Kazuhisa Nakayama

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation
    Chisa Shinotsuka
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, 1 1 1 Tennohdai, Tsukuba Science City, Ibaraki 305 8572, Japan
    J Biol Chem 277:9468-73. 2002
  2. ncbi request reprint Membrane traffic: editorial overview
    Kazuhisa Nakayama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biochem 136:751-3. 2004
  3. ncbi request reprint The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads
    Kazuhisa Nakayama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Cell Struct Funct 28:431-42. 2003
  4. ncbi request reprint Guanine nucleotide-exchange factors for arf GTPases: their diverse functions in membrane traffic
    Hye Won Shin
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biochem 136:761-7. 2004
  5. ncbi request reprint [Regulation of membrane traffic by ubiquitin]
    Kazuhisa Nakayama
    Tanpakushitsu Kakusan Koso 51:1325-30. 2006
  6. pmc ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
    Waka Nakai
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 24:2570-81. 2013
  7. ncbi request reprint Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101
    Yuko Yanagida-Ishizaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Cell Struct Funct 33:91-100. 2008
  8. pmc Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes
    Kirika Nishimoto-Morita
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 284:10583-92. 2009
  9. pmc Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes
    Ray Ishizaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Mol Biol Cell 19:2650-60. 2008
  10. ncbi request reprint ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway
    Yumika Kondo
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Cell Struct Funct 37:141-54. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation
    Chisa Shinotsuka
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, 1 1 1 Tennohdai, Tsukuba Science City, Ibaraki 305 8572, Japan
    J Biol Chem 277:9468-73. 2002
    ..These observations indicate that BFA-induced AP-1 dissociation from TGN membranes and tubulation of TGN membranes are not coupled events and suggest that a BFA target other than ARF-GEFs exists in the cell...
  2. ncbi request reprint Membrane traffic: editorial overview
    Kazuhisa Nakayama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biochem 136:751-3. 2004
    ..This Minireview series composed of eight articles highlights the recent progress in this rapidly expanding research field...
  3. ncbi request reprint The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads
    Kazuhisa Nakayama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Cell Struct Funct 28:431-42. 2003
    ..Together with or independent of the adaptor protein complex AP-1, GGAs regulate selective transport of cargo proteins, such as mannose 6-phosphate receptors, from the trans-Golgi network to endosomes mediated by clathrin-coated vesicles...
  4. ncbi request reprint Guanine nucleotide-exchange factors for arf GTPases: their diverse functions in membrane traffic
    Hye Won Shin
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biochem 136:761-7. 2004
    ..Here we review the structures and functions of Arf-GEFs by focusing on the regulation of membrane traffic...
  5. ncbi request reprint [Regulation of membrane traffic by ubiquitin]
    Kazuhisa Nakayama
    Tanpakushitsu Kakusan Koso 51:1325-30. 2006
  6. pmc ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
    Waka Nakai
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 24:2570-81. 2013
    ....
  7. ncbi request reprint Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101
    Yuko Yanagida-Ishizaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Cell Struct Funct 33:91-100. 2008
    ..Taken into account the topological equivalency among the events of the MVB formation, viral egress from the cell, and cytokinesis, the data obtained here suggest that Tom1L1 is implicated in these three distinct cellular processes...
  8. pmc Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes
    Kirika Nishimoto-Morita
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 284:10583-92. 2009
    ..Furthermore, we have obtained evidence suggesting that a SNARE complex containing Vti1a, syntaxin 6, and syntaxin 16 is involved in Shiga toxin transport downstream of ARL1...
  9. pmc Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes
    Ray Ishizaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Mol Biol Cell 19:2650-60. 2008
    ..Taken together with previous reports, these observations indicate that BIG2 and BIG1 play redundant roles in trafficking between the TGN and endosomes that involves the AP-1 complex...
  10. ncbi request reprint ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway
    Yumika Kondo
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Cell Struct Funct 37:141-54. 2012
    ....
