Thus, the potentiation or sensitization of TRPV1 activity through EP1 or IP activation might be one important mechanism underlying the peripheral nociceptive actions of PGE2 or PGI2...
  2. pmc The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke
    Muzamil Ahmad
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, 21205, USA
    Exp Transl Stroke Med 2:12. 2010
    ....
  3. ncbi request reprint Rho effectors and reorganization of actin cytoskeleton
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo, Japan
    FEBS Lett 410:68-72. 1997
    ..p160ROCK induces focal adhesions and stress fibers by activating integrin and clustering them by the use of myosin-based contractility...
  4. ncbi request reprint Prostanoids in immunity: roles revealed by mice deficient in their receptors
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, 606 8501, Kyoto, Japan
    Life Sci 74:391-5. 2003
    ..Here I summarize our findings obtained by these and other studies. These findings suggest that selective manipulation of the prostanoid receptors may be beneficial in treatment of certain immunological disorders...
  5. ncbi request reprint Rho GTPases in animal cell mitosis
    Shuh Narumiya
    Department of Pharmacology and Horizontal Medical Research Organization, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Curr Opin Cell Biol 18:199-205. 2006
    ..Recent work indicates that they may function during both spindle orientation and chromosome congression. However, their involvement is cell-type-specific, raising arguments for and against a mitotic role for Rho GTPases...
  6. doi request reprint Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, 606 8501, Japan
    Cancer Metastasis Rev 28:65-76. 2009
    ..Thus, Rho mediates various phenotypes of malignant transformation by Ras and Src through its effectors, ROCK and mDia...
  7. doi request reprint Prostanoids and inflammation: a new concept arising from receptor knockout mice
    Shuh Narumiya
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Mol Med (Berl) 87:1015-22. 2009
    ..Thus, a new concept on the role of prostanoids in inflammation has arisen from studies using the receptor knockout mice...
  8. ncbi request reprint A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Cell Cycle 3:855-7. 2004
    ..We also discuss redundancy of dc42 and Cdc42-related GTPase(s) and potential mechanisms of chromosome instability in cancer...
  9. ncbi request reprint Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia
    Koji Takayama
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Nat Med 11:562-6. 2005
    ..Our results show that inflammatory tachycardia is caused by a direct action on the heart of TXA(2) and PGF(2alpha) formed under systemic inflammatory conditions...
  10. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ....
  11. ncbi request reprint Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor
    Akiyoshi Hara
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Circulation 112:84-92. 2005
    ..However, their roles in cardiac hypertrophy in vivo remain unknown. We intended to clarify the roles of these receptors in pressure overload-induced cardiac hypertrophy using mice lacking each of their receptors...
  12. pmc Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression
    Kitipong Soontrapa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:6668-73. 2011
    ..Thus, prostaglandin E(2) (PGE(2))-EP4 signaling mediates UV-induced immunosuppression by elevating the number of Treg cells through regulation of RANKL expression in the epidermis...
  13. pmc Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
    Takayuki Fujino
    Department of Pharmacology, Asahikawa Medical College, Japan
    J Clin Invest 114:805-12. 2004
    ..These results indicate that PGI2 derived from COX-2 plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo...
  14. pmc Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
    Fabian Oceguera-Yanez
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Cell Biol 168:221-32. 2005
    ..These results suggest that Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis...
  15. doi request reprint A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors
    Ryota Shinohara
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nat Neurosci 15:373-80, S1-2. 2012
    ..These results suggest that Rho signaling via mDia and ROCK critically regulates nuclear translocation through F-actin dynamics in tangential migration, whereas this mechanism is dispensable in radial migration...
  16. doi request reprint Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation
    Kanako Hosono
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, 228 8555, Japan
    Arterioscler Thromb Vasc Biol 31:1049-58. 2011
    ..However, it remains unknown whether they enhance lymphangiogenesis. We examined the roles of cyclooxygenase-2 (COX-2) and PGE2 receptor signaling in enhancement of lymphangiogenesis during proliferative inflammation...
  17. pmc Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
    Miyako Nagamachi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Exp Med 204:2865-74. 2007
    ..These results suggest that PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation...
