R Kageyama

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
  2. ncbi Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
    Akihisa Fukuda
    Department of Surgery and Surgical Basic Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 116:1484-93. 2006
  3. ncbi The role of neurogenesis in olfaction-dependent behaviors
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Behav Brain Res 227:459-63. 2012
  4. ncbi The bHLH gene Hes1 regulates differentiation of multiple cell types
    R Kageyama
    Institute for Virus Research, Kyoto University, Japan
    Mol Cells 10:1-7. 2000
  5. ncbi [Transcription factor network that regulates brain development]
    R Kageyama
    No To Hattatsu 40:204-7. 2008
  6. ncbi The Notch-Hes pathway in mammalian neural development
    R Kageyama
    Institute for Virus Research, Kyoto University, Japan
    Cell Res 9:179-88. 1999
  7. ncbi Rhythmic gene expression in somite formation and neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Mol Cells 27:497-502. 2009
  8. ncbi Roles of Hes genes in neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Dev Growth Differ 50:S97-103. 2008
  9. ncbi Roles of bHLH genes in neural stem cell differentiation
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Exp Cell Res 306:343-8. 2005
  10. ncbi Dynamic regulation of Notch signaling in neural progenitor cells
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Kyoto, Japan
    Curr Opin Cell Biol 21:733-40. 2009

Detail Information

Publications100

  1. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ....
  2. ncbi Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
    Akihisa Fukuda
    Department of Surgery and Surgical Basic Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 116:1484-93. 2006
    ....
  3. ncbi The role of neurogenesis in olfaction-dependent behaviors
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Behav Brain Res 227:459-63. 2012
    ..In this minireview, we discuss the recent findings surrounding the functional significance of adult neurogenesis in olfaction-dependent behaviors...
  4. ncbi The bHLH gene Hes1 regulates differentiation of multiple cell types
    R Kageyama
    Institute for Virus Research, Kyoto University, Japan
    Mol Cells 10:1-7. 2000
    ..Taken together, these results indicate that the Notch-Hes1 pathway, which is controlled by cell-cell interaction, plays an essential role in differentiation of many cell types...
  5. ncbi [Transcription factor network that regulates brain development]
    R Kageyama
    No To Hattatsu 40:204-7. 2008
  6. ncbi The Notch-Hes pathway in mammalian neural development
    R Kageyama
    Institute for Virus Research, Kyoto University, Japan
    Cell Res 9:179-88. 1999
    ..These results indicate that the two Hes genes are essential effectors for the Notch pathway and that neuronal differentiation is controlled by the pathway "Notch-Hes1/Hes5-|Mash1"...
  7. ncbi Rhythmic gene expression in somite formation and neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Mol Cells 27:497-502. 2009
    ..Taken together, these results suggest that oscillatory expression with short periods (ultradian oscillation) plays an important role in many biological events...
  8. ncbi Roles of Hes genes in neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Dev Growth Differ 50:S97-103. 2008
    ..Thus, Hes genes play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells...
  9. ncbi Roles of bHLH genes in neural stem cell differentiation
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Exp Cell Res 306:343-8. 2005
    ..This regulation is essential for generation of complex brain structures of appropriate size, shape and cell arrangement...
  10. ncbi Dynamic regulation of Notch signaling in neural progenitor cells
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Kyoto, Japan
    Curr Opin Cell Biol 21:733-40. 2009
    ..We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells...
  11. ncbi [Developmental chronobiology: two-hour cycle biological clocks]
    Ryoichiro Kageyama
    Tanpakushitsu Kakusan Koso 49:2939-42. 2004
  12. ncbi Oscillator mechanism of Notch pathway in the segmentation clock
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, and Japan Science and Technology Agency, CREST, Kyoto, Japan
    Dev Dyn 236:1403-9. 2007
    ..This review summarizes the recent finding about roles and mechanism of Notch signaling in the segmentation clock and discusses the significance of Hes1 oscillation in non-PSM cells...
  13. ncbi The Hes gene family: repressors and oscillators that orchestrate embryogenesis
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Development 134:1243-51. 2007
    ..This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis...
