A Matsumori

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice
    Kanjo Yamamoto
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 42:2000-6. 2003
  2. pmc Evidence for a role of mast cells in the evolution to congestive heart failure
    Masatake Hara
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8397, Japan
    J Exp Med 195:375-81. 2002
  3. ncbi request reprint High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: a possible mechanism of digitalis toxicity
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:934-40. 1999
  4. ncbi request reprint Roles of hepatocyte growth factor and mast cells in thrombosis and angiogenesis
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Cardiovasc Drugs Ther 18:321-6. 2004
  5. ncbi request reprint Hypertrophic cardiomyopathy as a manifestation of cardiac sarcoidosis
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:679-83. 2000
  6. ncbi request reprint Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:805-7. 2000
  7. ncbi request reprint Pimobendan inhibits the activation of transcription factor NF-kappaB: a mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2513-9. 2000
  8. ncbi request reprint Nifedipine inhibits activation of transcription factor NF-kappaB
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2655-61. 2000
  9. ncbi request reprint Treatment options in myocarditis: what we know from experimental data and how it translates to clinical trials
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Herz 32:452-6. 2007
  10. ncbi request reprint The role of inflammatory mediators in the failing heart: immunomodulation of cytokines in experimental models of heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Heart Fail Rev 6:129-36. 2001

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice
    Kanjo Yamamoto
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 42:2000-6. 2003
    ..This study examined the role of angiotensin II (Ang-II) in a murine model of viral myocarditis...
  2. pmc Evidence for a role of mast cells in the evolution to congestive heart failure
    Masatake Hara
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8397, Japan
    J Exp Med 195:375-81. 2002
    ..These observations suggest that mast cells play a critical role in the progression of heart failure. Stabilization of mast cells may represent a new approach in the management of heart failure...
  3. ncbi request reprint High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: a possible mechanism of digitalis toxicity
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:934-40. 1999
    ..These results suggest that digoxin worsens viral myocarditis, and that its use in high doses should be avoided in patients suffering from heart failure due to viral myocarditis...
  4. ncbi request reprint Roles of hepatocyte growth factor and mast cells in thrombosis and angiogenesis
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Cardiovasc Drugs Ther 18:321-6. 2004
    ..This new pathway, thrombus formation-mast cell activation- degranulation-heparin-HGF-angiogenesis, may be both diagnostically useful and a therapeutic target...
  5. ncbi request reprint Hypertrophic cardiomyopathy as a manifestation of cardiac sarcoidosis
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:679-83. 2000
    ..One patient had an 'ace-of-spades' deformity of the left ventricle. Cardiac sardoidosis can mimic, and even present as, hypertrophic cardiomyopathy...
  6. ncbi request reprint Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 64:805-7. 2000
    ..The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina...
  7. ncbi request reprint Pimobendan inhibits the activation of transcription factor NF-kappaB: a mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2513-9. 2000
    ..Electrophoretic mobility shift assay also showed inhibition of NF-kappaB activation by pimobendan. Pimobendan possesses the unique property of inhibiting NF-kappaB, which may be independent of phosphodiesterase inhibition...
  8. ncbi request reprint Nifedipine inhibits activation of transcription factor NF-kappaB
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Life Sci 67:2655-61. 2000
    ..Nifedipine possesses the unique property of inhibiting NF-kappaB, which may be independent of its calcium channel blocking activity, and may, in part, explain its immunosuppressive effect...
  9. ncbi request reprint Treatment options in myocarditis: what we know from experimental data and how it translates to clinical trials
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Herz 32:452-6. 2007
    ..Pimobendan, FTY720 and Pycnogenol are promising agents for the treatment of viral myocarditis...
  10. ncbi request reprint The role of inflammatory mediators in the failing heart: immunomodulation of cytokines in experimental models of heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Heart Fail Rev 6:129-36. 2001
    ..Endothelin-1 plays an important pathophysiological role in heart failure, and treatment with an endothelin antagonist had a cardioprotective effect in experimental models of heart failure...
  11. ncbi request reprint Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 66:216-8. 2002
    ..The results suggests that circulating HGF is a reliable early marker of cerebral infarction, and that this new sensitive HGF assay may be useful for diagnosing cerebral thrombosis...