  18. pmc Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells
    Yoshikazu Ando
    Department of Pharmacology and Horizontal Medical Research Organization, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Mol Biol Cell 18:3752-63. 2007
    ..These results suggest that Rho GTPases function in G2/M transition of mammalian cells by mediating multiple signaling pathways converging to centrosomal activation of Aurora-A...
  19. pmc COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems
    Hiroshi Katoh
    Department of Pharmacology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Am J Pathol 176:1469-83. 2010
    ....
  20. doi request reprint Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Pharmacol Exp Ther 325:601-9. 2008
    ..These results clearly indicate that the PGI(2)-IP system together with the complement system plays a key role in exudate formation in zymosan-induced pleurisy...
  21. doi request reprint Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells
    Hideaki Tanizaki
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Blood 116:5875-84. 2010
    ..These results suggest that actin polymerization, which is mediated by mDia1, is essential for several aspects of DC-initiated acquired immune responses...
  22. pmc mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion
    Masahiro Tanji
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 30:4604-15. 2010
    ..Given overexpression of c-Src in various cancers, these findings suggest that Rho-mDia1 signaling facilitates malignant transformation and invasion by manipulating the actin cytoskeleton and targeting Src to the cell periphery...
  23. pmc Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice
    Kohei Tanaka
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurosci 32:4319-29. 2012
    ..Taken together, our data suggest that PGE(2)-EP1 signaling is critical for susceptibility to repeated social defeat stress in mice through attenuation of mesocortical dopaminergic pathway...
  24. ncbi request reprint Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
    Tomonori Kunikata
    Department of Pharmacology and Faculty of Medicine and Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nat Immunol 6:524-31. 2005
    ..Thus, the PGE(2)-EP3 pathway is an important negative modulator of allergic reactions...
  25. ncbi request reprint Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
    ..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
  26. ncbi request reprint Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats
    Takayoshi Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Hypertension 42:1183-90. 2003
    ..This study opens a novel therapeutic potential of selective blockade of EP1 for the treatment of hypertensive renal disease...
  27. ncbi request reprint Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells
    Xin Zhuge
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 351:865-71. 2006
    ..These results indicate that the protection of atherogenesis in TP(-/-) mice is not associated with TP in BM-derived cells...
  28. ncbi request reprint ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
    Dean Thumkeo
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 10:825-34. 2005
    ..Consistently, ROCK-I(+/-)ROCK-II(+/-) double heterozygous mice also show the EOB and omphalocele phenotype...
  29. doi request reprint Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta
    Toru Oga
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Nat Med 15:1426-30. 2009
    ..These findings show that PGF(2alpha)-FP signaling facilitates pulmonary fibrosis independently of TGF-beta and suggests this signaling pathway as a therapeutic target for IPF...
  30. doi request reprint Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
    Hidefumi Kubo
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biomed Pharmacother 64:101-6. 2010
    ..Host EP3 blockade together with COX-2 inhibition may be a novel therapeutic strategy to suppress tumor-associated lymphangiogenesis...
  31. pmc Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 100:4132-7. 2003
    ..These findings suggest that EP1- and EP3-mediated neuronal pathways converge at corticotropin-releasing hormone-containing neurons in the PVN to induce HPA axis activation upon sickness...
  32. pmc mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells
    Sadanori Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Mol Biol Cell 19:2328-38. 2008
    ..These results demonstrate that mDia2 is essential in mammalian cell cytokinesis and that mDia2-induced F-actin forms a scaffold for the contractile ring and maintains its position in the middle of a dividing cell...
  33. pmc Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
    Tetsuya Honda
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Exp Med 203:325-35. 2006
    ..Our results show significant roles of both PGI2-IP and PGE2-EP2/EP4 signaling in the development of CIA, and suggest that inhibition of PGE2 synthesis alone may not be sufficient for suppression of RA symptoms...
  34. doi request reprint mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism
    Takashi Miki
    Department of Pharmacology and Frontier Technology Center, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 284:5753-62. 2009
    ..These results suggest that mDia2 continuously shuttles between the nucleus and the cytoplasm using specific nuclear transport machinery composing of importin-alpha/beta and CRM1...
  35. pmc ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
    ..These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles...
