Taeko Kobayashi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Dynamic advances in NF-kappaB signaling analysis
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Sci Signal 2:pe47. 2009
  2. pmc The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Genes Dev 23:1870-5. 2009
  3. pmc Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Japan
    Genes Cells 15:689-98. 2010
  4. ncbi request reprint Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates
    Taeko Kobayashi
    Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Genes Cells 12:889-901. 2007
  5. doi request reprint Roles of Hes genes in neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Dev Growth Differ 50:S97-103. 2008
  6. doi request reprint Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7
    Akiko Ishii
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 372:142-6. 2008
  7. ncbi request reprint The Hes gene family: repressors and oscillators that orchestrate embryogenesis
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Development 134:1243-51. 2007
  8. doi request reprint Ultradian oscillations in Notch signaling regulate dynamic biological events
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Curr Top Dev Biol 92:311-31. 2010
  9. ncbi request reprint Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells
    Taeko Kobayashi
    Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Biol Chem 277:47358-65. 2002

Collaborators

Detail Information

Publications9

  1. doi request reprint Dynamic advances in NF-kappaB signaling analysis
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Sci Signal 2:pe47. 2009
    ..An analysis of NF-kappaB dynamics suggests that the oscillation frequency of NF-kappaB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways...
  2. pmc The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Genes Dev 23:1870-5. 2009
    ..Thus, Hes1-null ES cells display less heterogeneity in both the differentiation timing and fate choice, suggesting that the cyclic gene Hes1 contributes to heterogeneous responses of ES cells even under the same environmental conditions...
  3. pmc Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Japan
    Genes Cells 15:689-98. 2010
    ..Our results indicate that sustained Hes1 expression delays the differentiation of ES cells and promotes the preference for the mesodermal rather than the neural fate by suppression of Notch signaling...
  4. ncbi request reprint Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates
    Taeko Kobayashi
    Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Genes Cells 12:889-901. 2007
    ..We thus propose that VCP functions as a mediator for both aggregate formation and clearance depending upon the concentration of soluble aggregate-prone proteins, indicating dual VCP functions as an aggregate formase and an unfoldase...
  5. doi request reprint Roles of Hes genes in neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Dev Growth Differ 50:S97-103. 2008
    ..Thus, Hes genes play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells...
  6. doi request reprint Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7
    Akiko Ishii
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 372:142-6. 2008
    ..These results indicate that common amino acid residues are involved in both the transcriptional repressor activity and the instability of Hes7 protein, suggesting of a critical link between the transcription and degradation control...
  7. ncbi request reprint The Hes gene family: repressors and oscillators that orchestrate embryogenesis
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Development 134:1243-51. 2007
    ..This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis...
  8. doi request reprint Ultradian oscillations in Notch signaling regulate dynamic biological events
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Curr Top Dev Biol 92:311-31. 2010
    ..Taken together, these results suggest that Notch signaling can drive short-period oscillatory expression of Hes7 and Hes1 (ultradian oscillation) and that ultradian oscillations are important for many biological events...
  9. ncbi request reprint Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells
    Taeko Kobayashi
    Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Biol Chem 277:47358-65. 2002
    ..Excessive accumulation of misfolded proteins may inactivate p97/VCP in several neurodegenerative disorders, eventually leading to the neurodegenerations...