Akio Koizumi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi A cluster of lysinuric protein intolerance (LPI) patients in a northern part of Iwate, Japan due to a founder effect. The Mass Screening Group
    A Koizumi
    Department of Health and Environmental Sciences, Kyoto University School of Public Health, Kyoto 606 8501, Japan
    Hum Mutat 16:270-1. 2000
  2. pmc Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan
    Akio Koizumi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:235-46. 2009
  3. ncbi [An overview of genetic analysis for neurosurgical diseases and disorders]
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyoku, Kyoto City, Kyoto 606 8501, Japan
    No Shinkei Geka 32:1203-13. 2004
  4. pmc Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans
    Akio Koizumi
    Department of Health and Environmental Sciences Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:52-9. 2009
  5. pmc Past, present, and future of environmental specimen banks
    Akio Koizumi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:307-18. 2009
  6. doi Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women
    Yohei Mineharu
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    J Epidemiol Community Health 65:230-40. 2011
  7. ncbi [Toward a more rational field-genetic epidemiology]
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nihon Eiseigaku Zasshi 65:37-47. 2010
  8. ncbi Assessment of human exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in Japan using archived samples from the early 1980s and mid-1990s
    Akio Koizumi
    Graduate School of Medicine, Department of Health and Environmental Sciences, Kyoto University, Yoshida Konoecho, Kyoto 606 8501, Japan
    Environ Res 99:31-9. 2005
  9. ncbi Evaluation of a mass screening program for lysinuric protein intolerance in the northern part of Japan
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University School of Public Health, Kyoto 606 8501, Japan
    Genet Test 7:29-35. 2003
  10. ncbi Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan
    Miwako Dakeishi
    Department of Hygiene, Akita University School of Medicine, Akita, Japan
    Hum Mutat 19:140-8. 2002

Detail Information

Publications103 found, 100 shown here

  1. ncbi A cluster of lysinuric protein intolerance (LPI) patients in a northern part of Iwate, Japan due to a founder effect. The Mass Screening Group
    A Koizumi
    Department of Health and Environmental Sciences, Kyoto University School of Public Health, Kyoto 606 8501, Japan
    Hum Mutat 16:270-1. 2000
    ..The R410X mutation was shown to be useful as a molecular marker for screening LPI patients in the northern part of Japan...
  2. pmc Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan
    Akio Koizumi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:235-46. 2009
    ..The primary goal of the present study was to investigate the long-term trends and congener profiles of serum and dietary levels of PCBs using historical samples...
  3. ncbi [An overview of genetic analysis for neurosurgical diseases and disorders]
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyoku, Kyoto City, Kyoto 606 8501, Japan
    No Shinkei Geka 32:1203-13. 2004
  4. pmc Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans
    Akio Koizumi
    Department of Health and Environmental Sciences Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:52-9. 2009
    ..We applied a new technology - synchrotron radiation microbeams (SRXRF) - for analysis of heavy metals in human permanent teeth in modern and historical samples...
  5. pmc Past, present, and future of environmental specimen banks
    Akio Koizumi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto, 606 8501, Japan
    Environ Health Prev Med 14:307-18. 2009
    ..Finally, we give a perspective of new functions for environmental specimen banks in the next 20 years...
  6. doi Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women
    Yohei Mineharu
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    J Epidemiol Community Health 65:230-40. 2011
    ..The effects of coffee and green, black and oolong teas and caffeine intake on cardiovascular disease (CVD) mortality have not been well defined in Asian countries...
  7. ncbi [Toward a more rational field-genetic epidemiology]
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nihon Eiseigaku Zasshi 65:37-47. 2010
    ..This newly proposed method is expected to provide polymorphisms, which have large odds ratios, requiring only minimum research budgets...
  8. ncbi Assessment of human exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in Japan using archived samples from the early 1980s and mid-1990s
    Akio Koizumi
    Graduate School of Medicine, Department of Health and Environmental Sciences, Kyoto University, Yoshida Konoecho, Kyoto 606 8501, Japan
    Environ Res 99:31-9. 2005
    ..8) to 26.0 (5.0). The serum levels of PCBs decreased in the younger generation but not in the older, although levels in daily intakes decreased significantly. Exposure levels of PBDEs appear to be increasing in an area-specific manner...