  36. ncbi request reprint Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan
    Lab Invest 87:49-55. 2007
    ..These data suggest that PGE(2)-EP2/EP4 signaling is mandatory in UV-induced acute skin inflammation, presumably by enhancing blood flow in the microenvironment...
  37. ncbi request reprint Cdc42 and mDia3 regulate microtubule attachment to kinetochores
    Shingo Yasuda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nature 428:767-71. 2004
    ..We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores...
  38. doi request reprint Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis
    Hideki Amano
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Cancer Sci 100:2318-24. 2009
    ..An EP3 receptor antagonist may be useful to protect against tumor metastasis...
  39. doi request reprint The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice
    Naoki Nakagawa
    Department of Pharmacology, Asahikawa Medical University, Asahikawa, Japan
    Kidney Int 82:158-71. 2012
    ..Hence, an endogenous PGE(2)-EP(4) system in the tubular epithelium limits the development of tubulointerstitial fibrosis by suppressing inflammatory responses...
  40. doi request reprint Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization
    Satoko Sakamoto
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cell Sci 125:108-20. 2012
    ..Thus, Liprin-α negatively regulates the activity of mDia in the cell by displacing it from the plasma membrane through binding to the DID-DD region...
  41. ncbi request reprint Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4
    Chun Yang Xiao
    Department of Pharmacology, Asahikawa Medical College, Japan
    Circulation 109:2462-8. 2004
    ..The role of PGE2 in cardiac ischemia-reperfusion (I/R) injury, however, remains unknown. We intended to clarify the role of PGE2 via EP4, an EP subtype, in I/R injury using mice lacking EP4 (EP4-/- mice)...
  42. pmc Rho and anillin-dependent control of mDia2 localization and function in cytokinesis
    Sadanori Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Mol Biol Cell 21:3193-204. 2010
    ....
  43. pmc Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons
    Yoshiki Arakawa
    Dept of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8315, Japan
    J Cell Biol 161:381-91. 2003
    ..Furthermore, RNAi knockdown of mDia1 abolished SDF-1alpha-induced axon elongation. Together, our results support a critical role for an SDF-1alpha/Rho/mDia1 pathway in mediating axon elongation...
  44. doi request reprint Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity
    Tetsuya Honda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 124:809-18.e2. 2009
    ..Although EP(3) is also expressed in skin and PGE(2) is produced abundantly during skin allergic inflammation, the role of PGE(2)-EP(3) signaling in skin allergic inflammation remains unknown...
  45. pmc The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src
    Norikazu Yamana
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Mol Cell Biol 26:6844-58. 2006
    ..Thus, the Rho-mDia1 pathway regulates polarization and adhesion turnover by aligning microtubules and actin filaments and delivering Apc/Cdc42 and c-Src to their respective sites of action...
  46. doi request reprint Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity
    Saeko Nakajima
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Immunol 184:5595-603. 2010
    ..These results suggest that PGI(2)-IP signaling promotes Th1 differentiation through a cAMP-protein kinase A pathway and thereby initiates acquired cutaneous immune responses...
  47. ncbi request reprint Thromboxane A2 regulates vascular tone via its inhibitory effect on the expression of inducible nitric oxide synthase
    Takehiro Yamada
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Circulation 108:2381-6. 2003
    ..Details of the cross talk between thromboxane (TX) A2 and the iNOS-NO system, however, remain unknown. We intended to clarify the role of TXA2, via the cross talk, in vascular hyporesponsiveness...
  48. doi request reprint Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis
    Takako Hirata
    Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Int Immunol 24:705-17. 2012
    ..Our findings identify a previously unknown, non-redundant function of moesin in lymphocyte homeostasis in regulating lymphocyte egress from lymphoid organs...
  49. pmc Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia
    Dean Thumkeo
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    PLoS ONE 6:e25465. 2011
    ....
  50. doi request reprint Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake
    Tomoyuki Mitsumori
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Eur J Neurosci 34:594-604. 2011
    ..These data suggest that TP stimulation in the striatum locally facilitates dopamine overflow evoked by synaptic inputs via NO synthesis in endothelial cells...
