Shinae Kizaka-Kondoh

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia
    Shinae Kizaka-Kondoh
    Innovative Techno Hub for Integrated Medical Bio imaging, Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Sci 100:1366-73. 2009
  2. doi request reprint Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
    Shinae Kizaka-Kondoh
    Innovative Techno Hub for Integrated Medical Bio Imaging and Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Clin Cancer Res 15:3433-41. 2009
  3. ncbi request reprint Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Mol Imaging Biol 15:713-21. 2013
  4. ncbi request reprint Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions
    Lihua Zeng
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Sci 98:1394-401. 2007
  5. ncbi request reprint The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 360:791-6. 2007
  6. doi request reprint Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Cancer Sci 102:2090-6. 2011
  7. doi request reprint The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 284:5332-42. 2009
  8. doi request reprint TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
    Lihua Zeng
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Sci 99:2327-35. 2008
  9. doi request reprint PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18F-labeled biotin derivative
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Imaging Biol 13:1003-10. 2011
  10. ncbi request reprint Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 580:5718-22. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia
    Shinae Kizaka-Kondoh
    Innovative Techno Hub for Integrated Medical Bio imaging, Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Sci 100:1366-73. 2009
    ..In this review, we will discuss the significance of pimonidazole and HIF-1 as exogenous and endogenous hypoxia markers, respectively, as well as their evaluation and imaging of tumor hypoxia...
  2. doi request reprint Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
    Shinae Kizaka-Kondoh
    Innovative Techno Hub for Integrated Medical Bio Imaging and Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Clin Cancer Res 15:3433-41. 2009
    ..However, the behavior of the cells having HIF-1 activity during the malignant progression in pancreatic cancer has not been tested...
  3. ncbi request reprint Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Mol Imaging Biol 15:713-21. 2013
    ..We aimed to develop a radiolabeled peptide probe for the imaging of hypoxia-inducible factor-1 (HIF-1)-active tumors...
  4. ncbi request reprint Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions
    Lihua Zeng
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Sci 98:1394-401. 2007
    ..These data support the potential development of HIF-1 targeted approaches in combination with PTX, where drug resistance tends to contribute to treatment failure...
  5. ncbi request reprint The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 360:791-6. 2007
    ..The superiority of the novel reporter gene will surely accelerate analysis of the intratumoral HIF-1 activity during tumor progression and cancer treatments...
  6. doi request reprint Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
    Masashi Ueda
    Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Cancer Sci 102:2090-6. 2011
    ..01). These findings indicate that [(125) I]IPOS accumulation reflects HIF-1 expression. Thus, [(123/125) I]IPOS can serve as a useful probe for the molecular imaging of HIF-1-active tumors...
  7. doi request reprint The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 284:5332-42. 2009
    ....
  8. doi request reprint TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
    Lihua Zeng
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Sci 99:2327-35. 2008
    ..Our findings strengthen the importance of both HIF-1 and its downstream gene, such as vascular endothelial cell growth factor, as therapeutic targets to enhance the effect of radiotherapy...
  9. doi request reprint PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel 18F-labeled biotin derivative
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Imaging Biol 13:1003-10. 2011
    ..We aimed to evaluate the feasibility of using streptavidin-biotin-based pretargeting for positron emission tomography (PET) imaging of hypoxia-inducible factor (HIF)-1-active tumors...
  10. ncbi request reprint Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 580:5718-22. 2006
    ..These data demonstrated that the VHL-mediated protein destruction motif of HIF-1alpha endowed procaspase-3 with hypoxia-specific cytotoxicity...
  11. doi request reprint The HIF-1-active microenvironment: an environmental target for cancer therapy
    Shinae Kizaka-Kondoh
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Adv Drug Deliv Rev 61:623-32. 2009
    ..Therefore targeting strategies to overcome the HIF-1-active microenvironment are important for cancer therapy...
  12. doi request reprint Imaging of HIF-1-active tumor hypoxia using a protein effectively delivered to and specifically stabilized in HIF-1-active tumor cells
    Takashi Kudo
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Nucl Med 50:942-9. 2009
    ..The purpose of this study was to evaluate the feasibility of (123)I-IPOS as an imaging probe for HIF-1-active tumor hypoxia...
  13. pmc Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation
    Takashi Ushiki
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 5:e11114. 2010
    ..Noninvasive observation of donor cell homing shortly after transplantation is potentially valuable for improving therapeutic outcomes of BMT by diagnosing the early stages of these diseases...
  14. pmc In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe
    Youshi Fujita
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    PLoS ONE 7:e48051. 2012
    ..The results demonstrate that POH-N enables the in vivo monitoring and ex vivo detection of HIF-1-active regions after ischemic brain injury and suggest its potential in imaging and drug delivery to HIF-1-active areas in ischemic brains...
  15. ncbi request reprint [Development of fluorescent in vivo imaging probes for cancers]
    Shotaro Tanaka
    Dept of Radiation Oncology and Image applied Therapy, Kyoto University, Kyoto, Japan
    Gan To Kagaku Ryoho 35:1272-6. 2008
    ..This review gives an overview of recent progress in fluorescent in vivo imaging techniques and introduces our study for developing NIR fluorescent probes specific to tumor hypoxia, a hallmark of malignant tumors...
  16. ncbi request reprint Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
    Hiroshi Harada
    Kyoto University Graduate School of Medicine, Japan
    Mol Imaging 4:182-93. 2005
    ....
  17. ncbi request reprint Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Shogoin, Kyoto, 606 8507, Japan
    Breast Cancer 13:16-26. 2006
    ..In addition, we discuss the unique characteristics of breast cancer, which are expected to facilitate the application of PTD to develop novel protein therapy for breast cancer...