  9. ncbi Evaluation of a mass screening program for lysinuric protein intolerance in the northern part of Japan
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University School of Public Health, Kyoto 606 8501, Japan
    Genet Test 7:29-35. 2003
    ..Therefore, we conclude that a mass screening program for LPI can be introduced effectively and economically into an area where an LPI cluster is located as the result of a founder mutation...
  10. ncbi Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan
    Miwako Dakeishi
    Department of Hygiene, Akita University School of Medicine, Akita, Japan
    Hum Mutat 19:140-8. 2002
    ..We recommend that families with HHT be screened for gene mutations in order that high-risk individuals receive early diagnosis and treatment initiation that will substantially alter their clinical course and prognosis...
  11. pmc P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure
    Akio Koizumi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Konoe cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Environ Health Prev Med 18:121-9. 2013
    ..RNF213 has been identified as a susceptibility gene for moyamoya disease. In the present study, the association of p.R4810K (G>A) with blood pressure (BP) was investigated in a Japanese population...
  12. ncbi The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-alpha
    Akihiro Asakawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Int J Mol Med 21:439-45. 2008
    ..Our studies demonstrated that the ubiquitous environmental pollutant PFOA works as an imitator of OEA mimicking its action in the feeding regulatory system, providing a new mode of action as represented by environmental 'anorexigens'...
  13. doi Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008
    Kouji H Harada
    Department of Health and Environmental Sciences, Kyoto University, Yoshida, Japan
    Chemosphere 79:314-9. 2010
    ....
  14. ncbi Combination of linkage and association studies for brain arteriovenous malformation
    Sumiko Inoue
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, Japan
    Stroke 38:1368-70. 2007
    ..We used a combination of a linkage study and an association study to explore the genetic background...
  15. ncbi Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm
    Youhei Mineharu
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, Japan
    Stroke 38:1174-8. 2007
    ..Each family was linked to a distinct locus, indicating locus heterogeneity. This study aimed to examine whether Japanese IA families consistent with autosomal-dominant mode of inheritance support linkage to these loci...
  16. doi The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality
    Toshiaki Hitomi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 439:419-26. 2013
    ..05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p<0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability...
  17. doi Ablation of Rnf213 retards progression of diabetes in the Akita mouse
    Hatasu Kobayashi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 432:519-25. 2013
    ..05 each). These findings indicated that the disruption of Rnf213 improved glucose tolerance by protecting islet β cells...
  18. ncbi A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population
    Ikuko Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 208:255-9. 2006
    ..However, c.188 A > G (Y63C) was not identified in 96 short individuals from the general population of 2,281 healthy adults. Thus, it is unlikely that PTPN11 is one of the genes underlying stature variations in the general population...
  19. ncbi Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Kyoto 606 8501, Japan
    Chemosphere 66:293-301. 2007
    ..6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively...
  20. doi Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women: the JACC Study
    Junko Nagura
    Department of Social Medicine and Cultural Sciences, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Br J Nutr 102:285-92. 2009
    ..In conclusion, intakes of plant-based foods, particularly fruit intake, were associated with reduced mortality from CVD and all causes among Japanese men and women...
  21. ncbi Genome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions
    Shigeki Yamada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 110:3727-33. 2004
    ..Genetic factors have an important role in the pathogenesis of intracranial aneurysm (IA). The results of previous studies have suggested several loci...
  22. ncbi Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606 8501, Japan
    Environ Res 99:253-61. 2005
    ..We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS...
  23. doi Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam
    Kouji H Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Environ Int 37:1183-9. 2011
    ..The proportion of long-chain PFCAs in serum was relatively high compared to reports in Western countries. Further investigations into the sources and exposure routes are needed to predict the future trajectory of these serum PFCA levels...
  24. doi Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients
    Hirokuni Hashikata
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, 606 8501, Japan
    Stroke 41:1138-44. 2010
    ..Recently, a multinational, genome-wide association study identified 3 loci associated with IA, located on 2q (rs700651), 8q (rs10958409), and 9p (rs1333040 and rs10757278). The aim of this study was to evaluate these associations...
