Noriyuki Kioka

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells
    Takuhito Sezaki
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 7:e35519. 2012
  2. ncbi request reprint Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo
    Noriyuki Kioka
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Exp Cell Res 316:1728-38. 2010
  3. ncbi request reprint Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction
    Noriyuki Kioka
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
    Cell Struct Funct 27:1-7. 2002
  4. ncbi request reprint Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 279:34570-7. 2004
  5. ncbi request reprint Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact
    Makoto Wakabayashi
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 278:21709-14. 2003
  6. ncbi request reprint Alpha1-syntrophin modulates turnover of ABCA1
    Youichi Munehira
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 279:15091-5. 2004
  7. ncbi request reprint Abl kinase interacts with and phosphorylates vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    FEBS Lett 580:4288-95. 2006
  8. ncbi request reprint Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1
    Osamu Sano
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    J Lipid Res 48:2377-84. 2007
  9. ncbi request reprint Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 11:971-82. 2006
  10. ncbi request reprint Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 11:281-92. 2006

Collaborators

Detail Information

Publications47

  1. pmc Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells
    Takuhito Sezaki
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 7:e35519. 2012
    ..Furthermore, inhibition of the TGF-β receptor suppressed the effects of Dlg5 depletion. These observations suggest that Dlg5 is involved in the regulation of TGF-βreceptor-dependent signals and EMT...
  2. ncbi request reprint Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo
    Noriyuki Kioka
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Exp Cell Res 316:1728-38. 2010
    ..Together, these results strongly suggest a crucial role of vinexin in keratinocyte migration in vitro and cutaneous wound healing in vivo...
  3. ncbi request reprint Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction
    Noriyuki Kioka
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
    Cell Struct Funct 27:1-7. 2002
    ..There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family...
  4. ncbi request reprint Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 279:34570-7. 2004
    ..Together, these results suggest that vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation during cell spreading as well as in growth factor-induced responses...
  5. ncbi request reprint Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact
    Makoto Wakabayashi
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 278:21709-14. 2003
    ..Together these findings suggest that lp-dlg/KIAA0583 is a novel scaffolding protein that can link the vinexin-vinculin complex and beta-catenin at sites of cell-cell contact...
  6. ncbi request reprint Alpha1-syntrophin modulates turnover of ABCA1
    Youichi Munehira
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 279:15091-5. 2004
    ..These results suggest that alpha1-syntrophin is involved in intracellular signaling, which determines the stability of ABCA1 and modulates cellular cholesterol release...
  7. ncbi request reprint Abl kinase interacts with and phosphorylates vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    FEBS Lett 580:4288-95. 2006
    ..A mutational analysis identified tyrosine 127 on vinexin alpha as a major site of phosphorylation by c- or v-Abl. These results suggest that vinexin alpha is a novel substrate for Abl...
  8. ncbi request reprint Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1
    Osamu Sano
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    J Lipid Res 48:2377-84. 2007
    ..These results suggest that the ABCG1-mediated efflux of cholesterol and SM is dependent on the cellular SM level and distribution of cholesterol in the plasma membrane...
  9. ncbi request reprint Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 11:971-82. 2006
    ..These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl...
  10. ncbi request reprint Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 11:281-92. 2006
    ..These results suggest that vinexin beta regulates the proteasome-dependent degradation of WAVE2 in a PKA-dependent manner...
  11. pmc Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux
    Masako Hozoji
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 283:30057-63. 2008
    ..Thus, we provide the first demonstration that protein-protein interaction suppresses ABCA1 function. Furthermore, we show that LXRbeta is involved in both the transcriptional and post-transcriptional regulation of the ABCA1 transporter...
  12. pmc ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding
    Kohjiro Nagao
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Lipid Res 53:126-36. 2012
    ..These results suggest that ATP hydrolysis at both NBDs induces conformational changes in the ECDs, which are associated with apoA-I binding and cholesterol efflux...
  13. doi request reprint Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation
    Yuya Azuma
    Kyoto University, Japan
    Genes Cells 14:191-204. 2009
    ..These results suggest that the retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation when excess lipoprotein-derived cholesterol has accumulated in cells...
  14. ncbi request reprint Purification and ATPase activity of human ABCA1
    Kei Takahashi
