Shigekazu Nagata

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
  2. ncbi request reprint Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
  3. pmc Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
    Kenichi Asano
    Department of Genetics, Osaka University Medical School, Japan
    J Exp Med 200:459-67. 2004
  4. doi request reprint Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
    Hiroshi Yamaguchi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    J Leukoc Biol 83:1300-7. 2008
  5. pmc Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif
    Xi Liu
    INSERM Equipe Avenir, CNRS UPR9022, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    PLoS ONE 7:e42725. 2012
  6. doi request reprint Apoptosis and autoimmune diseases
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, University of Kyoto, Yoshida, Konoe, Sakyo, Kyoto, Japan
    Ann N Y Acad Sci 1209:10-6. 2010
  7. ncbi request reprint Rheumatoid polyarthritis caused by a defect in DNA degradation
    Shigekazu Nagata
    Department of Medical Science, Graduate School of Medicine, Kyoto University, Yoshida Konoe, 606 8501 Kyoto, Japan
    Cytokine Growth Factor Rev 19:295-302. 2008
  8. ncbi request reprint Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Immunol Rev 220:237-50. 2007
  9. doi request reprint Autoimmunity and the clearance of dead cells
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Cell 140:619-30. 2010
  10. doi request reprint Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity
    Masanori Miyanishi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Japan
    Int Immunol 24:551-9. 2012

Collaborators

  • Hiroshi Yamaguchi
  • Jun Suzuki
  • Satoshi Toda
  • Yasuo Uchiyama
  • Masato Koike
  • Toshihiro Fujii
  • Ami Aronheim
  • Takako Miyamae
  • Kenji Ishihara
  • Shumpei Yokota
  • Koichiro Ohmura
  • Junichi Takagi
  • Tsuneyo Mimori
  • Takayuki Suzuki
  • Tetsuji Naka
  • Masato Tanaka
  • Shuichi Miyazaki
  • Kohki Kawane
  • Rikinari Hanayama
  • Katsumori Segawa
  • Yasutaka Okabe
  • Hidehiro Fukuyama
  • Michio Nakaya
  • Teruyuki Sano
  • Keiko Miwa
  • Rie Watanabe-Fukunaga
  • Masanori Miyanishi
  • Hideyuki Yoshida
  • Rikiro Fukunaga
  • Yusuke Kitahara
  • Masahiro Kitano
  • Satoshi Iida
  • Chihiro Nishi
  • Takeshi Ueda
  • Xi Liu
  • Kazutoshi Tada
  • Hironori Ogawa
  • Michiyuki Matsuda
  • Masaki Nakahara
  • Anna Bergsmedh
  • Barry L Burgess
  • Kay Miyasaka
  • Akihiro Kimura
  • Kenichi Asano
  • Hiroko Nagase
  • Yoshiyuki Ohsawa
  • Sogo Nishimoto
  • Azusa Shinohara
  • Akihiro Iwamatsu
  • Sachiko Kurata
  • Yuichi Yanagihashi
  • Fumihiko Matsuda
  • Thijn R Brummelkamp
  • Naomi Mukae
  • Jules A Hoffmann
  • Yongsheng Guan
  • Shin Shimaoka
  • Hiromi Tanaka
  • Takeshi Nakamura
  • Kaori Uchida
  • Toshio Kitamura
  • Yujiro Higashi
  • Akiomi Nagasaka
  • Takuji Kizawa
  • Hideki Yoshikawa
  • Mayumi Ohtani
  • Jacob Ehnfors
  • Yoshichika Yoshioka
  • Michael O Hall
  • Toshka A Abrams
  • Noboru Motoyama
  • Lars Holmgren
  • Yoshiyuki Kanbara
  • Tadatsugu Taniguchi
  • Shizuo Akira
  • Yusuke Shimizu
  • Yoshimi Mori
  • Miyu Miwa
  • Ichiro Kawase
  • Tadamitsu Kishimoto
  • Katsuyuki Aozasa
  • Kazuhisa Okada
  • Tetsuya Iida
  • Takeshi Morimoto
  • Noriyasu Hashida
  • Yasuo Tano
  • Yutaka Fukuda
  • Tomohisa Aoyama
  • Nobuyuki Ohguro
  • Yasuhiko Sakoyama

Detail Information

Publications59

  1. ncbi request reprint Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
    ..These results indicate that MFG-E8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment...
