Naruhiko Mizuta

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. ncbi request reprint A case of non-metastatic giant mucinous carcinoma of the breast
    Yuki Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, 602 0841, Japan
    Breast Cancer 12:337-40. 2005
  2. pmc Myoid hamartoma of the breast that proved difficult to diagnose: a case report
    Naruhiko Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto, Japan
    World J Surg Oncol 10:12. 2012
  3. ncbi request reprint Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, Japan
    J Antibiot (Tokyo) 60:682-9. 2007
  4. ncbi request reprint Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto 602 0841, Japan
    Biochem Biophys Res Commun 356:260-5. 2007
  5. ncbi request reprint [Long-term complete response in a patient with breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid]
    Naruhiko Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine
    Gan To Kagaku Ryoho 37:1317-20. 2010
  6. doi request reprint Prognosis of Japanese breast cancer based on hormone receptor and HER2 expression determined by immunohistochemical staining
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    World J Surg 32:2477-82. 2008
  7. doi request reprint Clinical outcomes of video-assisted skin-sparing partial mastectomy for breast cancer and immediate reconstruction with latissimus dorsi muscle flap as breast-conserving therapy
    Hiroo Nakajima
    Department of Endocrine, Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamikyo ku, Kyoto 602 8566, Japan
    World J Surg 34:2197-203. 2010
  8. ncbi request reprint [Administration of nab-paclitaxel for 9 metastatic breast cancer patients]
    Koichi Sakaguchi
    Dept of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Japan
    Gan To Kagaku Ryoho 39:1081-5. 2012
  9. ncbi request reprint Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto 602 0841, Japan
    Cancer Lett 253:89-96. 2007
  10. doi request reprint Video-assisted skin-sparing breast-conserving surgery for breast cancer and immediate reconstruction with autologous tissue
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ann Surg 249:91-6. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A case of non-metastatic giant mucinous carcinoma of the breast
    Yuki Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, 602 0841, Japan
    Breast Cancer 12:337-40. 2005
    ..Although several reports have suggested that pure mucinous carcinoma of the breast has a favorable prognosis, we need to follow this case until the clinical behavior and the outcome become clear...
  2. pmc Myoid hamartoma of the breast that proved difficult to diagnose: a case report
    Naruhiko Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto, Japan
    World J Surg Oncol 10:12. 2012
    ..Histologically, the tumor was identified as fibroadenoma. A case of myoid hamartoma of the breast that proved difficult to diagnose is reported, and discussed with reference to the literature...
  3. ncbi request reprint Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, Japan
    J Antibiot (Tokyo) 60:682-9. 2007
    ..These results suggest that chemotherapy targeting AP-1 activity is a potent strategy for estrogen receptor-negative human breast cancers...
  4. ncbi request reprint Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto 602 0841, Japan
    Biochem Biophys Res Commun 356:260-5. 2007
    ..These results suggest that tetrocarcin A could be a potent chemotherapeutic agent for human breast cancer targeting the phosphatidylinositide-3'-kinase/Akt signaling pathway...
  5. ncbi request reprint [Long-term complete response in a patient with breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid]
    Naruhiko Mizuta
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine
    Gan To Kagaku Ryoho 37:1317-20. 2010
    ..After 3 cycles of treatment, the patient's tumor marker levels had decreased to normal values, and both the bone and pleura metastases had disappeared. A long-term complete response was obtained as a result of this combination therapy...
  6. doi request reprint Prognosis of Japanese breast cancer based on hormone receptor and HER2 expression determined by immunohistochemical staining
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    World J Surg 32:2477-82. 2008
    ..We classified Japanese breast cancer patients based on estrogen receptor (ER), progesterone receptor (PR), and HER2 protein expression and compared their prognoses...
  7. doi request reprint Clinical outcomes of video-assisted skin-sparing partial mastectomy for breast cancer and immediate reconstruction with latissimus dorsi muscle flap as breast-conserving therapy
    Hiroo Nakajima
    Department of Endocrine, Breast Surgery, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamikyo ku, Kyoto 602 8566, Japan
    World J Surg 34:2197-203. 2010
    ..We report the clinical outcomes for video-assisted SSPM (VA-SSPM) with immediate breast reconstruction using autogenous tissue...
