A Matsumori

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Amlodipine inhibits the production of cytokines induced by ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Cytokine 12:294-7. 2000
  2. ncbi request reprint Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis
    A Iwasaki
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 33:1400-7. 1999
  3. ncbi request reprint Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Circulation 96:1501-6. 1997
  4. ncbi request reprint Apical hypertrophic cardiomyopathy and hepatitis C virus infection
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:433-8. 1999
  5. ncbi request reprint Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis
    T Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 37:1713-8. 2001
  6. ncbi request reprint High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: a possible mechanism of digitalis toxicity
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:934-40. 1999
  7. ncbi request reprint Pimobendan inhibits the activation of transcription factor NF-kappaB: a mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2513-9. 2000
  8. ncbi request reprint The use of cytokine inhibitors. A new therapeutic insight into heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S3-12. 1997
  9. ncbi request reprint Hepatitis C virus from the hearts of patients with myocarditis and cardiomyopathy
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Lab Invest 80:1137-42. 2000
  10. ncbi request reprint Calcium channel blocker-induced protection against cardiovascular damage
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S39-46. 1997

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Amlodipine inhibits the production of cytokines induced by ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Cytokine 12:294-7. 2000
    ..The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients...
  2. ncbi request reprint Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis
    A Iwasaki
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 33:1400-7. 1999
    ..This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart...
  3. ncbi request reprint Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Circulation 96:1501-6. 1997
    ..To examine whether cardiac glycosides also modulate cytokine production, we evaluated the effects of ouabain on the production of cytokines in vitro and in vivo...
  4. ncbi request reprint Apical hypertrophic cardiomyopathy and hepatitis C virus infection
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:433-8. 1999
    ..A high prevalence of HCV infection was found in patients with HCM, particularly of the apical variety, suggesting that HCV is an important causal agent in the pathogenesis of the disease...
  5. ncbi request reprint Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis
    T Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 37:1713-8. 2001
    ..This report is the first to describe a beneficial effect by an immunosuppressive agent in the treatment of acute viral myocarditis...
  6. ncbi request reprint High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: a possible mechanism of digitalis toxicity
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:934-40. 1999
    ..These results suggest that digoxin worsens viral myocarditis, and that its use in high doses should be avoided in patients suffering from heart failure due to viral myocarditis...
  7. ncbi request reprint Pimobendan inhibits the activation of transcription factor NF-kappaB: a mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2513-9. 2000
    ..Electrophoretic mobility shift assay also showed inhibition of NF-kappaB activation by pimobendan. Pimobendan possesses the unique property of inhibiting NF-kappaB, which may be independent of phosphodiesterase inhibition...
  8. ncbi request reprint The use of cytokine inhibitors. A new therapeutic insight into heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S3-12. 1997
    ..Furthermore, the investigation of inotropic agents that are effective against the production of cytokines may help in the classification of these agents...
  9. ncbi request reprint Hepatitis C virus from the hearts of patients with myocarditis and cardiomyopathy
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Lab Invest 80:1137-42. 2000
    ..This method of detecting HCV genomes in formalin-fixed paraffin cardiac specimens has enabled us to widen our research into HCV infection and has been helpful in identifying the presence of HCV infection in cardiac myopathic disorders...
  10. ncbi request reprint Calcium channel blocker-induced protection against cardiovascular damage
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S39-46. 1997
    ..In this review, the possible roles of cytokines and NO in the pathophysiology of heart failure are discussed, along with the opportunities for therapeutic intervention...
  11. ncbi request reprint Amiodarone inhibits production of tumor necrosis factor-alpha by human mononuclear cells: a possible mechanism for its effect in heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Circulation 96:1386-9. 1997
    ..This study was performed to examine the effects of amiodarone (a drug shown to be beneficial in some patients suffering from heart failure) versus other antiarrhythmic agents on the production of cytokines in vitro...
  12. ncbi request reprint Relation between myoglobin and cardiac dysfunction in myocarditis--immunohistochemical study of endomyocardial biopsy specimens
    K Horike
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Jpn Circ J 55:24-32. 1991
    ..These results indicate that myoglobin staining reflects the intensity of myocarditis and a decrease of myoglobin may be important as one of the pathogenetic factors of cardiac dysfunction in myocarditis...
  13. ncbi request reprint Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice
    M Tominaga
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Circulation 83:2021-8. 1991
    ....
  14. ncbi request reprint Nifedipine inhibits activation of transcription factor NF-kappaB
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2655-61. 2000
    ..Nifedipine possesses the unique property of inhibiting NF-kappaB, which may be independent of its calcium channel blocking activity, and may, in part, explain its immunosuppressive effect...
  15. ncbi request reprint Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:805-7. 2000
    ..The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina...
  16. ncbi request reprint The role of inflammatory mediators in the failing heart: immunomodulation of cytokines in experimental models of heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Heart Fail Rev 6:129-36. 2001
    ..Endothelin-1 plays an important pathophysiological role in heart failure, and treatment with an endothelin antagonist had a cardioprotective effect in experimental models of heart failure...
  17. ncbi request reprint Hypertrophic cardiomyopathy as a manifestation of cardiac sarcoidosis
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:679-83. 2000
    ..One patient had an 'ace-of-spades' deformity of the left ventricle. Cardiac sardoidosis can mimic, and even present as, hypertrophic cardiomyopathy...
  18. ncbi request reprint Hepatitis C virus and cardiomyopathy
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Herz 25:249-54. 2000
    ..Although this study is preliminary, interferon therapy is a promising treatment for myocardial diseases caused by hepatitis C virus infection...
  19. ncbi request reprint Cytokine gene therapy for myocarditis by in vivo electroporation
    A Nakano
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8357, Japan
    Hum Gene Ther 12:1289-97. 2001
    ....
  20. ncbi request reprint Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT
    T Hirai
    Department of Cardiovascular Medicine, Graduate School of Medicine, and Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    J Nucl Cardiol 8:472-81. 2001
    ..Ten percent to 20% of it is metabolized through alpha-oxidation after beta-oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified...
  21. ncbi request reprint Proinflammatory cytokine inhibitor prolongs the survival of rats with heart failure induced by pressure overload
    T Shioi
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 65:584-5. 2001
    ..In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure...
  22. ncbi request reprint Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction
    K Nakamura
    Department of Cardiovascular Medicine, Okayama University Medical School, Japan
    Jpn Circ J 64:617-8. 2000
    ..HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis...
  23. ncbi request reprint Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling
    M W Hwang
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 38:1546-53. 2001
    ..In the acute phase of MI, IL-1beta appears to play a protective role...