Ikuo Konishi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606 8507, Japan
    Adv Anat Pathol 20:227-37. 2013
  2. doi request reprint Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Histopathology 54:184-91. 2009
  3. doi request reprint Carbonic anhydrase type IX expression in lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Pathol Res Pract 209:173-8. 2013
  4. doi request reprint The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer
    Shogo Yamamura
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cancer 130:20-8. 2012
  5. doi request reprint Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion
    Hiroshi Fujiwara
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Int J Gynecol Cancer 23:576-82. 2013
  6. doi request reprint Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation
    Akihito Horie
    Department of Gynecology and Obstetrics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Hum Reprod 27:1267-76. 2012
  7. doi request reprint The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Clin Immunol 141:338-47. 2011
  8. doi request reprint Suppression of metastatic murine ovarian cancer cells by transduced embryonic progenitor cells
    Masaki Mandai
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Horm Cancer 1:291-6. 2010
  9. doi request reprint GPR54 is a target for suppression of metastasis in endometrial cancer
    Hyun Sook Kang
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
    Mol Cancer Ther 10:580-90. 2011
  10. pmc ATP-binding cassette transporter A1 expression is decreased in preeclamptic placentas
    Yoshitsugu Chigusa
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Reprod Sci 20:891-8. 2013

Collaborators

Detail Information

Publications43

  1. doi request reprint Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606 8507, Japan
    Adv Anat Pathol 20:227-37. 2013
    ..They are occasionally associated with Peutz-Jeghers syndrome or are a component of "synchronous mucinous metaplasia and neoplasia of the female genital tract."..
  2. doi request reprint Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Histopathology 54:184-91. 2009
    ..To describe the gastric phenotype of synchronous mucinous metaplasia and neoplasms of the female genital tract (SMMN-FGT)...
  3. doi request reprint Carbonic anhydrase type IX expression in lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix
    Yoshiki Mikami
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Pathol Res Pract 209:173-8. 2013
    ..Although CA-IX appears to be involved in tumor progression and may be diagnostically useful in cases of endocervical adenocarcinoma and its precursors, LEGH can be a pitfall, and staining results should be combined with morphology...
  4. doi request reprint The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer
    Shogo Yamamura
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cancer 130:20-8. 2012
    ..015). In summary, these results show that the activated TGF-β signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer...
  5. doi request reprint Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion
    Hiroshi Fujiwara
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Int J Gynecol Cancer 23:576-82. 2013
    ..In this study, we examined the possible involvement of the Eph-ephrin system in the invasion of malignant gestational trophoblastic diseases using a human choriocarcinoma-derived cell line, JEG-3...
  6. doi request reprint Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation
    Akihito Horie
    Department of Gynecology and Obstetrics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Hum Reprod 27:1267-76. 2012
    ..Thus, this study was designed to elucidate the molecular characteristics and physiological roles of laeverin in human EVT...
  7. doi request reprint The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Clin Immunol 141:338-47. 2011
    ..In conclusion the comprehensive analysis of local immune status led to subdivide ovarian cancers into groups with better or worse prognoses and may guide precise understanding of the local immunity...
  8. doi request reprint Suppression of metastatic murine ovarian cancer cells by transduced embryonic progenitor cells
    Masaki Mandai
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Horm Cancer 1:291-6. 2010
    ..Alteration of local immune environment by this method may be used in the future for individualized cancer immune therapy...
  9. doi request reprint GPR54 is a target for suppression of metastasis in endometrial cancer
    Hyun Sook Kang
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
    Mol Cancer Ther 10:580-90. 2011
    ..These data suggest that metastin-10 may be effective at inhibiting the metastatic spread of endometrial cancers in combination with demethylating agents to induce GPR54 expression...
  10. pmc ATP-binding cassette transporter A1 expression is decreased in preeclamptic placentas
    Yoshitsugu Chigusa
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Reprod Sci 20:891-8. 2013
    ..These results suggest that low LOX-1 expression may lead to insufficient oxLDL uptake, thereby contributing to reduced LXR activation and decreased ABCA1 expression in preeclamptic placentas. ..
  11. doi request reprint Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers
    Budiman Kharma
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Cancer 133:2234-44. 2013
    ..Fludarabine may be useful in targeting high-grade, chemorefractory endometrial cancer. ..
  12. doi request reprint Ovarian clear cell carcinoma as a stress-responsive cancer: influence of the microenvironment on the carcinogenesis and cancer phenotype
    Masaki Mandai
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Lett 310:129-33. 2011
    ..In this review, by referring to other articles in this field, we explore how the carcinogenic microenvironment affects the phenotype and gene expression of a cancer, and how we can develop new treatment based on this concept...
  13. doi request reprint Primary squamous cell carcinoma of fallopian tube accompanied by gastric metaplasia of female genital tract: case report and review
    Hiroshi Satoh
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 37:1106-11. 2011
    ..All patients were alive without disease where optimal resection had been successfully achieved. These findings imply that radical tumor resection is mandatory for satisfactory treatment of primary SCCFT...