  25. ncbi Risk and protective factors related to mortality from pneumonia among middleaged and elderly community residents: the JACC Study
    Yusuke Inoue
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Epidemiol 17:194-202. 2007
    ..There have been few systematic investigations into risk and protective factors for pneumonia related mortality for community residents. This study investigated these factors utilizing a large cohort study on Japanese community residents...
  26. ncbi Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm
    Youhei Mineharu
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 37:1189-94. 2006
    ..We aimed to examine the association of single-nucleotide polymorphisms (SNPs) with IA in these candidate genes...
  27. doi Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin
    Michi Hirosawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 371:320-3. 2008
    ..These results indicate that ERalpha plays an essential role in leptin- and insulin-stimulated upregulation of the POMC gene. This action of ERalpha is likely mediated in a ligand-independent manner...
  28. doi Combined linkage analysis and exome sequencing identifies novel genes for familial goiter
    Junxia Yan
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Hum Genet 58:366-77. 2013
    ..Moreover, these four genes are novel with regard to their involvement in familial goiter, supporting genetic heterogeneity of this disease. ..
  29. ncbi Risk factors for fatal subarachnoid hemorrhage: the Japan Collaborative Cohort Study
    Shigeki Yamada
    Dept of Health and Environmental Sciences, Graduate School of Medicine Kyoto University, Konoe cho, Yoshida, Sakyo ku, Kyoto, 606 8501, Japan
    Stroke 34:2781-7. 2003
    ..The present study aimed to identify risk factors for mortality due to subarachnoid hemorrhage (SAH) using a comprehensive questionnaire from the Japan Collaborative Cohort (JACC) Study, a Japan-wide population-based prospective study...
  30. ncbi The bioconcentration factor of perfluorooctane sulfonate is significantly larger than that of perfluorooctanoate in wild turtles (Trachemys scripta elegans and Chinemys reevesii): an Ai river ecological study in Japan
    Akiko Morikawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Ecotoxicol Environ Saf 65:14-21. 2006
    ..The GM (GSD) of the BCF of PFOA was 3.2 (7.9). Furthermore, the BCF of PFOA decreased as the PFOA level in the surface water increased. PFOS could be preferentially bioconcentrated in biota, and PFOA, slightly bioconcentrated...
  31. doi Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia
    Yukiko Fujii
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Chemosphere 86:315-21. 2012
    ..05), but not in China (p>0.05). In conclusion, various PFCAs were detected in human breast milk samples from East Asian countries...
  32. doi Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23
    Yohei Mineharu
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, Japan
    J Hum Genet 53:325-32. 2008
    ..048). This association was confirmed in the replication cohort (p=0.0046 for allelic association, p=0.0060 for haplotype association). Our findings confirm 14q23 to be a susceptibility locus for intracranial aneurysm...
  33. doi Cleft palate caused by perfluorooctane sulfonate is caused mainly by extrinsic factors
    Saho Era
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 6068501, Japan
    Toxicology 256:42-7. 2009
    ..PFOS prevented elevation of the PSs above the tongue because their growth/fusion potential was maintained. Mandibular hypoplasia did not seem to play a critical role in the pathogenesis of CP...
  34. ncbi Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm: a preliminary study
    Kayoko Inoue
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 113:2002-10. 2006
    ..Our previous studies have shown a significant linkage of intracranial aneurysms (IAs) to chromosome 17...
  35. doi Alcohol consumption and mortality from stroke and coronary heart disease among Japanese men and women: the Japan collaborative cohort study
    Satoyo Ikehara
    Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan
    Stroke 39:2936-42. 2008
    ..However, the sex-specific association between alcohol consumption and mortality from stroke and coronary heart disease remains unclear...
  36. ncbi History of blood transfusion before 1990 is a risk factor for stroke and cardiovascular diseases: the Japan collaborative cohort study (JACC study)
    Shigeki Yamada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, Japan
    Cerebrovasc Dis 20:164-71. 2005
    ..This study was conducted to assess history of transfusion as a risk factor for other hemorrhagic stroke or ischemic stroke and cardiovascular diseases...