  11. ncbi request reprint Mitosis-coupled, microtubule-dependent clustering of endosomal vesicles around centrosomes
    Hiroyuki Takatsu
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Cell Struct Funct 38:31-41. 2013
    ..Our observations indicate that ERC clustering around centrosomes plays a fundamental role in restricting membrane delivery to the plasma membrane during early mitotic phases, when the cell surface-to-volume ratio reaches its minimum...
  12. pmc ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner
    Hiroyuki Takatsu
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biol Chem 286:38159-67. 2011
    ..These results indicate that ATP9B is able to exit the ER and localize to the TGN independently of CDC50 proteins and that this protein contains a Golgi localization signal in its N-terminal cytoplasmic region...
  13. doi request reprint Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells
    Senye Takahashi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Japan
    Genes Cells 16:938-50. 2011
    ....
  14. doi request reprint Rab11 regulates exocytosis of recycling vesicles at the plasma membrane
    Senye Takahashi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 125:4049-57. 2012
    ....
  15. pmc Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4
    Hideaki Yamamoto
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 21:2746-55. 2010
    ..Depletion of Rab14 or RUFY1, as well as Rab4, inhibits efficient recycling of endocytosed transferrin, suggesting that Rab14 and Rab4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1...
  16. doi request reprint EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis
    Tomoko Ueda
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    FEBS Lett 587:1617-23. 2013
    ..Expression of an EFA6 mutant suppresses Arf6 recruitment onto the Flemming body. These results suggest that EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis...
  17. ncbi request reprint Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts
    Hirotsugu Takano
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biol Pharm Bull 35:408-12. 2012
    ..These findings suggest that the extracellular matrix containing hyaluronan may have a potential to restrict proliferation of cutaneous mast cells in a CD44-independent manner...
  18. ncbi request reprint Histamine synthesis is required for granule maturation in murine mast cells
    Shunsuke Nakazawa
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Eur J Immunol 44:204-14. 2014
    ..These results suggest that histamine promotes granule maturation in mast cells and acts as an proinflammatory mediator. ..
  19. doi request reprint Involvement of CD44 in mast cell proliferation during terminal differentiation
    Hirotsugu Takano
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Lab Invest 89:446-55. 2009
    ..These results suggest that CD44 plays a crucial role in the regulation of the cutaneous mast cell number...
  20. ncbi request reprint GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis
    Kouhei Takashima
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Cell Struct Funct 36:223-35. 2011
    ..On the basis of these results, we propose other mechanisms how the GBF1-Arf-COPI-ArfGAP transport machinery is implicated in the regulation of lipid homeostasis...
  21. pmc Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs
    Zhiqiu Man
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biol Chem 286:11569-78. 2011
    ..These observations indicate that arfaptins are recruited onto trans-Golgi membranes by interacting with Arl1, and capable of inducing membrane deformation via their BAR domains...
  22. ncbi request reprint AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors
    Ray Ishizaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Genes Cells 11:949-59. 2006
    ....
  23. ncbi request reprint Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking
    Hye Won Shin
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    J Cell Sci 118:4039-48. 2005
    ....
  24. ncbi request reprint Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic
    Junko Yamane
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Exp Cell Res 313:3472-85. 2007
    ..These observations suggest critical roles for TMF in two Rab6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER...
  25. ncbi request reprint [GGAs: structure and function of a novel family of clathrin adaptors involved in membrane trafficking between the TGN and endosomes]
    Kazuhisa Nakayama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Seikagaku 77:1367-81. 2005
  26. pmc Three homologous ArfGAPs participate in coat protein I-mediated transport
    Akina Saitoh
    Graduate School of Pharmaceutical Sciences and Career Path Promotion Unit for Young Life Scientists, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 284:13948-57. 2009
    ..On the basis of these observations, we conclude that ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport...