  51. pmc Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis
    Emi Kamoshita
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Am J Pathol 169:1458-72. 2006
    ..These results indicate that the recruitment of EP3-expressing cells to wound granulation tissues is critical for surgical wound healing and angiogenesis via up-regulation of VEGF...
  52. ncbi request reprint Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice
    Koichi Nagao
    Department of Pharmacology, Gifu Pharmaceutical University, Japan
    Am J Respir Cell Mol Biol 29:314-20. 2003
    ....
  53. pmc Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1
    Daiji Sakata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Exp Med 204:2031-8. 2007
    ..Similarly, mDia1(-/-) thymocytes showed reduced chemotaxis and impaired egression from the thymus. These results suggest that mDia1 plays a distinct role in chemotaxis in T lymphocyte trafficking...
  54. doi request reprint Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    Chengcan Yao
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 15:633-40. 2009
    ..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
  55. doi request reprint Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth
    Yasuhumi Ogawa
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 382:720-5. 2009
    ..The present study suggests that the blockade of EP3 signaling and the recruitment of EP3-expressing stromal cells may become a novel strategy to treat solid tumors...
  56. ncbi request reprint Measurement of activity of rho GTPases during mitosis
    Fabian Oceguera-Yanez
    Department of Pharmacology, Kyoto University, Faculty of Medicine, Japan
    Methods Enzymol 406:332-45. 2006
    ..These results suggest that Rho GTPases are activated at specific points in mitosis and regulate each step. Here we describe the methods to analyze the activity and regulation of Rho GTPases during mitosis...
  57. pmc Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis
    James Monypenny
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yosida Konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 29:2730-47. 2009
    ....
  58. pmc Prostaglandin E receptor EP1 controls impulsive behavior under stress
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:16066-71. 2005
    ..These results suggest that prostaglandin E(2) acts through EP1 to control impulsive behavior under stress, a finding potentially exploitable for development of drugs that attenuate impulsive behavior in humans...
  59. pmc Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth
    Hideki Amano
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa 228 8555, Japan
    J Exp Med 197:221-32. 2003
    ..These results demonstrate significance of host stromal PGE(2)-EP3 receptor signaling in tumor development and angiogenesis. An EP3 receptor antagonist may be a candidate of chemopreventive agents effective for malignant tumors...
  60. doi request reprint Prostaglandins and chronic inflammation
    Tomohiro Aoki
    Department of Pharmacology, Kyoto University Graduate School of Medicine, and Core Research for Evolutional Science and Technology CREST, Kyoto 606 8501, Japan
    Trends Pharmacol Sci 33:304-11. 2012
    ..Although such roles of PGs should be verified in human diseases, these findings suggest that PG signaling is a promising therapeutic target of chronic inflammatory diseases...
  61. pmc Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing
    Takushi Miyoshi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 175:947-55. 2006
    ..We predict that filament severing and end-to-end annealing might take place fairly frequently in the dendritic nucleation actin arrays...
  62. doi request reprint Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 123:466-71. 2009
    ..We previously demonstrated that the prostaglandin E(2) (PGE(2))-EP3 pathway negatively regulates allergic reactions in a murine allergic asthma model...
  63. pmc Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death
    Dean Thumkeo
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 23:5043-55. 2003
    ....
  64. doi request reprint Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum
    Yasuhiro Tanaka
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Eur J Neurosci 30:2338-46. 2009
    ..Therefore, the prostaglandin E(2)-EP1 signaling directly enhances GABAergic inputs to SNc dopaminergic neurons. The lack of this EP1 action may lead to a hyperdopaminergic state of EP1-deficient mice...
  65. ncbi request reprint Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Immunol 4:694-701. 2003
    ..Similar immune responses were seen in wild-type mice treated with a TP antagonist during the sensitization period. Thus, TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions...
  66. doi request reprint Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment
    Tsutomu Minamino
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 252 0374, Japan
    Toxicol Appl Pharmacol 259:104-14. 2012
    ....
  67. doi request reprint G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers
    Chiharu Higashida
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 121:3403-12. 2008
    ..Taken together, we propose that transient accumulation of G-actin works as a cue to promote mDia1-catalyzed actin nucleation to execute rapid reassembly of actin filaments...