  14. ncbi Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
    K Tomita
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 19:5460-72. 2000
    ..These results indicated that Mash1 and Math3 direct neuronal versus glial fate determination in the CNS and raised the possibility that downregulation of these bHLH genes is one of the mechanisms to initiate gliogenesis...
  15. ncbi The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina
    T Satow
    Institute for Virus Research, Kyoto University, and Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    J Neurosci 21:1265-73. 2001
    ....
  16. ncbi The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation
    S Bae
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Development 127:2933-43. 2000
    ....
  17. ncbi Roles of homeobox and bHLH genes in specification of a retinal cell type
    J Hatakeyama
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Development 128:1313-22. 2001
    ....
  18. ncbi Dynamic expression and essential functions of Hes7 in somite segmentation
    Y Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 15:2642-7. 2001
    ..These results indicate that Hes7 controls the cyclic expression of lunatic fringe and is essential for coordinated somite segmentation...
  19. ncbi Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
    M Hojo
    Institute for Virus Research, Kyoto University and Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Development 127:2515-22. 2000
    ..Conversely, Hes5-deficient retina showed 30-40% decrease of Müller glial cell number without affecting cell survival. These results indicate that Hes5 modulates glial cell fate specification in mouse retina...
  20. ncbi Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain
    H Hirata
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 20:4454-66. 2001
    ..These results indicate that Hes1 and Hes3 prevent premature differentiation and maintain the organizer activity of the isthmic cells, thereby regulating the development of the midbrain and anterior hindbrain...
  21. ncbi Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation
    C Inoue
    Institute for Virus Research, Kyoto University, Department of Neurology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 6:977-86. 2001
    ..Whereas multiple basic helix-loop-helix (bHLH) genes are expressed in the developing nervous system, they account for the differentiation of only subsets of neurones, suggesting that there may be as-yet unidentified bHLH genes...
  22. ncbi Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain
    T Ohtsuka
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 276:30467-74. 2001
    ..These results indicate that Hes1 and Hes5 play an important role in the maintenance of neural stem cells but not in gliogenesis in the embryonal telencephalon...
  23. ncbi Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
    Hiromi Hirata
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Science 298:840-3. 2002
    ..Because Hes1 oscillation can be seen in many cell types, this clock may regulate timing in many biological systems...
  24. ncbi Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
    Y Bessho
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 6:175-85. 2001
    ....
  25. ncbi Structure and promoter analysis of Math3 gene, a mouse homolog of Drosophila proneural gene atonal. Neural-specific expression by dual promoter elements
    H Tsuda
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 273:6327-33. 1998
    ..These results indicate that Math3 promoter contains two essential regulatory regions, the proximal 193-base pair region, which confers efficient neural-specific expression, and a region further upstream, required for retinal expression...
  26. ncbi Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Development 131:5539-50. 2004
    ..Our data also indicate that embryonic neural stem cells change their characters over time in the following order: Hes-independent neuroepithelial cells, transitory Hes-dependent neuroepithelial cells and Hes-dependent radial glial cells...
  27. ncbi Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
    T Ohtsuka
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, USA
    EMBO J 18:2196-207. 1999
    ..These results demonstrate that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation...
  28. ncbi Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons
    H Hirata
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 275:19083-9. 2000
    ..Thus, alternative promoters and first exons that are differentially utilized during neural development generate structurally and functionally distinct proteins from a single Hes3 gene locus...
  29. ncbi The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain
    Masami Sakamoto
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 278:44808-15. 2003
    ..These results indicate that Hesr1 and Hesr2 negatively regulate neuronal bHLH genes, promote maintenance of neural precursor cells, and increase late-born cell types in the developing brain...
  30. ncbi Retinal cell fate determination and bHLH factors
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan
    Semin Cell Dev Biol 15:83-9. 2004
    ..Thus, combinations of proper bHLH and homeodomain factors are required for neuronal subtype specification...
  31. ncbi Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis
    K Tomita
    Institute for Immunology, Kyoto University, Faculty of Medicine, Japan
    Neuron 16:723-34. 1996
    ..Furthermore, in the mutant retina, bipolar cells extensively died, and finally disappeared. These studies provide evidence that HES1 regulates differentiation of retinal neurons and is essential for eye morphogenesis...
