Y Naito

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. pmc A case of inoperable duodenal cancer achieving long-term survival after multidisciplinary treatment
    Takashi Ando
    Department of Gastroenterology, Social Insurance Kyoto Hospital, Kyoto Prefectural University of Medicine, Kyoto, Moriguchi, Japan
    Case Rep Gastroenterol 6:111-7. 2012
  2. pmc Prevention of Indomethacin-Induced Gastric Mucosal Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study Rebamipide vs Famotidine
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 43:34-40. 2008
  3. pmc Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells
    Hitomi Okada
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 50:47-52. 2012
  4. pmc Transcriptome Analysis for Cytoprotective Actions of Rebamipide against Indomethacin-Induced Gastric Mucosal Injury in Rats
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 41:202-10. 2007
  5. pmc Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells
    Ying Qin
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 49:174-81. 2011
  6. pmc Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:178-82. 2011
  7. pmc Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:170-7. 2011
  8. pmc Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:126-33. 2011
  9. pmc Neutrophil-dependent oxidative stress in ulcerative colitis
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 41:18-26. 2007
  10. pmc A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice
    Satomi Akagiri
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 42:150-7. 2008

Collaborators

Detail Information

Publications157 found, 100 shown here

  1. pmc A case of inoperable duodenal cancer achieving long-term survival after multidisciplinary treatment
    Takashi Ando
    Department of Gastroenterology, Social Insurance Kyoto Hospital, Kyoto Prefectural University of Medicine, Kyoto, Moriguchi, Japan
    Case Rep Gastroenterol 6:111-7. 2012
    ....
  2. pmc Prevention of Indomethacin-Induced Gastric Mucosal Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study Rebamipide vs Famotidine
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 43:34-40. 2008
    ..In conclusion, these data recommend rebamipide (100 mg, t.i.d.) or famotidine (10 mg, b.i.d.) for the prevention of acute gastric injury induced by NSAID in patients without a particular risk factor...
  3. pmc Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells
    Hitomi Okada
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 50:47-52. 2012
    ..These data indicate that N(ε)-(hexanoyl)lysine modification of tropomyosin 1 may be related to neoplastic transformation by N-methyl-N'-nitro-N-nitrosoguanidine in gastric epithelial cells...
  4. pmc Transcriptome Analysis for Cytoprotective Actions of Rebamipide against Indomethacin-Induced Gastric Mucosal Injury in Rats
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 41:202-10. 2007
    ....
  5. pmc Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells
    Ying Qin
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 49:174-81. 2011
    ....
  6. pmc Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:178-82. 2011
    ..Enolase-1 and albumin were found to be DiBrY modified. These proteins may be responsible for the development of neutrophil-associated intestinal injury induced by indomethacin...
  7. pmc Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:170-7. 2011
    ..In conclusion, activation of gastric epithelial PPAR-γ receptor by its ligands may represent a novel therapeutic approach for gastric inflammation via up-regulation of heat shock proteins and endoplasmic reticulum-related proteins...
  8. pmc Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:126-33. 2011
    ..In addition, CO derived from HO-1 is shown to be involved in the regulation in gastro-intestinal motility. These in vitro and in vivo data suggest that HO-1 may be a novel therapeutic target in patients with gastrointestinal diseases...
  9. pmc Neutrophil-dependent oxidative stress in ulcerative colitis
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 41:18-26. 2007
    ..In clinically, we have succeeded to develop a novel granulocytes adsorptive apheresis therapy for UC. In this article, we discuss current advances to define the role of neutrophils-dependent oxidative stress in UC...
  10. pmc A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice
    Satomi Akagiri
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 42:150-7. 2008
    ..These data indicate that our mouse model would be useful for future studies that investigate the role of visceral WAT and its products in the development of metabolic syndrome...
  11. pmc Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice
    Satomi Akagiri
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 42:158-66. 2008
    ..These results suggest that BOF decreases the weight and size gains of WAT along with up-regulating UCP1 mRNA in WAT in high-fat diet-fed mice...
  12. pmc The expression of heme oxygenase-1 induced by lansoprazole
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 45:9-13. 2009
    ..In this review, we focused on lansoprazole-induced HO-1 expression, its anti-inflammatory action, and the role of Nrf2 in its expression...
  13. ncbi request reprint Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo ku, Kyoto, 602 8566, Japan
    Subcell Biochem 77:137-48. 2014
    ....
