Yoshihiko Miyata

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    Mol Cell Biol 24:4065-74. 2004
  2. doi request reprint Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Mol Cell Biochem 316:127-34. 2008
  3. ncbi request reprint The therapeutic target Hsp90 and cancer hallmarks
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Curr Pharm Des 19:347-65. 2013
  4. doi request reprint DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Kyoto University, Kyoto, Japan
    Biochim Biophys Acta 1813:1728-39. 2011
  5. doi request reprint Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Mol Cell Biochem 356:191-200. 2011
  6. doi request reprint Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery
    Y Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Cell Mol Life Sci 66:1840-9. 2009
  7. ncbi request reprint Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    FEBS J 274:5690-703. 2007
  8. ncbi request reprint CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Mol Cell Biochem 274:171-9. 2005
  9. ncbi request reprint Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents
    Y Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Curr Pharm Des 11:1131-8. 2005
  10. ncbi request reprint Supervision of multiple signaling protein kinases by the CK2-Cdc37 couple, a possible novel cancer therapeutic target
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Ann N Y Acad Sci 1030:150-7. 2004

Collaborators

  • Shigenobu Yonemura
  • Len Neckers
  • Masaubmi Shibuya
  • RICHARD BERT VALLEE
  • Hiroshi Yamashita
  • Shinichi Nakamura
  • Yoshiki Tsuchiya
  • Eiichi Takaki
  • Mutsuyo Gokuden
  • Naoko Hitosugi
  • Satoshi Mizukami
  • Hiroshi Nagasaka
  • Mitsuhiro Matsuda
  • Koichi Node
  • Makoto Akashi
  • Eisuke Nishida
  • Kyoko Goto
  • Mitsuaki Fujimoto
  • Tsuyoshi Mikuriya
  • Naoki Hayashida
  • Kaoru Yamamoto
  • Takashi Nakahari
  • Akira Nakai
  • Kazuma Sugahara
  • Sachiye Inouye
  • Toshiro Honda
  • Nobuhiro Ueno
  • Tsuyoshi Kuramoto
  • Kanji Ishitani
  • Naomi Shinkawa
  • Ken Ichiro Yoshikuni
  • Hideo Sakamaki
  • Masaaki Nishida
  • Masahiko Tsuchiya
  • Kazuhito Hayashi
  • Yasuo Murakami
  • Masaru Mishima
  • Tomohiro Takahara
  • Ikusuke Hatsukari
  • Masahiko Suzuki
  • Rie Ohno

