Junya Kobayashi

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e49245. 2012
  2. ncbi Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 380:752-7. 2009
  3. ncbi Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mol Cancer 9:34. 2010
  4. ncbi WRN participates in translesion synthesis pathway through interaction with NBS1
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mech Ageing Dev 131:436-44. 2010
  5. ncbi NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis
    Hiromi Yanagihara
    Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mol Cell 43:788-97. 2011
  6. ncbi Differential role of repair proteins, BRCA1/NBS1 and Ku70/DNA-PKcs, in radiation-induced centrosome overduplication
    Mikio Shimada
    Radiation Biology Center, Kyoto University, Kyoto, Japan
    Cancer Sci 101:2531-7. 2010
  7. ncbi Regulation of homologous recombination by RNF20-dependent H2B ubiquitination
    Kyosuke Nakamura
    Radiation Biology Center, Kyoto University, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell 41:515-28. 2011
  8. ncbi Current topics in DNA double-strand break repair
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    J Radiat Res 49:93-103. 2008
  9. ncbi Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway
    Mikio Shimada
    Radiation Biology Center, Kyoto University, Kyoto, Japan
    Cancer Res 69:1768-75. 2009

Collaborators

Detail Information

Publications9

  1. ncbi Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e49245. 2012
    ..Taken together, nucleolin could promote both ATM-dependent cell cycle checkpoint and DSB repair by functioning in an MDC1-related pathway through its FACT-like function...
  2. ncbi Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 380:752-7. 2009
    ..Moreover, H2AX-deficient cells exhibited a defect in ATM-dependent cell cycle checkpoints. Taken together, gamma-H2AX has important role for effective DSB-dependent activation of ATM-related damage responses via NBS1...
  3. ncbi Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mol Cancer 9:34. 2010
    ..Therefore, we investigated whether a bisbenzamidine derivative, pentamidine, which can inhibit endoexonuclease activity, might influence DSB-induced damage responses via inhibition of MRE11...
  4. ncbi WRN participates in translesion synthesis pathway through interaction with NBS1
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mech Ageing Dev 131:436-44. 2010
    ..Taken together, these results indicate that WRN participates in the TLS pathway to prevent genomic instability in an ATM/NBS1-dependent manner...
  5. ncbi NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis
    Hiromi Yanagihara
    Radiation Biology Center, Kyoto University, Kyoto 606 8501, Japan
    Mol Cell 43:788-97. 2011
    ..Thus, in addition to chromosomal break repair, NBS1 plays a key role in translesion DNA synthesis...
  6. ncbi Differential role of repair proteins, BRCA1/NBS1 and Ku70/DNA-PKcs, in radiation-induced centrosome overduplication
    Mikio Shimada
    Radiation Biology Center, Kyoto University, Kyoto, Japan
    Cancer Sci 101:2531-7. 2010
    ....
  7. ncbi Regulation of homologous recombination by RNF20-dependent H2B ubiquitination
    Kyosuke Nakamura
    Radiation Biology Center, Kyoto University, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell 41:515-28. 2011
    ..Finally, the function of RNF20 in HRR can be partially bypassed by forced chromatin relaxation. Thus, the RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling...
  8. ncbi Current topics in DNA double-strand break repair
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    J Radiat Res 49:93-103. 2008
    ..In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed...
  9. ncbi Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway
    Mikio Shimada
    Radiation Biology Center, Kyoto University, Kyoto, Japan
    Cancer Res 69:1768-75. 2009
    ..These results suggest that, although centrosomes lack DNA, the NBS1/ATR/BRCA1 repair machinery affects centrosome behavior, and this might be a crucial role in the prevention of malignances...