Yoshihisa Kitamura

Summary

Affiliation: Kyoto Pharmaceutical University
Country: Japan

Publications

  1. pmc Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury
    Takashi Yanagida
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    Oxid Med Cell Longev 2:36-42. 2009
  2. pmc Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
    Yoshihisa Kitamura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 6:48. 2011
  3. ncbi request reprint Aryl hydrocarbon receptor nuclear translocator is induced by kainic acid in rat hippocampal glial cells
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Neurosci Lett 291:117-20. 2000
  4. ncbi request reprint Intracerebroventricular injection of microglia protects against focal brain ischemia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 94:203-6. 2004
  5. doi request reprint The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Glia 58:1686-700. 2010
  6. ncbi request reprint Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Neurochem Res 28:1035-40. 2003
  7. ncbi request reprint [Dopaminergic neuroprotection and reconstruction of neural network tiara]
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Yakugaku Zasshi 130:1263-72. 2010
  8. doi request reprint Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurochem Int 58:721-7. 2011
  9. ncbi request reprint Hyperbilirubinemia protects against focal ischemia in rats
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 71:544-50. 2003
  10. ncbi request reprint Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 92:137-42. 2003

Collaborators

Detail Information

Publications63

  1. pmc Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury
    Takashi Yanagida
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    Oxid Med Cell Longev 2:36-42. 2009
    ..In addition, GST-DJ-1 protein directly scavenged (*)OH. These results suggest that oxidative stress induces the release of astrocytic DJ-1 protein, which may contribute to astrocyte-mediated neuroprotection...
  2. pmc Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
    Yoshihisa Kitamura
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 6:48. 2011
    ..abstract:..
  3. ncbi request reprint Aryl hydrocarbon receptor nuclear translocator is induced by kainic acid in rat hippocampal glial cells
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Neurosci Lett 291:117-20. 2000
    ..These results suggest that ARNT expression in glial cells may participate in KA-induced episodes in the hippocampus...
  4. ncbi request reprint Intracerebroventricular injection of microglia protects against focal brain ischemia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 94:203-6. 2004
    ..At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion...
  5. doi request reprint The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Glia 58:1686-700. 2010
    ..These results suggest that microglia-like NG2 glial cells may help protect DA neurons and may lead to new therapeutic targets in PD...
  6. ncbi request reprint Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Neurochem Res 28:1035-40. 2003
    ..Their neuroprotective effects may be mediated directly and/or indirectly by antioxidant effects, mitochondrial stabilization or induction of the antiapoptotic Bcl-2 family...
  7. ncbi request reprint [Dopaminergic neuroprotection and reconstruction of neural network tiara]
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    Yakugaku Zasshi 130:1263-72. 2010
    ....
  8. doi request reprint Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurochem Int 58:721-7. 2011
    ..These results suggest that G-CYPMPO attenuates 6-OHDA-induced dopaminergic neurodegeneration in a rat model of PD, and is a useful tool for biological research...
  9. ncbi request reprint Hyperbilirubinemia protects against focal ischemia in rats
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 71:544-50. 2003
    ..These results suggest that bilirubin has essentially a neuroprotective effect against focal ischemia and may participate in HO1-induced neuroprotection...
  10. ncbi request reprint Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 92:137-42. 2003
    ..These results suggest that the degeneration of planarian dopaminergic system induced by rotenone or MPTP may be mediated through caspase-like activation...
  11. ncbi request reprint Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Neurosci Lett 333:25-8. 2002
    ..These results suggest that rotenone may induce activation of both mitochondria- and endoplasmic reticulum-dependent caspases in human SH-SY5Y cells...
  12. ncbi request reprint Antiparkinsonian drugs and their neuroprotective effects
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 25:284-90. 2002
    ..This review summarizes current findings regarding the pathogenesis and antiparkinsonian drugs, and discusses their possibilities of targets to develop novel neuroprotective drugs...
  13. ncbi request reprint Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8412, Kyoto, Japan
    Brain Res 898:181-5. 2001
    ..These results suggest that alpha-synuclein protein may be so scarcely scavenged by glial cells that it readily condenses in neurodegenerative regions...
  14. ncbi request reprint Effects of 15-deoxy-delta(12,14) prostaglandin J(2) and interleukin-4 in Toll-like receptor-4-mutant glial cells
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8412, Japan