  14. pmc Protective effect of the Japanese traditional medicine juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification of a potential biomarker of this effect
    Kazuo Ogawa
    Tsumura Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    BMC Complement Altern Med 12:118. 2012
    ....
  15. pmc Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Med Gas Res 2:23. 2012
    ..abstract:..
  16. doi request reprint A questionnaire-based survey on screening for gastric and colorectal cancer by physicians in East Asian countries in 2010
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Digestion 86:94-106. 2012
    ..The incidence of gastric cancer (GC) is high, and colorectal cancer (CRC) has significantly increased in Asian countries...
  17. doi request reprint Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1
    Akifumi Fukui
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G927-36. 2012
    ..Our findings indicate that ASA-induced ROS production can specifically modify the expression of ZO-1 protein and induce increased cell permeability, which may ultimately cause small intestinal mucosal injury...
  18. doi request reprint Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis
    Kazuhiko Uchiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G1163-70. 2012
    ..These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease...
  19. ncbi request reprint Therapeutic potential of carbon monoxide (CO) for intestinal inflammation
    Y Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Curr Med Chem 19:70-6. 2012
    ..These results indicate that CO may have a potential to be one of the therapeutic strategies in IBD patients...
  20. pmc Exercise and functional foods
    Wataru Aoi
    Research Center for Sports Medicine, Doshisha University, Kyoto 602 8580, Japan
    Nutr J 5:15. 2006
    ..This article describes various "functional foods" that have been reported to be effective for improving exercise performance or health promotion, along with the relevant physiological changes that occur during exercise...
  21. ncbi request reprint Inhibitory effects of red wine extracts on endothelial-dependent adhesive interactions with monocytes induced by oxysterols
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramchi Hirokoji, Kyoto 602 8566 Japan
    Biol Res 37:231-8. 2004
    ..These results suggest that RWE works as an anti-atherogenic agent through the inhibition of endothelial-dependent adhesive interactions with monocytes induced by oxysterols...
  22. ncbi request reprint Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Mol Med 14:191-6. 2004
    ..These data suggest that persistent and marked blockade of IL-6 bioactivity provides some beneficial effects on intestinal inflammation...
  23. ncbi request reprint Thiazolidinediones: a new class of drugs for the therapy of ischemia-reperfusion injury
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Drugs Today (Barc) 40:423-30. 2004
    ..Altogether, recent findings suggest that thiazolidinediones could represent a novel therapeutic approach to reducing or preventing reperfusion injury...
  24. ncbi request reprint Heme oxygenase-1: a new therapeutic target for inflammatory bowel disease
    Y Naito
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Aliment Pharmacol Ther 20:177-84. 2004
    ..These in vitro and in vivo data suggest that HO-1 may be a novel therapeutic target in patients with inflammatory bowel disease...
  25. ncbi request reprint An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice
    Y Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, 602 8566, Kyoto, Kawaramachi Hirokoji, Japan
    Inflamm Res 53:462-8. 2004
    ..A dextran sulfate sodium (DSS) colitis model was established to examine the effects of MMP inhibition, by an orally active MMP inhibitor ONO-4847, on colonic inflammation...
  26. ncbi request reprint Laser capture microdissection/GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice
    Yuji Naito
    Departments of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 9:307-12. 2004
    ..In the present study we report larger groups of transcripts displaying significant expression modulation in glomerular cells obtained from the early phase of diabetic nephropathy...
  27. ncbi request reprint Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    World J Gastroenterol 12:2024-30. 2006
    ....
  28. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Japan
    Int J Mol Med 17:997-1004. 2006
    ..These results suggest that rosuvastatin prevents the development of DSS-induced colitis in mice via the inhibition of mucosal inflammatory responses associated with the preservation of eNOS transcription...
  29. ncbi request reprint Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Dig Dis Sci 50:S104-12. 2005
    ..Inhibition of apoptosis-related genes is possibly important for the cytoprotective effect of rebamipide against indomethacin-induced gastric mucosal cell injury...
  30. ncbi request reprint Biomarkers in patients with gastric inflammation: a systematic review
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Digestion 72:164-80. 2005
    ..However, this system is based on the histological classification derived from biopsy specimens. Therefore, more convenient, objective and practical biomarkers are recommended...
  31. ncbi request reprint Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers, oxykine, in mice
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Biofactors 23:85-95. 2005
    ..These results indicated that the oxykine reduced the diabetes-induced oxidative stress and renal mesangial cell injury. In conclusion, oxykine might be a novel approach for the prevention of diabetes nephropathy...
