Nobuo Kanazawa

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 118:261-6. 2002
  2. doi Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice
    Fukumi Furukawa
    Department of Dermatology, Wakayama Medical University, Wakayama City, Japan
    Autoimmun Rev 8:495-9. 2009
  3. ncbi Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 278:32645-52. 2003
  4. ncbi Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Kyoto, Japan
    Blood 105:1195-7. 2005
  5. ncbi Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Immunobiology 209:179-90. 2004
  6. doi Severe ulceration with impaired induction of growth factors and cytokines in keratinocytes after trichloroacetic acid application on TRPV1-deficient mice
    Hong Jin Li
    Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Eur J Dermatol 22:614-21. 2012
  7. doi Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis
    Ikuo Okafuji
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 60:242-50. 2009
  8. doi Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosus
    Seiko Toyozawa
    Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, Japan
    Eur J Dermatol 19:594-6. 2009
  9. ncbi [Genetic involvement of bacterial sensor molecules in Japanese leprosy]
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:255-61. 2009
  10. ncbi The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders
    Naotomo Kambe
    Department of Dermatology, Kyoto University, Graduate School of Medicine, Shogoin, Sakyo ku, Japan
    J Dermatol Sci 39:71-80. 2005

Collaborators

Detail Information

Publications34

  1. ncbi DCIR acts as an inhibitory receptor depending on its immunoreceptor tyrosine-based inhibitory motif
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 118:261-6. 2002
    ..In conclusion, mouse dendritic cell immunoreceptor expressed on antigen-presenting cells can exert two distinct inhibitory signals depending on its immunoreceptor tyrosine-based inhibitory motif tyrosine residue...
  2. doi Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice
    Fukumi Furukawa
    Department of Dermatology, Wakayama Medical University, Wakayama City, Japan
    Autoimmun Rev 8:495-9. 2009
    ..The accumulation of mast cells expressing H2R and prolonged effects of histamine may occur to regulate the production of Th1 and Th2 cytokines in the skin lesions of MRL/l mice...
  3. ncbi Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 278:32645-52. 2003
    ..The identification of this activating immunoreceptor provides an example of signaling via a dendritic cell-expressed C-type lectin receptor...
  4. ncbi Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Kyoto, Japan
    Blood 105:1195-7. 2005
    ..These findings indicate that the majority of EOS and BS cases share the common genetic etiology of CARD15 mutations that cause constitutive NF-kappaB activation...
  5. ncbi Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2
    Nobuo Kanazawa
    Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Immunobiology 209:179-90. 2004
    ..Here we propose to designate these four highly related molecules as the "DCIR family lectins" and discuss their signaling mechanisms, carbohydrate recognition, and other features that contribute to the function of DC to control immunity...
  6. doi Severe ulceration with impaired induction of growth factors and cytokines in keratinocytes after trichloroacetic acid application on TRPV1-deficient mice
    Hong Jin Li
    Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Eur J Dermatol 22:614-21. 2012
    ....
  7. doi Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis
    Ikuo Okafuji
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Arthritis Rheum 60:242-50. 2009
    ....
  8. doi Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosus
    Seiko Toyozawa
    Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, Japan
    Eur J Dermatol 19:594-6. 2009
    ..These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE...
  9. ncbi [Genetic involvement of bacterial sensor molecules in Japanese leprosy]
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:255-61. 2009
    ..Especially, among those with a particular TLR2 -16934 genotype, frequency of the polymorphisms in DC-SIGN -336 showed significant difference between the patients and the controls, suggesting any cooperation of these SNPs...
  10. ncbi The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders
    Naotomo Kambe
    Department of Dermatology, Kyoto University, Graduate School of Medicine, Shogoin, Sakyo ku, Japan
    J Dermatol Sci 39:71-80. 2005
    ..Because Nod2 is predominantly expressed in monocytes and recognizes a component of bacterial peptidoglycan, analysis of its function may help in understanding the role of the immune system in granuloma formation...
  11. doi Influence of chemical peeling on the skin stress response system
    Ayako Kimura
    Department of Dermatology, Naga Municipal Hospital, Wakayama, Japan
    Exp Dermatol 21:8-10. 2012
    ....
  12. doi Influence of trichloroacetic acid peeling on the skin stress response system
    Ayako Kimura
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 38:740-7. 2011
    ....
  13. doi Identification of 736T>A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair
    Takashi Yoshimasu
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 38:900-4. 2011
    ..Collectively, it has been suggested that 736T>A transition is highly specific and common in ARWH/hypotrichosis of Japanese origin...
  14. doi Effects of sarpogrelate hydrochloride on skin ulcers and quality of life in patients with systemic sclerosis
    Takashi Yoshimasu
    Department of Dermatology, Arida Municipal Hospital, Arida, Japan
    J Dermatol 39:536-40. 2012
    ..The score was significantly improved after 6 months of sarpogrelate intake. There were no obvious side-effects during this study. Sarpogrelate was considered to be a useful drug to improve skin ulcers and QOL in patients with SSc...
  15. doi Lupus erythematosus tumidus in Japan: a case report and a review of the literature
    Mizuho Nishiyama
    Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Mod Rheumatol 19:567-72. 2009
    ..A review of ten LET cases previously reported in Japan revealed that all of these cases had clinicopathological features similar to those reported for European cases, although not all of the former fully satisfied the European criteria...
  16. doi Cutaneous polyarteritis nodosa: revisiting its definition and diagnostic criteria