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 281:10760-8. 2006
    ..This study with purified human ABCA1 provides the first biochemical basis of the mechanism for HDL formation mediated by ABCA1...
  15. doi request reprint Dlg5 interacts with the TGF-β receptor and promotes its degradation
    Takuhito Sezaki
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    FEBS Lett 587:1624-9. 2013
    ..Furthermore, the overexpression of Dlg5 enhances the degradation of TβRI. Proteasome inhibitors inhibited this enhanced degradation. These results suggest that Dlg5 interacts with TβRs and promotes their degradation...
  16. ncbi request reprint Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation
    Masaru Mitsushima
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Exp Cell Res 313:1830-8. 2007
    ....
  17. ncbi request reprint Role of interaction with vinculin in recruitment of vinexins to focal adhesions
    Honami Takahashi
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 336:239-46. 2005
    ..These observations suggest a model that "activated" vinculin localized at focal adhesions recruits vinexins to focal adhesions...
  18. ncbi request reprint Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1
    Aya Kobayashi
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    J Lipid Res 47:1791-802. 2006
    ....
  19. pmc Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1
    Masako Hozoji
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    J Biol Chem 284:11293-300. 2009
    ....
  20. pmc ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin
    Hiroshi Hirayama
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    J Lipid Res 54:496-502. 2013
    ..These results suggest that ABCG1 is an active lipid transporter and possesses different binding sites for cholesterol and sphingomyelin, which may be synergistically coupled...
  21. doi request reprint v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin
    Tsutomu Umemoto
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Cancer Lett 279:22-9. 2009
    ..Taken together, these observations suggest that cellular transformation by v-Src suppressed vinexin expression and that down-regulation of vinexin may be associated with oncogenic transformation...
  22. ncbi request reprint Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin
    Tsutomu Umemoto
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto, Japan
    Biochem Biophys Res Commun 387:191-5. 2009
    ..In conclusion, vinexin alpha is tyrosine phosphorylated in v-Src-transformed cells, and this tyrosine phosphorylation of vinexin alpha attenuates the association of vinexin alpha with vinculin...
  23. pmc Liver X receptor beta (LXRbeta) interacts directly with ATP-binding cassette A1 (ABCA1) to promote high density lipoprotein formation during acute cholesterol accumulation
    Masako Hozoji-Inada
    Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto, Japan
    J Biol Chem 286:20117-24. 2011
    ..LXRβ can cause a post-translational response by binding directly to ABCA1, as well as a transcriptional response, to maintain cholesterol homeostasis...
  24. ncbi request reprint Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells
    Kohjiro Nagao
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    J Biol Chem 282:14868-74. 2007
    ....
  25. ncbi request reprint Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4
    Shin ya Morita
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Hepatology 46:188-99. 2007
    ..PC vesicles induced cholesterol diffusion from cell membrane, but did not accept cholesterol from ABCB4...
  26. doi request reprint ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1
    Masato Ishigami
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    Biochim Biophys Acta 1831:683-90. 2013
    ..To our knowledge, this is the first study analyzing the features of human MDR3 NBDs...
  27. ncbi request reprint Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release
    Yuika Ikeda
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 311:313-8. 2003
    ..Alternative splicing could be involved in the post-transcriptional regulation of the expression and function of human ABCA7...
  28. ncbi request reprint [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]
    Noriyuki Kioka
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502
    Seikagaku 74:1356-60. 2002
  29. ncbi request reprint Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis
    Arowu R Tanaka
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
    J Biol Chem 278:8815-9. 2003
    ..These results suggest that the defect of HDL assembly in R587W and Q597R is due to the impaired localization to the PM, whereas W590S has a functional defect other than the initial ATP binding and hydrolysis...
  30. ncbi request reprint Detection of ABCA7-positive cells in salivary glands from patients with Sjögren's syndrome
    Yoshinobu Toda
    Center for Anatomical Studies, Graduate School of Medicine, Kyoto University, Japan
    Pathol Int 55:639-43. 2005
    ..Although the pathological or biological significance is not clear, it will be intriguing to further examine the relationship between ABCA7 and Sjögren's syndrome...
  31. ncbi request reprint Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles
    Koh Nagata
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 324:262-8. 2004
    ..Some fuzzy components such as lipids accumulate in the vesicles. These results suggest that ABCA3 shows ATPase activity, which is induced by lipids, and may be involved in the biogenesis of lamellar body-like structures...
  32. ncbi request reprint Vinexin beta regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor
    Akira Suwa
