Research Topics
Genomes and Genes | Kazuhiro NakamuraSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
Central circuitries for body temperature regulation and feverKazuhiro Nakamura
Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011..This central thermoregulatory mechanism also functions for metabolic regulation and stress-induced hyperthermia...
Central efferent pathways for cold-defensive and febrile shiveringKazuhiro Nakamura
Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
J Physiol 589:3641-58. 2011..These results provide the interesting notion that, under the demand for increasing levels of heat production, parallel central efferent pathways control the somatic and sympathetic motor systems to drive thermogenesis...- A thermosensory pathway mediating heat-defense responsesKazuhiro Nakamura
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
Proc Natl Acad Sci U S A 107:8848-53. 2010..These findings provide a fundamental framework for understanding the neural circuitry maintaining thermal homeostasis, which is critical to survive severe environmental temperatures... - Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamusYoshiko Nakamura
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Eur J Neurosci 22:3137-46. 2005..These results suggest that a direct projection of EP3 receptor-expressing POA neurons to the DMH/DH region mediates febrile responses via a GABAergic mechanism... 
Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functionsKazuhiro Nakamura
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
J Neurosci 24:5370-80. 2004....- Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissueKazuhiro Nakamura
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
Am J Physiol Regul Integr Comp Physiol 292:R127-36. 2007.... - Central neural pathways for thermoregulationShaun F Morrison
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Front Biosci 16:74-104. 2011..A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction... - Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's diseaseMaria Manczak
Oregon National Primate Research Center, Beaverton, 97006, USA
Hum Mol Genet 18:3876-93. 2009..These findings indicating the ability of the anti-GM-CSF antibody to reduce Abeta1-42 and microglial activity in Tg2576 mice may have therapeutic implications for Alzheimer's disease... - Sympathetic premotor neurons mediating thermoregulatory functionsKazuhiro Nakamura
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Neurosci Res 51:1-8. 2005..The VGLUT3-expressing premotor neurons would mediate thermoregulation including fever induction, and could be also involved in the control of energy metabolism... - The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic areaKazuhiro Nakamura
Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Department of Intelligence Science and Technology, Japan Science and Technology, Sakyo ku, Kyoto 606 8502, Japan
J Neurosci 22:4600-10. 2002..Our results demonstrate that the rRPa, which has never been associated with the fever mechanism, mediates the pyrogenic neurotransmission from the POA to the peripheral sympathetic effectors contributing to fever development... - In vivo function of Rnd2 in the development of neocortical pyramidal neuronsKazuhiro Nakamura
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Neurosci Res 54:149-53. 2006..These results indicate that Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons... - Chemically specific circuit composed of vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortexHiroyuki Hioki
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Cereb Cortex 14:1266-75. 2004..Thus, VGLUT3-expressing GABAergic interneurons form a chemically specific circuit within the PPTB-producing interneuron group and it is likely that glutamate is used within the chemically specific circuit... - Central control of thermogenesis in mammalsShaun F Morrison
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Exp Physiol 93:773-97. 2008.... - Preoptic mechanism for cold-defensive responses to skin coolingKazuhiro Nakamura
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
J Physiol 586:2611-20. 2008.... - Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's disease and multiple sclerosisP Hemachandra Reddy
Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurochem 111:1514-28. 2009..The findings from this study may have implications for anti-inflammatory effects of Alzheimer's disease and experimental autoimmune encephalomyelitis mice (a multiple sclerosis mouse model)... - Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zoneSheng Xi Wu
Department of Morphological Brain Science and Laboratory of Immunological Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 102:17172-7. 2005..Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain... - Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptorsHiroyoshi Tsuchiya
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Biol Chem 283:11064-71. 2008..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever... - Developmental changes in expression of small GTPase RhoG mRNA in the rat brainYukio Ishikawa
Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Japan
Brain Res Mol Brain Res 106:145-50. 2002..These results suggest distinct pre- and postnatal roles of RhoG in the development of the central nervous system... - A thermosensory pathway that controls body temperatureKazuhiro Nakamura
Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
Nat Neurosci 11:62-71. 2008..These findings make an important contribution to our understanding of both the somatosensory system and thermal homeostasis -- two mechanisms that are fundamental to the nervous system and to our survival... - Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neuronsKazuhiro Nakamura
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Neuroreport 15:431-6. 2004..These results indicate at least two independent glutamatergic terminal populations, which include a distinct monoaminergic subpopulation, making excitatory inputs onto SPNs...