  32. ncbi Mash1 promotes neuronal differentiation in the retina
    K Tomita
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Sakyo ku, Japan
    Genes Cells 1:765-74. 1996
    ..Because Mash1-null mice die soon after birth, their postnatal development cannot be examined in vivo. Thus, it remains to be determined whether or not Mash1 functions in postnatal development of retina...
  33. ncbi The bHLH gene Hes1 is essential for expansion of early T cell precursors
    K Tomita
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 13:1203-10. 1999
    ..Both the initial T cell receptor (TCR)-independent and the subsequent TCR-dependent selective expansion during the DN stage are severely affected. Thus, Hes1 is essential for the earliest thymocyte expansion in a cell-autonomous manner...
  34. ncbi Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system
    Joung Hee Baek
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Kyoto 606 8507, Japan
    Development 133:2467-76. 2006
    ....
  35. ncbi Ectopic expression of the bHLH gene Math1 disturbs neural development
    F Isaka
    Institute for Virus Research, Kyoto University, Sakyo ku 606 8507, Japan
    Eur J Neurosci 11:2582-8. 1999
    ..We found that these embryos exhibited abnormal morphology of the brain and extensive cell death in the nervous system. These results suggest that ectopic expression of Math1 is toxic to neurons and leads to apoptosis...
  36. ncbi Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1
    Kaoru Murata
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 25:4262-71. 2005
    ..These results have suggested that Hes1 directly contributes to the promotion of progenitor cell proliferation through transcriptional repression of a cyclin-dependent kinase inhibitor, p27(Kip1)...
  37. ncbi The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock
    Yasutaka Niwa
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Cell 13:298-304. 2007
    ..We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling...
  38. ncbi Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system
    Jun Hatakeyama
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cereb Cortex 16:i132-7. 2006
    ..We propose that initiation of Notch1 expression is one of the key features for switch from the symmetric to asymmetric cell divisions of neural stem cells and that this process is negatively regulated by Notch1-independent Hes genes...
  39. ncbi Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal
    K Takebayashi
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Japan
    EMBO J 16:384-95. 1997
    ....
  40. ncbi The role of notch signaling in the development of intrahepatic bile ducts
    Yuzo Kodama
    Department of Gastroenterology and Hepatology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Gastroenterology 127:1775-86. 2004
    ..The mechanism underlying the contribution of the Notch signaling pathway to IHBD formation, however, remains unknown. Here we investigated the role of Notch signaling in IHBD development...
  41. ncbi Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis
    Goichi Miyoshi
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Neurosci 24:3672-82. 2004
    ..These results suggest that combinations of distinct bHLH factors promote formation of distinct neuronal subtypes, thereby increasing neuronal diversity...
  42. ncbi Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Dev Neurosci 28:92-101. 2006
    ..These results indicate that Hes1 and Hes5 play an important role in the formation of the cranial and spinal nerve systems...
  43. ncbi Oscillations in notch signaling regulate maintenance of neural progenitors
    Hiromi Shimojo
    Institute for Virus Research, Kyoto University, and Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Neuron 58:52-64. 2008
    ..These results suggest that Hes1 oscillation regulates Ngn2 and Dll1 oscillations, which in turn lead to maintenance of neural progenitors by mutual activation of Notch signaling...
  44. ncbi Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells
    Yoshito Masamizu
    Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan
    Proc Natl Acad Sci U S A 103:1313-8. 2006
    ....
  45. ncbi Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue
    Tadamichi Akagi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Invest Ophthalmol Vis Sci 45:4570-5. 2004
    ..That both Crx and Otx2 induced phenotype generation in cells derived from iris or ciliary tissue may suggest an approach to photoreceptor cell preparation for retinal transplantation...
  46. ncbi Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto 606-8507, Japan
    Proc Natl Acad Sci U S A 101:13654-9. 2004
    ..The Müller glial cells constitute a potential source for the regeneration of adult mammalian retina and can be a target for drug delivery and gene therapy in retinal degenerative diseases...
  47. ncbi Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development
    Aya Kita
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Mol Endocrinol 21:1458-66. 2007
    ..Thus, Hes genes control not only maintenance of progenitor cells but also intermediate vs. anterior lobe specification during the adenohypophysis development. Hes genes are also essential for the formation of the neurohypophysis...
  48. ncbi [Transcription factor network that regulates neural development]
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Brain Nerve 60:329-33. 2008
    ..These transcription factors will be useful for regeneration of the nervous system...
