Nobuyuki Itoh

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto, Japan
    Biol Pharm Bull 30:1819-25. 2007
  2. pmc Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    J Biochem 149:121-30. 2011
  3. pmc FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology
    Yusuke Murata
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    J Nutr Metab 2011:981315. 2011
  4. ncbi request reprint Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine
    N Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Curr Mol Med 14:504-9. 2014
  5. pmc Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16
    Emi Matsumoto
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Genes Cells 18:544-53. 2013
  6. pmc Roles of FGF20 in dopaminergic neurons and Parkinson's disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences Kyoto, Japan
    Front Mol Neurosci 6:15. 2013
  7. ncbi request reprint The zebrafish fgf family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    Zebrafish 4:179-86. 2007
  8. ncbi request reprint Evolution of the Fgf and Fgfr gene families
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Trends Genet 20:563-9. 2004
  9. ncbi request reprint Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
  10. pmc Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    Cell Tissue Res 342:1-11. 2010

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto, Japan
    Biol Pharm Bull 30:1819-25. 2007
    ..Although most Fgfs act in development in a paracrine and/or autocrine manner, some have potential roles in metabolism in an endocrine manner. In humans, Fgf signaling disorders result in hereditary diseases and cancers...
  2. pmc Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    J Biochem 149:121-30. 2011
    ..During metazoan evolution, the Fgf family expanded in two phases, after the separation of protostomes and deuterostomes and in the evolution of early vertebrates. These expansions enabled FGFs to acquire diverse actions and functions...
  3. pmc FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology
    Yusuke Murata
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    J Nutr Metab 2011:981315. 2011
    ..Serum FGF21 levels are increased in patients with metabolic diseases having insulin resistance, indicating that FGF21 is a metabolic regulator and a biomarker for these diseases...
  4. ncbi request reprint Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine
    N Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Curr Mol Med 14:504-9. 2014
    ..Fgf10 also induces the differentiation of embryonic stem cells into a gut-like structure, cardiomyocytes, and hepatocytes. These findings indicate the crucial roles of Fgf10 in development, disease, and regenerative medicine. ..
  5. pmc Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16
    Emi Matsumoto
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Genes Cells 18:544-53. 2013
    ..The present findings should provide new insights into the roles of Fgf signaling in cardiac remodeling...
  6. pmc Roles of FGF20 in dopaminergic neurons and Parkinson's disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences Kyoto, Japan
    Front Mol Neurosci 6:15. 2013
    ..These findings indicate the importance of FGF20 for the differentiation and survival of dopaminergic neurons and the etiology and therapy of Parkinson's disease...
  7. ncbi request reprint The zebrafish fgf family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    Zebrafish 4:179-86. 2007
    ..As the zebrafish system has proved useful for studying gene functions and genetic diseases, the present findings will be useful for elucidation of roles of FGFs in zebrafish and humans...
  8. ncbi request reprint Evolution of the Fgf and Fgfr gene families
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Trends Genet 20:563-9. 2004
    ..The expansion of the Fgf and Fgfr gene families has enabled this signaling system to acquire functional diversity and, therefore, an almost ubiquitous involvement in developmental and physiological processes...
  9. ncbi request reprint Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
    ..During the evolution of early vertebrates, the Fgf subfamilies further expanded to contain three or four members in each subfamily...
  10. pmc Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
    Cell Tissue Res 342:1-11. 2010
    ..In addition, serum Fgf19 or Fgf21 levels are significantly increased by metabolic disorders. Hormone-like Fgfs are newly emerging and quite unique in their evolution and function...
  11. doi request reprint A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
    Hiroyuki Miwa
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    FEBS Lett 583:3643-8. 2009
    ..The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development. Brorin-like potentially plays roles in neural development and functions...
  12. ncbi request reprint Fgf19 is required for zebrafish lens and retina development
    Yoshiaki Nakayama
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 313:752-66. 2008
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish...