  12. ncbi request reprint Epidemiologic and clinical characteristics of cardiomyopathies in Japan: results from nationwide surveys
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 66:323-36. 2002
    ..Thus, the nationwide surveys of Japanese patients have yielded important current epidemiological and clinical information on the characteristics of cardiomyopathies in Japan...
  13. ncbi request reprint Hepatitis C virus from the hearts of patients with myocarditis and cardiomyopathy
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Lab Invest 80:1137-42. 2000
    ..This method of detecting HCV genomes in formalin-fixed paraffin cardiac specimens has enabled us to widen our research into HCV infection and has been helpful in identifying the presence of HCV infection in cardiac myopathic disorders...
  14. ncbi request reprint Hepatitis C virus and cardiomyopathy
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Herz 25:249-54. 2000
    ..Although this study is preliminary, interferon therapy is a promising treatment for myocardial diseases caused by hepatitis C virus infection...
  15. ncbi request reprint Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure
    Akira Matsumori
    Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Heart Fail 5:669-77. 2003
    ..Candesartan cilexetil is a new angiotensin II receptor blocker with a high affinity for the angiotensin II-subtype 1 receptor...
  16. ncbi request reprint Amiodarone inhibits production of tumor necrosis factor-alpha by human mononuclear cells: a possible mechanism for its effect in heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Circulation 96:1386-9. 1997
    ..This study was performed to examine the effects of amiodarone (a drug shown to be beneficial in some patients suffering from heart failure) versus other antiarrhythmic agents on the production of cytokines in vitro...
  17. ncbi request reprint Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Circulation 96:1501-6. 1997
    ..To examine whether cardiac glycosides also modulate cytokine production, we evaluated the effects of ouabain on the production of cytokines in vitro and in vivo...
  18. ncbi request reprint The use of cytokine inhibitors. A new therapeutic insight into heart failure
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S3-12. 1997
    ..Furthermore, the investigation of inotropic agents that are effective against the production of cytokines may help in the classification of these agents...
  19. ncbi request reprint Calcium channel blocker-induced protection against cardiovascular damage
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Int J Cardiol 62:S39-46. 1997
    ..In this review, the possible roles of cytokines and NO in the pathophysiology of heart failure are discussed, along with the opportunities for therapeutic intervention...
  20. ncbi request reprint Apical hypertrophic cardiomyopathy and hepatitis C virus infection
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 63:433-8. 1999
    ..A high prevalence of HCV infection was found in patients with HCM, particularly of the apical variety, suggesting that HCV is an important causal agent in the pathogenesis of the disease...
  21. doi request reprint Effects of free immunoglobulin light chains on viral myocarditis
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Circ Res 106:1533-40. 2010
    ..Viral infection could lead to increased synthesis of free immunoglobulin light chains (FLC) and our earlier work showed that FLC can trigger mast cell activation...
  22. ncbi request reprint Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Eur J Heart Fail 6:137-44. 2004
    ....
  23. ncbi request reprint Anti-inflammatory therapy for heart failure
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8397, Japan
    Curr Opin Pharmacol 4:171-6. 2004
    ..Accumulating evidence shows that heart failure is an inflammatory disease, and anti-inflammatory therapy by various agents would be a promising future treatment for heart failure...
  24. ncbi request reprint Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 74:567-71. 2010
    ....
  25. ncbi request reprint Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis
    A Iwasaki
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 33:1400-7. 1999
    ..This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart...
  26. ncbi request reprint ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury
    K Kobuke
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    J Biol Chem 276:34105-14. 2001
    ..Thus, ESDN is considered to play a role in regulation of vascular cell growth and may have a wide variety of functions in other tissues including the nervous system, like neuropilins...
  27. ncbi request reprint Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis
    T Miyamoto
    Department of Cardiovascular Medicine, Kyoto University, Japan
    J Am Coll Cardiol 37:1713-8. 2001
    ..This report is the first to describe a beneficial effect by an immunosuppressive agent in the treatment of acute viral myocarditis...
  28. ncbi request reprint Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling
    M W Hwang
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 38:1546-53. 2001
    ..In the acute phase of MI, IL-1beta appears to play a protective role...
  29. ncbi request reprint Cytokine gene therapy for myocarditis by in vivo electroporation
    A Nakano
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8357, Japan
    Hum Gene Ther 12:1289-97. 2001
    ....