  14. doi request reprint PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction
    Kaoru Abiko
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 19:1363-74. 2013
    ..Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be expressed in cancer cells. The purpose of this study is to elucidate the function of PD-L1 in peritoneal dissemination...
  15. doi request reprint Ileal perforation and massive intestinal haemorrhage from endometriosis in pregnancy: case report and literature review
    Ai Nishikawa
    Department of Gynaecology and Obstetrics, Kyoto University, Kyoto, Japan
    Eur J Obstet Gynecol Reprod Biol 170:20-4. 2013
    ....
  16. doi request reprint Solitary fibrous tumor arising slowly in the vulva over 10 years: case report and review
    Mana Taki
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 38:884-8. 2012
    ..We report a case of vulvar SFT slowly growing for 10 years, and propose a strategy for the diagnosis and treatment of gynecological SFT...
  17. doi request reprint EphrinA1 stimulates cell attachment and inhibits cell aggregation through the EphA receptor pathway in human endometrial carcinoma-derived Ishikawa cells
    Haruko Fujii
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Hum Reprod 26:1163-70. 2011
    ....
  18. doi request reprint Expression of p53 and p21(WAF-1), apoptosis, and proliferation of smooth muscle cells in normal myometrium during the menstrual cycle: implication of DNA damage and repair for leiomyoma development
    Ayako Suzuki
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Kyoto 606 8507, Japan
    Med Mol Morphol 45:214-21. 2012
    ..In addition, smooth muscle cells proliferate in the luteal phase, which may be a vulnerable period for DNA damage. Thus, these cyclic events during the menstrual cycle may contribute to a high incidence of leiomyoma development...
  19. doi request reprint Adenoid cystic carcinoma of skene glands: a rare origin in the female genital tract and the characteristic clinical course
    Yusuke Ueda
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Gynecol Pathol 31:596-600. 2012
    ..Although the precise preoperative assessment and the preparation for an extended operation are difficult, they are necessary for the successful treatment of this rare disease...
  20. doi request reprint Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling
    Noriomi Matsumura
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Sci 101:2658-63. 2010
    ..This report demonstrates a method to utilize genome-wide information to facilitate translational research for treatments against less common subtypes of cancers...
  21. doi request reprint Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation
    Kaoru Abiko
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Surg Pathol 34:1842-8. 2010
    ....
  22. doi request reprint Serial magnetic resonance imaging of placenta percreta with bladder involvement during pregnancy and postpartum: a case report
    Yusuke Ueda
    Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan
    J Obstet Gynaecol Res 39:359-63. 2013
    ..The placenta was never expelled and spontaneously disappeared 4 months after surgery. We demonstrate serial magnetic resonance imaging of the placenta percreta during pregnancy and the postpartum period...
  23. doi request reprint Vaginal delivery in the presence of huge vulvar varicosities: a case report with MRI evaluation
    Nozomi Furuta
    Department of Gynaecology and Obstetrics, Kyoto University, Kyoto, Japan
    Eur J Obstet Gynecol Reprod Biol 167:127-31. 2013
    ..Women with vulvar varicosities can be allowed to attempt a vaginal birth regardless of their severity. The use of MRI aids in the overall anatomical understanding of vulvar varicosities in pregnancy...
  24. doi request reprint Management of fetal death with placenta previa
    Mana Taki
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Matern Fetal Neonatal Med 25:196-9. 2012
    ..Vaginal delivery was achieved with total blood loss of 1900 ml. Homologous blood transfusion was obviated owing to autologous blood that had been stored during the waiting period...
  25. doi request reprint Cervical clamp with ring forceps to prevent prolapse of an intrauterine balloon in the management of postpartum hemorrhage
    Akeo Kawamura
    Department of Gynecology and Obstetrics, Kyoto University, Sakyo ku, Kyoto, Japan
    J Obstet Gynaecol Res 39:733-7. 2013
    ..Clamping the cervix with two ring forceps to retain the balloon can be a simple and readily available approach to consider when an intrauterine balloon tamponade does not work due to its expulsion...
  26. doi request reprint Endothelial function progressively deteriorates during normal pregnancy
    Kohei Fujita
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Hypertens Pregnancy 32:129-38. 2013
    ..To elucidate changes in endothelial function throughout the gestational period in normal pregnancy and its relationship with plasma soluble fms-like tyrosine kinase-1 (sFlt-1) levels...
  27. doi request reprint Complement split product C4d deposition in placenta in systemic lupus erythematosus and pregnancy-induced hypertension
    Sachiko Minamiguchi
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Pathol Int 63:150-7. 2013
    ..05), and lower gestational age (P < 0.05) in PIH cases. These results suggest that C4d might be utilized as a biomarker evaluating the subsequent risk for IUGR and disease control during the gestation period in these patients...