  49. ncbi Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7
    Akiko Ishii
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 372:142-6. 2008
    ..These results indicate that common amino acid residues are involved in both the transcriptional repressor activity and the instability of Hes7 protein, suggesting of a critical link between the transcription and degradation control...
  50. ncbi Retrovirus-mediated gene transfer to retinal explants
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Japan
    Methods 28:387-95. 2002
    ..Thus, retrovirus-mediated gene transfer to the retinal explant culture system offers a powerful and unique tool to analyze the molecular mechanism of neural development...
  51. ncbi Math3 and NeuroD regulate amacrine cell fate specification in the retina
    Tomoyuki Inoue
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Development 129:831-42. 2002
    ....
  52. ncbi MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system
    C Shimizu
    Institute for Immunology, Kyoto University Faculty of Medicine, Sakyo ku, Japan
    Eur J Biochem 229:239-48. 1995
    ..These results raise the possibility that MATH-2 may be a trans-acting factor involved in the development and maintenance of the mammalian nervous system...
  53. ncbi Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
    J Neurosci 30:3489-98. 2010
    ..These results indicated an absolute requirement of Notch signaling for the maintenance of neural stem cells and a proper control of neurogenesis in both embryonic and adult brains...
  54. ncbi Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification
    Tadamichi Akagi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:28492-8. 2004
    ..These results indicate that multiple bHLH genes cross-regulate each other, cooperatively specify neuronal subtypes, and regulate neuronal survival in the developing retina...
  55. ncbi Roles of the bHLH gene Hes1 in retinal morphogenesis
    Kenji Takatsuka
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo, Kyoto 606 8507, Japan
    Brain Res 1004:148-55. 2004
    ..These results indicate that Hes1 maintains precursors and the outer limiting membrane and thereby regulates retinal morphogenesis...
  56. ncbi Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes
    Tadamichi Akagi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
    Invest Ophthalmol Vis Sci 46:3411-9. 2005
    ..These iris-derived photoreceptor-like cells have electrophysiological characteristics of rod photoreceptors. Furthermore, they can integrate in the developing retina under coculture conditions...
  57. ncbi Temporal regulation of Cre recombinase activity in neural stem cells
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Genesis 44:233-8. 2006
    ..Thus, Nes-CreER(T2) mice offer a powerful tool to manipulate neural stem cells genetically at desired time points...
  58. ncbi Ultradian oscillators in somite segmentation and other biological events
    R Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cold Spring Harb Symp Quant Biol 72:451-7. 2007
    ..All of these data suggest that ultradian oscillations are more general responses than were previously thought and that oscillatory and sustained gene expression results in different biological outcomes...
  59. ncbi Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
    R Kageyama
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Japan
    Curr Opin Genet Dev 7:659-65. 1997
    ..This antagonistic regulation may be essential for generation of the proper number of neurons and for morphogenesis of the nervous system...
  60. ncbi Dynamic advances in NF-kappaB signaling analysis
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku Japan Science and Technology Agency, CREST, Kyoto 606 8507, Japan
    Sci Signal 2:pe47. 2009
    ..An analysis of NF-kappaB dynamics suggests that the oscillation frequency of NF-kappaB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways...
  61. ncbi [Mechanisms for maintenance and differentiation of neural stem cells]
    Toshiyuki Ohtsuka
    Tanpakushitsu Kakusan Koso 49:234-40. 2004
  62. ncbi Continuous neurogenesis in the adult brain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Growth Differ 51:379-86. 2009
    ..We further address the potential significance of adult neurogenesis in higher brain functions such as olfactory and spatial memory...
  63. ncbi Hopf bifurcation in the presomitic mesoderm during the mouse segmentation
    Aitor Gonzalez
    Institute for Virus Research, Kyoto University, Japan
    J Theor Biol 259:176-89. 2009
    ..After moving to the anterior PSM, where Fgf signaling is missing, Notch signaling compensates the damping of Hes7 oscillations in the anterior PSM...
  64. ncbi Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine
    Takahisa Kayahara
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 535:131-5. 2003
    ..These findings suggest that not only the cells just above Paneth cells but also the crypt base columnar cells between the Paneth cells have stem cell characteristics...