  2. ncbi request reprint Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
    ..These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases...
  3. pmc Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
    Kenichi Asano
    Department of Genetics, Osaka University Medical School, Japan
    J Exp Med 200:459-67. 2004
    ..These results indicated that the impairment of apoptotic cell phagocytosis led to autoantibody production...
  4. doi request reprint Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
    Hiroshi Yamaguchi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    J Leukoc Biol 83:1300-7. 2008
    ..These results suggested that the aberrant expression of MFG-E8 is involved in the pathoetiology of some cases of hSLE...
  5. pmc Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif
    Xi Liu
    INSERM Equipe Avenir, CNRS UPR9022, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    PLoS ONE 7:e42725. 2012
    ..Our data provide the first in vivo demonstration for the immune function of EYA and point to their conserved immune function in response to endogenous DNA, throughout evolution...
  6. doi request reprint Apoptosis and autoimmune diseases
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, University of Kyoto, Yoshida, Konoe, Sakyo, Kyoto, Japan
    Ann N Y Acad Sci 1209:10-6. 2010
    ..Data from these mutant mice and human patients indicate that defects in cell death or dead-cell clearance leads to autoimmunity. This review examines the cell death and clearance processes and briefly discusses the diseases they cause...
  7. ncbi request reprint Rheumatoid polyarthritis caused by a defect in DNA degradation
    Shigekazu Nagata
    Department of Medical Science, Graduate School of Medicine, Kyoto University, Yoshida Konoe, 606 8501 Kyoto, Japan
    Cytokine Growth Factor Rev 19:295-302. 2008
    ..Here, I summarize recent findings on inflammatory diseases induced by such defects in DNA degradation...
  8. ncbi request reprint Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Immunol Rev 220:237-50. 2007
    ..In contrast, failure to efficiently degrade the DNA of dead cells or erythroid cell nuclei activates innate immunity, causing lethal anemia in the fetus and chronic arthritis in adults...
  9. doi request reprint Autoimmunity and the clearance of dead cells
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Cell 140:619-30. 2010
    ..Here, we discuss how the endogenous components of dead cells activate the immune system through both extracellular and intracellular pathways...
  10. doi request reprint Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity
    Masanori Miyanishi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Japan
    Int Immunol 24:551-9. 2012
    ..These results suggest that the double deficiency of Tim4 and MFG-E8, phosphatidylserine-binding proteins, can trigger autoimmunity and that TNF╬▒ and type I IFN regulate reciprocally the development of autoimmune disease...
  11. pmc Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression
    Toshihiro Fujii
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 285:30214-23. 2010
    ..These results indicate that p400/mDomino plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes...
  12. ncbi request reprint Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus
    Hiroshi Yamaguchi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan
    Eur J Immunol 40:1778-85. 2010
    ..These results suggested that the intronic mutation in the human MFG-E8 gene can lead to the development of SLE...
  13. doi request reprint Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells
    Jun Suzuki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, Kyoto 606 8501, Japan
    Science 341:403-6. 2013
    ..Thus, Xk-family proteins have evolutionarily conserved roles in promoting the phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane. ..
  14. pmc Two-step engulfment of apoptotic cells
    Satoshi Toda
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Kyoto, Japan
    Mol Cell Biol 32:118-25. 2012
    ..Furthermore, the Tim4/integrin-mediated engulfment by the Ba/F3 cells was enhanced in cells expressing Rac1 and Rab5, suggesting that this system well reproduces the engulfment of apoptotic cells by macrophages...
  15. pmc Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
    Kohki Kawane
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:19432-7. 2010
    ....
