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Genomes and Genes | Nobuo KanazawaSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motifNobuo Kanazawa
Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
J Invest Dermatol 118:261-6. 2002..In conclusion, mouse dendritic cell immunoreceptor expressed on antigen-presenting cells can exert two distinct inhibitory signals depending on its immunoreceptor tyrosine-based inhibitory motif tyrosine residue...
Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr miceFukumi Furukawa
Department of Dermatology, Wakayama Medical University, Wakayama City, Japan
Autoimmun Rev 8:495-9. 2009..The accumulation of mast cells expressing H2R and prolonged effects of histamine may occur to regulate the production of Th1 and Th2 cytokines in the skin lesions of MRL/l mice...- Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chainNobuo Kanazawa
Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
J Biol Chem 278:32645-52. 2003..The identification of this activating immunoreceptor provides an example of signaling via a dendritic cell-expressed C-type lectin receptor... - Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndromeNobuo Kanazawa
Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Kyoto, Japan
Blood 105:1195-7. 2005..These findings indicate that the majority of EOS and BS cases share the common genetic etiology of CARD15 mutations that cause constitutive NF-kappaB activation... - Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2Nobuo Kanazawa
Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
Immunobiology 209:179-90. 2004.... - Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosisIkuo Okafuji
Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
Arthritis Rheum 60:242-50. 2009.... - Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosusSeiko Toyozawa
Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, Japan
Eur J Dermatol 19:594-6. 2009..These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE... - [Genetic involvement of bacterial sensor molecules in Japanese leprosy]Nobuo Kanazawa
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
Nihon Hansenbyo Gakkai Zasshi 78:255-61. 2009..Especially, among those with a particular TLR2 -16934 genotype, frequency of the polymorphisms in DC-SIGN -336 showed significant difference between the patients and the controls, suggesting any cooperation of these SNPs... - The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disordersNaotomo Kambe
Department of Dermatology, Kyoto University, Graduate School of Medicine, Shogoin, Sakyo ku, Japan
J Dermatol Sci 39:71-80. 2005..Because Nod2 is predominantly expressed in monocytes and recognizes a component of bacterial peptidoglycan, analysis of its function may help in understanding the role of the immune system in granuloma formation... - Influence of chemical peeling on the skin stress response systemAyako Kimura
Department of Dermatology, Naga Municipal Hospital, Wakayama, Japan
Exp Dermatol 21:8-10. 2012.... - Influence of trichloroacetic acid peeling on the skin stress response systemAyako Kimura
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
J Dermatol 38:740-7. 2011.... - Severe ulceration with impaired induction of growth factors and cytokines in keratinocytes after trichloroacetic acid application on TRPV1-deficient miceHong Jin Li
Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
Eur J Dermatol 22:614-21. 2012.... - Identification of 736T>A mutation of lipase H in Japanese siblings with autosomal recessive woolly hairTakashi Yoshimasu
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
J Dermatol 38:900-4. 2011..Collectively, it has been suggested that 736T>A transition is highly specific and common in ARWH/hypotrichosis of Japanese origin... - Effects of sarpogrelate hydrochloride on skin ulcers and quality of life in patients with systemic sclerosisTakashi Yoshimasu
Department of Dermatology, Arida Municipal Hospital, Arida, Japan
J Dermatol 39:536-40. 2012..The score was significantly improved after 6 months of sarpogrelate intake. There were no obvious side-effects during this study. Sarpogrelate was considered to be a useful drug to improve skin ulcers and QOL in patients with SSc... - Lupus erythematosus tumidus in Japan: a case report and a review of the literatureMizuho Nishiyama
Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
Mod Rheumatol 19:567-72. 2009..A review of ten LET cases previously reported in Japan revealed that all of these cases had clinicopathological features similar to those reported for European cases, although not all of the former fully satisfied the European criteria... - Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cellsAkihiro Fujisawa
Department of Dermatology, Kyoto University Graduate School of Medicine, Japan
Blood 109:2903-11. 2007..These results indicated that monocytes undergo rapid cell death in a cathepsin B-dependent manner upon activation of cryopyrin, which is also a specific phenomenon induced by disease-associated mutation of CIAS1... - Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cellsNobuo Kanazawa
Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