  27. doi request reprint Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation
    Yuya Azuma
    Kyoto University, Japan
    Genes Cells 14:191-204. 2009
    ..These results suggest that the retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation when excess lipoprotein-derived cholesterol has accumulated in cells...
  28. ncbi request reprint Dual control of membrane targeting by PtdIns(4)P and ARF
    Hye Won Shin
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Trends Biochem Sci 29:513-5. 2004
    ....
  29. ncbi request reprint Expression of BIG2 and analysis of its function in mammalian cells
    Hye Won Shin
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Methods Enzymol 404:206-15. 2005
    ..This article describes methods used for examining the function of BIG2 including basic protocols, which are not conventional because of cytotoxicity of BIG2 in Escherichia coli cells and its low expression efficiency in mammalian cells...
  30. ncbi request reprint Recruitment of clathrin onto endosomes by the Tom1-Tollip complex
    Yohei Katoh
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biochem Biophys Res Commun 341:143-9. 2006
    ..These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions...
  31. ncbi request reprint Analysis of Arf interaction with GGAs in vitro and in vivo
    Kazuhisa Nakayama
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Methods Enzymol 404:367-77. 2005
    ..This chapter describes methods to examine the interaction between Arfs and GGAs and to analyze the cellular function of GGAs regulated by Arfs...
  32. ncbi request reprint Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion
    Jun Matsukawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 278:36470-5. 2003
    ..These results suggest that ARF6 regulates gastric acid secretion in parietal cell and that the GTP hydrolysis cycle of ARF6 is essential for the activation pathway...
  33. doi request reprint Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells
    Hirotsugu Takano
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    FEBS Lett 582:1444-50. 2008
    ..The gene expression profile obtained by the microarray analyses was found to reflect many aspects of the differentiation. Our system is thus helpful to gain deeper insights into terminal differentiation of CTMCs...
  34. ncbi request reprint Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815
    Kazuyuki Furuta
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 282:13438-46. 2007
    ..These results suggest that, in P-815 cells, histamine synthesis is augmented through the post-translational cleavage of HDC, which is mediated by caspase-9...
  35. ncbi request reprint Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport
    Tomoo Shiba
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Nat Struct Biol 10:386-93. 2003
    ..These data reveal a molecular mechanism underlying membrane recruitment of adaptor proteins by ARF-GTP...
  36. ncbi request reprint Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1
    Michio Inoue
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Traffic 8:904-13. 2007
    ....
  37. pmc Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1
    Tomoo Shiba
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305 0801, Japan
    Proc Natl Acad Sci U S A 103:15416-21. 2006
    ..The bivalent interaction of FIP3 with Rab11 at the C terminus allows FIP3 to coordinately function with other binding partners, including ARFs...
  38. ncbi request reprint GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination
    Yoko Shiba
    Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    J Biol Chem 279:7105-11. 2004
    ....
  39. ncbi request reprint Predominant expression of the short form of GGA3 in human cell lines and tissues
    Masaki Wakasugi
    Department of Cell Biology and Neuroscience A1, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 306:687-92. 2003
    ..These results indicate that GGA3-S which would not be directly involved in the cargo protein recognition is predominantly expressed in human tissues except the brain and in cell lines...
  40. ncbi request reprint Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins
    Chisa Shinotsuka
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 294:254-60. 2002
    ..These observations indicate that BIG2 is involved in trafficking from the TGN by regulating membrane association of AP-1 and GGA through activating ARF...
  41. ncbi request reprint GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat
    Kazumasa Kawamoto
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    Traffic 3:483-95. 2002
    ..These observations indicate that GBF1 is involved in the formation of COPI-coated vesicles from the cis-Golgi or the pre-Golgi intermediate compartment through activating ADP-ribosylation factors...
  42. ncbi request reprint Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain
    Terukazu Nogi
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Nat Struct Biol 9:527-31. 2002
    ....
