Kazumasa Morita

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease
    K Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoinkawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Br J Dermatol 151:328-34. 2004
  2. ncbi request reprint Expression of claudin-5 in dermal vascular endothelia
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Dermatol 12:289-95. 2003
  3. ncbi request reprint Tight junctions in the skin
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 606 8507, Kyoto, Japan
    J Dermatol Sci 31:81-9. 2003
  4. ncbi request reprint Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Invest Dermatol 118:1073-9. 2002
  5. doi request reprint Tight junctions in epidermis: from barrier to keratinization
    Kazumasa Morita
    Department of Dermatology, Tenri Hospital, Tenri 632 8552, Japan
    Eur J Dermatol 21:12-7. 2011
  6. ncbi request reprint Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
    Shin iciro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Hear Res 187:25-34. 2004
  7. ncbi request reprint Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Invest Dermatol 110:862-6. 1998
  8. pmc Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
    Tatsuo Miyamoto
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    J Cell Biol 169:527-38. 2005
  9. ncbi request reprint Expression of prostate-specific antigen and androgen receptor in extramammary Paget's disease and carcinoma
    N Inoguchi
    Department of Dermatology, Gradutate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Exp Dermatol 32:91-4. 2007
  10. ncbi request reprint Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands
    K Yoneda
    Department of Dermatology, Kyoto University Faculty of Medicine, Japan
    Br J Dermatol 138:37-44. 1998

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease
    K Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoinkawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Br J Dermatol 151:328-34. 2004
    ..The epidermis, which is a typical stratified epithelium, has tight junctions (TJs) in the granular layer, as do simple epithelia. So far, abnormalities of TJs and involvement of claudin-1 have been reported in tumours of simple epithelia...
  2. ncbi request reprint Expression of claudin-5 in dermal vascular endothelia
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Dermatol 12:289-95. 2003
    ..These findings confirmed that TJs in dermal vascular endothelial cells are composed of claudin-5...
  3. ncbi request reprint Tight junctions in the skin
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 606 8507, Kyoto, Japan
    J Dermatol Sci 31:81-9. 2003
    ..Furthermore, several TJ-related junctions were identified in epidermis. In this review article, the history of the investigation into TJs in epidermis and the perspectives of investigation into TJs in dermatology are described...
  4. ncbi request reprint Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Invest Dermatol 118:1073-9. 2002
    ....
  5. doi request reprint Tight junctions in epidermis: from barrier to keratinization
    Kazumasa Morita
    Department of Dermatology, Tenri Hospital, Tenri 632 8552, Japan
    Eur J Dermatol 21:12-7. 2011
    ..The two models of lacking-claudin-1 indicate that TJs are related not only to the epidermal barrier but also to keratinization. Research of TJs in epidermis is reviewed in view of the barrier to keratinization...
  6. ncbi request reprint Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
    Shin iciro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Hear Res 187:25-34. 2004
    ..These findings, i.e., very complex expression patterns of claudin species in the inner ear, would reflect the importance and the complexity of the barrier function of TJs in the inner ear...
  7. ncbi request reprint Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Invest Dermatol 110:862-6. 1998
    ..In addition, ZO-1 but not occludin were localized weakly at the outer root sheath and intensely at the hair cortex/matrix...
  8. pmc Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
    Tatsuo Miyamoto
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    J Cell Biol 169:527-38. 2005
    ....
  9. ncbi request reprint Expression of prostate-specific antigen and androgen receptor in extramammary Paget's disease and carcinoma
    N Inoguchi
    Department of Dermatology, Gradutate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Exp Dermatol 32:91-4. 2007
    ..Immunohistological staining showed correlation of PSA and AR in expression. These results suggest that PSA and the androgen signalling pathway may be involved in the pathogenesis of EPD...
  10. ncbi request reprint Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands
    K Yoneda
    Department of Dermatology, Kyoto University Faculty of Medicine, Japan
    Br J Dermatol 138:37-44. 1998
    ..A high level of fluorescence was observed at the cuticle of the cortex. Sebaceous and sweat gland cells contained abundant TGase 1. Possible functions of TGase 1 in these epidermal appendages are discussed...
  11. ncbi request reprint An ascidian homologue of vertebrate BMPs-5-8 is expressed in the midline of the anterior neuroectoderm and in the midline of the ventral epidermis of the embryo
    T Miya
    Department of Zoology, Graduate School of Science, Kyoto University, Japan
    Mech Dev 57:181-90. 1996
    ..This HrBMPa expression profile resembled that of Xenopus BMP-7, implying a primordial function of BMP-7 among vertebrate BMPs-5-8...
  12. ncbi request reprint Altered expression of occludin and tight junction formation in psoriasis
    Y Yoshida
    Department of Dermatology, Kyoto University, Graduate School of Medicine, Japan
    Arch Dermatol Res 293:239-44. 2001
    ..These findings indicate that occludin and the formation of tight junctions are related to the proliferation and differentiation of keratinocytes, and to the pathogenesis of psoriasis...