  37. doi Relationship between dietary exposure and serum perfluorochemical (PFC) levels--a case study
    Anna Karrman
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Sakyo Konoe, Kyoto 606 8501, Japan
    Environ Int 35:712-7. 2009
    ..1 ng/mL (Miyagi). Based on one-compartment model under steady state, dietary intake of PFOS and PFOA accounted for only 22.4% and 23.7% of serum levels in Osaka females, and in contrast 92.5% and 110.6% in Miyagi females, respectively...
  38. pmc Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka
    Shanika Nanayakkara
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto, Japan
    Environ Health Prev Med 17:213-21. 2012
    ..This study concludes that tubulointerstitial damage is the major pathological lesion in CKDu. Exposure(s) to an environmental pathogen(s) should be systematically investigated to elucidate such tubulointerstitial damage in CKDu...
  39. pmc Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development
    Wanyang Liu
    Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e22542. 2011
    ..Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility gene is unknown...
  40. ncbi Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families
    Shigeki Yamada
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan
    Stroke 34:892-900. 2003
    ..We sought to test the linkage of familial intracranial aneurysms (FIAs) to the ELN (elastin) locus in chromosome 7q11 reported previously...
  41. ncbi Large-scale evaluation of the current level of polybrominated diphenyl ethers (PBDEs) in breast milk from 13 regions of Japan
    Bita Eslami
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Chemosphere 63:554-61. 2006
    ..69), 0.88; Wakayama 1.33 (3.80), 1.70; Shimane 0.83 (2.51), 0.66; Yamaguchi 1.74 (2.82), 1.76; Kochi 0.50 (2.69), 0.74 and Okinawa 1.91 (2.75), 1.22. This is the first large-scale study of current PBDE levels in breast milk in Japan...
  42. doi Comparative survey of levels of chlorinated cyclodiene pesticides in breast milk from some cities of China, Korea and Japan
    Yukiko Fujii
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Chemosphere 89:452-7. 2012
    ..0 ng g(-1) lipid). α- and β-endosulfans were detected at a range of 0.9-1.5 ng g(-1) lipid levels in all samples analyzed, and their levels were higher in Korean than in Chinese samples...
  43. pmc Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation
    Akio Koizumi
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Environ Health Prev Med 17:292-8. 2012
    ..This study aims to estimate the ecological exposure of adult residents of Fukushima Prefecture to ¹³⁴cesium (Cs) and ¹³⁷Cs through ingestion and inhalation between July 2 and July 8, 2011...
  44. pmc Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka
    Lalantha Senevirathna
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Environ Health Prev Med 17:191-8. 2012
    ....
  45. pmc Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers
    Kayoko Inoue
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, and Department of Neurosurgery, Takayama Red Cross Hospital, Japan
    Environ Health Perspect 114:1179-85. 2006
    ..During the first weeks of lactation, the predicted partitioning of PBDE and PCB congeners from serum to milk agreed with the observed values. However, the prediction became weaker after 10 weeks of nursing...
  46. ncbi Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus
    Akihiro Asakawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Mol Med 19:733-9. 2007
    ..These observations indicate that PFCs may act centrally to influence behavior and physiological functions in humans...
  47. ncbi Distributions of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in Japan and their toxicities
    Shoji Nakayama
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Environ Sci 12:293-313. 2005
    ..Additionally, peroxisome proliferation and calcium channel modulation are demonstrated effects. There are large interspecies differences in toxicokinetics...
  48. pmc Evidence of tubular damage in the very early stage of chronic kidney disease of uncertain etiology in the North Central Province of Sri Lanka: a cross-sectional study
    Shanika Nanayakkara
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Environ Health Prev Med 17:109-17. 2012
    ..In the North Central Province of Sri Lanka, chronic kidney disease of uncertain etiology (CKDue) has increased markedly over the past 15-20 years...
  49. doi Historical trends in human dietary intakes of endosulfan and toxaphene in China, Korea and Japan
    Biruck Desalegn
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida, Kyoto 606 8501, Japan
    Chemosphere 83:1398-405. 2011
    ..It appears important to refine dietary intake estimates targeting food types and source identification to ensure safe food for consumers...
