Osam Mazda


Affiliation: Kyoto Prefectural University of Medicine
Country: Japan


  1. Morimoto Y, Kishida T, Kotani S, Takayama K, Mazda O. Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells. Biochem Biophys Res Commun. 2018;507:330-336 pubmed publisher
    ..These results strongly suggest that the type I IFN receptor signal elicits an increase in PD-L1 expression in lung cancer cells through IRF9-dependent and independent pathways. ..
  2. Sato Y, Yamamoto K, Horiguchi S, Tahara Y, Nakai K, Kotani S, et al. Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration. Sci Rep. 2018;8:15824 pubmed publisher
    ..The present findings suggest that the combination of the NanoCliP-FD gel and dOBs may provide a feasible therapeutic modality for bone diseases. ..
  3. Fujioka K, Kishida T, Ejima A, Yamamoto K, Fujii W, Murakami K, et al. Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Biochem Biophys Res Commun. 2015;456:785-91 pubmed publisher
    ..7 cells as well as LPS-induced production of inflammatory cytokine by macrophages. The IL-10-iOBs may be applicable to novel cell-based therapy against bone destruction associated with RA. ..
  4. Kishida T, Ejima A, Yamamoto K, Tanaka S, Yamamoto T, Mazda O. Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes. Stem Cell Reports. 2015;5:569-81 pubmed publisher
    ..Thus, highly functional BAs can be generated by cellular reprogramming, suggesting a promising tailor-made cell therapy against metabolic disorders including type 2 diabetes mellitus. ..
  5. Nakamura K, Kishida T, Ejima A, Tateyama R, Morishita S, Ono T, et al. Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes. Biometals. 2018;: pubmed publisher
    ..These results suggest that bLF promotes UCP1 gene expression in brown adipocytes through the cAMP-PKA signaling pathway via the LRP1 receptor, leading to increased energy expenditure. ..
  6. Shimomura S, Inoue H, Arai Y, Nakagawa S, Fujii Y, Kishida T, et al. Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model. Int J Mol Sci. 2018;19: pubmed publisher
    ..These findings indicate that treadmill running in CIA rats inhibited synovial hyperplasia and joint destruction. ..
  7. Inoue H, Arai Y, Kishida T, Terauchi R, Honjo K, Nakagawa S, et al. Hydrostatic pressure influences HIF-2 alpha expression in chondrocytes. Int J Mol Sci. 2015;16:1043-50 pubmed publisher
    ..Hydrostatic pressure may influence cartilage degeneration, inducing MMP-13 and MMP-3 expression through HIF-2α. ..
  8. Yamamoto K, Kishida T, Sato Y, Nishioka K, Ejima A, Fujiwara H, et al. Direct conversion of human fibroblasts into functional osteoblasts by defined factors. Proc Natl Acad Sci U S A. 2015;112:6152-7 pubmed publisher
    ..These findings strongly suggest successful direct reprogramming of fibroblasts into functional osteoblasts by RXOL, a technology that may provide bone regeneration therapy against bone disorders. ..
  9. Yamamoto K, Kishida T, Nakai K, Sato Y, Kotani S, Nishizawa Y, et al. Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-? signal. Sci Rep. 2018;8:8463 pubmed publisher
    ..The present procedure realizes a highly efficient direct conversion of human fibroblasts into transgene-free and highly functional osteoblasts, which might be applied in a novel strategy of bone regeneration therapy in bone diseases. ..

More Information


  1. Nishioka K, Kishida T, Masui S, Mazda O. De novo CpG methylation on an artificial chromosome-like vector maintained for a long-term in mammalian cells. Biotechnol Lett. 2016;38:731-40 pubmed publisher
    ..CpG methylation thus was not solely dependent on the nucleotide sequence at the DNA locus. The epigenosome may become a useful tool to study the mechanisms of epigenetic regulation of a genetic region of interest in mammalian cells. ..
  2. Yamamoto K, Sato Y, Honjo K, Ichioka H, Oseko F, Sowa Y, et al. Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein. J Cell Biochem. 2016;117:2538-45 pubmed publisher
    ..These results strongly suggest that p-dOBs can be put into practical use for a novel cell-based therapy against bone diseases. J. Cell. Biochem. 117: 2538-2545, 2016. © 2016 Wiley Periodicals, Inc. ..
  3. Ichimaru S, Nakagawa S, Arai Y, Kishida T, Shin Ya M, Honjo K, et al. Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage. Int J Mol Sci. 2016;17: pubmed publisher
    ..The anabolic effects of exogenous HA may increase as OA progresses. ..
  4. Mizoshiri N, Kishida T, Yamamoto K, Shirai T, Terauchi R, Tsuchida S, et al. Transduction of Oct6 or Oct9 gene concomitant with Myc family gene induced osteoblast-like phenotypic conversion in normal human fibroblasts. Biochem Biophys Res Commun. 2015;467:1110-6 pubmed publisher
    ..The results may also lead to establishment of novel regenerative therapy for various bone resorption diseases. ..
  5. Wakao J, Kishida T, Fumino S, Kimura K, Yamamoto K, Kotani S, et al. Efficient direct conversion of human fibroblasts into myogenic lineage induced by co-transduction with MYCL and MYOD1. Biochem Biophys Res Commun. 2017;488:368-373 pubmed publisher