Affiliation: Kyoto University
- Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem. 2004;12:4575-83 pubmed..By the rapid screening system using this C1 peptide library, 5-prenyl-indolactam-V was identified as a promising lead for the novel protein kinase C isozyme specific ligands. ..
- Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, et al. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules. 2017;22: pubmed publisher..However, the translocation profiles for PKCδ-GFP due to induction by 1-3 were similar. ..
- Hanaki M, Murakami K, Katayama S, Akagi K, Irie K. Mechanistic analyses of the suppression of amyloid ?42 aggregation by apomorphine. Bioorg Med Chem. 2018;26:1538-1546 pubmed publisher..These results demonstrate that extension of the conjugated system in 1 by autoxidation can promote its planarity, which is required for intercalation into the ?-sheet of A?42 nuclei, thereby suppressing further aggregation. ..
- Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018;495:438-445 pubmed publisher..Since the mechanism underlying 10-Me-aplog-1's anti-proliferative activities resembles that of DAT, 10-Me-aplog-1 may be regarded as a special key derived from pleiotropic DAT as a bunch of keys. ..