    Eur J Pharmacol 411:223-30. 2001
    ....
  15. ncbi request reprint The parkinsonian models: invertebrates to mammals
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Jpn J Pharmacol 84:237-43. 2000
    ..To develop novel neuroprotective drugs, it is necessary to have a model for each type of parkinsonism. This review summarizes current findings regarding parkinsonian models in vertebrates and invertebrates and discusses their value...
  16. ncbi request reprint PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model
    Masatoshi Inden
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Neurobiol Dis 24:144-58. 2006
    ..These findings suggest that DJ-1 is a therapeutic target for PD...
  17. ncbi request reprint Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Neurochem Int 55:760-7. 2009
    ..These results suggest that pramipexole may protect DA neurons against exposure to rotenone by chronic oral administration, and this effect is mediated by multiple functions including scavenging of *OH and induction of Bcl-2 protein...
  18. ncbi request reprint Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, the wild-type of familial Parkinson's disease-linked PARK7
    Takashi Yanagida
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 109:463-8. 2009
    ..These results suggest that UCP0054278 interacts with endogenous DJ-1 and then exhibits antioxidant and neuroprotective responses...
  19. ncbi request reprint Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Neurochem 95:950-61. 2005
    ..These results suggest that serofendic acid protects against 6-OHDA-induced SNpc dopaminergic neurodegeneration in a rat model of Parkinson's disease...
  20. ncbi request reprint Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    J Pharmacol Sci 117:189-203. 2011
    ..The present study raises the possibility that DJ-1 stimulatory modulators, such as UCP0054278, may be a new type of dopaminergic neuroprotective drug for the treatment of PD...
  21. doi request reprint Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model
    Takashi Yanagida
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Neurosci Res 62:254-61. 2008
    ..These results suggest that galantamine synergistically enhances the neuroprotective effect of nicotine against 6-OHDA-induced dopaminergic neuronal loss through an allosteric modulation of alpha7 nAChR activation...
  22. ncbi request reprint Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats
    Masatoshi Inden
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi Yamashina ku, Kyoto 607 8414, Japan
    Neurosci Lett 387:151-6. 2005
    ..These results suggest that both the involvement of ST as a place of transplantation and the number of ES cell-derived neurons are essential factors for efficacy on hemiparkinsonian behaviors...
  23. ncbi request reprint Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells
    Daijiro Yanagisawa
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurosci Lett 407:74-9. 2006
    ..These results suggest that intrastriatal-transplantation of ES or ES-N cells improved the dopaminergic function and subsequently recover behavioral dysfunction in focal ischemic rats...
  24. ncbi request reprint Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, 607 8412, Kyoto, Japan
    Neurosci Lett 346:149-52. 2003
    ..These results suggest that N-WASP, WISH and WAVE may participate in the neurodegenerative aberrant sprouting in AD neurons...
  25. doi request reprint Protective effect of planarian DJ-1 against 6-hydroxydopamine-induced neurotoxicity
    Jun Tsushima
    Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurosci Res 74:277-83. 2012
    ..These results suggest that planarians have a DJ-1 ortholog, which has conserved antioxidant and neuroprotective functions...
  26. ncbi request reprint Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
    Masatoshi Inden
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurochem 101:1491-1504. 2007
    ..These results suggest that this rotenone mouse model may be useful for understanding the mechanism of DA neurodegeneration in PD, and that 4-PBA has a neuroprotective effect in the treatment of PD...
  27. doi request reprint Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..These results suggest that the rotenone mouse model may be useful for assessing candidate antiparkinson agents, and that nAChR (nicotinic acetylcholine receptor) stimulation can protect DA neurons against degeneration...
  28. pmc Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7
    Koichiro Yamane
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Int J Mol Sci 10:4789-804. 2009
    ..In contrast, DJ-1-knockdown SH-SY5Y cells lost the protective activity of UCP0045037. These results suggest that UCP0045037 interacts with endogenous DJ-1 and produces a neuroprotective response...
  29. doi request reprint Regeneration of dopaminergic neurons after 6-hydroxydopamine-induced lesion in planarian brain
    Kaneyasu Nishimura
    Department of Biophysics, Graduate School of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto, Japan
    J Neurochem 119:1217-31. 2011
    ..These new findings obtained from planarian regeneration provide hints about how to conduct cell-transplantation therapy for future regenerative medicine...
  30. ncbi request reprint Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain
