Research Topics
| Shigeyuki MatsuiSummaryAffiliation: Kyoto University Country: Japan Publications
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Detail Information
Publications
Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: an updated analysis of incubation timeShigeyuki Matsui
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan
Neuroepidemiology 24:22-5. 2005..These results suggest that some host factors may have an influence on the incubation time of the disease...
Reducing false positive findings in statistical analysis of pharmacogenomic biomarker studies using high-throughput technologiesShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto, Japan
Curr Drug Saf 1:135-41. 2006..The evaluation of stability and reproducibility of the results of statistical analysis are claimed to reduce chance that false positive findings are subject to further investigation in subsequent studies...
Sample size calculations based on ranking and selection in microarray experimentsShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Biometrics 64:217-26. 2008..We provide strategies for conservative designs to cope with issues of unknown number of informative genes and unknown correlation structure across genes. Application of the formulae to a clinical study for multiple myeloma is given...
Clustering of significant genes in prognostic studies with microarrays: application to a clinical study for multiple myelomaShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
Stat Med 27:1106-20. 2008..Application of such clustering to the data set from a clinical study for patients with multiple myeloma and associated microarrays is given...
Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression modelsShigeyuki Matsui
Department of Pharmacoepidemiology, Graduate School of Public Health, Kyoto University, Kyotom, Japan
Bioinformatics 23:732-8. 2007..Although many class comparisons concerned only a single phenotype, simultaneous assessment of the relationship between gene expression and multiple phenotypes would be warranted to better understand the underlying biological structure...
Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarraysShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
BMC Bioinformatics 7:156. 2006..The primary analytical task in such studies is to select a small fraction of relevant genes, typically from a list of significant genes, for further investigation in subsequent studies...
Stratified analysis in randomized trials with noncomplianceShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto 606 8501, Japan
Biometrics 61:816-23. 2005..Application to a field trial for coronary heart disease is provided...
Sample size calculations for comparative clinical trials with over-dispersed Poisson process dataShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto 606 8501, Japan
Stat Med 24:1339-56. 2005..This formula can accommodate time heterogeneity, inter-patient heterogeneity in event rate, and also, time-varying treatment effects. An application of the formula to a trial for chronic granulomatous disease is provided...
Analysis of times to repeated events in two-arm randomized trials with noncompliance and dependent censoringShigeyuki Matsui
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto 606 8501, Japan
Biometrics 60:965-76. 2004..A simulation study is conducted to evaluate the performance of the developed methods. An illustration of the methods using data from an acute myeloid leukemia trial is provided...
P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancerMasaaki Ito
Department of Urology and Pharmacoepidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Urol 178:1073-9. 2007..We developed molecular markers for predicting intravesical recurrence of superficial bladder transitional cell carcinoma using oligo-microarray analysis...
Bayesian ranking and selection methods using hierarchical mixture models in microarray studiesHisashi Noma
Department of Biostatistics, Kyoto University School of Public Health, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
Biostatistics 11:281-9. 2010..The accuracy of our ranking methods is compared with that of conventional methods through simulation studies. An application to a clinical study for breast cancer is provided...
Sample size calculations for controlling the distribution of false discovery proportion in microarray experimentsTomonori Oura
Department of Biostatistics, Kyoto University School of Public Health, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Biostatistics 10:694-705. 2009..Gene clustering is proposed to identify gene blocks using historical data sets. The adequacy of the procedure is demonstrated using simulated data sets. An application to a clinical study for lymphoma is also provided...
The optimal discovery procedure in multiple significance testing: an empirical Bayes approachHisashi Noma
Department of Biostatistics, Kyoto University School of Public Health, Yoshidakonoe cho, Sakyo ku, Kyoto, 606 8501, Japan
Stat Med 31:165-76. 2012..Simulations and applications to clinical studies of leukemia and breast cancer demonstrated that our empirical Bayes method achieved theoretical optimality and performed well in comparison with existing multiple testing procedures...
Critical issues for effective collaboration between academia and industry in the field of regenerative medicine in JapanMina Tsubouchi
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoecho, Sakyoku, Kyoto 606 8501, Japan
Regen Med 3:497-504. 2008..To identify which factors are important barriers to effective collaboration between Japanese academia and industry in the field of regenerative medicine...
Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profilingNoriomi Matsumura
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
Cancer Sci 101:2658-63. 2010..This report demonstrates a method to utilize genome-wide information to facilitate translational research for treatments against less common subtypes of cancers...
Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label studyKoji Yoshimura
Department of Urology, Translational Research Center, Graduate School of Medicine Kyoto University, Sakyo ku, Kyoto, Japan
Int J Urol 17:548-54. 2010..The aim of this study was to assess the efficacy and safety of two different types of medical mushrooms in patients with prostate cancer in Japan...
Prognostic factor analysis for plaque psoriasisRie Sakai
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto, Japan
Dermatology 211:103-6. 2005..Little is known about the long-term prognostic factors which affect clinical outcomes after the diagnosis of psoriasis...
Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythmHiromitsu Negoro
Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
Nat Commun 3:809. 2012..Therefore, circadian oscillation of connexin43 is associated with the biological clock and contributes to diurnal changes in bladder capacity, which avoids disturbance of sleep by micturition...
Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathyDaisuke Watanabe
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
N Engl J Med 353:782-92. 2005..CONCLUSIONS: Our data suggest that erythropoietin is a potent ischemia-induced angiogenic factor that acts independently of VEGF during retinal angiogenesis in proliferative diabetic retinopathy...
Estimating effect sizes of differentially expressed genes for power and sample-size assessments in microarray experimentsShigeyuki Matsui
Department of Data Science, The Institute of Statistical Mathematics, 10 3 Midori cho, Tachikawa, Tokyo 190 8562, Japan
Biometrics 67:1225-35. 2011..Applications to two real datasets from cancer clinical studies are provided...
Overview of the clinical application of regenerative medicine products in JapanMina Tsubouchi
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan
Health Policy 88:62-72. 2008..To identify barriers to the clinical application of regenerative medicine products (RMPs) in Japan...