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 277:13053-8. 2002
    ..Together, these observations indicate that vinexin beta plays a key role in regulating the anchorage dependence of ERK2 activation through PKA-PAK signaling...
  33. doi request reprint The COP9 signalosome controls ubiquitinylation of ABCA1
    Yuya Azuma
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 382:145-8. 2009
    ..These results suggest that CSN is a key molecule which controls the ubiquitinylation and deubiquitinylation of ABCA1, and is thus an important target for developing potential drugs to prevent atherosclerosis...
  34. pmc Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol
    Yasuhisa Kimura
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    Biochem J 401:597-605. 2007
    ....
  35. pmc The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression
    Tomohiro Yamazaki
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Mol Biol Cell 21:2953-65. 2010
    ..Taken together, the two closely related RNA helicases have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps...
  36. ncbi request reprint ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein
    Yasuhisa Kimura
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Curr Drug Metab 5:1-10. 2004
    ..To do so, large amounts of pure and stable proteins are required. Heterologous expression systems, which have been used to express P-glycoprotein, are also described...
  37. pmc WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions
    Hiroshi Yamashita
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    J Biol Chem 286:3907-14. 2011
    ..Together, these results suggest that WAVE2 works as an A-kinase-anchoring protein that recruits PKA at membrane protrusions and plays a role in the enlargement of membrane protrusions induced by PKA activation...
  38. ncbi request reprint Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A
    Hiroshi Umehara
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 301:324-9. 2003
    ..These results suggest that cisplatin affects RNA splicing by changing the subnuclear distribution of SR proteins including CROP...
  39. ncbi request reprint The role of the interaction of the vinculin proline-rich linker region with vinexin α in sensing the stiffness of the extracellular matrix
    Hiroshi Yamashita
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    J Cell Sci 127:1875-86. 2014
    ..These results suggest that the interaction of the PRL region of vinculin with vinexin α plays a crucial role in sensing ECM stiffness and in mechanotransduction. ..
  40. pmc Non-specific protein modifications by a phytochemical induce heat shock response for self-defense
    Kohta Ohnishi
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e58641. 2013
    ..We considered these bioactivities to be xenohormesis, an adaptation mechanism against xenobiotic chemical stresses. Heat shock response by phytochemicals may be a fundamental mechanism underlying their various bioactivities...
  41. doi request reprint 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1
    Akihiro Matsuda
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto, Japan
    J Neurochem 126:93-101. 2013
    ..These results suggest that ABCA1 actively eliminates 24-OHC in the presence of HDL as a lipid acceptor and protects neuronal cells...
  42. ncbi request reprint ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
    Arowu R Tanaka
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 277:40142-7. 2002
    ..PMP70 and ALDP were also phosphorylated at a tyrosine residue(s). ATP binding/hydrolysis by and phosphorylation of PMP70 and ALDP are involved in the regulation of fatty acid transport into peroxisomes...
  43. doi request reprint Small-molecule-induced clustering of heparan sulfate promotes cell adhesion
    Naohiro Takemoto
    Institute for Integrated Cell Material Sciences WPI iCeMS, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Am Chem Soc 135:11032-9. 2013
    ..Further studies of adhesamine and other small molecules could lead to the design of assembly-inducing molecules for use in cell biology and cell therapy. ..
  44. doi request reprint Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability
    Yuki Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Arch Biochem Biophys 528:141-7. 2012
    ..Confocal microscopy observation revealed that LPS exposure reduced the localization of GAPDH in nuclei. Our results indicate that GAPDH negatively regulates COX-2 by binding to its ARE...
  45. pmc Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament
    Keiko Momma
    Graduate School of Biostudies, Kyoto University, Kyoto, 606 8502, Japan
    Cytotechnology 56:33-9. 2008
    ..When NIH-3T3 cells exogenously expressing YFP-labeled actin were treated with Cuc E, firstly the aggregation of globular actin and secondly the aggregation of actin including disrupted fibrous actin in the cells was observed...
  46. ncbi request reprint SHIP2 interaction with the cytoskeletal protein Vinexin
    Nathalie Paternotte
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS J 272:6052-66. 2005
    ..The complex formation between Vinexin and SHIP2 may increase cellular adhesion. The data reinforce the concept that SHIP2 is active both as a PtdIns(3,4,5)P3 5-phosphatase and as a modulator of focal contact formation...
  47. pmc Spatial distribution and functional significance of activated vinculin in living cells
    Hui Chen
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 169:459-70. 2005
    ..Beyond providing direct evidence that vinculin is activated at focal adhesions, this study shows that the specific functional conformation correlates with regional cellular dynamics...