  32. ncbi request reprint Role of matrix metalloproteinases in inflammatory bowel disease
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Mol Aspects Med 26:379-90. 2005
    ..This review focuses on recent progress in elucidating the biological and pathological roles of MMPs in inflammatory bowel disease...
  33. ncbi request reprint Oxidative stress-related molecules as a therapeutic target for inflammatory and allergic diseases
    Y Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Curr Drug Targets Inflamm Allergy 4:511-5. 2005
    ....
  34. ncbi request reprint Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Atherosclerosis 180:19-25. 2005
    ..These superior inhibitory effects of tocotrienols may be dependent on their intracellular accumulation...
  35. ncbi request reprint Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Nutr Biochem 17:402-9. 2006
    ..These results suggest that chronic ingestion of PHGG prevents the development of DSS-induced colitis in mice via the inhibition of mucosal inflammatory response...
  36. ncbi request reprint Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species
    Yuji Naito
    Department of Medical Proteomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Eur J Pharmacol 546:11-8. 2006
    ..These results suggest that azelnidipine works as an anti-atherogenic agent by inhibiting the reactive oxygen species-dependent expression of VCAM-1 induced by 7-ketocholesterol and TNF-alpha...
  37. ncbi request reprint Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: a nutrigenomic approach
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 18:685-95. 2006
    ..In addition, the present approach may help us gain a better understanding of the genes and pathways involved in the anti-diabetic mechanism of astaxanthin...
  38. ncbi request reprint Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis
    Yuji Naito
    Department of Medical Proteomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 18:821-8. 2006
    ..This transcriptome approach provided insight into genes and putative genetic pathways thought to be affected by stimulation with gastroduodenal refluxates...
  39. ncbi request reprint Global analysis of gene expression in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective drugs
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Dig Dis Sci 50:S45-55. 2005
    ..This comprehensive approach enabled the simultaneous analysis of many genes, including transcriptional factors, as well as the generation of novel hypothesis on the mechanism of action of gastro-protective agents...
  40. doi request reprint Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 25:S144-8. 2010
    ..The aim of this study was to identify new intestinal proteins potentially associated with acute inflammation using proteomic profiling of an in vivo mice model of ulcerative colitis...
  41. ncbi request reprint Rebamipide: a gastrointestinal protective drug with pleiotropic activities
    Yuji Naito
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Expert Rev Gastroenterol Hepatol 4:261-70. 2010
    ..The aim of this article is to provide an update on the pharmacological and clinical profile of rebamipide and to explore further possibilities for additional indications...
  42. ncbi request reprint Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Free Radic Biol Med 33:323-36. 2002
    ..This review highlights recent advances in understanding of the mechanisms underlying chronic inflammation following infection with H. pylori...
  43. ncbi request reprint alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Antioxid Redox Signal 4:195-206. 2002
    ..NF-kappaB is essential to DSS-induced colitis, suggesting molecular approach targeting of NF-kappaB for treatment of inflammatory bowel disease...
  44. ncbi request reprint Telomerase activity and expression of telomerase RNA component and catalytic subunits in precancerous and cancerous colorectal lesions
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Tumour Biol 22:374-82. 2001
    ....
  45. ncbi request reprint Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Aliment Pharmacol Ther 15:865-73. 2001
    ....
  46. ncbi request reprint Protective role of intracellular glutathione against nitric oxide-induced necrosis in rat gastric mucosal cells
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Aliment Pharmacol Ther 14:145-52. 2000
    ..Nitric oxide synthase activity is increased in the stomach in association with Helicobacter pylori infection and portal hypertension, but the mechanism by which nitric oxide contributes to mucosal damage remains unclear...
  47. ncbi request reprint Effect of vitamin E in gastric mucosal injury induced by ischaemia-reperfusion in nitric oxide-depleted rats
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Aliment Pharmacol Ther 13:553-9. 1999
    ..Neutrophil infiltration and lipid peroxide accumulation are involved in reperfusion-induced gastric mucosal injury in nitric oxide-depleted rats...
  48. ncbi request reprint Ubiquitin-proteasome inhibitor enhances tumour necrosis factor-alpha-induced apoptosis in rat gastric epithelial cells
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Japan
    Aliment Pharmacol Ther 16:59-66. 2002
    ..In the present study, we examined whether gastric epithelial cells are resistant to TNF-alpha-induced apoptosis, and whether this resistance is related to ubiquitin-proteasome-associated nuclear factor-kappaB (NF-kappaB) activation...
