Yoshinori Marunaka

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. pmc Regulation of epithelial sodium transport via epithelial Na+ channel
    Yoshinori Marunaka
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biomed Biotechnol 2011:978196. 2011
  2. doi request reprint Blockade of chloride ion transport enhances the cytocidal effect of hypotonic solution in gastric cancer cells
    Daisuke Iitaka
    Department of Surgery, Division of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Surg Res 176:524-34. 2012
  3. doi request reprint Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium
    Junji Asano
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Respir Cell Mol Biol 41:688-95. 2009
  4. ncbi request reprint Epithelial Na+ channel and ion transport in human nasal polyp and paranasal sinus mucosa
    Makoto Yasuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 362:753-8. 2007
  5. doi request reprint Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells
    Rumi Ohsawa
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Cell Physiol 223:764-70. 2010
  6. doi request reprint Enhancement of the cytocidal effects of hypotonic solution using a chloride channel blocker in pancreatic cancer cells
    Yoshito Nako
    Department of Surgery, Division of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii cho, Kamigyo ku, Kyoto, Japan
    Pancreatology 12:440-8. 2012
  7. ncbi request reprint Action of neltenexine on anion secretion in human airway epithelia
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 356:1050-5. 2007
  8. ncbi request reprint Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 31:1288-91. 2007
  9. ncbi request reprint Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases
    Akiyuki Taruno
    Dept of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Physiol Renal Physiol 293:F128-38. 2007
  10. ncbi request reprint Overexpression of manganese superoxide dismutase by N-acetylcysteine in hyperoxic lung injury
    Kazuhiro Nagata
    Department of Respiratory Medicine, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Respir Med 101:800-7. 2007

Collaborators

Detail Information

Publications64

  1. pmc Regulation of epithelial sodium transport via epithelial Na+ channel
    Yoshinori Marunaka
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biomed Biotechnol 2011:978196. 2011
    ..In this paper, we discuss two major factors in ENaC regulation: (1) activity of individual ENaC and (2) number of ENaC located at the apical membrane...
  2. doi request reprint Blockade of chloride ion transport enhances the cytocidal effect of hypotonic solution in gastric cancer cells
    Daisuke Iitaka
    Department of Surgery, Division of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Surg Res 176:524-34. 2012
    ..Although peritoneal lavage with distilled water is applied in some cancer surgeries to kill tumor cells, there is no consensus regarding the optimal methodology and its effects...
  3. doi request reprint Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium
    Junji Asano
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Respir Cell Mol Biol 41:688-95. 2009
    ..These observations indicate that quercetin stimulates Cl(-) secretion by activating NKCC1 via translocation of an NKCC1-activating factor through an EGFR kinase-dependent pathway...
  4. ncbi request reprint Epithelial Na+ channel and ion transport in human nasal polyp and paranasal sinus mucosa
    Makoto Yasuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 362:753-8. 2007
    ....
  5. doi request reprint Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells
    Rumi Ohsawa
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Cell Physiol 223:764-70. 2010
    ....
  6. doi request reprint Enhancement of the cytocidal effects of hypotonic solution using a chloride channel blocker in pancreatic cancer cells
    Yoshito Nako
    Department of Surgery, Division of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii cho, Kamigyo ku, Kyoto, Japan
    Pancreatology 12:440-8. 2012
    ..This study investigated the cytocidal effects of hypotonic shock and enhancement using chloride channel blocker in pancreatic cancer cells...
  7. ncbi request reprint Action of neltenexine on anion secretion in human airway epithelia
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 356:1050-5. 2007
    ....
  8. ncbi request reprint Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 31:1288-91. 2007
    ....
  9. ncbi request reprint Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases
    Akiyuki Taruno
    Dept of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Physiol Renal Physiol 293:F128-38. 2007
    ....