  16. doi request reprint IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation
    Yasutaka Okabe
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Immunol 38:3150-8. 2008
    ..These results indicate that the mammalian chromosomal DNA that accumulates in macrophages due to inefficient degradation activates genes in both IRF3/IRF7-dependent and -independent manners...
  17. ncbi request reprint Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
    Katsumori Segawa
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Kyoto 606 8501, Japan
    Science 344:1164-8. 2014
    ..CDC50A-deficient cells displayed PtdSer on their surface and were engulfed by macrophages, indicating that PtdSer is sufficient as an "eat me" signal. ..
  18. ncbi request reprint Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells
    Hideyuki Yoshida
    Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Nature 437:754-8. 2005
    ..Fetal liver macrophages efficiently engulfed the nuclei; masking the phosphatidylserine on the nuclei with the dominant-negative form of milk-fat-globule EGF8 (MFG-E8) prevented this engulfment...
  19. pmc Spatiotemporal activation of Rac1 for engulfment of apoptotic cells
    Michio Nakaya
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 105:9198-203. 2008
    ..These results indicate that activated Rac1 is necessary to assemble F-actin, but closing the phagocytic cup requires Rac1 to be deactivated...
  20. ncbi request reprint Regulation of the innate immune response by threonine-phosphatase of Eyes absent
    Yasutaka Okabe
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Kyoto 606 8501, Japan
    Nature 460:520-4. 2009
    ....
  21. doi request reprint Interferon-induced TRAIL-independent cell death in DNase II-/- embryos
    Yusuke Kitahara
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Yoshida Konoe, Kyoto, Japan
    Eur J Immunol 40:2590-8. 2010
    ....
  22. pmc Functional swapping between transmembrane proteins TMEM16A and TMEM16F
    Takayuki Suzuki
    From the Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan and
    J Biol Chem 289:7438-47. 2014
    ..These results indicate that TMEM16A and -16F use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ. ..
  23. pmc Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages
    Chihiro Nishi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Mol Cell Biol 34:1512-20. 2014
    ..Taken together, these results indicate that the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK-mediated cell engulfment. ..
  24. doi request reprint Essential role of C/EBPalpha in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes
    Satoshi Iida
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Genes Cells 13:313-27. 2008
    ..These results indicate that C/EBPalpha is activated by G-CSF to bind target promoters, and plays critical roles in the transcriptional activation and dynamic chromatin modification of target genes during neutrophil differentiation...
  25. pmc Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members
    Jun Suzuki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 288:13305-16. 2013
    ..TMEM16A and 16B work as Cl(-) channel, whereas 16F works as phospholipid scramblase. The function of other TMEM16 members is unknown...
  26. doi request reprint Autoinflammation by endogenous DNA
    Shigekazu Nagata
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, Japan
    Adv Immunol 110:139-61. 2011
    ..Here, we discuss when, where, and how DNA is degraded to maintain mammalian homeostasis...
  27. doi request reprint Calcium-dependent phospholipid scrambling by TMEM16F
    Jun Suzuki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Nature 468:834-8. 2010
    ..A patient with Scott syndrome, which results from a defect in phospholipid scrambling activity, was found to carry a mutation at a splice-acceptor site of the gene encoding TMEM16F, causing the premature termination of the protein...
  28. doi request reprint Nucleases in programmed cell death
    Kohki Kawane
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto, Japan
    Methods Enzymol 442:271-87. 2008
    ..These techniques are useful for studying DNases that are involved in programmed cell death and for following the engulfment of apoptotic cells by phagocytes...
  29. ncbi request reprint SEI family of nuclear factors regulates p53-dependent transcriptional activation
    Rie Watanabe-Fukunaga
    Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 10:851-60. 2005
    ..These results indicate that the SEI family of nuclear proteins regulates p53 transcriptional activity and a p53-independent signaling pathway leading to growth inhibition...
  30. pmc Constitutive exposure of phosphatidylserine on viable cells
    Katsumori Segawa
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:19246-51. 2011
    ..c. into nude mice, they generated tumors as efficiently as parental lymphoma cells that did not expose PS. These results indicated that PS exposure alone is not sufficient to be recognized by macrophages as an eat-me signal...