  49. ncbi request reprint Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal
    Y Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Physiol Pharmacol 60:123-30. 2009
    ....
  50. ncbi request reprint Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-gamma ligand, pioglitazone, in rats
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Redox Rep 7:294-9. 2002
    ..In conclusion, activation of PPAR-gamma may represent a novel approach to the treatment of intestinal inflammation induced by ischemia-reperfusion...
  51. ncbi request reprint A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Nitric Oxide 10:170-7. 2004
    ....
  52. doi request reprint Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa
    Yuji Naito
    Medical Proteomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 23:S250-7. 2008
    ..In the present study, we investigated the correlation between endoscopic findings and iNOS mRNA expression/NO-modified proteins in the gastric mucosa...
  53. doi request reprint Green tea and heart health
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
    J Cardiovasc Pharmacol 54:385-90. 2009
    ....
  54. ncbi request reprint Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 18:560-9. 2003
    ..To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene...
  55. doi request reprint Oxidative stress-induced posttranslational modification of proteins as a target of functional food
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Forum Nutr 61:39-54. 2009
    ..In this review, we present the use of these monoclonal antibodies in several diseases, from which new insights have emerged into mechanisms of metabolism and inflammation in these disorders that are associated with oxidative stress...
  56. ncbi request reprint The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, 602 8566, Kamigyo ku, Kyoto, Japan
    Eur J Pharmacol 412:91-9. 2001
    ..Nitric oxide produced by inducible nitric oxide synthase may contribute to colonic inflammation by nitrosation, oxidative damage, and enhanced inflammatory cytokines...
  57. ncbi request reprint The effect of rebamipide on Helicobacter pylori extract-mediated changes of gene expression in gastric epithelial cells
    N Yoshida
    Molecular Gastroenterology and Hepatology and Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Aliment Pharmacol Ther 18:63-75. 2003
    ..pylori-stimulation through the attenuated activation of nuclear factor-kappaB (NF-kappaB)...
  58. ncbi request reprint A novel water-soluble vitamin E derivative protects against experimental colitis in rats
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Antioxid Redox Signal 1:555-62. 1999
    ..These results suggest that TMG is effective for the treatment of colitis in rats induced by TNBS...
  59. ncbi request reprint A new mechanism for anti-inflammatory actions of proton pump inhibitors--inhibitory effects on neutrophil-endothelial cell interactions
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Aliment Pharmacol Ther 14:74-81. 2000
    ..Neutrophil-endothelial cell interactions mediated by adhesion molecules may be involved in gastric mucosal inflammation associated with Helicobacter pylori or nonsteroidal anti-inflammatory drugs...
  60. ncbi request reprint Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins
    S Kokura
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 23:17-28. 2007
    ..Hyperthermia is known to protect against cellular injury through the expression of heat shock proteins. In this study, the therapeutic effects of hyperthermia on experimental colitis in the rat were evaluated...
  61. ncbi request reprint Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Aliment Pharmacol Ther 16:191-7. 2002
    ..H. pylori infection potentiates aspirin-induced gastric mucosal injury by mechanisms that include accumulation of activated neutrophils...
  62. ncbi request reprint Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade
    Tomohisa Takagi
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 7:283-9. 2002
    ..These data suggest that peroxisome proliferator-activated receptor-gamma may be a novel therapeutic target for the therapy of inflammatory bowel disease...
  63. ncbi request reprint Differing effects of two nitric oxide synthase inhibitors on experimental colitis
    T Yamaguchi
    Department of Gastroenterology, Takeda Hospital, Kyoto, Japan
    Hepatogastroenterology 48:118-22. 2001
    ..CONCLUSIONS: These results suggest that an inhibitor of inducible nitric oxide synthase, but not of constitutive nitric oxide synthase, was effective in treating experimental colitis in rats...
  64. doi request reprint Dextran sulfate sodium-induced acute colonic inflammation in angiotensin II type 1a receptor deficient mice
    K Katada
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Inflamm Res 57:84-91. 2008
    ..In this study we assessed the role of angiotensin II type 1a (AT1a) receptor on the outcome of dextran sulfate sodium (DSS)-induced acute colitis by employing AT1a receptor deficient mice...
  65. ncbi request reprint Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors
    O Handa
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokouji, Kamigyo ku, Kyoto, Japan, 602 8566
    Inflamm Res 55:476-80. 2006
    ....