  10. ncbi request reprint Overexpression of manganese superoxide dismutase by N-acetylcysteine in hyperoxic lung injury
    Kazuhiro Nagata
    Department of Respiratory Medicine, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Respir Med 101:800-7. 2007
    ..N-acetylcysteine (NAC) is a precursor of glutathione (GSH), which functions as an antioxidant by reducing hydrogen peroxide to water and alcohols. NAC has been shown to diminish lung injury in a large variety of animal models...
  11. doi request reprint Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 33:949-56. 2009
    ..Taken together, these observations suggest that certain factors controlled by the basolateral osmolality and the basolaterally applied hydrostatic pressure mainly regulate the Gp, G(Na) and G(Cl)...
  12. ncbi request reprint An inhaled inducible nitric oxide synthase inhibitor reduces damage of Candida-induced acute lung injury
    Shuji Ohsugi
    Department of Respiratory Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biomed Res 28:91-9. 2007
    ..Survival was prolonged by inhalation of ONO-1714. We conclude that pretreatment with inhaled ONO-1714 suppresses the production of peroxinitrite and decreases oxidative stress associated with peroxinitrite in Candida-induced ALI...
  13. ncbi request reprint Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression
    Naomi Niisato
    Dept of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Physiol Renal Physiol 287:F932-9. 2004
    ..These findings support the hypothesis that changes in cytosolic Cl(-) concentration are an important and novel signal in hypotonicity-induced regulation of alpha-ENaC expression and Na(+) reabsorption...
  14. ncbi request reprint Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 341:376-81. 2006
    ....
  15. ncbi request reprint Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury
    Shigekuni Hosogi
    Department of Respiratory Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biomed Res 29:257-66. 2008
    ..Inhibition of iNOS-derived NO production by ONO-1714 inhalation ameliorated Candida-induced ALI and improved survival by suppressing apoptosis of alveolar epithelial cells...
  16. ncbi request reprint Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 363:566-71. 2007
    ..These observations suggest the interaction of cations and anions on paracellular ionic conductances; i.e., cations affect paracellular anion conductances and anions affect paracellular cation conductances...
  17. ncbi request reprint Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium
    Tomoko Ueda-Nishimura
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 332:1042-52. 2005
    ....
  18. ncbi request reprint Regulation of the paracellular Na+ and Cl- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:464-70. 2008
    ....
  19. ncbi request reprint Physiological significance of hypotonicity-induced regulatory volume decrease: reduction in intracellular Cl- concentration acting as an intracellular signaling
    Hiroaki Miyazaki
    Departments of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 292:F1411-7. 2007
    ....
  20. ncbi request reprint Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells
    Hiroaki Miyazaki
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:506-12. 2008
    ....
  21. ncbi request reprint Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls
    Tadaaki Yamada
    Department of Respiratory Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Pulm Pharmacol Ther 20:650-9. 2007
    ..Thioredoxin-1 (TRX-1) is a small ubiquitous protein that acts as an important radical scavenger. We investigated the effect of TRX-1 on apoptosis in hyperoxia-induced lung injury...
  22. doi request reprint NaCl flux between apical and basolateral side recruits claudin-1 to tight junction strands and regulates paracellular transport
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 393:390-6. 2010
    ..Our present findings indicated that TJ protein localization and barrier function are regulated depending on the environmental differences between apical and basolateral side...
  23. ncbi request reprint Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium
    Naomi Niisato
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 358:819-24. 2007
    ..Based on these observations, it is suggested that the chronic hypotonicity stimulates the renal transepithelial Na(+) reabsorption by upregulating the mRNA expression of beta- and gamma-ENaC via a p38 MAPK-dependent pathway...
  24. doi request reprint A regulatory role of K(+)-Cl(-) cotransporter in the cell cycle progression of breast cancer MDA-MB-231 cells
    Maki Kitagawa
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan Electronic address
    Arch Biochem Biophys 539:92-8. 2013
    ..These findings suggest that KCC plays an important role in the early phase of cell cycle progression by regulating the expression of cyclin D1, cyclin E2, and p21, the molecules essential for the cell cycle progression...
