A Nakai

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
    A Nakai
    Department of Cell Biology, Kyoto University, Japan
    Mol Cell Biol 17:469-81. 1997
  2. pmc HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts
    K Hirayoshi
    Department of Cell Biology, Kyoto University, Japan
    Mol Cell Biol 11:4036-44. 1991
  3. ncbi The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing
    M Tanabe
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 274:27845-56. 1999
  4. ncbi Ubiquitous and cell-specific members of the avian small heat shock protein family
    Y Kawazoe
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    FEBS Lett 455:271-5. 1999
  5. ncbi Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells
    H Takechi
    Department of Cell Biology, Kyoto University, Japan
    Eur J Biochem 206:323-9. 1992
  6. pmc Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1
    A Nakai
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, USA
    EMBO J 19:1545-54. 2000
  7. ncbi Cloning and expression of murine high molecular mass heat shock proteins, HSP105
    K Yasuda
    Department of Biochemistry, Kyoto Pharmaceutical University, Japan
    J Biol Chem 270:29718-23. 1995
  8. pmc Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway
    A Nakai
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Mol Cell Biol 13:1983-97. 1993
  9. ncbi p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3
    J Tanikawa
    Laboratory of Molecular Genetics, RIKEN Tsukuba Life Sciences Center, Japan Science and Technology, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 275:15578-85. 2000
  10. ncbi Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiency
    Y Kikawa
    Department of Pediatrics, Fukui Medical School, Japan
    Biochem Biophys Res Commun 210:797-804. 1995

Collaborators

Detail Information

Publications16

  1. pmc HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
    A Nakai
    Department of Cell Biology, Kyoto University, Japan
    Mol Cell Biol 17:469-81. 1997
    ..hHSF4 represents a novel hHSF that exhibits tissue-specific expression and functions to repress the expression of genes encoding heat shock proteins and molecular chaperones...
  2. pmc HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts
    K Hirayoshi
    Department of Cell Biology, Kyoto University, Japan
    Mol Cell Biol 11:4036-44. 1991
    ..Conversely, it is the first serpin family member that is not secreted from cells, which could be explained by acquisition of the RDEL retention signal during evolution...
  3. ncbi The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing
    M Tanabe
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 274:27845-56. 1999
    ..These results suggest that differential splicing of HSF4 mRNA gives rise to both an inhibitor and activator of tissue-specific heat shock gene expression...
  4. ncbi Ubiquitous and cell-specific members of the avian small heat shock protein family
    Y Kawazoe
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    FEBS Lett 455:271-5. 1999
    ..Thus, cHsp25 is the first member of the sHsps in vertebrates the expression of which is ubiquitous in tissues exposed to external stresses similar to Hsp70...
  5. ncbi Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells
    H Takechi
    Department of Cell Biology, Kyoto University, Japan
    Eur J Biochem 206:323-9. 1992
    ..These results suggested that HSP47 was closely related to collagens in terms of its expression as well as in its functional relevance...
  6. pmc Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1
    A Nakai
    Department of Molecular and Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8397, USA
    EMBO J 19:1545-54. 2000
    ..These results suggest that male infertility caused by thermal insult is at least partly due to the activation of HSF1, which induces the primary spermatocytes to undergo apoptosis...
  7. ncbi Cloning and expression of murine high molecular mass heat shock proteins, HSP105
    K Yasuda
    Department of Biochemistry, Kyoto Pharmaceutical University, Japan
    J Biol Chem 270:29718-23. 1995
    ..Furthermore, by Northern blot analysis, HSP105 mRNA was revealed to be present in most murine tissues and to be highly expressed in the brain...
  8. pmc Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway
    A Nakai
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Mol Cell Biol 13:1983-97. 1993
    ..The HSF3 message, like HSF1 and HSF2 messages, is coexpressed during development and in most tissues, which suggests a general role for the regulatory pathway involving HSF3...
  9. ncbi p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3
    J Tanikawa
    Laboratory of Molecular Genetics, RIKEN Tsukuba Life Sciences Center, Japan Science and Technology, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 275:15578-85. 2000
    ..The regulation of HSF3 activity by c-Myb and p53 sheds light on the molecular events that govern HSP expression during cellular proliferation and apoptosis...
  10. ncbi Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiency
    Y Kikawa
    Department of Pediatrics, Fukui Medical School, Japan
    Biochem Biophys Res Commun 210:797-804. 1995
    ..Thus, this mutation is concluded to be responsible for fructose-1,6-bisphosphatase deficiency in this patient...
  11. pmc Characterization of a thyroid hormone receptor expressed in human kidney and other tissues
    A Nakai
    Department of Medicine, Howard Hughes Medical Institute, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 85:2781-5. 1988
    ....
  12. ncbi Expression of three forms of thyroid hormone receptor in human tissues
    A Sakurai
    Department of Medicine, University of Chicago, Illinois 60637
    Mol Endocrinol 3:392-9. 1989
    ..The relative amounts of the three hTR mRNAs were roughly parallel in each tissue. It is of interest that none of these hTRs was abundant in liver, which is the major thyroid hormone-responsive organ. Another hTR may be present in liver...
  13. pmc Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta
    A Sakurai
    Thyroid Study Unit, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 86:8977-81. 1989
    ..Thus, generalized resistance to thyroid hormone can result from expression of an abnormal thyroid hormone nuclear receptor molecule...
  14. ncbi Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues
    A Nakai
    Department of Medicine, University of Chicago, Illinois 60637
    Mol Endocrinol 2:1087-92. 1988
    ..At least three types of thyroid hormone receptors (hTR alpha 1, alpha 2, beta), which possess similar affinities for hormone ligands, can be expressed in the same tissue...
  15. ncbi A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily
    A Nakai
    Department of Medicine, University of Chicago, Illinois 60637
    Mol Endocrinol 4:1438-43. 1990
    ..It is expressed in human fetal muscle and adult liver, brain, and thyroid. NAK1 could be a nuclear receptor. It will be of great interest to determine the ligand for NAK1 and the genes that are regulated by it...
  16. ncbi cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency
    Y Kikawa
    Department of Pediatrics, Fukui Medical School, Japan
    Biochem Biophys Res Commun 199:687-93. 1994
    ..Monocytes were thus useful as an alternative source for mRNA from human liver for the molecular analysis of fructose 1,6-bisphosphatase deficiency...