A Matsumori

..CONCLUSIONS: These results indicate that the AT(1)R signal is obligatory for the development of virus-induced myocardial injury through the proinflammatory action of Ang-II via the NF-kB/cytokine pathway...

..These results suggest that digoxin worsens viral myocarditis, and that its use in high doses should be avoided in patients suffering from heart failure due to viral myocarditis...

..The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina...

..Electrophoretic mobility shift assay also showed inhibition of NF-kappaB activation by pimobendan. Pimobendan possesses the unique property of inhibiting NF-kappaB, which may be independent of phosphodiesterase inhibition...

..Nifedipine possesses the unique property of inhibiting NF-kappaB, which may be independent of its calcium channel blocking activity, and may, in part, explain its immunosuppressive effect...

..Endothelin-1 plays an important pathophysiological role in heart failure, and treatment with an endothelin antagonist had a cardioprotective effect in experimental models of heart failure...

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..Thus, the nationwide surveys of Japanese patients have yielded important current epidemiological and clinical information on the characteristics of cardiomyopathies in Japan...

..The results suggests that circulating HGF is a reliable early marker of cerebral infarction, and that this new sensitive HGF assay may be useful for diagnosing cerebral thrombosis...

..Pimobendan, FTY720 and Pycnogenol are promising agents for the treatment of viral myocarditis...

..This new pathway, thrombus formation-mast cell activation- degranulation-heparin-HGF-angiogenesis, may be both diagnostically useful and a therapeutic target...

..Accumulating evidence shows that heart failure is an inflammatory disease, and anti-inflammatory therapy by various agents would be a promising future treatment for heart failure...

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..Candesartan cilexetil is a new angiotensin II receptor blocker with a high affinity for the angiotensin II-subtype 1 receptor...

..One patient had an 'ace-of-spades' deformity of the left ventricle. Cardiac sardoidosis can mimic, and even present as, hypertrophic cardiomyopathy...

..A high prevalence of HCV infection was found in patients with HCM, particularly of the apical variety, suggesting that HCV is an important causal agent in the pathogenesis of the disease...

..In this review, the possible roles of cytokines and NO in the pathophysiology of heart failure are discussed, along with the opportunities for therapeutic intervention...

..Viral infection could lead to increased synthesis of free immunoglobulin light chains (FLC) and our earlier work showed that FLC can trigger mast cell activation...

..Furthermore, the investigation of inotropic agents that are effective against the production of cytokines may help in the classification of these agents...

..To examine whether cardiac glycosides also modulate cytokine production, we evaluated the effects of ouabain on the production of cytokines in vitro and in vivo...

..This study was performed to examine the effects of amiodarone (a drug shown to be beneficial in some patients suffering from heart failure) versus other antiarrhythmic agents on the production of cytokines in vitro...

..Although this study is preliminary, interferon therapy is a promising treatment for myocardial diseases caused by hepatitis C virus infection...

..This method of detecting HCV genomes in formalin-fixed paraffin cardiac specimens has enabled us to widen our research into HCV infection and has been helpful in identifying the presence of HCV infection in cardiac myopathic disorders...

..This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart...

..This report is the first to describe a beneficial effect by an immunosuppressive agent in the treatment of acute viral myocarditis...

..Thus, ESDN is considered to play a role in regulation of vascular cell growth and may have a wide variety of functions in other tissues including the nervous system, like neuropilins...

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..In the acute phase of MI, IL-1beta appears to play a protective role...

..The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients...

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..This study suggests that the beneficial effects of amiodarone in viral myocarditis may be mediated by decreasing interleukin 6 production in myocardial tissue...

..The aim of this study was to determine whether Pycnogenol had a beneficial effect on viral myocarditis in mice...

..These results indicate that myoglobin staining reflects the intensity of myocarditis and a decrease of myoglobin may be important as one of the pathogenetic factors of cardiac dysfunction in myocarditis...

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..In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure...

..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...

..HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis...

..The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis...

