Research Topics
Species | Kenichi MatsudaSummaryAffiliation: Kyoto Prefectural University of Medicine Country: Japan Publications
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Publications
Epigenetic mechanisms are involved in sexual differentiation of the brainKen ichi Matsuda
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Rev Endocr Metab Disord 13:163-71. 2012..Taken together, these results suggest that epigenetic mechanisms play a central role in the transduction and maintenance of early hormonal and social cues to organize sexually differentiated brain functions...
Intranuclear mobility of estrogen receptor alpha and progesterone receptors in association with nuclear matrix dynamicsKenichi Matsuda
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Cell Biochem 103:136-48. 2008..These results indicate that the mobility of ER alpha and PR-A/B is associated with the dynamics of the nuclear matrix...
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formationKenichi Matsuda
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
Neurosci Lett 441:94-9. 2008..Expression levels were not different among male, female in proestrus and female in estrus at the adult stage, but were higher in newborn male than newborn female...
Histone deacetylation during brain development is essential for permanent masculinization of sexual behaviorKen ichi Matsuda
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Endocrinology 152:2760-7. 2011..These results demonstrate that HDAC activity during the early postnatal period plays a crucial role in the masculinization of the brain via modifications of histone acetylation status...
[High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening]Hiroshi Komura
Department of Research Pharmacokinetics, Research Center Kyoto, Bayer Yakuhin, Ltd, Kyoto 619 0216, Japan
Yakugaku Zasshi 125:131-9. 2005..The compound also showed a desirable in vivo pharmacokinetic profile in rats, suggesting that the SMR study on the confirmed in vitro and in vivo correlation is essential to the optimization...
[High throughput screening of pharmacokinetics and metabolism in drug discovery (III)--investigation on in- silico model for membrane permeability and CYP1A2 inhibition]Hiroshi Komura
Department of Research Pharmacokinetics, Research Center Kyoto, Bayer Yakuhin, Ltd, Kyoto 619 0216, Japan
Yakugaku Zasshi 125:141-7. 2005..These results suggest that the PSA and RB are key parameters to design chemical structures in terms of the improvement of both membrane permeability in the brain and gastrointestine and CYP1A2 inhibition, respectively...
Management of intra-abdominal hypertension in patients with severe acute pancreatitis with continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilterShigeto Oda
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Ther Apher Dial 9:355-61. 2005..Continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter appears to be effective for prevention and treatment of IAH in patients with SAP through the removal of causative cytokines of hyperpermeability...