  25. pmc Hypotonic stress upregulates β- and γ-ENaC expression through suppression of ERK by inducing MKP-1
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 303:F240-52. 2012
    ....
  26. ncbi request reprint Epithelial ion transport of human nasal polyp and paranasal sinus mucosa
    Makoto Yasuda
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Respir Cell Mol Biol 36:466-72. 2007
    ..These observations suggest that in human PSM and NP, cAMP stably stimulates anion secretion by activating the Cl(-) (anion) channels, and that UTP just transiently elevates anion secretion via activation of some Cl(-) (anion) channels...
  27. ncbi request reprint Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells
    Akiyuki Taruno
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 294:F177-86. 2008
    ..These observations indicate for the first time that intracellular Ca(2+) plays a role as the second messenger in hypotonic stress-induced Na(+) transport by stimulating transcription of SGK1 and ENaC subunits...
  28. ncbi request reprint Aldosterone-induced modification of osmoregulated ENaC trafficking
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 361:162-8. 2007
    ....
  29. ncbi request reprint Quercetin and NPPB-induced diminution of aldosterone action on Na+ absorption and ENaC expression in renal epithelium
    Shin Ichiro Fujimoto
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 336:401-7. 2005
    ....
  30. ncbi request reprint [Molecular mechanism in biological transport in the kidney: Epithelial Na+ channel]
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    Nihon Rinsho 64:119-22. 2006
  31. doi request reprint Action of N-acylated ambroxol derivatives on secretion of chloride ions in human airway epithelia
    Takahiro Yamada
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 380:586-90. 2009
    ....
  32. pmc Role of the Na(+)/K(+)/2Cl(-) cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma
    Atsushi Shiozaki
    Atsushi Shiozaki, Yoshito Nako, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    World J Gastroenterol 20:6844-59. 2014
    ..To investigate the role of Na(+)/K(+)/2Cl(-) cotransporter 1 (NKCC1) in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell carcinoma (ESCC)...
  33. doi request reprint Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma
    Toshiyuki Kosuga
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Oncol Rep 26:577-86. 2011
    ..These findings demonstrated the cytocidal effects of hypotonic shock on ESCC cells, and clearly support the efficacy of pleural lavage with distilled water during surgery for ESCC...
  34. ncbi request reprint Blockers of K+/Cl- transporter/channels diminish proliferation of osteoblastic cells
    Masahiro Maki
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    Biomed Res 30:137-40. 2009
    ..Taken together, the observations indicate that both increases and decreases in [Cl-]i diminish the proliferation of MC3T3-E1 osteoblastic cells...
  35. ncbi request reprint Genistein enhances the NGF-induced neurite outgrowth
    Ken Ichi Nakajima
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biomed Res 32:351-6. 2011
    ..On the other hand, genistein activates NKCC1 as shown in our previous study. Taken together, these observations indicate that genistein enhanced the NGF-induced neurite outgrowth in PC12 cells via activation of NKCC1...
  36. ncbi request reprint H89, an inhibitor of protein kinase A (PKA), stimulates Na+ transport by translocating an epithelial Na+ channel (ENaC) in fetal rat alveolar type II epithelium
    Yoshinori Marunaka
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Pharmacol 66:1083-9. 2003
    ....
  37. doi request reprint Chloride ion modulates cell proliferation of human androgen-independent prostatic cancer cell
    Kenji Hiraoka
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 25:379-88. 2010
    ..Furosemide and bumetanide decreased [Cl(-)](i) and cell growth of PC3 cells. These results suggest that a change in [Cl(-)](i) would play a critical role in this growth mechanism...
  38. doi request reprint Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance
    Hiroki Hayata
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 445:170-4. 2014
    ..Our present study suggests that lowered extracellular pH conditions may produce the pathogenesis of insulin resistance in skeletal muscle cells. ..
