Genomes and Genes

Species

Manabu Minami

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. Ikedo T, Minami M, Kataoka H, Hayashi K, Nagata M, Fujikawa R, et al. Dipeptidyl Peptidase-4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Accordingly, the ERK5 inhibitor also counteracted the suppression of p65 phosphorylation in vitro. A DPP-4 inhibitor, anagliptin, prevents the growth of IAs via its anti-inflammatory effects on macrophages. ..
  2. Fujikawa R, Higuchi S, Nakatsuji M, Yasui M, Ikedo T, Nagata M, et al. Deficiency in EP4 Receptor-Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease. Am J Pathol. 2017;187:1848-1854 pubmed publisher
    ..Further research is required to identify the role of EPRAP in AD, but our results indicate that EPRAP may be related to behavioral and psychological symptoms of dementia and inflammation in patients with AD. ..
  3. Fujikawa R, Higuchi S, Nakatsuji M, Yasui M, Ikedo T, Nagata M, et al. EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain. Am J Pathol. 2016;186:1982-1988 pubmed publisher
  4. request reprint
    Higuchi S, Fujikawa R, Ikedo T, Hayashi K, Yasui M, Nagata M, et al. EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice. J Immunol. 2016;197:4436-4443 pubmed
    ..For these reasons, we believe the EPRAP-PP2A axis in macrophages holds the key to treating chronic inflammatory disorders. ..
  5. Fujikawa R, Higuchi S, Ikedo T, Nagata M, Hayashi K, Yang T, et al. Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice. Biochem Biophys Res Commun. 2017;486:584-588 pubmed publisher
    ..These behavioral abnormalities in EPRAP-KO mice may result from the dysfunction of monoamines, in particular, norepinephrine. Our results suggest that EPRAP participates in the pathogenesis of various behavioral disorders. ..
  6. Ikedo T, Minami M, Kataoka H, Hayashi K, Nagata M, Fujikawa R, et al. Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms. Biochem Biophys Res Commun. 2018;495:332-338 pubmed publisher
    ..PI (18:0/20:4) accumulated at high levels in the thickened aneurysmal wall where synthetic dedifferentiated SMCs exist, suggesting that this phospholipid may be involved in the phenotypic switching of medial SMCs in the IA wall. ..