  30. ncbi request reprint Amlodipine inhibits the production of cytokines induced by ouabain
    A Matsumori
    Department of Cardiovascular Medicine, Kyoto University, Japan
    Cytokine 12:294-7. 2000
    ..The unique property of amlodipine to inhibit the production of IL-1alpha, IL-1beta and IL-6 may contribute to its beneficial effects in heart failure patients...
  31. ncbi request reprint Role of cytokines in autoimmune myocarditis and cardiomyopathy
    Y Furukawa
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Autoimmunity 34:165-8. 2001
    ....
  32. ncbi request reprint French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis
    Akira Matsumori
    Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Card Fail 13:785-91. 2007
    ..The aim of this study was to determine whether Pycnogenol had a beneficial effect on viral myocarditis in mice...
  33. ncbi request reprint Amiodarone inhibits interleukin 6 production and attenuates myocardial injury induced by viral myocarditis in mice
    Haruyasu Ito
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cytokine 17:197-202. 2002
    ..This study suggests that the beneficial effects of amiodarone in viral myocarditis may be mediated by decreasing interleukin 6 production in myocardial tissue...
  34. ncbi request reprint Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction
    K Nakamura
    Department of Cardiovascular Medicine, Okayama University Medical School, Japan
    Jpn Circ J 64:617-8. 2000
    ..HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis...
  35. ncbi request reprint Relation between myoglobin and cardiac dysfunction in myocarditis--immunohistochemical study of endomyocardial biopsy specimens
    K Horike
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Jpn Circ J 55:24-32. 1991
    ..These results indicate that myoglobin staining reflects the intensity of myocarditis and a decrease of myoglobin may be important as one of the pathogenetic factors of cardiac dysfunction in myocarditis...
  36. ncbi request reprint Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice
    M Tominaga
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Circulation 83:2021-8. 1991
    ....
  37. ncbi request reprint Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    H Nishimura
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
    Science 291:319-22. 2001
    ..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...
  38. ncbi request reprint Proinflammatory cytokine inhibitor prolongs the survival of rats with heart failure induced by pressure overload
    T Shioi
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Jpn Circ J 65:584-5. 2001
    ..In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure...
  39. doi request reprint Anti-inflammatory effects of eplerenone on viral myocarditis
    Jie Xiao
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Heart Fail 11:349-53. 2009
    ..The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis...
  40. ncbi request reprint Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis
    Katsura Kitaura-Inenaga
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circ J 67:881-4. 2003
    ..These findings suggest that mast cell chymase and tryptase participate in the acute inflammation and remodeling process of viral myocarditis...
  41. ncbi request reprint [Roles of cytokines in the pathogenesis of heart failure]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 61:745-50. 2003
    ..Mast cells have been shown to play important role in the pathogenesis of heart failure due to viral myocarditis, and transition from compensated hypertrophy to heart failure...
  42. ncbi request reprint Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus
    Ryosuke Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    J Am Coll Cardiol 41:340-5. 2003
    ..This study was designed to examine the effects of carvedilol in a murine model of viral myocarditis induced by encephalomyocarditis virus (EMCV) infection...
  43. doi request reprint Role of substance P in viral myocarditis in mice
    Yong Wang
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawaracho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Heart Vessels 25:348-52. 2010
    ....
  44. ncbi request reprint Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT
    T Hirai
    Department of Cardiovascular Medicine, Graduate School of Medicine, and Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    J Nucl Cardiol 8:472-81. 2001
    ..Ten percent to 20% of it is metabolized through alpha-oxidation after beta-oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified...
  45. ncbi request reprint Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells
    Makoto Kinoshita
    Department of Cardiovascular Medicine, Kyoto University, Kyoto, Japan
    Circulation 106:3133-8. 2002
    ..The mechanism of this thrombus-associated HGF release, however, is unknown...
  46. doi request reprint Mast cells play a critical role in the pathogenesis of viral myocarditis
    Hirokazu Higuchi
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Circulation 118:363-72. 2008
    ..We examined the role of mast cells in murine models of heart failure due to viral myocarditis, using 2 strains of mast cell-deficient mice...
