K Irie

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. request reprint
    Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem. 2004;12:4575-83 pubmed
    ..By the rapid screening system using this C1 peptide library, 5-prenyl-indolactam-V was identified as a promising lead for the novel protein kinase C isozyme specific ligands. ..
  2. Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, et al. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules. 2017;22: pubmed publisher
    ..However, the translocation profiles for PKC?-GFP due to induction by 1-3 were similar. ..
  3. Hanaki M, Murakami K, Katayama S, Akagi K, Irie K. Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine. Bioorg Med Chem. 2018;: pubmed publisher
    ..These results demonstrate that extension of the conjugated system in 1 by autoxidation can promote its planarity, which is required for intercalation into the β-sheet of Aβ42 nuclei, thereby suppressing further aggregation. ..
  4. Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018;495:438-445 pubmed publisher
    ..Since the mechanism underlying 10-Me-aplog-1's anti-proliferative activities resembles that of DAT, 10-Me-aplog-1 may be regarded as a special key derived from pleiotropic DAT as a bunch of keys. ..

Detail Information

Publications4

  1. request reprint
    Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s. Bioorg Med Chem. 2004;12:4575-83 pubmed
    ..By the rapid screening system using this C1 peptide library, 5-prenyl-indolactam-V was identified as a promising lead for the novel protein kinase C isozyme specific ligands. ..
  2. Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, et al. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules. 2017;22: pubmed publisher
    ..However, the translocation profiles for PKC?-GFP due to induction by 1-3 were similar. ..
  3. Hanaki M, Murakami K, Katayama S, Akagi K, Irie K. Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine. Bioorg Med Chem. 2018;: pubmed publisher
    ..These results demonstrate that extension of the conjugated system in 1 by autoxidation can promote its planarity, which is required for intercalation into the β-sheet of Aβ42 nuclei, thereby suppressing further aggregation. ..
  4. Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K. Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines. Biochem Biophys Res Commun. 2018;495:438-445 pubmed publisher
    ..Since the mechanism underlying 10-Me-aplog-1's anti-proliferative activities resembles that of DAT, 10-Me-aplog-1 may be regarded as a special key derived from pleiotropic DAT as a bunch of keys. ..