  65. ncbi The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Genes Dev 23:1870-5. 2009
    ..Thus, Hes1-null ES cells display less heterogeneity in both the differentiation timing and fate choice, suggesting that the cyclic gene Hes1 contributes to heterogeneous responses of ES cells even under the same environmental conditions...
  66. ncbi Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
    Yasumasa Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 17:1451-6. 2003
    ..Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock...
  67. ncbi Visualization of embryonic neural stem cells using Hes promoters in transgenic mice
    Toshiyuki Ohtsuka
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mol Cell Neurosci 31:109-22. 2006
    ..Our results suggest that pHes-EGFP transgenic mice can be used to explore similarities and differences among neural stem cells during development...
  68. ncbi Automatic reconstruction of the mouse segmentation network from an experimental evidence database
    Aitor Gonzalez
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Biosystems 102:16-21. 2010
    ..This method can be applied in any system where gene expression changes are observed as a response to some gene perturbation, for instance in cancer cells...
  69. ncbi Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Japan
    Genes Cells 15:689-98. 2010
    ..Our results indicate that sustained Hes1 expression delays the differentiation of ES cells and promotes the preference for the mesodermal rather than the neural fate by suppression of Notch signaling...
  70. ncbi Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine
    Katsumasa Suzuki
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 328:348-52. 2005
    ..Thus, Hes1 appears to have an inhibitory role in Paneth cell differentiation in the small intestine...
  71. ncbi Instability of Hes7 protein is crucial for the somite segmentation clock
    Hiromi Hirata
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Genet 36:750-4. 2004
    ..We simulated this effect mathematically using a direct autorepression model. Thus, instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock...
  72. ncbi [Biological clock as a conductor for embryogenesis]
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan
    Seikagaku 78:492-500. 2006
  73. ncbi Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors
    Ryosuke Ohsawa
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Neurosci 25:5857-65. 2005
    ....
  74. ncbi Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Development 135:2531-41. 2008
    ....
  75. ncbi Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
    Kyoko Masuda
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    EMBO J 24:4052-60. 2005
    ..These findings disclose a prethymic stage of T-cell development programmed for immigration of the thymus, which is genetically separable from intrathymic stages...
  76. ncbi Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum
    Shigeki Yoshiura
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 104:11292-7. 2007
    ..These results indicate that coupled Stat and Hes1 oscillations are important for efficient cell proliferation and provide evidence that expression modes of signaling molecules affect downstream cellular events...
  77. ncbi Regulation of retinal cell fate specification by multiple transcription factors
    Ryosuke Ohsawa
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Brain Res 1192:90-8. 2008
    ..Moreover, it has been shown that bHLH genes implicated in retinal cell fate determination regulate expression of other bHLH genes, implying that there is a complicated transcription network regulating retinal development...
  78. ncbi Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell
    Hideyuki Kano
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8315, Japan
    Biochem Biophys Res Commun 317:902-8. 2004
    ..Furthermore, RNAi knockdown of p53 abolished RFT-induced apoptosis in U87MG. Taken together, our results support that RFT regulates G1-S transition and apoptosis via p53/p21(Waf1) pathway...
  79. ncbi Mash1 is required for neuroendocrine cell development in the glandular stomach
    Hiroshi Kokubu
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 13:41-51. 2008
    ....
  80. ncbi Ultradian oscillations in Notch signaling regulate dynamic biological events
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Curr Top Dev Biol 92:311-31. 2010
    ..Taken together, these results suggest that Notch signaling can drive short-period oscillatory expression of Hes7 and Hes1 (ultradian oscillation) and that ultradian oscillations are important for many biological events...
  81. ncbi Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University and Japan Science and Technology Agency, CREST, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1247-51. 2008
    ..This dynamic mode of gene expression would require a revision of the traditional view of how Notch-mediated lateral inhibition operates in the developing mammalian nervous system...
  82. ncbi Retroviral vectors for gene delivery to neural precursor cells
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan
    Int Rev Neurobiol 55:123-47. 2003
  83. ncbi Spatiotemporal pattern in somitogenesis: a non-Turing scenario with wave propagation
    Hiroki Nagahara
    Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Phys Rev E Stat Nonlin Soft Matter Phys 80:021906. 2009
    ..We also discuss the framework of spatial discreteness based on the reaction-diffusion model in relation to a cellular array, by comparison with an actual experimental observation...