  47. ncbi request reprint [Effect of angiotensin II receptor antagonist on heart failure]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:203-10. 2004
    ..8% vs 22.9%) with risk reduction of 50.2%. ARCH-J study showed that candesartan cilexetil, 8 mg/day, significantly improved the progression of heart failure when compared with placebo...
  48. ncbi request reprint DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries
    T Nakamura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:22476-83. 1999
    ..DANCE is thus a novel vascular ligand for integrin receptors and may play a role in vascular development and remodeling...
  49. ncbi request reprint [Anti-TNF-alpha therapy for heart failure: etanercept, infliximab]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 65:176-81. 2007
  50. ncbi request reprint Heparin accelerates liver regeneration following portal branch ligation in normal and cirrhotic rats with increased plasma hepatocyte growth factor levels
    Teizo Nakao
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Hepatol 37:87-92. 2002
    ..Therefore, we investigated the effects of heparin administration on liver regeneration following portal branch ligation (PBL) in normal and cirrhotic rats...
  51. ncbi request reprint Myocarditis and heart failure associated with hepatitis C virus infection
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Card Fail 12:293-8. 2006
    ..HCV infection has recently been noted in patients with cardiomyopathies and myocarditis. However, prevalence of HCV infection in myocarditis and heart failure remains to be clarified...
  52. ncbi request reprint [Effect of IFN treatment for extrahepatic manifestations]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:569-73. 2004
  53. ncbi request reprint Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo
    Shoichi Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 113:679-90. 2006
    ..However, the role of p300-histone acetyltransferase activity in LV remodeling after myocardial infarction in vivo is unknown...
  54. ncbi request reprint Preformed angiotensin II is present in human mast cells
    Masatake Hara
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cardiovasc Drugs Ther 18:415-20. 2004
    ..However, their function remains unclear. In this study, preformed angiotensin II (ANG II), a potent growth factor, was found to be contained in, and released by, human mast cells...
  55. ncbi request reprint Improvement of oxygen metabolism in ischemic myocardium as a result of enhanced external counterpulsation with heparin pretreatment for patients with stable angina
    Daisuke Masuda
    Division of Cardiology, Jujo Hospital, Kyoto, Japan
    Heart Vessels 19:59-62. 2004
    ..05) from 0.038 +/- 0.004 to 0.053 +/- 0.007. In conclusion, EECP with heparin pretreatment appears to be a new treatment remedy for patients with stable angina...
  56. pmc Cardiac p300 is involved in myocyte growth with decompensated heart failure
    Tetsuhiko Yanazume
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 23:3593-606. 2003
    ..These findings suggest that p300-mediated nuclear acetylation plays a critical role in the development of myocyte hypertrophy and represents a pathway that leads to decompensated heart failure...
  57. ncbi request reprint Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model
    Haruyasu Ito
    The Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan
    Lab Invest 83:1715-21. 2003
    ..These observations demonstrate that pioglitazone has anti-inflammatory effects in MI/R injury that are independent of its insulin-sensitizing effect...
  58. ncbi request reprint Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
    Taku Okazaki
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Nat Med 9:1477-83. 2003
    ..These findings suggest that antibodies to cTnI induce heart dysfunction and dilatation by chronic stimulation of Ca2+ influx in cardiomyocytes...
  59. ncbi request reprint Left ventricular pressure-volume relationship in a murine model of congestive heart failure due to acute viral myocarditis
    Ryosuke Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 40:1506-14. 2002
    ..This study, performed in a murine model of encephalomyocarditis virus myocarditis, used a new Millar 1.4F conductance-micromanometer system for the in vivo determination of the left ventricular (LV) pressure-volume relationship (PVR)...
  60. ncbi request reprint Mast cell tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells
    Makoto Kinoshita
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho Shogoin, Kyoto, 606 8397, Japan
    Arterioscler Thromb Vasc Biol 25:1858-63. 2005
    ..The purpose of this study was to clarify the role of mast cells as an activator of ECs...
  61. ncbi request reprint Heminephrectomy causes the progression of glomerulosclerosis and apoptosis in high IgA strain ddY mice
    Hitoshi Kusano
    Nephrology Division, Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, 54 Shogo in Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Nephron 92:389-98. 2002
    ....