  50. ncbi The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Occup Health 46:141-7. 2004
    ..This finding suggests that there are sources of PFOA in the Kinki area that have raised the PFOA serum levels of its inhabitants. Further studies are needed to elucidate these sources in the Kinki area of Japan...
  51. ncbi Effects of perfluorooctane sulfonate on tracheal ciliary beating frequency in mice
    Eriko Matsubara
    Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 6068501, Japan
    Toxicology 236:190-8. 2007
    ..12-fold (P<0.05) of vehicle control), indicating that the actions of PFOS are not mediated via PPARalpha. These findings collectively suggest that PFOS stimulates CBF by increasing cytoplasmic Ca(2+) through VDCC...
  52. doi Environmental ecological modeling of human blood lead levels in East Asia
    Tamon Niisoe
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Environ Sci Technol 45:2856-62. 2011
    ..Finally, we applied EEM to simulate BLLs of children in Hanoi. The probability of children having BLLs greater than 50 μg L(-1) was 7.5%, which was greater than those observed in developed countries...
  53. doi Dietary exposure to short-chain chlorinated paraffins has increased in Beijing, China
    Kouji H Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Environ Sci Technol 45:7019-27. 2011
    ..Preliminary evidence on the significant increase in SCCP exposure in Beijing in 2009 warrants urgent investigations to refine dietary intake estimates by targeting food types and source identification...
  54. ncbi Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system
    Akihiro Asakawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Int J Mol Med 19:649-52. 2007
    ..Further, melanocortin systems may be therapeutic targets not only for diabetes but also for its associated complications...
  55. ncbi ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element
    Naomi Mizobuchi
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Cell Struct Funct 32:41-50. 2007
    ..ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the ER...
  56. doi Long-term simulation of human exposure to atmospheric perfluorooctanoic acid (PFOA) and perfluorooctanoate (PFO) in the Osaka urban area, Japan
    Tamon Niisoe
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Environ Sci Technol 44:7852-7. 2010
    ..The results indicated a dominant contribution of the atmospheric component to serum PFO(A) in humans near the point source in the Keihanshin area. In 2008, that contribution was about 70%...
  57. doi Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan)
    Yoshio Ikeda
    The Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Neurology 79:333-41. 2012
    ..To characterize the phenotype of spinocerebellar ataxia type 36 (SCA36), a novel dominant disorder (nicknamed "Asidan") caused by a hexanucleotide GGCCTG repeat expansion in intron 1 of the NOP56 gene...
  58. ncbi Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver
    Mutsuko Minata
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Ind Health 48:96-107. 2010
    ..Biliary bile acid/phospholipid ratios were higher in Pparalpha-null mice than in wild-type mice. Results from these studies suggest that PPARalpha is protective against PFOA and have a critical role in drug induced hepatobiliary injury...
  59. doi GCKR mutations in Japanese families with clustered type 2 diabetes
    Daisuke Tanaka
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Mol Genet Metab 102:453-60. 2011
    ..The aim was to investigate the genetic background of familial clustering of type 2 diabetes...
  60. doi Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan
    Yukiko Fujii
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Sakyo, Japan
    Chemosphere 82:25-31. 2011
    ..In the present study, dicofol was confirmed to be detectable in human breast milk. This is the first report to identify dicofol in human samples...
  61. doi Current levels of airborne polyfluorinated telomers in Japan
    Sayoko Oono
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Chemosphere 73:932-7. 2008
    ..This study is the first national wide-scale survey of FTOHs and 8:2 FTOAcryl across Japan, showing that 8:2 FTOH was ubiquitous in the environment in Japan...
  62. doi Polyfluorinated telomers in precipitation and surface water in an urban area of Japan
    Manal A M Mahmoud
    Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Chemosphere 74:467-72. 2009
    ..8 ng L(-1)). Taken together, the results of this study indicate that FTOHs released into the air contaminate rain and that those released from water disposal sites contaminate surface water...