  8. ncbi request reprint [Administration of nab-paclitaxel for 9 metastatic breast cancer patients]
    Koichi Sakaguchi
    Dept of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Japan
    Gan To Kagaku Ryoho 39:1081-5. 2012
    ..Concurrent trastuzumab administration was safe also. In conclusion, nab-paclitaxel could be administered safely, and may contribute to the treatment of refractory advanced or recurrent breast cancer...
  9. ncbi request reprint Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto 602 0841, Japan
    Cancer Lett 253:89-96. 2007
    ..These results suggest that YM529 is a potent therapeutic agent for human breast cancers, activating the mitochondria-dependent apoptotic pathway through the inhibition of protein farnesylation...
  10. doi request reprint Video-assisted skin-sparing breast-conserving surgery for breast cancer and immediate reconstruction with autologous tissue
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ann Surg 249:91-6. 2009
    ..To analyze therapeutic results of video-assisted breast-conserving surgery (VA-BCS) for early stage breast cancer...
  11. doi request reprint Video-assisted skin-sparing breast-conserving surgery for breast cancer and immediate reconstruction with autologous tissue: clinical outcomes
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ann Surg Oncol 16:1982-9. 2009
    ..This study analyzed clinical results of video-assisted breast-conserving surgery for breast cancer...
  12. ncbi request reprint Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines
    Koichi Sakaguchi
    Department of Endocrine, Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyo ku, Kyoto 602 0841, Japan
    Biochem Biophys Res Commun 329:46-50. 2005
    ..Our results suggest that AP-1 is an effective clinical target molecule for the treatment of estrogen receptor-negative human breast cancer...
  13. doi request reprint Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver
    Hiroo Nakajima
    Department of Endocrine, Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Apoptosis 13:1013-21. 2008
    ..Our results suggest that blockage of the Fas/Fas ligand interaction is a promising strategy for suppression of hepatic ischemia-reperfusion injury...
  14. doi request reprint Development of HER2-antagonistic peptides as novel anti-breast cancer drugs by in silico methods
    Hiroo Nakajima
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 0841, Japan
    Breast Cancer 15:65-72. 2008
    ..Thus, HRAP is the first HER2-binding small peptide antagonist rationally designed by a computer-aided SBDD method and is useful for the development of peptide mimetics to generate novel anti-breast cancer drugs...
  15. ncbi request reprint Fas ligand released by activated monocytes causes apoptosis of lung epithelial cells in human acute lung injury model in vitro
    Mitsuhiko Mizuta
    Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Biol Pharm Bull 31:386-90. 2008
    ..These results suggest that Fas ligand released by monocytes causes alveolar epithelial cell death through a Fas-dependent apoptotic mechanism in the development of acute lung injury...
  16. ncbi request reprint [A case of breast cancer with brain metastases responding to paclitaxel and capecitabine therapy]
    Koichi Sakaguchi
    Dept of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Japan
    Gan To Kagaku Ryoho 39:261-3. 2012
    ..After 5 courses of treatment, the level of tumor markers and all metastases were reduced. The combination treatment of paclitaxel and capecitabine is considered to be effective for metastatic breast cancer with brain metastases...
  17. ncbi request reprint [Sentinel lymph node biopsy and low axillary node sampling for breast cancer]
    Kiyoshi Sawai
    Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Nihon Geka Gakkai Zasshi 103:825-30. 2002
    ..If randomized studies, clinical practice guidelines, and the coverage of lymphoscintigraphy under health insurance were introduced, SLN biopsy would be used more widely in Japan...
  18. ncbi request reprint Different mechanisms for membrane and nuclear damages in apoptosis induced by an immunosuppressant, FTY720
    Hiroo Nakajima
    Department of Endocrine, Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Mol Cells 14:332-8. 2002
    ..Exogenously-added sphingolipids partially suppressed the FTY720-induced membrane damage. These results suggest that FTY720 induces membrane damage through the caspase-3-independent pathway that is modulated by sphingolipids...