  13. ncbi request reprint Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins
    K Ueda
    Laboratory of Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    Biochim Biophys Acta 1461:305-13. 1999
    ..The interaction of SUR1 with nucleotides is quite different from that of MDR1. Variations in the interactions with nucleotides of ABC proteins may account for the differences in their functions...
  14. ncbi request reprint Angiosarcoma of the scalp: absence of vascular endothelial cadherin in primary and metastatic lesions
    M Tanioka
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Br J Dermatol 144:380-3. 2001
    ..On immunofluorescence staining, the expression of vascular endothelial cadherin, which is present in normal endothelium, was absent from both primary and metastatic sites. This may have promoted local invasion and metastasis...
  15. ncbi request reprint Papular elastolytic giant cell granuloma: a clinical variant of annular elastolytic giant cell granuloma or generalized granuloma annulare?
    K Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Eur J Dermatol 9:647-9. 1999
    ..However, centrifugal annular lesions were not clinically observed. He was successfully treated with tranilast and topical steroids...
  16. pmc Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    Proc Natl Acad Sci U S A 96:511-6. 1999
    ..These findings indicated that multiple claudin family members are involved in the formation of TJ strands in various tissues...
  17. pmc Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 147:185-94. 1999
    ..e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands...
  18. pmc Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 145:579-88. 1999
    ....
  19. pmc Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 147:1351-63. 1999
    ..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed...
  20. ncbi request reprint Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
    M Itoh
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:5981-6. 1999
    ..These findings indicated that ZO-2 forms a complex with ZO-1/occludin or ZO-1/alpha catenin to establish TJ or AJ domains, respectively...
  21. ncbi request reprint Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Japan
    J Dermatol 29:661-4. 2002
    ..Our cases indicate that combination therapy of topical SADBE with other therapies can be a choice for alopecia areata which is refractory to topical SADBE therapy alone...
  22. ncbi request reprint Expression of CCR5 in graft-versus-host disease (GVHD) of the skin: immunohistochemical staining of 38 cases
    Naoko I Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Dermatol 34:254-7. 2007
    ..These findings suggest that the immunopathological mechanism that differentiates between acute and chronic GVHD is a CCR5-mediated immunoreaction...
  23. ncbi request reprint Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells
    N Kanazawa
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Eur J Immunol 29:1925-32. 1999
    ..In conclusion, while fractalkine and MDC belong to different families of chemokines, both may be involved in recruitment of T cells for interaction with mature DC in the immune response...
  24. ncbi request reprint Pedunculated basal cell epithelioma which is not Pinkus tumor
    K Morita
    Department of Dermatology, Shimane Prefectural Central Hospital, Izumo, Japan
    J Dermatol 28:103-5. 2001
    ..It developed gradually and clinically resembled fibroma or pigmented nevus. Total resection was performed, and its histopathology revealed the solid or cystic type of basal cell epithelioma...
  25. ncbi request reprint A case of chronic perianal pyoderma treated with the recycled skin graft method
    Tetstuya Honda
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Japan
    J Dermatol 29:96-9. 2002
    ..This operation procedure, which we call the "recycled skin graft method" is less invasive, because a donor site for the skin graft is unnecessary. We considered it to be as one of the effective treatments for CPP...
  26. ncbi request reprint Tight junction proteins in keratinocytes: localization and contribution to barrier function
    Takuo Yuki
    Basic Research Laboratory, Kanebo Cosmetics Inc, Kanagawa, Japan
    Exp Dermatol 16:324-30. 2007
    ..We also found that the addition of ochratoxin A weakened the permeability barrier and the expression of claudin-4. Our findings suggest that TJ proteins contribute to the permeability barrier in epidermal keratinocytes...
  27. ncbi request reprint Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation
    Takeshi Matsui
    KAN Research Institute Inc, Shimogyo ku, Kyoto 600 8815, Japan
    J Biol Chem 281:27512-25. 2006
    ..This study provides the first evidence that retroviral-like aspartic protease is functionally important in mammalian tissue organization...
  28. ncbi request reprint HAN11 binds mDia1 and controls GLI1 transcriptional activity
    Kazumasa Morita
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, England, UK
    J Dermatol Sci 44:11-20. 2006
    ..GLI1-dependent transcription is positively regulated by DYRK1A, which is reported to bind HAN11. HAN11 is the human homologue of AN11, which controls flavonoid synthesis in plants...
  29. ncbi request reprint Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1
    Takeshi Matsui
    KAN Research Institute, Inc, Shimogyo ku, Kyoto 600 8815, Japan
    Genomics 84:384-97. 2004
    ..These findings indicated that dermokine-alpha/-beta, suprabasin, and Kdap are secreted from the spinous layer of the stratified epithelia and that these genes form a novel gene complex on the chromosome...
  30. doi request reprint Expression of claudin in melanoma cells
    Kazumasa Morita
    J Dermatol 35:36-8. 2008
  31. doi request reprint Necrotizing fasciitis of the leg due to Photobacterium damsela
    Yoshitaka Nakamura
    J Dermatol 35:44-5. 2008