  68. doi request reprint Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling
    Jun ichi Kawabe
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Arterioscler Thromb Vasc Biol 30:464-70. 2010
    ..We evaluated whether prostaglandin I(2) plays a role in the regulation of the function of EPCs to limit vascular remodeling...
  69. ncbi request reprint Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, Japan
    J Pharmacol Exp Ther 311:1218-24. 2004
    ..These results demonstrate participation of EP2 and EP3 along with IP in pleural exudate formation but not in leukocyte migration in carrageenin-induced mouse pleurisy...
  70. doi request reprint Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan
    Pharmacol Ther 129:195-205. 2011
    ..Roles of prostanoids in the generation of inflammatory tachycardia and the regulation of platelet function have also been clarified. In this review, we summarize these roles of prostanoids revealed from knockout mouse studies...
  71. doi request reprint Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling
    Shigero Tamba
    Department of Physiological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Biochimie 92:665-75. 2010
    ....
  72. pmc RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly
    Rieko Yodoi
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Endocrinology 150:3345-52. 2009
    ..Based on these results, we propose that prostaglandin E(2)-EP2 signaling negatively regulates chemokine-induced Rho/ROCK signaling in cumulus cells for successful fertilization...
  73. pmc Augmentation of allergic inflammation in prostanoid IP receptor deficient mice
    Yoshimasa Takahashi
    Department of Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Br J Pharmacol 137:315-22. 2002
    ..These findings suggest a regulatory role of PGI(2) in allergic inflammation...
  74. doi request reprint Emerging roles of prostanoids in T cell-mediated immunity
    Daiji Sakata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    IUBMB Life 62:591-6. 2010
    ..These findings shed a new light on the roles of prostanoids in T cell-mediated immunity and immune diseases...
  75. doi request reprint Roles of prostaglandin E receptors in stress responses
    Tomoyuki Furuyashiki
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Curr Opin Pharmacol 9:31-8. 2009
    ..In addition, EP1 controls impulsive behaviors under psychological stress through the dopaminergic system. PGE(2) produced by various cell types may integrate multiple stress stimuli through PGE receptor subtypes for adaptive responses...
  76. ncbi request reprint Function of prostanoid receptors: studies on knockout mice
    Takuya Kobayashi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Prostaglandins Other Lipid Mediat 68:557-73. 2002
    ..Here, we review the findings obtained in these studies. The results from these knockout mice studies may be useful in the development of novel therapeutics that can selectively manipulate actions mediated by each receptor...
  77. doi request reprint Stress responses: the contribution of prostaglandin E(2) and its receptors
    Tomoyuki Furuyashiki
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Nat Rev Endocrinol 7:163-75. 2011
    ..Dependent on the type of stress stimuli, PGE(2) released from different cell types activates distinct EP receptors, which mobilize multiple neuronal pathways, resulting in stress responses...
  78. doi request reprint The roles of prostanoids in infection and sickness behaviors
    Toshiyuki Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Infect Chemother 14:270-8. 2008
    ....
  79. ncbi request reprint Prostanoids in health and disease; lessons from receptor-knockout mice
    Takuya Kobayashi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Adv Exp Med Biol 507:593-7. 2002
  80. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response...
  81. ncbi request reprint [The roles of the prostanoids played in the body]
    Fumitaka Ushikubi
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Nihon Yakurigaku Zasshi 119:201-7. 2002
    ..These novel findings on the roles of the prostanoids would contribute to the development of drugs targeting the prostanoid receptors...
  82. ncbi request reprint Prostaglandin E receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:11613-7. 2007
    ..Here we review recent advances in PGE receptor research...
  83. ncbi request reprint Analysis of a mitotic role of Cdc42
    Shingo Yasuda
    Department of Pharmacology, Kyoto University, Faculty of Medicine, Japan
    Methods Enzymol 406:656-65. 2006
    ..Recently, we have found a mitosis-specific role of Cdc42 by enrichment of cells in mitosis by cell cycle synchronization and interfering with functions of Rho GTPases. This chapter describes the procedures we used in these studies...
  84. pmc Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells
    Takayuki Fujino
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Br J Pharmacol 136:530-9. 2002
    ....