  63. doi Regional variation and possible sources of brominated contaminants in breast milk from Japan
    Yukiko Fujii
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto, Japan
    Environ Pollut 162:269-74. 2012
    ..45 ng/g lipid). The regional variation may be caused by source differences, i.e. southern seafood for MeO-PBDEs and northern biota for halogenated bipyrroles in the Japanese coastal water...
  64. ncbi Mutation analysis in PKD1 of Japanese autosomal dominant polycystic kidney disease patients
    Sumiko Inoue
    Department of Environmental and Health Sciences, Kyoto University School of Public Health, Kyoto, Japan
    Hum Mutat 19:622-8. 2002
    ..Six other polymorphisms were found. Most PKD1 mutations in Japanese ADPKD patients were novel and definitely pathogenic. One pedigree did not link to either PKD1 or PKD2...
  65. ncbi The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells
    Jun ichi Nozaki
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
    Genes Cells 9:261-70. 2004
    ..These results indicate that this cell line is subject to continuous ER stress and that the Ins2 C96Y mutation induces the expression of ER chaperones through the activation of ATF6 and XBP1...
  66. doi Mycotoxin detection in urine samples from patients with chronic kidney disease of uncertain etiology in Sri Lanka
    Biruck Desalegn
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Bull Environ Contam Toxicol 87:6-10. 2011
    ..The higher detection rate of urinary ochratoxins in Sri Lankans indicates that exposure is common in the region...
  67. ncbi A historical aspect of lysinuric protein intolerance in a northern part of Iwate, Japan
    Yusuke Inoue
    Department of Global Health and Socio Epidemiology, Kyoto University, School of Public Health, Kyoto, 606 8501 Japan
    Hum Biol 75:81-90. 2003
    ..The present results also give an estimate of the geographical distribution of the R410X mutation, providing a basis for targeting populations for mass screening for LPI...
  68. doi Can children catch up in growth after living donor liver transplantation?
    Walid Mohamed El Moghazy
    Department of Hepatobiliary, Kyoto University, Kyoto, Japan
    Liver Transpl 16:453-60. 2010
    ..Young age is a determinant for early height gain, whereas ABO-incompatible grafts and graft dysfunction are determinants for late growth retardation. In contrast, the baseline z score is a determinant for both...
  69. ncbi A nonsense polymorphism (Y319X) of the solute carrier family 6 member 18 (SLC6A18) gene is not associated with hypertension and blood pressure in Japanese
    Bita Eslami
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Tohoku J Exp Med 208:25-31. 2006
    ..The nonsense allele was not a significant predictor for systolic or diastolic blood pressure. This is the first report showing that a single polymorphism in SLC6A18 is not associated with hypertension or blood pressure in Japanese...
  70. ncbi Roles of neuropeptides in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice
    Linfang Huang
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 362:177-82. 2007
    ..At doses higher than 5mg/kg, i.c.v. injection induced continuous hypophagia from 20min to 72h after dosing, accompanied by hypothermia and lung injury. OOS-TMP was considered to induce hypophagia through enhancing expression of CRF...
  71. ncbi [Current knowledge on the genetic factors involved in moyamoya disease]
    Hirokuni Hashikata
    Department of Health, Kyoto University Graduate School of Medicine, Japan
    Brain Nerve 60:1261-9. 2008
    ..Pathophysiological investigations at molecular levels have uncovered the upregulation of various growth and stress response factors that are associated with angiogenesis in occlusive cerebral arteries...
  72. doi Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan
    Wanyang Liu
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Chemosphere 85:1734-41. 2011
    ..These findings suggest that there are several sources of PFCAs with different origins in indoor environment. Further investigations into the origins of PFCAs are needed to evaluate indoor contamination with PFCAs...
  73. pmc Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement
    Hatasu Kobayashi
    Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Japan
    Am J Hum Genet 89:121-30. 2011
    ..In addition, transcription of MIR1292, a neighboring miRNA, was significantly decreased in lymphoblastoid cells of SCA patients. Our finding suggests that SCA36 is caused by hexanucleotide repeat expansions through RNA gain of function...
  74. ncbi Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface
    Takeo Yoshinaga
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Biol Chem 386:1077-85. 2005
    ..These findings indicate that increased hydrophobicity of mutant proinsulin facilitates aggregate formation, providing a clue to the dominant negative effect in the Akita mouse...