  13. pmc Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development
    Ayumi Miyake
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biol Open 2:515-24. 2013
    ..Furthermore, fgf22 partially rescued the fgf3/fgf8 double morphant phenotype. The present results indicate Fgf22 to be involved in midbrain development downstream of Fgf3 and Fgf8 in the MHB but not of Hh in the floor plate. ..
  14. ncbi request reprint Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells
    Ikuo Kimura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    J Neurosci Res 83:1415-24. 2006
    ..The expression profile and activity indicate that neudesin plays unique roles in neural development. The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation...
  15. ncbi request reprint Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells
    Naomi Koike
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 282:15843-50. 2007
    ..Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. The present findings indicate that Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions...
  16. doi request reprint Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
    ..The present findings indicate that Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish...
  17. doi request reprint Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart
    Yuhei Hotta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:2947-54. 2008
    ..The embryonic heart phenotype is similar to that of the Fgf9 knockout heart, indicating Fgf9 and Fgf16 to synergistically act as growth factors for embryonic cardiomyocytes...
  18. doi request reprint Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish
    Ayumi Miyake
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Mech Dev 128:577-90. 2012
    ..Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues and plays roles in neural development in zebrafish...
  19. pmc Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
    Yusuke Murata
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    PLoS ONE 8:e69330. 2013
    ..As hepatic Fgf21 expression was markedly induced in mice fed KD, we examined the effects of KD feeding on metabolism and the roles of Fgf21 in metabolism in mice fed KD using Fgf21 knockout mice...
  20. ncbi request reprint Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish
    Takashi Wakahara
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 303:527-35. 2007
    ..The present findings have revealed a novel secreted lateral plate mesoderm signal essential for fin initiation in the lateral plate mesoderm...
  21. ncbi request reprint FGF10 and FGF21 as regulators in adipocyte development and metabolism
    Hiroya Ohta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocr Metab Immune Disord Drug Targets 11:302-9. 2011
    ..FGF21 may be a "thrifty factor". Serum FGF21 levels are increased in patients with metabolic diseases related with obesity, indicating potential roles of FGF21 in adipocyte metabolism...
  22. ncbi request reprint Role of Fgf10 in cell proliferation in white adipose tissue
    Morichika Konishi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Mol Cell Endocrinol 249:71-7. 2006
    ..In contrast, expression but not phosphorylation of pRb was impaired in the Fgf10(-/-) WAT. As pRb is essential for adipogenesis, Fgf10 might play a role in adipogenesis by inducing its expression...
  23. ncbi request reprint Fgf18 is required for embryonic lung alveolar development
    Hiroko Usui
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 322:887-92. 2004
    ..The cell proliferation during the terminal saccular stage stimulated by Fgf18 might play roles in the remodeling of the distal lung...
  24. ncbi request reprint Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity
    Ikuo Kimura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    J Neurosci Res 79:287-94. 2005
    ..The identification of neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity, will provide new insights into the development and maintenance of neuron..
  25. doi request reprint Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    Yuhei Hotta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocrinology 150:4625-33. 2009
    ..The present results indicate that Fgf21 regulates lipolysis in adipocytes in response to the metabolic state but is not required for ketogenesis and triglyceride clearance in the liver...
  26. doi request reprint Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue
    Morichika Konishi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Mol Cell Endocrinol 287:13-9. 2008
    ....
  27. ncbi request reprint Fgf16 is essential for pectoral fin bud formation in zebrafish
    Ryohei Nomura
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto, Japan
    Biochem Biophys Res Commun 347:340-6. 2006
    ..These findings have revealed that Fgf16, a newly identified AER factor, plays a crucial role in pectoral fin bud outgrowth by mediating the interactions of AER-mesenchyme and AER-ZPA...
  28. ncbi request reprint Functions of MAPR (membrane-associated progesterone receptor) family members as heme/steroid-binding proteins
    Ikuo Kimura
    Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Curr Protein Pept Sci 13:687-96. 2012
    ..In this review, we summarize the identification, structure, and bioactivity of members of the MAPR family, and present an essential overview of the current understanding of their physiological roles...
