Affiliation: Kyoto University
- Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantationTakaaki Koshiba
Department of Transplantation and Immunology, Horizontal Medical Research Organization, Faculty of Medicine, Kyoto University, 54 Kawaramachi Shogoin, Sakyo ku, Kyoto City 606 8507, Japan
Transpl Immunol 17:94-7. 2007..This warrants serial protocol biopsy before and after complete cessation of immunosuppression even in the presence of normal liver function...
- Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA matchHidenori Ohe
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Transpl Int 25:97-106. 2012..In this large cohort of pediatric LDLT recipients, absence of early rejection, HLA-A match and the later predominance of Tregs are factors associated with OT...
- The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerant patients after pediatric living-donor liver transplantationHanaa Nafady-Hego
Department of Hepatobiliary and Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Transplantation 90:1547-55. 2010..However, their contribution to transplant tolerance remains to be elucidated...
- The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipientsYing Li
Innovation Center for Immunoregulation Technologies and Drugs, Transplant Tolerance Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Transplantation 86:1837-43. 2008..The results were compared with biopsies from the recipients on maintenance immunosuppression (Gr-IS), grafts removed because of chronic rejection (Gr-CR), or normal liver (Gr-NL)...
- [Regulatory T cell based transplant tolerance--freedom from immunosuppression]Takaaki Koshiba
Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University
Nihon Rinsho 65:557-67. 2007..Thus, the exploitation of precursor like Tregs as a cellular source of ex vivo and in vivo expansion may lead to the widespread clinical use of Tregs for Tx...
- Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantationMami Yoshitomi
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Transplantation 87:606-14. 2009..Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology...
- [Liver transplantation]Eiji Nishimura
Department of Transplantation and Immunology, Faculty of Medicine, Kyoto University
Nippon Rinsho 63:670-7. 2005
- Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantationYing Li
Department of Transplantation and Immunology, Horizontal Medical Research Organization, Transplant Tolerance Unit, Kyoto University, Faculty of Medicine, Kyoto, Japan
Am J Transplant 4:2118-25. 2004..Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT...
- ET-Kyoto solution plus dibutyryl cyclic adenosine monophosphate is superior to University of Wisconsin solution in rat liver preservationXiangdong Zhao
Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
Cell Transplant 17:99-109. 2008..In conclusion, ET-K supplemented with db-cAMP is superior to UW in rat liver preservation. This modified ET-K might therefore be a novel candidate for the procurement and preservation of multiple organs...
- Value of FOXP3 expression in peripheral blood as rejection marker after miniature swine lung transplantationNaoki Satoda
Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
J Heart Lung Transplant 27:1293-301. 2008..There is emerging clinical evidence that, paradoxically, expression of forkhead box P3 (FOXP3, a specific marker for the regulatory T cells) is upregulated within rejecting grafts...
- Complete freedom from rejection after intestinal transplantation using a new tolerogenic protocol combined with low immunosuppressionJacques Pirenne
Catholic University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Jacques.Pirenne@ uz.kuleuven.ac.be
Transplantation 73:966-8. 2002..We hypothesize that intraoperative immunomodulation via intraportal donor-specific blood transfusion in the absence of nonspecific overimmunosuppression promoted Itx acceptance...
- The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptanceTakaaki Koshiba
Abdominal Transplant Department, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
Transpl Int 16:383-90. 2003..In Htx, however, FTY 720 allows full development of tolerance. The mechanisms by which FTY 720 causes rejection in primary intestinal but not in heart grafts need to be elucidated...
- Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up reportJacques Pirenne
Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Clin Transplant 17:177-82. 2003..We report the long-term (median = 40 months) follow-up data of a prospective pilot study designed to determine whether liver transplantation could be performed with no steroids at all (neither during nor after surgery)...
- Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver transplant recipientsMikiko Kawasaki
Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo, Japan
Int Surg 92:276-86. 2007..Our data indicated that cDNA microarray technology was useful for this application and provided many informative insights into transplant tolerance mechanism...
- Regulatory cell-mediated tolerance does not protect against chronic rejectionTakaaki Koshiba
Abdominal Transplant Surgery Department, Catholic University Leuven (KUL, Belgium
Transplantation 76:588-96. 2003..CONCLUSIONS: Regulatory cells that prevent graft loss to acute rejection in primary and secondary grafts do not protect against the development of chronic rejection...
- Regulatory cells, TH1/TH2 unbalance, and antibody-induced chronic rejection in operational tolerance induced by donor-specific blood transfusionJacques Pirenne
Abdominal Transplant Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
Transplantation 79:S25-7. 2005..Development of chronic rejection in a regulation-based tolerance model suggests that deletion-based tolerogenic strategies may offer a more robust protection against chronic rejection...
- FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine ATakaaki Koshiba
Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium
Transplantation 75:945-52. 2003..Prevention of chronic rejection by maintenance treatment with FTY720 and CsA represents indirect evidence that normal lymphocyte trafficking and function are mandatory for development of chronic rejection...
- Paradoxical early upregulation of intragraft Th1 cytokines is associated with graft acceptance following donor-specific blood transfusionTakaaki Koshiba
Abdominal Transplant Department, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
Transpl Int 16:179-85. 2003..The mechanisms by which an early Th1 response promotes tolerance need to be further studied...
- Aplastic anemia after transplantation for non-A, non-B, non-C fulminant hepatic failure: case report and review of the literaturePatrick Itterbeek
Abdominal Transplant Surgery Department, University Hospitals Leuven, Belgium
Transpl Int 15:117-23. 2002..In unresponsive patients, six-HLA-identical bone marrow transplantation has been successful...
- Early accumulation of interferon-gamma in grafts tolerized by donor-specific blood transfusion: friend or enemy?Hiroaki Kitade
Abdominal Transplant Surgery Department, University Hospitals Leuven, Leuven, Belgium
Transplantation 78:1747-55. 2004..This contrasted with the IFN-gamma peak seen later (day 5) in rejecting but not in tolerant rats...