  31. ncbi request reprint Identification of Tim4 as a phosphatidylserine receptor
    Masanori Miyanishi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Nature 450:435-9. 2007
    ..These results indicate that Tim4 and Tim1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved...
  32. doi request reprint Characterization of the threonine-phosphatase of mouse eyes absent 3
    Teruyuki Sano
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Kyoto, Japan
    FEBS Lett 585:2714-9. 2011
    ....
  33. ncbi request reprint MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands
    Satoshi Toda
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, and
    Blood 123:3963-71. 2014
    ..These results suggest that macrophages use similar mechanisms to engulf both pyrenocytes and apoptotic cells. ..
  34. ncbi request reprint A SWI2/SNF2-type ATPase/helicase protein, mDomino, interacts with myeloid zinc finger protein 2A (MZF-2A) to regulate its transcriptional activity
    Hironori Ogawa
    Department of Genetics B 3, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Genes Cells 8:325-39. 2003
    ..To understand the mechanism of the MZF-2A-dependent transcriptional activation, we screened for molecules that interact with the transactivation domain (TAD) of MZF-2A...
  35. doi request reprint Imaging of Rab5 activity identifies essential regulators for phagosome maturation
    Masahiro Kitano
    Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Nature 453:241-5. 2008
    ..We therefore propose a mechanistic model in which the recruitment of Gapex-5 to phagosomes through the microtubule network induces the transient Rab5 activation...
  36. ncbi request reprint Phospholipid scrambling on the plasma membrane
    Jun Suzuki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Methods Enzymol 544:381-93. 2014
    ..In this chapter, we describe procedures for assaying phospholipid scrambling. ..
  37. ncbi request reprint DNA degradation in development and programmed cell death
    Shigekazu Nagata
    Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Japan
    Annu Rev Immunol 23:853-75. 2005
    ..I discuss what might be or will be learned from understanding the molecular mechanisms of DNA degradation that occurs during mammalian development...
  38. pmc Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    Yasutaka Okabe
    Department of Genetics, Osaka University Medical School, Japan
    J Exp Med 202:1333-9. 2005
    ..These results indicate that there is a TLR-independent sensing mechanism to activate the innate immunity for the endogenous DNA escaping lysosomal degradation...
  39. ncbi request reprint Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
    Kohki Kawane
    Department of Genetics, Osaka University Medical School, Japan
    Nat Immunol 4:138-44. 2003
    ....
  40. ncbi request reprint Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, Osaka, Japan
    J Immunol 172:3876-82. 2004
    ..These results suggest the existence of macrophage subsets that use MFG-E8 or Del-1 differently to engulf apoptotic cells...
  41. ncbi request reprint Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    Hideyuki Yoshida
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 6:49-56. 2005
    ....
  42. ncbi request reprint MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, Osaka, Japan
    Curr Dir Autoimmun 9:162-72. 2006
    ..In this review, we discuss the importance of the MFG-E8-mediated clearance of apoptotic cells in the prevention of autoimmune diseases...
  43. ncbi request reprint Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    Kohki Kawane
    Department of Genetics, Osaka University, Osaka 565 0871, Japan
    Nature 443:998-1002. 2006
    ....
  44. ncbi request reprint Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens
    Masaki Nakahara
    Department of Genetics, Osaka University Medical School, Japan
    FEBS J 274:3055-64. 2007
    ..These results suggest that the lysosomal system plays a role in the degradation of cellular organelles during lens cell differentiation...
  45. ncbi request reprint Breakdown of chromosomal DNA
    Shigekazu Nagata
    Department of Genetics, Osaka University Medical School, Suita, Japan
    Cornea 21:S2-6. 2002
    ..In this article, the molecular mechanism of the apoptotic DNA degradation and the enucleation process of erythroid cells are discussed...