  84. ncbi Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis
    Xiaoyan Zhu
    Howard Hughes Medical Institute, Department and School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 20:2739-53. 2006
    ....
  85. ncbi High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly
    Paolo E Forni
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, 10126 Turin, Italy
    J Neurosci 26:9593-602. 2006
    ..Furthermore, they underscore the potential risks for developmental studies of high levels of nuclear Cre in neurogenic cells...
  86. ncbi Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    Ryosuke Tsunematsu
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 279:9417-23. 2004
    ..Expression of Notch1, -2, or -3 or of cyclin E was unaffected in Fbw7(-/-) embryos. Mammalian Fbw7 thus appears to play an indispensable role in negative regulation of the Notch4-Hey1 pathway and is required for vascular development...
  87. ncbi Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells
    Mariko Moriyama
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Hyogo 650 0047, Japan
    J Cell Biol 173:333-9. 2006
    ..Thus, these data provide evidence that Notch signaling, acting through Hes1, plays a crucial role in the survival of immature Mbs by preventing initiation of apoptosis...
  88. ncbi Otx2 regulates subtype specification and neurogenesis in the midbrain
    Bertrand Vernay
    Institut de Génétique et de Biologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale, Universite Louis Pasteur, 67404 Illkirch Cedex, Strasbourg, France
    J Neurosci 25:4856-67. 2005
    ..Altogether, these results demonstrate that Otx2 is required from E10.5 onward to regulate neuronal subtype identity and neurogenesis in the midbrain...
  89. ncbi Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability
    Chin Tong Ong
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:5106-19. 2006
    ....
  90. ncbi CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo
    Annie Paquin
    Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Neurosci 25:10747-58. 2005
    ..Thus, activation of an MEK-C/EBP pathway in cortical precursors in vivo biases them to become neurons and against becoming astrocytes, thereby acting as a growth factor-regulated switch...
  91. ncbi Notch and HES5 are regulated during human cartilage differentiation
    Camilla Karlsson
    Institute for Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Cell Tissue Res 327:539-51. 2007
    ....
  92. ncbi HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
    Atsushi Kunisato
    Departments of Hematology and Oncology, Graduate School of Medicine, and Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Japan
    Blood 101:1777-83. 2003
    ..Up-regulation of HES-1 protein in the 34-KSL population before unnecessary cell division, that is, without retrovirus transduction, may represent a potent approach to absolute expansion of hematopoietic stem cells...
  93. ncbi Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1
    Ge Bai
    Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Dev Cell 13:283-97. 2007
    ..These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos...
  94. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  95. ncbi Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells
    Takahiro Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841 Japan
    Stem Cells 26:1265-74. 2008
    ..Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells...
  96. ncbi Fate of neural stem cells grafted into injured inner ears of mice
    Ichiro Tateya
    Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, 606-8507 Kyoto, Japan
    Neuroreport 14:1677-81. 2003
    ..This finding suggests that transplanted neural stem cells have the potential to differentiate and restore inner ear hair cells...
  97. ncbi Defective brain development in mice lacking the Hif-1alpha gene in neural cells
    Shuhei Tomita
    Department of Immune System Development, RIKEN Research Center for Allergy and Immunology, Tokushima 770 8503, Japan
    Mol Cell Biol 23:6739-49. 2003
    ....
  98. ncbi Oscillations, clocks and segmentation
    Yasumasa Bessho
    Institute for Virus Research Kyoto University Shogoin-Kawahara, Sakyo-ku Kyoto 606-8507, Japan
    Curr Opin Genet Dev 13:379-84. 2003
    ..Thus, Hes1 acts as a device that transduces a direct current of input into an alternating current, which ticks the hours in many biological systems...
  99. ncbi FGF induces oscillations of Hes1 expression and Ras/ERK activation
    Kei Nakayama
    Curr Biol 18:R332-4. 2008
  100. ncbi Six1 is essential for early neurogenesis in the development of olfactory epithelium
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 311:53-68. 2007
    ..Our study indicates that Six1 plays critical roles in early neurogenesis by regulating Ngn1, NeuroD, Hes1, and Hes5...