..These findings suggest that mast cell chymase and tryptase participate in the acute inflammation and remodeling process of viral myocarditis...

..Mast cells have been shown to play important role in the pathogenesis of heart failure due to viral myocarditis, and transition from compensated hypertrophy to heart failure...

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..Carvedilol may be effective in patients with viral myocarditis by boosting IL-12 and IFN-gamma production...

..Ten percent to 20% of it is metabolized through alpha-oxidation after beta-oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified...

..CONCLUSIONS: These observations indicate that mast cell degranulation stimulated by thrombin is necessary for the rapid induction of plasma HGF in intravascular thrombus-associated disorders...

..We examined the role of mast cells in murine models of heart failure due to viral myocarditis, using 2 strains of mast cell-deficient mice...

..8% vs 22.9%) with risk reduction of 50.2%. ARCH-J study showed that candesartan cilexetil, 8 mg/day, significantly improved the progression of heart failure when compared with placebo...

..DANCE is thus a novel vascular ligand for integrin receptors and may play a role in vascular development and remodeling...

..In regions where its prevalence is high, HCV infection may be an important cause of myocarditis and HF. NT-proBNP is a more sensitive marker of myocardial injury than cardiac troponins in patients with heart failure from HCV myocarditis...

..These observations suggest that mast cells play a critical role in the progression of heart failure. Stabilization of mast cells may represent a new approach in the management of heart failure...

..Heparin administration may make an extensive hepatectomy clinically feasible even for cirrhotic livers...

..However, the role of p300-histone acetyltransferase activity in LV remodeling after myocardial infarction in vivo is unknown...

..CONCLUSIONS: These hemodynamic data provide new insights into the pathophysiology of acute viral myocarditis and may be useful in the development of therapeutic interventions...

..05) from 0.038 +/- 0.004 to 0.053 +/- 0.007. In conclusion, EECP with heparin pretreatment appears to be a new treatment remedy for patients with stable angina...

..These findings suggest that p300-mediated nuclear acetylation plays a critical role in the development of myocyte hypertrophy and represents a pathway that leads to decompensated heart failure...

..These observations demonstrate that pioglitazone has anti-inflammatory effects in MI/R injury that are independent of its insulin-sensitizing effect...

..These findings suggest that antibodies to cTnI induce heart dysfunction and dilatation by chronic stimulation of Ca2+ influx in cardiomyocytes...

..CONCLUSIONS: The presence of preformed ANG II and gene expression of the renin-angiotensin system were detected in human mast cells. The release and synthesis of ANG II in mast cells was regulated by CGRP...

..The purpose of this study was to clarify the role of mast cells as an activator of ECs...

..The pathological role of apoptosis is apparently involved in these disease processes, possibly through upregulated RAS...

..The aim of this study was to investigate this relationship in patients with chest pain...

..To investigate prognosis and prognostic factors in patients with hypertrophic cardiomyopathy (HCM) in Japan...

..There have been few large-scale nationwide studies investigating both the prognosis and the prognostic factors of idiopathic dilated cardiomyopathy (IDC). A predictive score that can be used in clinical practice has not been established...

..A total of 41% of ED patients are either willing to receive pharmacotherapy for ED or will consider treatment. Active treatment of ED with sildenafil is suitable for patients with CVD...

..Prospectively controlled trials will be necessary to confirm this preventive effect of hydrocortisone on coronary in-stent restenosis...

..0025). 4. This study is the first to demonstrate that serum HGF levels increase in atrial fibrillation and decrease after successful DC cardioversion. This may reflect the fact that atrial fibrillation induces vascular endothelial injury...

..Prospectively controlled trials will be necessary to confirm this preventive effect of hydrocortisone...

..CONCLUSION: These results suggest that HCV infection is a potent pathogenic factor of tubulointerstitial injury...

..CONCLUSIONS: ED is one of the symptoms frequently observed among male ambulatory patients. Physicians should be encouraged to ask their patients about their ED, in order to identify their unmet need for treatment...