  75. doi Pediatric living-donor liver transplantation for acute liver failure: analysis of 57 cases
    Walid Mohamed El Moghazy
    Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University, Kyoto, Japan
    Transpl Int 23:823-30. 2010
    ..961-76.1763] (P < 0.05). In conclusion, Infants had poorer prognosis than children and refractory ACR was the leading cause of death. Using additional immunosuppressant for cases with severe and atypical rejections is recommended...
  76. ncbi Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene
    Ikuko Takahashi
    Department of Pediatrics, Akita University Graduate School of Medicine, Akita, Japan
    Endocr J 57:509-16. 2010
    ..Further investigations are called for to address the molecular mechanism...
  77. ncbi Survey of airborne polyfluorinated telomers in Keihan area, Japan
    Sayoko Oono
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Kyoto, Sakyo 6068501, Japan
    Bull Environ Contam Toxicol 80:102-6. 2008
    ..Compared to data published for North America and Europe, 8:2 FTOH levels are significantly higher in Keihan, suggesting a possible point source...
  78. ncbi Age-associated cardiomyopathy in heterozygous carrier mice of a pathological mutation of carnitine transporter gene, OCTN2
    E Xiaofei
    Department of Hygiene, Akita University School of Medicine, Japan
    J Gerontol A Biol Sci Med Sci 57:B270-8. 2002
    ..The present study and our previous work suggest that the carrier state of OCTN2 pathological mutations might be a risk factor for age-associated cardiomyopathy...
  79. ncbi Biochemical hypoglycemia in female nurses during clinical shift work
    Kayoko Inoue
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Res Nurs Health 27:87-96. 2004
    ..Subjective symptoms were not associated with hypoglycemia. More research on hypoglycemia is needed in order to improve working environment for nurses...
  80. ncbi Effects of perfluorinated amphiphiles on backward swimming in Paramecium caudatum
    Eriko Matsubara
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068501, Japan
    Biochem Biophys Res Commun 339:554-61. 2006
    ..8008, p<0.001). In summary, several perfluorochemicals and PFOS and PFOA had similar effects in Paramecium, while chain length, CMC, and electric charge were major determinants of BWS duration...
  81. ncbi Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance
    Yutaka Shoji
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Hum Mutat 20:375-81. 2002
    ..Expression of SLC7A7 and SLC7A6 may thus be interrelated in cultured lymphoblasts...
  82. ncbi Long-acting gonadotropin-releasing hormone analogue treatment for central precocious puberty in maternal uniparental disomy chromosome 14
    Ikuko Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 207:333-8. 2005
    ..This is the first report that describes GnRH analogue treatment for CPP associated with matUPD(14), suggesting that the GnRH analogue treatment is appropriate even for such a specific type of CPP...
  83. ncbi A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density
    Motoyuki Shimizu
    Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Mamm Genome 13:335-40. 2002
    ..The CAG trinucleotide repeat numbers in exon 1 of this gene differ among SAM strains. We found an association of CAG repeat length with relative peak bone mass in mice...
  84. ncbi [The legal issue of the present occupational physician system in crisis management of health damage]
    Tomoshi Yuki
    Department of Health and Environmental Sciences, Kyoto University School of Public Health, Yosidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Sangyo Eiseigaku Zasshi 46:159-67. 2004
    ..The company should take such a social responsibility in a crisis when it is the primary responsible party to the crisis...
  85. ncbi Secular trends and geographical variations in the dietary intake of polybrominated diphenyl ethers (PBDEs) using archived samples from the early 1980s and mid 1990s in Japan
    Yasuhiko Wada
    Hyogo College of Medicine, Japan
    J Occup Health 47:236-41. 2005
    ..In consideration of the significant increases in the serum concentration, inhalation may be more important than food ingestion as the route of human exposure to PBDEs...
  86. ncbi Effectiveness of cervical cancer screening over cervical cancer mortality among Japanese women
    Khandoker Aklimunnessa
    Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Jpn J Clin Oncol 36:511-8. 2006
    ..Therefore, the present study evaluated the association of CC mortality with self-reported CC screening and some other factors by a nationwide cohort study...