  39. doi request reprint K(+)-Cl(-) cotransporter 1 (KCC1) negatively regulates NGF-induced neurite outgrowth in PC12 cells
    Hikaru Nagao
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto, Japan
    Cell Physiol Biochem 30:538-51. 2012
    ..Knockdown of KCC1 using small interfering RNA (siRNA) enhanced the NGF-induced neurite outgrowth. These results suggest that KCC1 negatively regulates the NGF-induced neurite outgrowth of PC12 cells...
  40. doi request reprint Quercetin stimulates NGF-induced neurite outgrowth in PC12 cells via activation of Na(+)/K(+)/2Cl(-) cotransporter
    Ken Ichi Nakajima
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 28:147-56. 2011
    ..These observations indicate that quercetin stimulates the NGF-induced neurite outgrowth via an increase in Cl(-) incorporation into the intracellular space by activating NKCC1 in PC12 cell...
  41. doi request reprint Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer
    Atsushi Hiramatsu
    Division of Pulmonary Medicine, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Jpn J Clin Oncol 39:779-83. 2009
    ..Our aims were to determine the response rate, toxicity and survival time with this regimen in patients with Stage IIIB/IV disease...
  42. doi request reprint Hydrostatic pressure regulates tight junctions, actin cytoskeleton and transcellular ion transport
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 390:1315-21. 2009
    ..Our present findings indicate that the epithelial cell structures and functions are regulated by the hydrostatic pressure gradient which is generated and maintained by the epithelia themselves...
  43. ncbi request reprint Chloride-dependent acceleration of cell cycle via modulation of Rb and cdc2 in osteoblastic cells
    Masahiro Maki
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 361:1038-43. 2007
    ..Taken together, these observations indicate here for the first time that Cl(-) modulates Rb and cdc2, enhancing the proliferation of the MC3T3-E1 osteoblastic cells...
  44. doi request reprint An inhibitor of Na(+)/H(+) exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminishes proliferation of MKN28 human gastric cancer cells by decreasing the cytosolic Cl(-) concentration via DIDS-sensitive pathways
    Shigekuni Hosogi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 30:1241-53. 2012
    ..The purpose of the present study was to identify effects of ethyl-isopropyl amiloride (EIPA, an inhibitor of Na(+)/H(+) exchanger (NHE)) on proliferation of human gastric cancer MKN28 cells...
  45. ncbi request reprint Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells
    Naomi Niisato
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Pharmacol 67:795-801. 2004
    ..Based on these results, it is suggested that although both cAMP and flavones activate the Na+/K+/2Cl- cotransporter, these flavones have more powerful effects than cAMP on the Na+/K+/2Cl- cotransporter...
  46. doi request reprint Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels
    Akiyuki Taruno
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 26:925-34. 2010
    ..The newly established analysis of blocker-labeled ENaCs in the present study provides a useful tool to investigate the recycling of endogenously expressed ENaCs...
  47. ncbi request reprint Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 315:892-6. 2004
    ....
  48. ncbi request reprint Essential role of NKCC1 in NGF-induced neurite outgrowth
    Ken Ichi Nakajima
    Department of Molecular Cell Physiology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 359:604-10. 2007
    ..These observations suggest that NKCC1 plays a fundamental role in NGF-induced neurite outgrowth of PC12D cells...
  49. ncbi request reprint Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state
    Atsushi Shiozaki
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566 Japan
    J Physiol Sci 56:401-6. 2006
    ....
  50. ncbi request reprint Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation
    Nobuko Taguchi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 327:915-9. 2005
    ..The observation suggests that in acutely injured lung treated with HFOV an ENaC blocker, benzamil, can be applied as a therapeutic drug for acute lung injury combing with HFOV...
  51. ncbi request reprint Calmodulin-dependent regulation of hypotonicity-induced translocation of ENaC in renal epithelial A6 cells
    Shinsaku Tokuda
    Department of Cellular and Molecular Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 084, Japan
    Biochem Biophys Res Commun 298:619-23. 2002
    ....