    Takashi Yanagida
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 102:243-7. 2006
    ..At that time, DJ-1 shifted to acid forms. These results suggest that distributional changes, translocation, and acidic shift of DJ-1 may be compensatory responses to protect against 6-OHDA-induced oxidative stress...
  31. ncbi request reprint DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats
    Daijiro Yanagisawa
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    J Cereb Blood Flow Metab 28:563-78. 2008
    ..These results indicate that GST-DJ-1 exerts a neuroprotective effect by reducing ROS-mediated neuronal injury, suggesting that DJ-1 may be a useful therapeutic target for ischemic neurodegeneration...
  32. ncbi request reprint Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 119:10-9. 2012
    ..These results suggest that fluoxetine may influence motor function in PD via pharmacological modification of interactions between serotonergic and dopaminergic neuronal networks...
  33. doi request reprint Characterization of tyramine beta-hydroxylase in planarian Dugesia japonica: cloning and expression
    Kaneyasu Nishimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurochem Int 53:184-92. 2008
    ..Here, we demonstrated that DjTBH clearly contributes to OA biosynthesis, and DjTBH antibody is a useful tool for detecting octopaminergic neurons in planarians...
  34. ncbi request reprint Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    J Pharmacol Sci 91:330-3. 2003
    ..These results suggest that small oligomers, rather than large molecular aggregates, mediate microglial activation induced by Abeta peptides...
  35. ncbi request reprint Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biochem Biophys Res Commun 301:699-703. 2003
    ..These results suggest that HMG1 may regulate the homeostasis of extracellular Abeta (1-42) and Abeta oligomerization...
  36. ncbi request reprint High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurosci Res 78:880-91. 2004
    ..These results suggest that HMGB1 released from dying neurons may inhibit microglial Abeta42 clearance and enhance the neurotoxicity of Abeta42. HMGB1 may thus be another target in the investigation of a therapeutic strategy for AD...
  37. ncbi request reprint Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 97:203-11. 2005
    ..These results suggest that proteasome plays an important role in both the early phase of dopaminergic neuronal death and inclusion body formation...
  38. ncbi request reprint Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 97:289-93. 2005
    ..These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction...
  39. ncbi request reprint Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats
    Kazuyuki Takata
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    FEBS Lett 581:475-8. 2007
    ..These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD...
  40. ncbi request reprint Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:92-6. 2011
    ..Thus, this protocol for chronic administration of rotenone at 30 mg/kg for 56 d is more useful for understanding the mechanism of DA neurodegeneration...
  41. ncbi request reprint Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates
    Kaneyasu Nishimura
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Dev Neurobiol 67:1059-78. 2007
    ..In DjTH-knockdown planarians, muscle-mediated locomotion and behavior were significantly attenuated. These results suggest that DA neurons play a key role in the muscle-mediated movement in planarians...
  42. ncbi request reprint Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 92:115-23. 2003
    ..These results suggest that WAVE and Rac1 participate in the phagocytosis of A beta 42 by microglia...
  43. ncbi request reprint Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    J Pharmacol Sci 96:53-64. 2004
    ....
  44. doi request reprint Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice
    Masatoshi Inden
    Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Yamashina ku, Kyoto, Japan
    J Neurosci Res 91:62-72. 2013
    ....
  45. ncbi request reprint Detoxification of 6-hydroxydopamine-induced dopaminergic neurodegeneration by 5,5-dimethyl-1-pyrroline N-oxide, a radical trapper, in hemiparkinsonian rats
    Masatoshi Inden
    Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan
    Biol Pharm Bull 35:1603-6. 2012
    ..These results suggest that DMPO attenuates 6-OHDA-induced dopaminergic neurodegeneration in a rat model of PD via scavenging ·OH, and is a useful tool for biological research of oxidative stresses...
  46. ncbi request reprint Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells
    Daiju Tsuchiya
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 102:354-8. 2006
    ..Therefore, PS1 may be involved in neuritogenesis and morphological change in SH-SY5Y cells, and P117L mutation may linked to AD by different mechanisms...
  47. ncbi request reprint Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus
    Daiju Tsuchiya
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    Neurosci Res 56:459-69. 2006
    ..Taken together, N-WASP, WAVE and their related proteins may participate in normal brain development and synaptic plasticity by regulating the actin cytoskeleton...
  48. ncbi request reprint Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats
    Daijiro Yanagisawa
    Department of Neurobiology, 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Biol Pharm Bull 31:1121-30. 2008
    ..These results suggest that microglia play an important role in neuroprotection against rat cerebral ischemia, which is regulated by a P2X7 receptor-mediated ATP signal...
  49. ncbi request reprint Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
    Kaneyasu Nishimura
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Neurosci Res 59:101-6. 2007
    ..These results suggest that DjTPH is required for 5-HT biosynthesis, and DjTPH antibody is a useful marker for serotonergic neurons in planarians...
  50. pmc Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease
    Kazuyuki Takata
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Am J Pathol 175:17-24. 2009
    ....
  51. ncbi request reprint [Molecular mechanism of brain regeneration and reconstruction of dopaminergic neural network in planarians]
    Kaneyasu Nishimura
    Department of Neurobiology, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Brain Nerve 60:307-17. 2008
    ....
  52. ncbi request reprint Possible involvement of both endoplasmic reticulum-and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Sci 92:228-36. 2003
    ..These results suggest that thapsigargin may induce the activation of both ER- and mitochondria-dependent pathways in human SH-SY5Y cells...
  53. pmc Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Biol Chem 285:40180-91. 2010
    ..In conclusion, we propose a further advantage of galantamine in clinical AD treatment and microglial nAChRs as a new therapeutic target...
  54. ncbi request reprint Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University and 21st Century COE Program, Kyoto 607 8414, Japan
    Eur J Neurosci 26:2458-68. 2007
    ..We conclude that deglycosylated antibodies effectively induced Abeta sequestration without provoking neuroinflammation; thus, these deglycosylated antibodies may be optimal for sequestration therapy for Alzheimer's disease...
  55. ncbi request reprint [Stress proteins and regulation of microglial amyloid-beta phagocytosis]
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Nihon Yakurigaku Zasshi 124:407-13. 2004
    ..These results suggest that microglial clearance of A beta 42 may be another option for investigations in the search for a therapeutic strategy for AD, in addition to the study of production and degradation of A beta 42...
  56. ncbi request reprint Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Neurosci Lett 344:87-90. 2003
    ..In addition, simultaneous injection with Hsp90 significantly reduced the amount of A beta 42 and increased the production of cytokines. These results suggest that Hsp90 may facilitate microglial A beta 42 clearance in rat brain in vivo...
  57. ncbi request reprint Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes
    Kaneyasu Nishimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Biol Pharm Bull 32:1672-7. 2009
    ..Our results indicated that DjSER-7 responds to serotonin, as indicated by electrophysiological analysis using Xenopus oocytes...
  58. ncbi request reprint [Pathological changes induced by amyloid-β in Alzheimer's disease]
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina, Kyoto, Japan
    Yakugaku Zasshi 131:3-11. 2011
    ..Further studies on the Aβ-dependent AD pathologies may contribute to determining novel mechanisms of AD development and new therapeutic targets in AD...
  59. ncbi request reprint Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    Pharmacol Ther 97:35-53. 2003
    ..We summarize the current findings regarding the neuroprotective effects of stress proteins and glial cells, and discuss the possibility of using this knowledge to develop new therapeutic strategies to treat neurodegeneration...
  60. ncbi request reprint Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins
    Jun ichi Kakimura
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8412, Japan
    FASEB J 16:601-3. 2002
    ..These observations suggest that HSP-induced microglial activation may serve a neuroprotective role by facilitating Abeta clearance and cytokine production..
  61. ncbi request reprint Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica
    Natsuka Tashiro
    Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Biochem Biophys Res Commun 449:412-8. 2014
    ..These results suggest that planarians have a Djdat ortholog and the ability to regulate dopaminergic neurotransmission and association with spontaneous locomotion. ..
  62. ncbi request reprint Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-β, and microglia in Alzheimer's disease
    Kazuyuki Takata
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Pharmacol Sci 118:331-7. 2012
    ..Further studies on the interaction between pathologies induced in AD brain may contribute to provide deep insight into the pathogenesis of AD and to develop novel therapeutic, prophylactic, and early diagnostic strategies for AD...
  63. pmc Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease
    Kazuyuki Takata
    Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Int J Alzheimers Dis 2012:685739. 2012
    ..Taken together, microglial Aβ phagocytosis dysfunction may be caused by HMGB1 that accumulates extracellularly on Aβ plaques, and it may be critically involved in the pathological progression of AD...