  28. doi request reprint Deciduosis can cause remarkable leukocytosis and obscure abdominal pain
    Eiji Kondoh
    Departments of Gynecology and Obstetrics Pathology, Kyoto University, Kyoto, Japan
    J Obstet Gynaecol Res 38:1376-8. 2012
    ..Serum G-CSF concentration was 339 pg/mL at 28 weeks, and that of ascites was 312 000 pg/mL at cesarean section. G-CSF-producing deciduosis can induce leukocytosis as well as abdominal pain during pregnancy and postpartum...
  29. doi request reprint Endometrial cancer implanted within a cesarean section scar
    Tsukasa Baba
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicene, Kyoto, Japan
    J Obstet Gynaecol Res 37:245-9. 2011
    ..With increases in the incidence of both endometrial cancer and births by C-S, it is likely we will encounter more cases of iatrogenic implants of endometrial cancers in C-S scars...
  30. doi request reprint Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia
    Yoshitsugu Chigusa
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 97:E1862-70. 2012
    ..However, it has yet to be elucidated whether LOX-1, along with Nrf2, participates in the pathology of preeclampsia...
  31. doi request reprint Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy
    Hiroshi Takai
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 37:1717-9. 2011
    ..Prompt diagnosis and chemotherapy increases the chances of a relatively favorable outcome even in advanced gastric cancer presenting with DIC due to bone marrow involvement...
  32. doi request reprint Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation
    Yumiko Yoshioka
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Immunol 42:749-59. 2012
    ..Collectively, we describe multiple effects of dorsomorphin and Noggin on T-cell activation and differentiation, demonstrating a physiological role for BMP signalling in these processes...
  33. doi request reprint Advanced extragonadal yolk sac tumor serially followed up with (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography and serum alpha-fetoprotein
    Tsukasa Baba
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 38:605-9. 2012
    ....
  34. doi request reprint Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management
    Masaki Mandai
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Int J Clin Oncol 14:383-91. 2009
    ..Among the phenotypes of EAOC, clear cell carcinoma, seems to require a specific treatment strategy, including molecular targeting...
  35. doi request reprint Decidualized adenomyosis during pregnancy and post delivery: three cases of magnetic resonance imaging findings
    Fuki Shitano
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Abdom Imaging 38:851-7. 2013
    ..The MR imaging findings of adenomyosis after childbirth showed hemorrhage inside the lesion, which were assumed to be led by rapid decrease in a blood flow to adenomyosis post childbirth. ..
  36. doi request reprint Management of retained products of conception with marked vascularity
    Tomoko Kitahara
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Obstet Gynaecol Res 37:458-64. 2011
    ..Sixty-one days after the first D&C, reduction of the vascularity of RPOC was confirmed on color Doppler ultrasonography and D&C was successfully completed...
  37. doi request reprint Pyomayoma during pregnancy: a case report and review of the literature
    Fumimasa Kobayashi
    Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan
    J Obstet Gynaecol Res 39:383-9. 2013
    ..A brief review of the literature regarding pyomyoma associated with pregnancy is also described...
  38. doi request reprint Successful recovery from delayed amniotic fluid embolism with prolonged cardiac resuscitation
    Kanako Hosono
    Department of Gynecology and Obstetrics, Kyoto University, Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 37:1122-5. 2011
    ..The patient recovered without any aftereffects. This case report warrants that AFE should be considered when coagulopathy and dyspnea are observed during the postpartum period...
  39. doi request reprint Secondary postpartum hemorrhage due to uterine artery pseudoaneurysm rupture in von Willebrand disease
    Misao Shimizu
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 37:1887-90. 2011
    ..When it is determined that a patient has unexplained PPH or uterine artery pseudoaneurysm, a high index of suspicion and further investigation for underlying bleeding disorders is warranted...
  40. doi request reprint Role of platelets in placentation
    Yukiyasu Sato
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Med Mol Morphol 43:129-33. 2010
    ..Future studies should aim to elucidate other mechanisms that could regulate endovascular trophoblast infiltration...
  41. doi request reprint Ephrin A1 induces intercellular dissociation in Ishikawa cells: possible implication of the Eph-ephrin A system in human embryo implantation
    Haruko Fujii
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Hum Reprod 26:299-306. 2011
    ..Since Eph-ephrin interaction can induce repulsive forces to control cell position and movement, we examined the possible involvement of this system in intercellular dissociation among endometrial epithelial cells...
  42. doi request reprint Middle cerebral artery-peak systolic velocity in dizygotic twins with anti-E alloimmunization
    Yumiko Satake
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Obstet Gynaecol Res 36:1236-9. 2010
    ..Twin B showed moderate anemia with positive direct Coombs' test and was diagnosed as HFDN due to anti-E alloimmunization. Twin B required phototherapy and red cell transfusion, but exchange transfusion was safely obviated...
  43. doi request reprint Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpus
    Kaoru Abiko
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medical Science, Kyoto, Japan
    Pathol Int 60:42-7. 2010
    ..In summary, mucinous endometrial adenocarcinoma rarely shows features similar to MDA of the cervix. This case provokes a discussion on diagnostic and management strategy, and histogenesis of mucinous neoplasm of the endometrium...