Affiliation: Kyoto University
- [Immune regulation by dendritic cells]Tomonori Iyoda
Tanpakushitsu Kakusan Koso 47:2133-8. 2002
- Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responsesAoi Son
Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
Eur J Immunol 38:1358-67. 2008..In vivo delayed-type hypersensitivity responses in TBP-2(-/-) mice immunized with ovalbumin were significantly reduced compared to WT mice. These results indicate that TBP-2 plays a crucial role in DC to induce T cell responses...
- The innate functions of dendritic cells in peripheral lymphoid tissuesRalph M Steinman
Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021 6399, USA
Adv Exp Med Biol 560:83-97. 2005
- Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49QYoshiki Omatsu
Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Japan
J Immunol 174:6657-62. 2005..Therefore, Ly49Q is a new marker to identify a precursor form of PDCs that participates in innate immunity...
- TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient miceTakashi Kusunoki
Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Allergy Clin Immunol 111:136-42. 2003..Although the TH1/TH2 balance is important in many clinical situations, the regulatory mechanisms in vivo have not been well elucidated...
- Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent mannerNoriko Toyama-Sorimachi
Department of Gastroenterology, Research Institute, International Medical Center of Japan, Toyama, Tokyo, Japan
J Immunol 174:4621-9. 2005..Therefore, depending on IFN-alpha, our results imply that Ly49Q serves a role for the biological functions of certain DC subsets through recognition of MHC class I or related molecules...
- Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cellsSayuri Yamazaki
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 198:235-47. 2003..The capacity to expand CD25+ CD4+ T cells provides DCs with an additional mechanism to regulate autoimmunity and other immune responses...
- Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell traffickingKoko Katagiri
Department of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Nat Immunol 5:1045-51. 2004..Thus, RAPL is a crucial immune cell trafficking regulator essential for immunosurveillance...
- Dendritic cell function in vivo during the steady state: a role in peripheral toleranceRalph M Steinman
The Rockefeller University, Laboratories of Cellular Physiology and Immunology, Molecular Immunology, Molecular Genetics and Immunology, and Human Immunology and Immune Therapy, New York, New York 10021 6399, USA
Ann N Y Acad Sci 987:15-25. 2003..It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery...
- SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextranYoung Sun Kang
Laboratory of Cellular Physiology and Immunology, and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Int Immunol 15:177-86. 2003..Therefore, SIGN-R1 mediates the uptake of dextran polysaccharides, and it is predominantly expressed in the macrophages of the splenic marginal zone and lymph node medulla...
- Immune tolerance after delivery of dying cells to dendritic cells in situKang Liu
Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
J Exp Med 196:1091-7. 2002..The specific tolerance that develops when dendritic cells process self tissues in the steady state should prevent or reduce the development of autoimmunity when dying cells are subsequently processed during infection...
- The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivoTomonori Iyoda
Department of Animal Development and Physiology, Graduate School of Biostudies Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
J Exp Med 195:1289-302. 2002..Therefore CD8+ DCs are specialized to capture dying cells, and this helps to explain their selective ability to cross present cellular antigens to both CD4+ and CD8+ T cells...
- Identification and expression of mouse Langerin (CD207) in dendritic cellsKazuhiko Takahara
Laboratory of Immunobiology, Department of Animal Development and Physiology, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, 606 8502, Japan
Int Immunol 14:433-44. 2002..Recombinant m-Langerin could form multimers and bind to mannan-agarose. These findings indicate that Langerin expression is regulated at several levels: by TGF-beta1, DC subsets, DC maturation and the tissue environment...