T Kuwata

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12
    T Kuwata
    Institute for Virus Research, Kyoto University, Japan
    AIDS Res Hum Retroviruses 16:465-70. 2000
  2. ncbi request reprint Infection of macaques with chimeric simian and human immunodeficiency viruses containing Env from subtype F
    T Kuwata
    Institute for Virus Research, Kyoto University, Japan
    Arch Virol 147:1121-32. 2002
  3. ncbi request reprint Protective effects of nef-deleted SHIV or that having IFN-gamma against disease induced with a pathogenic virus early after vaccination
    Y Enose
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Arch Virol 149:1705-20. 2004
  4. ncbi request reprint Characterization of less pathogenic infectious molecular clones derived from acute-pathogenic SHIV-89.6p stock virus
    I L Kozyrev
    Laboratory of Viral Pathogenesis, Graduate School of Medicine, Kyoto University, 606-8507, Japan
    Virology 282:6-13. 2001
  5. ncbi request reprint Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine
    T Kuwata
    Institute for Virus Research, Kyoto University, Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    Trends Microbiol 9:475-80. 2001
  6. ncbi request reprint Construction of SIV/HIV-1 chimeric viruses having the IL-5 gene and determination of their ability to replicate and produce IL-5
    I L Kozyrev
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Japan
    Arch Virol 146:1051-62. 2001
  7. ncbi request reprint Characterization of simian and human immunodeficiency chimeric viruses re-isolated from vaccinated macaque monkeys after challenge infection
    T B Kwofie
    Laboratory of Viral Pathogenesis, Research Center for AIDS, Institute for Virus Research, Kyoto University, Japan
    Arch Virol 147:1091-104. 2002
  8. ncbi request reprint The quantity and diversity of infectious viruses in various tissues of SHIV-infected monkeys at the early and AIDS stages
    A Miyake
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Arch Virol 149:943-55. 2004
  9. ncbi request reprint Augmentation of antigen-specific cytokine responses in the early phase of vaccination with a live-attenuated simian/human immunodeficiency chimeric virus expressing IFN-gamma
    T Iida
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arch Virol 149:743-57. 2004

Collaborators

  • M Hayami
  • T Miura
  • H Suzuki
  • Y Enose
  • K Ibuki
  • I L Kozyrev
  • A Miyake
  • T Yamamoto
  • T Iida
  • M Kita
  • M Ui
  • T Shimada
  • T B Kwofie
  • J Imanishi
  • O Narayan
  • K Kaneyasu
  • E Takahashi
  • K Shinohara
  • H Takahashi
  • S Ohkura
  • R Horiuchi
  • K Sakai
  • S Kato
  • T Takemura
  • T Haga

Detail Information

Publications9

  1. ncbi request reprint Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12
    T Kuwata
    Institute for Virus Research, Kyoto University, Japan
    AIDS Res Hum Retroviruses 16:465-70. 2000
    ..These IL-12-producing SHIVs are candidates for a live-attenuated vaccine to induce effective cellular immunity against HIV-1...
  2. ncbi request reprint Infection of macaques with chimeric simian and human immunodeficiency viruses containing Env from subtype F
    T Kuwata
    Institute for Virus Research, Kyoto University, Japan
    Arch Virol 147:1121-32. 2002
    ..This SHIV containing Env from HIV-1 subtype F will be a valuable source for the analysis of HIV-1 subtype F and the evaluation of vaccine candidates as a genetically divergent challenge virus...
  3. ncbi request reprint Protective effects of nef-deleted SHIV or that having IFN-gamma against disease induced with a pathogenic virus early after vaccination
    Y Enose
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Arch Virol 149:1705-20. 2004
    ....
  4. ncbi request reprint Characterization of less pathogenic infectious molecular clones derived from acute-pathogenic SHIV-89.6p stock virus
    I L Kozyrev
    Laboratory of Viral Pathogenesis, Graduate School of Medicine, Kyoto University, 606-8507, Japan
    Virology 282:6-13. 2001
    ..These results demonstrate the polyclonal nature of the parental SHIV-89.6P virus stock and demonstrate that cl 64, aside from its high replicability, may differ qualitatively from the parental virus...
  5. ncbi request reprint Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine
    T Kuwata
    Institute for Virus Research, Kyoto University, Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    Trends Microbiol 9:475-80. 2001
    ..The most important advantage of gene-deleted SHIVs is that their efficacy and safety can be evaluated in macaques before they are used in humans...
  6. ncbi request reprint Construction of SIV/HIV-1 chimeric viruses having the IL-5 gene and determination of their ability to replicate and produce IL-5
    I L Kozyrev
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Japan
    Arch Virol 146:1051-62. 2001
    ..These results show that co-expression of IL-5 stimulates SHIV replication in vitro. Thus, it is expected that expression of IL-5 will also have an effect on viral replication and pathogenicity in vivo...
  7. ncbi request reprint Characterization of simian and human immunodeficiency chimeric viruses re-isolated from vaccinated macaque monkeys after challenge infection
    T B Kwofie
    Laboratory of Viral Pathogenesis, Research Center for AIDS, Institute for Virus Research, Kyoto University, Japan
    Arch Virol 147:1091-104. 2002
    ..This further enhances the prospects of this nef-deleted SHIV as the bases for effective anti-HIV vaccine candidates...
  8. ncbi request reprint The quantity and diversity of infectious viruses in various tissues of SHIV-infected monkeys at the early and AIDS stages
    A Miyake
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Arch Virol 149:943-55. 2004
    ..However, the viruses in the brain were almost identical to the inoculated virus, suggesting that the virus entered the brain early after infection and persisted without replication and genetic diversion until the AIDS stage...
  9. ncbi request reprint Augmentation of antigen-specific cytokine responses in the early phase of vaccination with a live-attenuated simian/human immunodeficiency chimeric virus expressing IFN-gamma
    T Iida
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arch Virol 149:743-57. 2004
    ..These results suggest that co-expression of IFN-gamma with SHIV can modulate the antiviral immune responses into the Th1 type response, which would probably provide more protective immunity...