K Irie


Affiliation: Kyoto University
Country: Japan


  1. Irie Y, Hanaki M, Murakami K, Imamoto T, Furuta T, Kawabata T, et al. Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation. Chem Commun (Camb). 2018;: pubmed publisher
    ..This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model. ..
  2. Jiang W, Zhou W, Uchida H, Kikumori M, Irie K, Watanabe R, et al. A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens. Mar Drugs. 2014;12:2748-59 pubmed publisher
  3. Murakami K, Yoshioka T, Horii S, Hanaki M, Midorikawa S, Taniwaki S, et al. Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid ?42 required for forming toxic oligomers. Chem Commun (Camb). 2018;54:6272-6275 pubmed publisher
    ..Such a direct interaction targeting the monomer, dimer, and trimer suppressed further oligomerization. In contrast, the corresponding congeners without carboxy groups failed to do so. ..
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    Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, et al. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol Ther. 2002;93:271-81 pubmed
    ..Moreover, we recently have found that a new lactone analogue of benzolactams (6) shows significant selectivity in PKCeta-C1B binding. ..
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    Irie K, Nakagawa Y, Ohigashi H. Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Curr Pharm Des. 2004;10:1371-85 pubmed
    ..Furthermore, our synthetic approach with the PKC C1 homology domains clarified that diacylglycerol kinase beta and gamma are new targets of phorbol esters. ..
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    Irie K, Murakami K, Masuda Y, Morimoto A, Ohigashi H, Hara H, et al. The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease. Mini Rev Med Chem. 2007;7:1001-8 pubmed
    ..Abeta42 is more neurotoxic than Abeta40. This review describes recent findings from a structural analysis of Abeta42 aggregates and discusses their relevance to neurotoxicity through the formation of radicals. ..
  7. Jiang W, Tan S, Hanaki Y, Irie K, Uchida H, Watanabe R, et al. Two new lyngbyatoxin derivatives from the Cyanobacterium, Moorea producens. Mar Drugs. 2014;12:5788-800 pubmed publisher
    ..These findings suggest that these new lyngbyatoxin derivatives may mediate their acute toxicities through a non-PKC activation pathway. ..
  8. Murakami K, Suzuki T, Hanaki M, Monobe Y, Akagi K, Irie K. Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region. Biochem Biophys Res Commun. 2015;466:463-7 pubmed publisher
    ..On the other hand, E22P-Aβ40 generated high molecular-weight oligomers into fibrils, and showed the neurotoxicity. These results suggest that such kind of Aβ40 dimer with a parallel β-sheet might not be pathological. ..
  9. Hanaki M, Murakami K, Akagi K, Irie K. Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids. Bioorg Med Chem. 2016;24:304-13 pubmed publisher
    ..The position and number of hydroxyl groups on the B-ring of non-catechol-type flavonoids could be important for their inhibitory potencies and mechanisms against Aβ42 aggregation. ..

More Information


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    Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem. 2004;12:4575-83 pubmed
    ..By the rapid screening system using this C1 peptide library, 5-prenyl-indolactam-V was identified as a promising lead for the novel protein kinase C isozyme specific ligands. ..
  2. Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, et al. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules. 2017;22: pubmed publisher
    ..However, the translocation profiles for PKCδ-GFP due to induction by 1-3 were similar. ..
  3. Hanaki M, Murakami K, Katayama S, Akagi K, Irie K. Mechanistic analyses of the suppression of amyloid ?42 aggregation by apomorphine. Bioorg Med Chem. 2018;26:1538-1546 pubmed publisher
    ..These results demonstrate that extension of the conjugated system in 1 by autoxidation can promote its planarity, which is required for intercalation into the ?-sheet of A?42 nuclei, thereby suppressing further aggregation. ..
  4. Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018;495:438-445 pubmed publisher
    ..Since the mechanism underlying 10-Me-aplog-1's anti-proliferative activities resembles that of DAT, 10-Me-aplog-1 may be regarded as a special key derived from pleiotropic DAT as a bunch of keys. ..