  66. ncbi request reprint Role of active oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats
    S Iinuma
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Dig Dis Sci 43:1657-64. 1998
    ..These results suggest that lipid peroxidation, mediated by active oxygen species generated from xanthine oxidase and PMNs, plays an important role in the pathogenesis of duodenal ulcers induced by mepirizole...
  67. ncbi request reprint Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice
    A Harusato
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Physiol Pharmacol 60:149-54. 2009
    ..Disruption of the Bach1 gene thus caused inhibition of mucosal injury, indicating that inhibition of Bach1 may be a novel therapeutic strategy for treating indomethacin-induced intestinal injury...
  68. ncbi request reprint Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease
    N Yoshida
    Molecular Gastroenterology and Hepatology, Department of Legal Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Scand J Gastroenterol 39:816-22. 2004
    ..In this study, we examined the expression of mRNA for interleukin (IL)-8, a potent chemokine for neutrophils, in the esophageal mucosa of patients with GERD and compared the results with their endoscopic findings and symptoms...
  69. ncbi request reprint Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis in rats
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Digestion 63:81-6. 2001
    ..These results suggest that neutrophil-endothelial cell interactions via P-selectin and ICAM-1 play an important role in the development of TNB-induced colitis in rats...
  70. ncbi request reprint Characteristics of the production of active oxygen species from adherent and non-adherent neutrophils
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Biofactors 9:19-26. 1999
    ..Results indicate that adherent and non-adherent neutrophils exhibit differing time course of AOS production...
  71. pmc Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Gut 50:594-8. 2002
    ..Helicobacter pylori infection and non-steroidal anti-inflammatory drugs are two major causes of gastric ulceration but interactions between H pylori and these drugs in gastric mucosal injury are unclear...
  72. ncbi request reprint Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury
    Y Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Dig Dis Sci 46:845-51. 2001
    ..Based on these data, the beneficial effects of polaprezinc on aspirin-induced gastric mucosal injury may be attributed to its antioxidative and antiinflammatory properties...
  73. ncbi request reprint Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats
    Yutaka Isozaki
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Int J Mol Med 17:497-502. 2006
    ..These results suggest that TMG is effective for the treatment of colitis in rats induced by TNBS. In the future, TMG could be a new therapeutic agent for IBD...
  74. ncbi request reprint Oxidative stress involvement and gene expression in indomethacin-induced gastropathy
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 11:243-53. 2006
    ....
  75. ncbi request reprint A novel water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol, protects against acute lung injury and mortality in endotoxemic rats
    Jun Ochiai
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Shock 18:580-4. 2002
    ..The therapeutic effects could be mediated at least partly through suppression of the increased expression of TNF-alpha and neutrophil sequestration in the lung that are caused by LPS...
  76. ncbi request reprint Prevention by rebamipide of acute reflux esophagitis in rats
    Kazuhiro Katada
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Dig Dis Sci 50:S97-S103. 2005
    ..The results of this study indicate that rebamipide protects against the occurrence of esophagitis and has highly promising potential as a new therapeutic agent for reflux esophagitis...
  77. ncbi request reprint A novel water-soluble vitamin E derivative protects against aspirin-induced gastric mucosal injury in rats
    Yutaka Isozaki
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 16:1035-40. 2005
    ..This anti-inflammatory effect of TMG seems to be related to impairment of lipid peroxidation, neutrophil function and cytokine production in gastric mucosa...
  78. ncbi request reprint CV-11974, angiotensin II type I receptor antagonist, protects against ischemia-reperfusion injury of the small intestine in rats
    Tomohisa Takagi
    Biomedical Safety Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Eur J Pharmacol 535:283-90. 2006
    ..The aim of the present study was to examine the effect of angiotensin II type I receptor antagonist, CV-11974, on reperfusion-induced small intestinal injury in rats...
  79. ncbi request reprint Heme oxygenase-1 (Hsp32) is involved in the protection of small intestine by whole body mild hyperthermia from ischemia/reperfusion injury in rat
    N Sakamoto
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Japan
    Int J Hyperthermia 21:603-14. 2005
    ..The aim of the present study was to explore whether heme oxygenase-1 (HO-1) is involved in the hyperthermia-provided protection of the small intestine from ischemia/reperfusion injury in rats...
  80. ncbi request reprint Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells
    N Yoshida
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Mol Med 19:335-40. 2007
    ....