  87. ncbi Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
    Robert Kleta
    Medical Genetics Branch, 10 Center Drive, MSC 1851, Building 10, Room 10C 107, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 36:999-1002. 2004
    ..The protein product of SLC6A19, the Hartnup transporter, is expressed primarily in intestine and renal proximal tubule and functions as a neutral amino acid transporter...
  88. ncbi Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)
    Hiroyasu Iso
    Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    Circulation 106:1229-36. 2002
    ..Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups...
  89. ncbi A Prospective Cohort Study of Employment Status and Mortality from Circulatory Disorders among Japanese Workers
    Yoshihisa Fujino
    Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health
    J Occup Health 47:510-7. 2005
    ..58; 95% confidence interval=0.35, 0.97). Our findings suggest that employed men are at increased risk of death from cerebrovascular disease compared with self-employed men...
  90. ncbi Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study
    Renzhe Cui
    Department of Public Health Medicine, Graduate School of Comprehensive Human Science and Institute of Community Medicine, University of Tsukuba
    J Epidemiol 16:177-84. 2006
    ..Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women...
  91. ncbi Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: the JACC study
    Renzhe Cui
    Department of Public Health Medicine, Graduate School of Comprehensive Human Science, and Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    Atherosclerosis 194:415-20. 2007
    ..14 mmol/l (160 mg/dl). Low serum total cholesterol levels are associated with high mortality from intraparenchymal hemorrhage while high levels are associated with high mortality from coronary heart disease among Japanese...
  92. ncbi Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China
    Yihe Jin
    Department of Environmental Science and Technology, Dalian University of Technology, Dalian, P R China
    Tohoku J Exp Med 212:63-70. 2007
    ..6 microg/l and 8.3 microg/l in median, respectively) are comparable to those in Italy. The data from this study indicate that females are likely to experience higher exposure to these chemicals...
  93. ncbi Smoking cessation and mortality from cardiovascular disease among Japanese men and women: the JACC Study
    Hiroyasu Iso
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki ken 305 3585, Japan
    Am J Epidemiol 161:170-9. 2005
    ..Findings imply the importance of smoking cessation at any age to prevent cardiovascular disease in Japanese...
  94. ncbi Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan
    Norimitsu Saito
    Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Japan
    J Occup Health 46:49-59. 2004
    ..07) ng/L] was significantly higher than in other areas. The present study confirms that recognizable amounts of PFOA are released in the Osaka area and that people are exposed to PFOA through drinking water ingestion...
  95. ncbi Walking and sports participation and mortality from coronary heart disease and stroke
    Hiroyuki Noda
    Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Am Coll Cardiol 46:1761-7. 2005
    ..We aimed to examine the impact of exercise on mortality from cardiovascular disease (CVD) in Asian populations...
  96. ncbi Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks
    Mitsumasa Umesawa
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and the Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
    Am J Clin Nutr 88:195-202. 2008
    ..Limited evidence is available about the relations between sodium and potassium intakes and cardiovascular disease in the general population...
  97. ncbi A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers
    Yoshihisa Fujino
    Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Am J Epidemiol 164:128-35. 2006
    ....
  98. doi Green tea consumption and the risk of pancreatic cancer in Japanese adults
    Yingsong Lin
    Department of Public Health, Aichi Medical University School of Medicine, Nagakute cho, Aichi, Japan
    Pancreas 37:25-30. 2008
    ..Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort...
  99. ncbi Cigarette smoking, alcohol drinking, and oral and pharyngeal cancer mortality in Japan
    R Ide
    Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyusyu, Japan
    Oral Dis 14:314-9. 2008
    ..To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan...
  100. ncbi Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
    Yingsong Lin
    Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan
    J Epidemiol 18:77-83. 2008
    ..We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk...
  101. ncbi Body mass index and mortality from cardiovascular disease among Japanese men and women: the JACC study
    Renzhe Cui
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tuskuba, Ibaraki 305 8575, Japan
    Stroke 36:1377-82. 2005
    ..Although overweight is an important risk factor for cardiovascular disease in Western countries, the impact of overweight has not been well elucidated in Japan, where its prevalence is low...