Detail Information

Publications20

  1. pmc CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    Mol Cell Biol 24:4065-74. 2004
    ....
  2. doi request reprint Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Mol Cell Biochem 316:127-34. 2008
    ..These results show that the anti-[pSer13]-Cdc37 antibody can be a promising new tool to evaluate in vivo CK2 activity...
  3. ncbi request reprint The therapeutic target Hsp90 and cancer hallmarks
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Curr Pharm Des 19:347-65. 2013
    ..Finally, we discuss the "Hsp90-addiction" of cancer cells, and suggest a role for Hsp90 in tumor evolution...
  4. doi request reprint DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Kyoto University, Kyoto, Japan
    Biochim Biophys Acta 1813:1728-39. 2011
    ..Taken together, these results suggest that DYRK1A binds specifically to WDR68 in cells, and that the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68...
  5. doi request reprint Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Mol Cell Biochem 356:191-200. 2011
    ..We suggest a possible general role for CK2-catalyzed phosphorylation in the regulation of NLS-dependent protein nuclear translocation...
  6. doi request reprint Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery
    Y Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Cell Mol Life Sci 66:1840-9. 2009
    ..The tumor kinome appears to become addicted to the Hsp90-Cdc37 chaperone system, thus, targeting Hsp90, Cdc37, and CK2 is a promising strategy for cancer treatment...
  7. ncbi request reprint Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    FEBS J 274:5690-703. 2007
    ..Our results show the physiological importance of CK2-dependent Cdc37 phosphorylation and the usefulness of phospho-affinity gel electrophoresis in protein phosphorylation analysis...
  8. ncbi request reprint CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Mol Cell Biochem 274:171-9. 2005
    ..The structure of Cdc37 and physiological importance of the CK2-Cdc37 interaction are discussed...
  9. ncbi request reprint Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents
    Y Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Curr Pharm Des 11:1131-8. 2005
    ..In fact, a modified geldanamycin with lower toxicity, 17-allylaminogeldanamycin (17-AAG), has been examined in phase I clinical trials with encouraging results...
  10. ncbi request reprint Supervision of multiple signaling protein kinases by the CK2-Cdc37 couple, a possible novel cancer therapeutic target
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Ann N Y Acad Sci 1030:150-7. 2004
    ..We propose that the CK2-Cdc37 couple can be a novel and efficient pharmacological target for cancer chemotherapy...
  11. ncbi request reprint [Involvement of Hsp90 in the quality control of signal transducing proteins]
    Yoshihiko Miyata
    Tanpakushitsu Kakusan Koso 49:862-6. 2004
  12. ncbi request reprint [Molecular chaperone HSP90 as a novel target for cancer chemotherapy]
    Yoshihiko Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Nihon Yakurigaku Zasshi 121:33-42. 2003
    ..In fact, a modified geldanamycin with lower toxicity, 17-allylaminogeldanamycin (17-AAG), has been examined in phase I clinic trials with encouraging results...
  13. ncbi request reprint Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily
    Y Miyata
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
    J Biol Chem 276:21841-8. 2001
    ..These results taken together suggest a role of a specific set of molecular chaperones in the stability of signal-transducing protein kinases...
  14. pmc Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52
    Y Miyata
    Institut National de la Santé et de la Recherche Médicale Unité 33, 94276 Le Kremlin Bicetre Cedex, France
    Proc Natl Acad Sci U S A 94:14500-5. 1997
    ..These results indicate that CK2 phosphorylates FKBP52 both in vitro and in vivo and thus may regulate the protein composition of chaperone-containing complexes such as those of steroid receptors and certain protein kinases...
  15. doi request reprint Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms
    Yoshiki Tsuchiya
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Sci Signal 2:ra26. 2009
    ..Thus, our study identifies CK2 as a regulatory element of mammalian circadian rhythms and uncovers a role for CK2 in PER2 degradation...
  16. ncbi request reprint Molecular cloning and characterization of a novel member of the MAP kinase superfamily
    Y Miyata
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 4:299-309. 1999
    ..However, the diversity and complexity of cellular responses in mammalian systems may imply existence of hitherto unidentified members of the MAP kinase superfamily...
  17. ncbi request reprint Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan
    Mutsuyo Gokuden
    Kagoshima Prefectural Institute of Environmental Research and Public Health, Kagoshima 892 0853, Japan
    Jpn J Infect Dis 59:273. 2006
  18. ncbi request reprint [Propofol depresses the activity of hypoglossal nerve more than that of phrenic nerve in rabbits]
    Shinichi Nakamura
    Department of Anesthesiology, Saitama Medical School, Saitama 350 0451
    Masui 52:135-42. 2003
    ..Respiratory depression, such as obstruction of upper airway and inadequate ventilation, often appears during sedation and anesthesia. We studied the effect of propofol on the upper airway patency and the inspiratory drives...
  19. ncbi request reprint Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice
    Eiichi Takaki
    Biochemistry and Molecular Biology and Otolaryngology, Yamaguchi University School of Medicine, Ube 755 8505, Japan
    J Biol Chem 282:37285-92. 2007
    ..These results indicate that HSF1 is required to maintain ciliary beating in postnatal mice, probably by regulating constitutive expression of Hsp90 that is important for tubulin polymerization...
  20. ncbi request reprint Flumazenil antagonizes respiratory depression caused by diazepam and induces expiratory excitation of hypoglossal nerve
    Shinichi Nakamura
    Department of Anesthesiology, Saitama Medical School, Saitama 350 0451
    Masui 51:1107-10. 2002