  62. ncbi request reprint [Pathogenesis of and therapy for extrahepatic lesions: myocarditis and cardiomyopathy]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:554-9. 2004
  63. ncbi request reprint [Molecular mechanisms of extrahepatic lesions]
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:544-9. 2004
  64. ncbi request reprint Hepatitis C virus infection and cardiomyopathies
    Akira Matsumori
    Circ Res 96:144-7. 2005
  65. ncbi request reprint Hepatocyte growth factor and cardiovascular thrombosis in patients admitted to the intensive care unit
    Noritake Hata
    Department of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan
    Circ J 68:645-9. 2004
    ..The aim of this study was to investigate this relationship in patients with chest pain...
  66. pmc Prognosis and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study
    Ali Nasermoaddeli
    Department of Epidemiology and Public Health, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, Japan
    Heart 93:711-5. 2007
    ..To investigate prognosis and prognostic factors in patients with hypertrophic cardiomyopathy (HCM) in Japan...
  67. ncbi request reprint Prognosis and prognostic factors in patients with idiopathic dilated cardiomyopathy in Japan
    Katsuyuki Miura
    Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
    Circ J 72:343-8. 2008
    ..There have been few large-scale nationwide studies investigating both the prognosis and the prognostic factors of idiopathic dilated cardiomyopathy (IDC). A predictive score that can be used in clinical practice has not been established...
  68. ncbi request reprint Men's Health Study: epidemiology of erectile dysfunction and cardiovascular disease
    Shigetake Sasayama
    Hamamatsu Rosai Hospital, Shizuoka, Japan
    Circ J 67:656-9. 2003
    ..A total of 41% of ED patients are either willing to receive pharmacotherapy for ED or will consider treatment. Active treatment of ED with sildenafil is suitable for patients with CVD...
  69. ncbi request reprint [Cytokine antagonists and endothelin antagonists for therapy of heart failure]
    Akira Matsumori
    Nihon Naika Gakkai Zasshi 94:276-82. 2005
  70. ncbi request reprint Hydrocortisone reduces restenosis after stenting of small coronary arteries
    Tadashi Kakio
    Department of Cardiology, Daio Municipal Hospital, Daio, Mie, Japan
    J Interv Cardiol 17:295-300. 2004
    ..Prospectively controlled trials will be necessary to confirm this preventive effect of hydrocortisone on coronary in-stent restenosis...
  71. ncbi request reprint Reduced high serum hepatocyte growth factor levels after successful cardioversion in patients with atrial fibrillation
    Harumi Katoh
    Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University School of Medicine, Shimane, Japan
    Clin Exp Pharmacol Physiol 31:145-51. 2004
    ..0025). 4. This study is the first to demonstrate that serum HGF levels increase in atrial fibrillation and decrease after successful DC cardioversion. This may reflect the fact that atrial fibrillation induces vascular endothelial injury...
  72. ncbi request reprint Hepatitis C virus-associated tubulointerstitial injury
    Kenji Kasuno
    Department of Biological Responses, Laboratory of Infection and Prevention, Institute for Virus Research, Japan
    Am J Kidney Dis 41:767-75. 2003
    ....
  73. ncbi request reprint The effect of hydrocortisone on reducing rates of restenosis and target lesion revascularization after coronary stenting less than 3 mm in stent diameter
    Tadashi Kakio
    Department of Cardiology, Hamamatsu Rosai Hospital, Hamamatsu, Japan
    Intern Med 42:1084-9. 2003
    ..Based on our experience for several years, we retrospectively investigated the effect of hydrocortisone on reducing in-stent restenosis...
  74. ncbi request reprint Measurements of serum cardiac troponin T in patients with heart failure
    Yukihito Sato
    Am Heart J 145:e18; author reply e19. 2003
  75. ncbi request reprint [Men's health study: current status of erectile dysfunction of 6,112 ambulatory patients at general practitioners offices in Japan]
    Shigetake Sasayama
    Hamamatsu Rosai Hospital, Shogen cho 25, Hamamatsu, Shizuoka 430 0802
    J Cardiol 42:57-65. 2003
    ..The survey was especially focused on the relationship between ED, depression, and benign prostatic hyperplasia, the effect of ED on quality of life, and current status of ED treatment...
  76. ncbi request reprint [IL-1beta, IL-6, IL-10]
    Ryosuke Nishio
    Division of Emergency Medicine, Kyoto University Hospital
    Nihon Rinsho 65:220-7. 2007