    Tomoyuki Nakamura
    Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 0012, Japan
    Arch Dermatol Res 301:117-21. 2009
    ..In conclusion, this study suggests that CPN does not progress to PN, and introduces new drafts for CPN and PN diagnostic criteria...
  17. ncbi Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    J Dermatol Sci 45:77-86. 2007
    ....
  18. ncbi Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
    Akihiro Fujisawa
    Department of Dermatology, Kyoto University Graduate School of Medicine, Japan
    Blood 109:2903-11. 2007
    ..These results indicated that monocytes undergo rapid cell death in a cathepsin B-dependent manner upon activation of cryopyrin, which is also a specific phenomenon induced by disease-associated mutation of CIAS1...
  19. doi A new infant case of Nakajo-Nishimura syndrome with a genetic mutation in the immunoproteasome subunit: an overlapping entity with JMP and CANDLE syndrome related to PSMB8 mutations
    Kayo Kunimoto
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Dermatology 227:26-30. 2013
    ..Identification of the PSMB8 mutation finalized the diagnosis of NNS at 5 years of age. Understanding a variety of clinicopathological features at the developmental stages is necessary to make an early diagnosis of NNS...
  20. doi Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 40:749-51. 2013
    ..The genetic analysis of the cases with these diseases would be important for establishment and application of the specific treatments targeting the IL-36 signaling. ..
  21. doi Rare hereditary autoinflammatory disorders: towards an understanding of critical in vivo inflammatory pathways
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama 641 0012, Japan
    J Dermatol Sci 66:183-9. 2012
    ..Since there still remain a number of predicted but undefined hereditary autoinflammatory syndromes, further clinical and genetic approaches are required to discover novel in vivo critical inflammatory pathways...
  22. doi Hydroxychloroquine administration for Japanese lupus erythematosus in Wakayama: a pilot study
    Takaharu Ikeda
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 39:531-5. 2012
    ..An additional effect to improve lipid profiles was also observed in our Japanese cases. It is necessary to confirm that these effects are reproducible when Japanese lupus erythematosus cases are given HCQ...
  23. ncbi Case report: a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes
    Seiko Toyozawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Dermatol Online J 14:17. 2008
    ..Then the subsequent autologous skin graft was successfully performed. This indicates that CDS is one of the useful tools for the treatment of intractable ulcers in patients with PG...
  24. pmc The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice
    Naoya Mikita
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Clin Dev Immunol 2009:673952. 2009
    ..Thus, UVA1 might exert its effects, at least in part, through the induction of the apoptosis of pathogenic mast cells. Our results supported the clinical efficacy of UVA1 irradiation for skin lesions of lupus patients...
  25. doi Race differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus from the aspect of Japanese studies
    Fukumi Furukawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Ann N Y Acad Sci 1173:552-6. 2009
    ..The incidence and degree of photosensitivity of SCLE and LET are much lower in Japanese than in Caucasians. This discrepancy may lead to investigations of CLE pathogenesis through global collaborations...
  26. ncbi Autoinflammatory syndromes with a dermatological perspective
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol 34:601-18. 2007
    ..In this review, major autoinflammatory syndromes are summarized and the pathophysiology of related skin disorders is discussed in association with dysregulated innate immune signaling...
  27. doi Nakajo-Nishimura syndrome: an autoinflammatory disorder showing pernio-like rashes and progressive partial lipodystrophy
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    Allergol Int 61:197-206. 2012
    ....
  28. ncbi Induction of PDGF-B in TCA-treated epidermal keratinocytes
    Nozomi Yonei
    Department of Dermatology, School of Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 0012, Japan
    Arch Dermatol Res 299:433-40. 2007
    ..This effect might contribute to a promotion of re-epithelialization and dermal regeneration without wound contraction and scarring...
  29. ncbi [Clinical features of Blau syndrome and early-onset sarcoidosis and associating CARD15/NOD2 gene mutations]
    Nobuo Kanazawa
    Department of Dermatology, Wakayama Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 30:123-32. 2007
    ..While the loss-of-function mutations in its LRR domain are associated with Crohn's disease, Blau syndrome and early-onset sarcoidosis are autoinflammatory diseases that are caused by the gain-of-function mutations in its NOD domain...
  30. ncbi Presence of a sporadic case of systemic granulomatosis syndrome with a CARD15 mutation
    Nobuo Kanazawa
    J Invest Dermatol 122:851-2. 2004
  31. ncbi Molecular cloning of human dectin-2
    Nobuo Kanazawa
    J Invest Dermatol 122:1522-4. 2004
  32. doi Guideline for the diagnosis and treatment of scabies in Japan (second edition)
    Norihisa Ishii
    The Japanese Dermatological Association, Tokyo, Japan
    J Dermatol 35:378-93. 2008
    ..For treating crusted scabies, concomitant administration of oral ivermectin and the topical preparation is necessary. Some safe and useful topical drug preparations are needed to be approved by health insurance...
  33. ncbi The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
    Michael Sixt
    Department for Experimental Pathology, Lund University, 22185 Lund, Sweden
    Immunity 22:19-29. 2005
    ..The conduit system is, therefore, not a closed compartment that shuttles substances through the lymph node but represents the morphological equivalent to the filtering function of the lymph node...
  34. ncbi Marked improvement of psychiatric symptoms after parathyroidectomy in elderly primary hyperparathyroidism
    Yuko Chiba
    Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Endocr J 54:379-83. 2007
    ..The quality of life in those patients was also improved by PTX. We propose here that PTX in elderly PHPT patients with psychiatric symptoms should be considered instead of oral administration, such as anti-depressants or bisphosphonates...