  43. pmc GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors
    Hiroyuki Takatsu
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    Biochem J 365:369-78. 2002
    ..In contrast, on the basis of similar experiments, ARF6 (Class III) may be involved in recruitment of GGA proteins to other compartments, possibly early endosomes...
  44. ncbi request reprint Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain
    Yoko Shiba
    Institute of Biological Sciences and Gene Research Center, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    J Biochem 131:327-36. 2002
    ..These results suggest that the gamma1-adaptin-Rabaptin-5 interaction may play a role in membrane trafficking between the TGN and endosomes...
  45. ncbi request reprint Structural basis for recognition of acidic-cluster dileucine sequence by GGA1
    Tomoo Shiba
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Nature 415:937-41. 2002
    ..This recognition mechanism provides the basis for regulation of protein transport from the TGN to endosomes/lysosomes, which is shared by sortilin and low-density lipoprotein receptor-related protein...
  46. ncbi request reprint Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER
    Abbas Shakoori
    Division of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Biochem Biophys Res Commun 312:850-7. 2003
    ..These results suggest that FinGERs function in maintenance of the Golgi structure and/or transport between the ER and the Golgi apparatus...
  47. ncbi request reprint Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes
    Yohei Katoh
    Institute of Biological Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    J Biol Chem 279:24435-43. 2004
    ..On the other hand, Tollip was localized on early endosomes and recruited Tom1 and ubiquitinated proteins. These observations suggest that Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins...
  48. ncbi request reprint Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Leukoc Biol 76:1151-61. 2004
    ....
  49. ncbi request reprint Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability
    Satomi Yogosawa
    Department of Neurochemistry, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 350:82-90. 2006
    ..These results suggest that the ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18...
  50. ncbi request reprint Structure determination of GGA-GAE and gamma1-ear in complex with peptides: crystallization of low-affinity complexes in membrane traffic
    Yusuke Yamada
    Structural Biology Research Center, Photon Factory, High Energy Accelerator Research Organization, Japan
    Acta Crystallogr D Biol Crystallogr 61:731-6. 2005
    ..The peptide-tagged gamma1-ear readily crystallized and the crystal diffracted far better, 1.9-2.2 A resolution, compared with the co-crystallized complex, giving significantly more details without affecting the overall complex structure...
  51. ncbi request reprint Membrane recruitment of effector proteins by Arf and Rab GTPases
    Masato Kawasaki
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Curr Opin Struct Biol 15:681-9. 2005
    ....
  52. ncbi request reprint Molecular mechanism of ubiquitin recognition by GGA3 GAT domain
    Masato Kawasaki
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Genes Cells 10:639-54. 2005
    ..The double-sided ubiquitin binding provides the GAT domain with higher efficiency in recognizing ubiquitinated receptors for lysosomal receptor degradation...
  53. ncbi request reprint Convergence of cell cycle regulation and growth factor signals on GRASP65
    Shin ichiro Yoshimura
    Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Japan
    J Biol Chem 280:23048-56. 2005
    ..The convergence of cell cycle regulation and growth factor signals on GRASP65 Ser-277 suggests that GRASP65 may function as a signal integrator controlling the cell growth...
  54. pmc BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity
    Hye Won Shin
    Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa 920 0934, Japan
    Mol Biol Cell 15:5283-94. 2004
    ..These observations together indicate that BIG2 is implicated in the structural integrity of the recycling endosome through activating class I ARFs...
  55. ncbi request reprint Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells
    Shigetsune Matsuya
    Division of Histology, Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurochem 93:674-85. 2005
    ..These findings suggest that EFA6C may be involved in the regulation of the membrane dynamics of the somatodendritic compartments of Purkinje cells through the activation of ARF6...
  56. ncbi request reprint Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain
    Masato Akutsu
    Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki, Japan
    FEBS Lett 579:5385-91. 2005
    ..The double-sided ubiquitin binding enhances the efficiency of recognition of ubiquitinated proteins by Tom1...