J Dermatol Sci 45:77-86. 2007.... - Cutaneous polyarteritis nodosa: revisiting its definition and diagnostic criteriaTomoyuki Nakamura
Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 0012, Japan
Arch Dermatol Res 301:117-21. 2009..In conclusion, this study suggests that CPN does not progress to PN, and introduces new drafts for CPN and PN diagnostic criteria... - Rare hereditary autoinflammatory disorders: towards an understanding of critical in vivo inflammatory pathwaysNobuo Kanazawa
Department of Dermatology, Wakayama Medical University, Wakayama 641 0012, Japan
J Dermatol Sci 66:183-9. 2012..Since there still remain a number of predicted but undefined hereditary autoinflammatory syndromes, further clinical and genetic approaches are required to discover novel in vivo critical inflammatory pathways... - Hydroxychloroquine administration for Japanese lupus erythematosus in Wakayama: a pilot studyTakaharu Ikeda
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
J Dermatol 39:531-5. 2012..An additional effect to improve lipid profiles was also observed in our Japanese cases. It is necessary to confirm that these effects are reproducible when Japanese lupus erythematosus cases are given HCQ... - Race differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus from the aspect of Japanese studiesFukumi Furukawa
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
Ann N Y Acad Sci 1173:552-6. 2009..The incidence and degree of photosensitivity of SCLE and LET are much lower in Japanese than in Caucasians. This discrepancy may lead to investigations of CLE pathogenesis through global collaborations... - Case report: a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutesSeiko Toyozawa
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
Dermatol Online J 14:17. 2008..Then the subsequent autologous skin graft was successfully performed. This indicates that CDS is one of the useful tools for the treatment of intractable ulcers in patients with PG... 
The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr miceNaoya Mikita
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
Clin Dev Immunol 2009:673952. 2009..Thus, UVA1 might exert its effects, at least in part, through the induction of the apoptosis of pathogenic mast cells. Our results supported the clinical efficacy of UVA1 irradiation for skin lesions of lupus patients...- Autoinflammatory syndromes with a dermatological perspectiveNobuo Kanazawa
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
J Dermatol 34:601-18. 2007..In this review, major autoinflammatory syndromes are summarized and the pathophysiology of related skin disorders is discussed in association with dysregulated innate immune signaling... - Nakajo-Nishimura syndrome: an autoinflammatory disorder showing pernio-like rashes and progressive partial lipodystrophyNobuo Kanazawa
Department of Dermatology, Wakayama Medical University, Wakayama, Japan
Allergol Int 61:197-206. 2012.... - Induction of PDGF-B in TCA-treated epidermal keratinocytesNozomi Yonei
Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 0012, Japan
Arch Dermatol Res 299:433-40. 2007..This effect might contribute to a promotion of re-epithelialization and dermal regeneration without wound contraction and scarring... - [Clinical features of Blau syndrome and early-onset sarcoidosis and associating CARD15/NOD2 gene mutations]Nobuo Kanazawa
Department of Dermatology, Wakayama Medical University
Nihon Rinsho Meneki Gakkai Kaishi 30:123-32. 2007..While the loss-of-function mutations in its LRR domain are associated with Crohn's disease, Blau syndrome and early-onset sarcoidosis are autoinflammatory diseases that are caused by the gain-of-function mutations in its NOD domain... - Presence of a sporadic case of systemic granulomatosis syndrome with a CARD15 mutationNobuo Kanazawa
J Invest Dermatol 122:851-2. 2004 - Marked improvement of psychiatric symptoms after parathyroidectomy in elderly primary hyperparathyroidismYuko Chiba
Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
Endocr J 54:379-83. 2007..The quality of life in those patients was also improved by PTX. We propose here that PTX in elderly PHPT patients with psychiatric symptoms should be considered instead of oral administration, such as anti-depressants or bisphosphonates... - Molecular cloning of human dectin-2Nobuo Kanazawa
J Invest Dermatol 122:1522-4. 2004 - The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph nodeMichael Sixt
Department for Experimental Pathology, Lund University, 22185 Lund, Sweden
Immunity 22:19-29. 2005..The conduit system is, therefore, not a closed compartment that shuttles substances through the lymph node but represents the morphological equivalent to the filtering function of the lymph node... - Guideline for the diagnosis and treatment of scabies in Japan (second edition)Norihisa Ishii
The Japanese Dermatological Association, Tokyo, Japan
J Dermatol 35:378-93. 2008..For treating crusted scabies, concomitant administration of oral ivermectin and the topical preparation is necessary. Some safe and useful topical drug preparations are needed to be approved by health insurance...