  46. ncbi request reprint Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1
    Kazutoshi Tada
    Department of Genetics, Osaka University Medical School, Osaka, Japan
    J Immunol 171:5718-26. 2003
    ..These results indicate that macrophages require CD47 and phosphatidylserine on apoptotic cells for engulfment, and suggest that the interaction between CD47 and SHPS-1 works as a tethering step in the phagocytosis...
  47. ncbi request reprint Apoptosis and autoimmune diseases
    Shigekazu Nagata
    Laboratory of Genetics, Department of Integrated Biology, Graduate School of Frontier Bioscience, Osaka University, Japan
    IUBMB Life 58:358-62. 2006
    ..The apoptotic process and the diseases caused by defects in it are briefly reviewed...
  48. pmc Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation
    Naomi Mukae
    Department of Genetics, Osaka University Medical School, Osaka 565 0871, Japan
    Genes Dev 16:2662-71. 2002
    ..These results indicated that CAD and DNase II work independently to degrade chromosomal DNA during apoptosis, and if the DNA is left undigested, it can activate the innate immunity in Drosophila...
  49. ncbi request reprint Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens
    Sogo Nishimoto
    Department of Genetics, Osaka University Medical School, Osaka 565 0871, Japan
    Nature 424:1071-4. 2003
    ..These results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation, and that if DNA is left undigested in the lens, it causes cataracts of the nucleus lentis, blocking the light path...
  50. pmc Intraperitoneal injection of lipopolysaccharide induces dynamic migration of Gr-1high polymorphonuclear neutrophils in the murine abdominal cavity
    Shuichi Miyazaki
    Department of Microbiology, Toho University School of Medicine, Omori nishi 5 21 16, Ota ku, Tokyo 143 8540, Japan
    Clin Diagn Lab Immunol 11:452-7. 2004
    ..Our results suggest that LPS induced PMN death and that many PMNs expressing Gr-1(high) undergo apoptosis 180 min postinjection of LPS...
  51. ncbi request reprint SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation
    Akihiro Kimura
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka, 565 0871, Japan
    Int Immunol 16:991-9. 2004
    ..Taken together, these results suggest that SOCS-1 inhibits TNF-alpha-induced apoptosis through regulation of Jaks...
  52. ncbi request reprint Requirement of Fas expression in B cells for tolerance induction
    Hidehiro Fukuyama
    Department of Genetics, Osaka University Medical School, Osaka, Japan
    Eur J Immunol 32:223-30. 2002
    ..These results indicate that both mature B cells and T cells must undergo Fas-mediated apoptosis to prevent the development of autoimmune diseases...
  53. pmc Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:16886-91. 2005
    ..These results demonstrate that MFG-E8-mediated phagocytosis of apoptotic epithelial cells and MFGs is important for efficient involution of mammary glands...
  54. ncbi request reprint Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages
    Michio Nakaya
    Department of Genetics, Osaka University Medical School, Osaka 565 0871, Japan
    J Biol Chem 281:8836-42. 2006
    ..The dominant-negative form of RhoG or Rac1 inhibited this process, which suggested RhoG and Rac1 are also involved in the integrin-mediated engulfment...
  55. ncbi request reprint DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA
    Anna Bergsmedh
    Cancer Center Karolinska Hospital, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Mol Cancer Res 4:187-95. 2006
    ....
  56. ncbi request reprint MFG-E8 in the retina and retinal pigment epithelium of rat and mouse
    Barry L Burgess
    Jules Stein Eye Institute, UCLA Medical Center, Los Angeles, CA 90095 7000, USA
    Mol Vis 12:1437-47. 2006
    ....
  57. ncbi request reprint Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis
    Takeshi Ueda
    Laboratory of Genetics B 3, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Japan Science and Technology Corporation, Osaka, Japan
    Genes Cells 12:581-92. 2007
    ..These results suggest that p400/mDomino plays a critical role in embryonic hematopoiesis by regulating the expression of developmentally essential genes such as those in the Hox gene cluster...
  58. pmc Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury
    Masato Koike
    Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Am J Pathol 172:454-69. 2008
    ....