Takaaki Koshiba

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    Takaaki Koshiba
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Faculty of Medicine, Kyoto University, 54 Kawaramachi Shogoin, Sakyo ku, Kyoto City 606 8507, Japan
    Transpl Immunol 17:94-7. 2007
  2. doi request reprint Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match
    Hidenori Ohe
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transpl Int 25:97-106. 2012
  3. doi request reprint The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerant patients after pediatric living-donor liver transplantation
    Hanaa Nafady-Hego
    Department of Hepatobiliary and Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 90:1547-55. 2010
  4. doi request reprint The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients
    Ying Li
    Innovation Center for Immunoregulation Technologies and Drugs, Transplant Tolerance Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 86:1837-43. 2008
  5. ncbi request reprint [Regulatory T cell based transplant tolerance--freedom from immunosuppression]
    Takaaki Koshiba
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University
    Nihon Rinsho 65:557-67. 2007
  6. doi request reprint Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation
    Mami Yoshitomi
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 87:606-14. 2009
  7. doi request reprint Intragraft Vδ1 γδ T cells with a unique T-cell receptor are closely associated with pediatric semiallogeneic liver transplant tolerance
    Xiangdong Zhao
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 95:192-202. 2013
  8. ncbi request reprint [Liver transplantation]
    Eiji Nishimura
    Department of Transplantation and Immunology, Faculty of Medicine, Kyoto University
    Nihon Rinsho 63:670-7. 2005
  9. ncbi request reprint Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
    Ying Li
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Transplant Tolerance Unit, Kyoto University, Faculty of Medicine, Kyoto, Japan
    Am J Transplant 4:2118-25. 2004
  10. ncbi request reprint ET-Kyoto solution plus dibutyryl cyclic adenosine monophosphate is superior to University of Wisconsin solution in rat liver preservation
    Xiangdong Zhao
    Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Cell Transplant 17:99-109. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    Takaaki Koshiba
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Faculty of Medicine, Kyoto University, 54 Kawaramachi Shogoin, Sakyo ku, Kyoto City 606 8507, Japan
    Transpl Immunol 17:94-7. 2007
    ..This warrants serial protocol biopsy before and after complete cessation of immunosuppression even in the presence of normal liver function...
  2. doi request reprint Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match
    Hidenori Ohe
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transpl Int 25:97-106. 2012
    ..In this large cohort of pediatric LDLT recipients, absence of early rejection, HLA-A match and the later predominance of Tregs are factors associated with OT...
  3. doi request reprint The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerant patients after pediatric living-donor liver transplantation
    Hanaa Nafady-Hego
    Department of Hepatobiliary and Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 90:1547-55. 2010
    ..However, their contribution to transplant tolerance remains to be elucidated...
  4. doi request reprint The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients
    Ying Li
    Innovation Center for Immunoregulation Technologies and Drugs, Transplant Tolerance Unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 86:1837-43. 2008
    ..The results were compared with biopsies from the recipients on maintenance immunosuppression (Gr-IS), grafts removed because of chronic rejection (Gr-CR), or normal liver (Gr-NL)...
  5. ncbi request reprint [Regulatory T cell based transplant tolerance--freedom from immunosuppression]
    Takaaki Koshiba
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University
    Nihon Rinsho 65:557-67. 2007
    ..Thus, the exploitation of precursor like Tregs as a cellular source of ex vivo and in vivo expansion may lead to the widespread clinical use of Tregs for Tx...
  6. doi request reprint Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation
    Mami Yoshitomi
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 87:606-14. 2009
    ..Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology...
  7. doi request reprint Intragraft Vδ1 γδ T cells with a unique T-cell receptor are closely associated with pediatric semiallogeneic liver transplant tolerance
    Xiangdong Zhao
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 95:192-202. 2013
    ..Vδ1 cells appear to play a role in fetomaternal tolerance and our aim was to examine their role in liver transplant tolerance...
  8. ncbi request reprint [Liver transplantation]
    Eiji Nishimura
    Department of Transplantation and Immunology, Faculty of Medicine, Kyoto University
    Nihon Rinsho 63:670-7. 2005
  9. ncbi request reprint Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
    Ying Li
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Transplant Tolerance Unit, Kyoto University, Faculty of Medicine, Kyoto, Japan
    Am J Transplant 4:2118-25. 2004
    ..Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT...