  29. doi request reprint Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
    ..Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages. The present findings indicate that Fgf20b is required for ectomesenchymal fate establishment via the activation of Fgfr1 in zebrafish...
  30. ncbi request reprint Fgf19 regulated by Hh signaling is required for zebrafish forebrain development
    Ayumi Miyake
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 288:259-75. 2005
    ..The present findings indicate that Fgf19 signaling is crucial for forebrain development by interacting with Hh and provide new insights into the roles of Fgf signaling in brain development...
  31. ncbi request reprint Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c
    Shigeki Ohmachi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    J Neurosci Res 72:436-43. 2003
    ..The present findings indicate that the activation of the MAPK pathway by FGF-20 signaling through FGFR-1c plays important roles in the survival of dopaminergic neurons in the SNPC...
  32. ncbi request reprint Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo
    Toshiyuki Asaki
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Mol Cell Endocrinol 218:119-28. 2004
    ..Unexpectedly, the transcriptional cascade of adipogenesis in vivo described here is distinct from the cascade in vitro previously reported...
  33. pmc Fgf21 is essential for haematopoiesis in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    EMBO Rep 7:649-54. 2006
    ..These results indicate that Fgf21 is a newly identified factor essential for the determination of myelo-erythroid progenitor cell fate in vivo...
  34. ncbi request reprint Regulation of mammalian tooth cusp patterning by ectodin
    Yoshiaki Kassai
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto 606 8501, Japan
    Science 309:2067-70. 2005
    ..Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps...
  35. doi request reprint Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling
    Ayumi Miyake
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 390:1051-5. 2009
    ..The expression pattern of Neucrin is distinct from that of any Dkk. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues...
  36. ncbi request reprint Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    Naoki Kusu
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 278:24113-7. 2003
    ..Our findings indicate that sclerostin plays an important role in bone remodeling and links bone resorption and bone apposition...
  37. ncbi request reprint FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development
    Masamitsu Hoshikawa
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Brain Res Mol Brain Res 105:60-6. 2002
    ..FGF-18 was found to have no neurotrophic activity. The present findings indicated that FGF-18 is a unique FGF that plays a role as a neuron-derived glial cell growth factor in early postnatal development when gliogenesis occurs...
  38. doi request reprint Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis
    Ikuo Kimura
    Laboratory of Applied Pharmacology, Faculty of Pharmacy, Chiba Institute of Sciences, Choshi, Chiba, Japan
    J Neurochem 112:1156-67. 2010
    ....
  39. doi request reprint Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade
    Ikuo Kimura
    Laboratory of Applied Pharmacology, Faculty of Pharmacy, Chiba Institute of Science, 15 8 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Biochem Biophys Res Commun 381:75-80. 2009
    ..These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway...
  40. ncbi request reprint Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
    Tetsuo Yamashita
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 277:28265-70. 2002
    ..Inhibitors of the MAPK pathway, PD98059 and SB203580, also blocked the activity of FGF-23. The present findings have revealed a novel MAPK-dependent mechanism of the regulation of phosphate uptake by FGF signaling...
  41. ncbi request reprint Cloning and expression of a brain-specific putative UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase gene
    Naosuke Nakamura
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kyoto, Japan
    Biol Pharm Bull 28:429-33. 2005
    ..The brain-specific expression of pt-GalNAc-T suggested its involvement in brain development, through O-glycosylation of proteins in the neurons...
  42. pmc Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
    Yasushi Takagi
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 115:102-9. 2005
    ..Behavioral studies and functional imaging revealed that the transplanted cells functioned as DA neurons and attenuated MPTP-induced neurological symptoms...
  43. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
    ..Conversely, chondrocyte proliferation and the number of differentiated chondrocytes are increased. Therefore, FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis...