  85. pmc Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization
    Shigero Tamba
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Proc Natl Acad Sci U S A 105:14539-44. 2008
    ..This interaction between PG and chemokine signaling is required for successful fertilization...
  86. ncbi request reprint The DP receptor, allergic inflammation and asthma
    Kenji Kabashima
    Faculty of Medicine, 2nd Department of Pharmacology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:187-94. 2003
    ..In this article, we summarize these findings and provide an overview of the current status of the DP receptor research to discuss the therapeutic potential of modulating the PGD(2)-DP pathway in allergic diseases...
  87. doi request reprint Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying
    Sumito Mizuguchi
    Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G1078-86. 2010
    ....
  88. ncbi request reprint [Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors]
    Akiyoshi Hara
    Department of Pharmacology, Asahikawa Medical College, Japan
    Nihon Yakurigaku Zasshi 122:384-90. 2003
    ....
  89. ncbi request reprint Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum
    Shiho Kitaoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    J Neurosci 27:12900-7. 2007
    ..These results suggest that PGE2 is formed in response to dopamine receptor stimulation in the striatum and amplifies both D1 and D2 receptor signaling via EP1...
  90. pmc Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation
    Keiji Yoshida
    Department of Pharmacology, Faculty of Medicine, Institute for Virus Research, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:4580-5. 2002
    ..These results suggest that activation of EP4 induces bone remodeling in vivo and that EP4-selective drugs may be beneficial in humans with osteoporosis...
  91. pmc ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
    Takahiro Tsuji
    Department of Pharmacology, Kyoto University Faculty of Medicine, 606 8501, Japan
    J Cell Biol 157:819-30. 2002
    ..Thus, these results have revealed the Rho-dependent Rac activation signaling that is mediated by mDia1 through Cas phosphorylation and antagonized by the action of ROCK...
  92. ncbi request reprint Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist
    Hisashi Makino
    Department of Medicine and Clinical Science, Department of Pharmacology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 806 8507, Japan
    J Am Soc Nephrol 13:1757-65. 2002
    ..This study reveals a potential usefulness of selective EP1 blockade as a novel therapeutic strategy for diabetic nephropathy and also brings a new insight into our understanding of this disease...
  93. ncbi request reprint Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection
    Katharina Hösl
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Pain 126:46-53. 2006
    ..Our results thus provide further evidence that inflammatory hyperalgesia and neuropathic pain involve different mechanisms of central sensitization...
  94. ncbi request reprint Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice
    Ichiro Takasaki
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Neuropharmacology 49:283-92. 2005
    ..It was further confirmed that the PG systems do not play a key role in delayed postherpetic pain...
  95. pmc Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
    Heiko Reinold
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Clin Invest 115:673-9. 2005
    ..Our results thus demonstrate that inflammatory hyperalgesia can be treated by targeting of a single PG receptor subtype and provide a rational basis for new analgesic strategies going beyond COX inhibition...
  96. ncbi request reprint Actin polymerization-driven molecular movement of mDia1 in living cells
    Chiharu Higashida
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
    Science 303:2007-10. 2004
    ..mDia1 probably moves processively along the growing end of actin filaments in cells, and Formins may be a molecular motility machinery that is independent from motor proteins...
  97. ncbi request reprint Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model...
  98. ncbi request reprint Signal transduction underlying cell morphogenesis: editorial overview
    Shuh Narumiya
    J Biochem 134:305-7. 2003
  99. ncbi request reprint Possible role of Rho/Rhotekin signaling in mammalian septin organization
    Hidenori Ito
    Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya cho, Kasugai 480 0392, Japan
    Oncogene 24:7064-72. 2005
    ..Taken together, we propose that Rhotekin is a novel regulator organizing mammalian septin structures and provide a new link between the septin and Rho-signaling...
  100. pmc Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
    Takakazu Oka
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience and Harvard Medical School, Boston, MA 02115, USA
    J Physiol 551:945-54. 2003
    ....
  101. ncbi request reprint The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis
    Maria Julia Marinissen
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 14:29-41. 2004
    ..Ultimately, these pathways converge in the nucleus to regulate AP1 activity...