  10. ncbi request reprint ET-Kyoto solution plus dibutyryl cyclic adenosine monophosphate is superior to University of Wisconsin solution in rat liver preservation
    Xiangdong Zhao
    Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Cell Transplant 17:99-109. 2008
    ..In conclusion, ET-K supplemented with db-cAMP is superior to UW in rat liver preservation. This modified ET-K might therefore be a novel candidate for the procurement and preservation of multiple organs...
  11. doi request reprint Value of FOXP3 expression in peripheral blood as rejection marker after miniature swine lung transplantation
    Naoki Satoda
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 27:1293-301. 2008
    ..There is emerging clinical evidence that, paradoxically, expression of forkhead box P3 (FOXP3, a specific marker for the regulatory T cells) is upregulated within rejecting grafts...
  12. ncbi request reprint Complete freedom from rejection after intestinal transplantation using a new tolerogenic protocol combined with low immunosuppression
    Jacques Pirenne
    Catholic University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium Jacques Pirenne uz kuleuven ac be
    Transplantation 73:966-8. 2002
    ..We applied a strategy to clinical Itx that combines intraportal donor-specific blood transfusion with a deliberately low immunosuppression protocol (no high-dose steroids; lower tacrolimus level)...
  13. ncbi request reprint The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance
    Takaaki Koshiba
    Abdominal Transplant Department, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Transpl Int 16:383-90. 2003
    ..In Htx, however, FTY 720 allows full development of tolerance. The mechanisms by which FTY 720 causes rejection in primary intestinal but not in heart grafts need to be elucidated...
  14. ncbi request reprint Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver transplant recipients
    Mikiko Kawasaki
    Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo, Japan
    Int Surg 92:276-86. 2007
    ..Our data indicated that cDNA microarray technology was useful for this application and provided many informative insights into transplant tolerance mechanism...
  15. ncbi request reprint Regulatory cell-mediated tolerance does not protect against chronic rejection
    Takaaki Koshiba
    Abdominal Transplant Surgery Department, Catholic University Leuven KUL, Belgium
    Transplantation 76:588-96. 2003
    ..Th2 cytokines stimulate B cells, which cause alloantibody-mediated chronic rejection. We searched to determine whether regulatory cell-mediated tolerance protects or not against chronic rejection...
  16. ncbi request reprint Regulatory cells, TH1/TH2 unbalance, and antibody-induced chronic rejection in operational tolerance induced by donor-specific blood transfusion
    Jacques Pirenne
    Abdominal Transplant Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Transplantation 79:S25-7. 2005
    ..Development of chronic rejection in a regulation-based tolerance model suggests that deletion-based tolerogenic strategies may offer a more robust protection against chronic rejection...
  17. ncbi request reprint Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report
    Jacques Pirenne
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 17:177-82. 2003
    ..We report the long-term (median = 40 months) follow-up data of a prospective pilot study designed to determine whether liver transplantation could be performed with no steroids at all (neither during nor after surgery)...
  18. ncbi request reprint FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A
    Takaaki Koshiba
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Transplantation 75:945-52. 2003
    ..FTY720, a new immunosuppressant altering lymphocyte trafficking, is effective against acute rejection, but its activity against chronic rejection is not known...
  19. ncbi request reprint Paradoxical early upregulation of intragraft Th1 cytokines is associated with graft acceptance following donor-specific blood transfusion
    Takaaki Koshiba
    Abdominal Transplant Department, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Transpl Int 16:179-85. 2003
    ..The mechanisms by which an early Th1 response promotes tolerance need to be further studied...
  20. ncbi request reprint Aplastic anemia after transplantation for non-A, non-B, non-C fulminant hepatic failure: case report and review of the literature
    Patrick Itterbeek
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Belgium
    Transpl Int 15:117-23. 2002
    ..In unresponsive patients, six-HLA-identical bone marrow transplantation has been successful...
  21. ncbi request reprint Early accumulation of interferon-gamma in grafts tolerized by donor-specific blood transfusion: friend or enemy?
    Hiroaki Kitade
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Leuven, Belgium
    Transplantation 78:1747-55. 2004
    ..This contrasted with the IFN-gamma peak seen later (day 5) in rejecting but not in tolerant rats...