  44. ncbi request reprint FGF10 maintains stem cell compartment in developing mouse incisors
    Hidemitsu Harada
    Second Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1, Manazuru, Kokurakita ku, Kitakyushu, 803 8580, Japan
    Development 129:1533-41. 2002
    ..However, recombinant human FGF10 protein rescued the cervical loop from apoptosis. Taken together, these results suggest that FGF10 is a survival factor that maintains the stem cell population in developing incisor germs...
  45. ncbi request reprint Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  46. ncbi request reprint Fibroblast growth factor 10 is required for proper development of the mouse whiskers
    Hideyo Ohuchi
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2 1 Minami Jyosanjima, Tokushima 770 8506, Japan
    Biochem Biophys Res Commun 302:562-7. 2003
    ..Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse...
  47. pmc Requirement of fibroblast growth factor 10 in development of white adipose tissue
    Hiroshi Sakaue
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Genes Dev 16:908-12. 2002
    ..Therefore, FGF10 plays an important role in adipogenesis, at least partly by contributing to the expression of C/EBPbeta through an autocrine/paracrine mechanism...
  48. ncbi request reprint Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10
    Takashi Shimoaka
    Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    J Biol Chem 277:7493-500. 2002
    ..All these effects of FGF-18 bore a close resemblance to those of FGF-2, whereas FGF-10 affects none of these cells. FGF-18 may therefore compensate for the action of FGF-2 on bone and cartilage...
  49. ncbi request reprint Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling
    Hiroshi Hasegawa
    Neural Organization Research Team, Mitsubishi Kagaku Institute of Life Sciences, Precursory Research for Embryonic Science and Technology, Japan Science and Technology, Machida, Tokyo, Japan
    J Neurosci 24:8711-9. 2004
    ....
  50. ncbi request reprint Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
    ..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis...
  51. ncbi request reprint Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
    Tuija Mustonen
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki FIN 00014, Finland
    Dev Biol 248:281-93. 2002
    ..We conclude that Lunatic fringe may play a role in boundary formation of the enamel knot and that Notch-signaling in the dental epithelium is regulated by mesenchymal FGFs and BMP...
  52. ncbi request reprint Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues
    Sarama Sathyaseelan Deepa
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Japan
    J Biol Chem 277:43707-16. 2002
    ..These findings suggest the possibility of CS-E being a binding partner, a coreceptor, or a genuine receptor for various Hep-binding growth factors in the brain and possibly also in other tissues...
  53. ncbi request reprint Tube or not tube: remodeling epithelial tissues by branching morphogenesis
    Markus Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056, Basel, Switzerland
    Dev Cell 4:11-8. 2003
    ....
  54. ncbi request reprint Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells
    Ami Ozasa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    Bone 36:1056-64. 2005
    ..Our results may explain one of the molecular mechanisms of the growth stimulating action of CNP and suggest that activation of the CNP/GC-B pathway may be effective as a novel therapeutic strategy for achondroplasia...
  55. ncbi request reprint Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
    Johanna Laurikkala
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 264:91-105. 2003
    ....
  56. ncbi request reprint Chondroitin sulfate/dermatan sulfate hybrid chains from embryonic pig brain, which contain a higher proportion of L-iduronic acid than those from adult pig brain, exhibit neuritogenic and growth factor binding activities
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Japan
    J Biol Chem 279:9765-76. 2004
    ....
  57. ncbi request reprint Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library
    Satoko Ashikari-Hada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 279:12346-54. 2004
    ..Thus, the library may provide new reagents to specifically regulate bindings of the growth factors to HS...
  58. ncbi request reprint Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
    Omar A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Hum Mol Genet 13:2313-24. 2004
    ..We suggest that elevated AS mutant FGFR2b signaling may account for the dermatological manifestations of AS...
  59. ncbi request reprint [Discovery of a novel BMP antagonist, ectodin, and its role in tooth morphogenesis]
    Yoshiaki Kassai
    Tanpakushitsu Kakusan Koso 51:335-41. 2006