Kazuhiro Nakamura

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc A thermosensory pathway mediating heat-defense responses
    Kazuhiro Nakamura
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 107:8848-53. 2010
  2. doi request reprint Central circuitries for body temperature regulation and fever
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011
  3. pmc Central efferent pathways for cold-defensive and febrile shivering
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Physiol 589:3641-58. 2011
  4. pmc Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus
    Yoshiko Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:3137-46. 2005
  5. ncbi request reprint Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 24:5370-80. 2004
  6. pmc Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 292:R127-36. 2007
  7. pmc Central neural pathways for thermoregulation
    Shaun F Morrison
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci (Landmark Ed) 16:74-104. 2011
  8. pmc Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
    Maria Manczak
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Hum Mol Genet 18:3876-93. 2009
  9. ncbi request reprint Sympathetic premotor neurons mediating thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 51:1-8. 2005
  10. ncbi request reprint In vivo function of Rnd2 in the development of neocortical pyramidal neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Neurosci Res 54:149-53. 2006

Collaborators

Detail Information

Publications21

  1. pmc A thermosensory pathway mediating heat-defense responses
    Kazuhiro Nakamura
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 107:8848-53. 2010
    ..These findings provide a fundamental framework for understanding the neural circuitry maintaining thermal homeostasis, which is critical to survive severe environmental temperatures...
  2. doi request reprint Central circuitries for body temperature regulation and fever
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011
    ..This central thermoregulatory mechanism also functions for metabolic regulation and stress-induced hyperthermia...
  3. pmc Central efferent pathways for cold-defensive and febrile shivering
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Physiol 589:3641-58. 2011
    ..These results provide the interesting notion that, under the demand for increasing levels of heat production, parallel central efferent pathways control the somatic and sympathetic motor systems to drive thermogenesis...
  4. pmc Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus
    Yoshiko Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:3137-46. 2005
    ..These results suggest that a direct projection of EP3 receptor-expressing POA neurons to the DMH/DH region mediates febrile responses via a GABAergic mechanism...
  5. ncbi request reprint Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 24:5370-80. 2004
    ....
  6. pmc Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 292:R127-36. 2007
    ....
  7. pmc Central neural pathways for thermoregulation
    Shaun F Morrison
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci (Landmark Ed) 16:74-104. 2011
    ..A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction...
  8. pmc Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
    Maria Manczak
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Hum Mol Genet 18:3876-93. 2009
    ..These findings indicating the ability of the anti-GM-CSF antibody to reduce Abeta1-42 and microglial activity in Tg2576 mice may have therapeutic implications for Alzheimer's disease...
  9. ncbi request reprint Sympathetic premotor neurons mediating thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 51:1-8. 2005
    ..The VGLUT3-expressing premotor neurons would mediate thermoregulation including fever induction, and could be also involved in the control of energy metabolism...
  10. ncbi request reprint In vivo function of Rnd2 in the development of neocortical pyramidal neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Neurosci Res 54:149-53. 2006
    ..These results indicate that Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons...
  11. ncbi request reprint The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area
    Kazuhiro Nakamura
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Department of Intelligence Science and Technology, Japan Science and Technology, Sakyo ku, Kyoto 606 8502, Japan
    J Neurosci 22:4600-10. 2002
    ..Our results demonstrate that the rRPa, which has never been associated with the fever mechanism, mediates the pyrogenic neurotransmission from the POA to the peripheral sympathetic effectors contributing to fever development...
  12. ncbi request reprint Chemically specific circuit composed of vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex
    Hiroyuki Hioki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cereb Cortex 14:1266-75. 2004
    ..Thus, VGLUT3-expressing GABAergic interneurons form a chemically specific circuit within the PPTB-producing interneuron group and it is likely that glutamate is used within the chemically specific circuit...
  13. pmc Central control of thermogenesis in mammals
    Shaun F Morrison
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Exp Physiol 93:773-97. 2008
    ....
  14. pmc Preoptic mechanism for cold-defensive responses to skin cooling
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Physiol 586:2611-20. 2008
    ....
  15. pmc Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's disease and multiple sclerosis
    P Hemachandra Reddy
    Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurochem 111:1514-28. 2009
    ..The findings from this study may have implications for anti-inflammatory effects of Alzheimer's disease and experimental autoimmune encephalomyelitis mice (a multiple sclerosis mouse model)...
  16. doi request reprint Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors
    Hiroyoshi Tsuchiya
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 283:11064-71. 2008
    ..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever...
  17. pmc Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
    Sheng Xi Wu
    Department of Morphological Brain Science and Laboratory of Immunological Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:17172-7. 2005
    ..Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain...
  18. pmc A thermosensory pathway that controls body temperature
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Nat Neurosci 11:62-71. 2008
    ..These findings make an important contribution to our understanding of both the somatosensory system and thermal homeostasis -- two mechanisms that are fundamental to the nervous system and to our survival...
  19. ncbi request reprint Developmental changes in expression of small GTPase RhoG mRNA in the rat brain
    Yukio Ishikawa
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Japan
    Brain Res Mol Brain Res 106:145-50. 2002
    ..These results suggest distinct pre- and postnatal roles of RhoG in the development of the central nervous system...
  20. ncbi request reprint Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia
    Naoya Kataoka
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Cell Metab 20:346-58. 2014
    ....
  21. ncbi request reprint Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuroreport 15:431-6. 2004
    ..These results indicate at least two independent glutamatergic terminal populations, which include a distinct monoaminergic subpopulation, making excitatory inputs onto SPNs...