Sho Kakizawa

Summary

Affiliation: Kyoto University
Location: Kyoto, Japan

Publications

  1. ncbi request reprint Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression
    Shin ichiro Kina
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Eur J Neurosci 26:2269-78. 2007
  2. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
  3. ncbi request reprint Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells
    Akiko Fujiwara
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuropharmacology 52:1663-70. 2007
  4. ncbi request reprint Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins
    Atsushi Ikeda
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 363:835-9. 2007
  5. pmc Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells
    Yuji Kamikubo
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Physiol 585:549-63. 2007
  6. ncbi request reprint Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 27:12096-108. 2007
  7. doi request reprint Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cerebellum 7:385-91. 2008
  8. doi request reprint Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity
    Sho Kakizawa
    Department of Anatomy and Neurobiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Neurobiol Aging 33:535-45. 2012
  9. pmc Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel
    Elisa Venturi
    School of Physiology and Pharmacology, Bristol Heart Institute and Centre for Nanoscience and Quantum Information, University of Bristol, Bristol, United Kingdom
    Biochemistry 50:2623-32. 2011
  10. doi request reprint Molecular architecture of Ca2+ signaling control in muscle and heart cells
    Xiaoli Zhao
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Channels (Austin) 5:391-6. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression
    Shin ichiro Kina
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Eur J Neurosci 26:2269-78. 2007
    ..These results suggest that tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity...
  2. pmc Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 26:1924-33. 2007
    ..Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions...
  3. ncbi request reprint Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells
    Akiko Fujiwara
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuropharmacology 52:1663-70. 2007
    ..These results indicate that calcineurin activation is essential for LTD induction downstream of the conjunctive-stimulation-induced Ca(2+) signal in Purkinje cells...
  4. ncbi request reprint Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins
    Atsushi Ikeda
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 363:835-9. 2007
    ..Moreover, gene expression was slightly altered in the JP-DKO cerebellum. Therefore, the mutant PCs bear marginal but widespread abnormalities, all of which likely cause cerebellar motor defects in JP-DKO mice...
  5. pmc Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells
    Yuji Kamikubo
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Physiol 585:549-63. 2007
    ..Furthermore, pharmacological inhibition of GABABR reduced the magnitude of LTD at parallel fibre-Purkinje cell synapses in cerebellar slices. These findings demonstrate a novel mechanism that would facilitate cerebellar motor learning...
  6. ncbi request reprint Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 27:12096-108. 2007
    ....
  7. doi request reprint Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cerebellum 7:385-91. 2008
    ..Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus...
  8. doi request reprint Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity
    Sho Kakizawa
    Department of Anatomy and Neurobiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Neurobiol Aging 33:535-45. 2012
    ..Therefore, oxidation was revealed to inhibit the S-nitrosylation-dependent signaling pathway essential for synaptic plasticity in a "competitive" manner...
  9. pmc Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel
    Elisa Venturi
    School of Physiology and Pharmacology, Bristol Heart Institute and Centre for Nanoscience and Quantum Information, University of Bristol, Bristol, United Kingdom
    Biochemistry 50:2623-32. 2011
    ..These building transitions may underlie the unusual channel gating behavior of MG23 and allow rapid cationic flux across intracellular membrane systems...
  10. doi request reprint Molecular architecture of Ca2+ signaling control in muscle and heart cells
    Xiaoli Zhao
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Channels (Austin) 5:391-6. 2011
    ....
  11. doi request reprint TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance
    Daiju Yamazaki
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Cell Metab 14:231-41. 2011
    ..Therefore, TRIC-A channels contribute to maintaining blood pressure, while TRIC-A SNPs could provide biomarkers for constitutional diagnosis and personalized medical treatment of essential hypertension...
  12. pmc Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 31:417-28. 2012
    ..These findings suggest that NICR via RyR1 plays a regulatory role in the physiological and pathophysiological functions of the brain...
  13. pmc Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF
    Kazuharu Furutani
    Department of Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 103:8528-33. 2006
    ..These results indicate that a signaling cascade comprising PF activity, postsynaptic mGluR-IP(3) signaling and subsequent BDNF signaling maintains presynaptic functions in the mature cerebellum...
  14. pmc Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain
    Sho Kakizawa
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Proc Natl Acad Sci U S A 102:19180-5. 2005
    ..These results indicate that, in the mature cerebellum, AMPA receptor-mediated excitatory postsynaptic activity maintains CF's functional glutamate-release sites and its innervation of PC shaft dendrites...
  15. ncbi request reprint PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum
    A W McGee
    Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
    J Neurosci 21:3085-91. 2001
    ..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity...
  16. ncbi request reprint Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells
    Y Okubo
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Neuron 32:113-22. 2001
    ..These results revealed a novel IP(3) signaling pathway in Purkinje cells that can be elicited by synaptic inputs from climbing fibers...
  17. ncbi request reprint Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development
    Sho Kakizawa
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Japan
    Eur J Neurosci 17:545-54. 2003
    ..Thus, IGF-I is a potentially important factor among various signalling molecules that can influence CF synapse elimination during cerebellar development...
  18. ncbi request reprint Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells
    Yohei Okubo
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 24:9513-20. 2004
    ....
  19. pmc NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum
    Shigeyuki Namiki
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Physiol 566:849-63. 2005
    ..These results suggest that synaptic NO signalling decodes the frequency of neuronal activity to mediate synaptic plasticity at the PF-Purkinje cell synapse...
  20. ncbi request reprint Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome
    S K E Koekkoek
    Department of Neuroscience, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neuron 47:339-52. 2005
    ..These data indicate that a lack of FMRP leads to cerebellar deficits at both the cellular and behavioral levels and raise the possibility that cerebellar dysfunctions can contribute to motor learning deficits in Fragile X patients...
  21. pmc Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor by endogenous nitric oxide
    Sho Kakizawa
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Channels (Austin) 7:1-5. 2013
    ..These results support that NICR is induced by endogenous nitric oxide produced by neuronal activity through S-nitrosylation of RyR1...