  52. ncbi request reprint Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells
    Naomi Niisato
    Department of Cellular and Molecular Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Life Sci 71:1199-207. 2002
    ....
  53. ncbi request reprint UT-B1 urea transporter plays a noble role as active water transporter in C6 glial cells
    Aya Ogami
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 351:619-24. 2006
    ..Taken together, these observations indicate that UT-B1 acts as an active water transporter, providing a new model on active water transport...
  54. ncbi request reprint A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice
    Tatsuya Yuba
    Department of Respiratory Molecular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Respir Med 101:793-9. 2007
    ..Overproduction of nitric oxide by nitric oxide synthase (NOS) is thought to promote hyperoxic lung injury. The present study was conducted to examine the role of inducible nitric oxide synthase (iNOS) in hyperoxic lung injury in mice...
  55. ncbi request reprint Effects of extracellular chloride ion on epithelial sodium channel (ENaC) in arginine vasotocin (AVT)-stimulated renal epithelial cells
    Toshiki Yamada
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biomed Res 30:193-8. 2009
    ..These results suggest that the extracellular Cl(-) regulates the ENaC-mediated Na(+) reabsorption by affecting ENaC properties in AVT-stimulated renal epithelial cells...
  56. ncbi request reprint Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia
    Isao Hasegawa
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 343:475-82. 2006
    ....
  57. doi request reprint Enhancement of tubulin polymerization by Cl(-)-induced blockade of intrinsic GTPase
    Ken Ichi Nakajima
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 425:225-9. 2012
    ....
  58. doi request reprint Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells
    Yukinori Sawabe
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Exp Physiol 95:858-68. 2010
    ..A novel autocrine mechanism mediated via PPARalpha enhances Ca(2+)-regulated exocytosis in guinea-pig antral mucous cells...
  59. pmc Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl⁻ secretion: useful tools as regulators of Cl⁻ secretion
    Hongxin Sun
    Department of Molecular Cell Physiology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biomed Res Int 2014:902735. 2014
    ..In conclusion, myricetin would be a useful compound for prevention from bacterial/viral infection even under conditions that the amount of water secretion driven by cAMP-stimulated epithelial Cl(-) secretion is insufficient. ..
  60. ncbi request reprint Translational research of photodynamic therapy with acridine orange which targets cancer acidity
    Katsuyuki Kusuzaki
    Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji Kajiicho 465, Kamigyo ku Kyoto 602 8566, Japan
    Curr Pharm Des 18:1414-20. 2012
    ..Therefore, it is suggested that AO excited by photon energy has excellent potential as an anticancer "Magic Bullet"...
  61. pmc Intracellular chloride regulates the G(1)/S cell cycle progression in gastric cancer cells
    Atsushi Shiozaki
    Atsushi Shiozaki, Eigo Otsuji, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    World J Gastrointest Oncol 3:119-22. 2011
    ..Our results suggest that the [Cl(-)](i) regulates important cellular functions in gastric cancer cells, leading to the development of novel therapeutic strategies...
  62. ncbi request reprint Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice
    Haruhiko Sugino
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:303-7. 2009
    ..These results suggest the unique efficacy of atypical antipsychotics in the suppression of proinflammatory cytokines, and the increase of anti-inflammatory cytokine, IL-10...
  63. ncbi request reprint Effects of Ca(2+) channel blockers on amiloride-sensitive Na(+) permeable channels and Na(+) transport in fetal rat alveolar type II epithelium
    Yoshinori Marunaka
    Department of Cellular and Molecular Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Biochem Pharmacol 63:1547-52. 2002
    ....
  64. doi request reprint KF-1 ubiquitin ligase: anxiety suppressor model
    Tamotsu Hashimoto-Gotoh
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Cell Biochem Biophys 60:69-75. 2011
    ..The kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation and for screening novel anxiolytic compounds, which may block the putative anxiety promoter...