  81. ncbi request reprint The role of neutrophils and inflammation in gastric mucosal injury
    T Yoshikawa
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Free Radic Res 33:785-94. 2000
    ..pylori and NSAIDs. This review describes the potential role of neutrophils and neutrophil-associated inflammation for gastric oxidative stress and injury induced by H. pylori and/or NSAID...
  82. ncbi request reprint 7-Ketocholesterol enhances the expression of adhesion molecules on human aortic endothelial cells by increasing the production of reactive oxygen species
    Makoto Shimozawa
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 9:370-5. 2004
    ..In conclusion, this study suggests that the endothelial adhesiveness to monocytic cells that was increased by 7-ketocholesterol was associated with enhanced expression of ICAM-1 and VCAM-1 mediated by ROS production...
  83. ncbi request reprint Pancreatic phospholipase A2 induces bacterial translocation in rats
    H Hongo
    First Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Immunopharmacol Immunotoxicol 21:717-26. 1999
    ....
  84. pmc Effect of shear stress and a stable prostaglandin I2 analogue on adhesive interactions of colon cancer cells and endothelial cells
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Clin Exp Immunol 117:430-4. 1999
    ....
  85. ncbi request reprint Astaxanthin protects beta-cells against glucose toxicity in diabetic db/db mice
    Kazuhiko Uchiyama
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 7:290-3. 2002
    ..In conclusion, these results indicate that astaxanthin can exert beneficial effects in diabetes, with preservation of beta-cell function. This finding suggests that anti-oxidants may be potentially useful for reducing glucose toxicity...
  86. ncbi request reprint [Pro-inflammatory chemokine IL-8 in gastroesophageal reflux disease]
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    Nihon Rinsho 62:1447-53. 2004
    ..The production of IL-8 from esophageal mucosal cells was enhanced by the exposure to bile acid. These results suggest that IL-8 chemokine may play a major role in the pathogenesis of esophageal inflammation in GERD...
  87. ncbi request reprint Inhibitory effects of catechins on neutrophil-dependent gastric inflammation
    Osamu Handa
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachidori Hirokouji Agaru, Kyoto, Japan
    Redox Rep 7:324-8. 2002
    ..These results suggest that tea may inhibit carcinogenesis partly through the anti-inflammatory effects of tea catechins on PMN-dependent gastric mucosal inflammation...
  88. ncbi request reprint Inhibitory effect of pioglitazone on expression of adhesion molecules on neutrophils and endothelial cells
    Eiko Imamoto
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biofactors 20:37-47. 2004
    ..Accordingly, pioglitazone may be useful for treating inflammatory diseases...
  89. doi request reprint Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells
    Rosaria Piga
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Br J Nutr 102:264-72. 2009
    ..These results identify a mechanism of action of serotonin derivatives against endothelial damage at a cellular level, and underline their benefits against the disorders and complications related to reactive oxygen species...
  90. doi request reprint Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells
    Tomohisa Takagi
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 25:1259-65. 2010
    ..In this study, we investigated the therapeutic efficacy of ES in an experimental rat model of colitis, and evaluated the restitution of intestinal epithelial cells treated with ES in vitro...
  91. doi request reprint Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis
    Tomohisa Takagi
    Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto Japan
    J Gastroenterol Hepatol 25:S129-33. 2010
    ..In the present study, we used microarray technology to identify miRNA induced in the colonic mucosa of patients with active ulcerative colitis (UC)...
  92. ncbi request reprint Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in rats
    Hisato Tsuboi
    Department of Inflammation and Immunology, Kyoto Prefectural Univ of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G678-83. 2007
    ....
  93. ncbi request reprint The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha
    Makoto Shimozawa
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 9:354-9. 2004
    ..These results suggest that alacepril works as anti-atherogenic agent through inhibiting endothelial-dependent adhesive interactions with monocytes induced by 7-KC and TNF-alpha...
  94. ncbi request reprint The role of methylglyoxal-modified proteins in gastric ulcer healing
    T Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Curr Med Chem 19:137-44. 2012
    ..In this review, we present what is currently known regarding the role of methylglyoxal in the healing of diabetic gastric ulcers...
  95. ncbi request reprint A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates
    Y Nakamura
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, 606 8502, Kyoto, Japan
    Cancer Lett 157:193-200. 2000
    ....
  96. doi request reprint Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 45:692-702. 2010
    ..In addition, the protective role of PZ and the possible mechanism of its effect on indomethacin-induced small intestinal injury were investigated...