Ken ichi Inui

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med 8:76. 2010
  2. ncbi request reprint Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE)
    Jun ichi Asaka
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Mol Pharmacol 71:1487-93. 2007
  3. ncbi request reprint Tacrolimus therapy according to mucosal MDR1 levels in small-bowel transplant recipients
    Satohiro Masuda
    Departmnet of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Clin Pharmacol Ther 75:352-61. 2004
  4. ncbi request reprint Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2
    Megumi Irie
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8507 Kyoto, Japan
    Pflugers Arch 449:186-94. 2004
  5. ncbi request reprint Cellular and molecular aspects of drug transport in the kidney
    K I Inui
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 58:944-58. 2000
  6. ncbi request reprint Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation
    Eriko Sato
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
    Drug Metab Pharmacokinet 21:492-500. 2006
  7. ncbi request reprint Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients
    Masahide Fukudo
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, Japan
    Clin Pharmacol Ther 80:331-45. 2006
  8. ncbi request reprint C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
    Maki Goto
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto, Japan
    Pharmacogenetics 12:451-7. 2002
  9. ncbi request reprint Cyclosporine exposure and calcineurin phosphatase activity in living-donor liver transplant patients: twice daily vs. once daily dosing
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Liver Transpl 12:292-300. 2006
  10. ncbi request reprint Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients
    Satohiro Masuda
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto Japan
    Clin Pharmacol Ther 79:90-102. 2006

Detail Information

Publications121 found, 100 shown here

  1. pmc Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med 8:76. 2010
    ..We tested the safety and efficacy of topical insulin-like growth factor 1 (IGF1) application using gelatin hydrogels as a treatment for SSHL...
  2. ncbi request reprint Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE)
    Jun ichi Asaka
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Mol Pharmacol 71:1487-93. 2007
    ..In the case of DEPC, no such protective effects were observed. These results suggest that histidine and cysteine residues are required for MATE1 to function and that cysteine residues may serve as substrate-recognition sites...
  3. ncbi request reprint Tacrolimus therapy according to mucosal MDR1 levels in small-bowel transplant recipients
    Satohiro Masuda
    Departmnet of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Clin Pharmacol Ther 75:352-61. 2004
    ....
  4. ncbi request reprint Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2
    Megumi Irie
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8507 Kyoto, Japan
    Pflugers Arch 449:186-94. 2004
    ..The behaviour of Gly-Sar in Caco-2 cells could be predicted by a mathematical model describing the peptide transporters...
  5. ncbi request reprint Cellular and molecular aspects of drug transport in the kidney
    K I Inui
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 58:944-58. 2000
    ..Detailed information concerning molecular and cellular aspects of drug transporters expressed in the kidney has facilitated studies of the mechanisms underlying renal disposition as well as transporter-mediated drug interactions...
  6. ncbi request reprint Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation
    Eriko Sato
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
    Drug Metab Pharmacokinet 21:492-500. 2006
    ..A high trough concentration of sirolimus might increase the risk of hematological toxicy, and adjustment of the dosage for immunosuppressive treatment will be necessary in Japanese patients...
  7. ncbi request reprint Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients
    Masahide Fukudo
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, Japan
    Clin Pharmacol Ther 80:331-45. 2006
    ....
  8. ncbi request reprint C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
    Maki Goto
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto, Japan
    Pharmacogenetics 12:451-7. 2002
    ..On the other hand, the C3435T polymorphism of MDR1 was suggested to correlate with the enterocyte expression of CYP3A4 rather than Pgp linking unknown genetic variation in CYP3A4 gene...
  9. ncbi request reprint Cyclosporine exposure and calcineurin phosphatase activity in living-donor liver transplant patients: twice daily vs. once daily dosing
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Liver Transpl 12:292-300. 2006
    ..Furthermore, CaN activity at trough time points would be a single surrogate predictor for the overall CaN activity throughout dosing intervals following cyclosporine administration...
  10. ncbi request reprint Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients
    Satohiro Masuda
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto Japan
    Clin Pharmacol Ther 79:90-102. 2006
    ....
  11. ncbi request reprint Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis
    Yuji Sakurai
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Pharm Res 22:2016-22. 2005
    ..However, the correlation coefficient was not so high. In the present study, therefore, we enrolled more patients to examine whether additional factors were responsible for the correlation...
  12. ncbi request reprint Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation
    Satohiro Masuda
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Liver Transpl 9:1108-13. 2003
    ..These results suggest that hepatic failure after LDLT, including chronic rejection and/or cholangitis, was accompanied by upregulation of intestinal PGP expression, which could depress the bioavailability of the immunosuppressant...
  13. ncbi request reprint CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation
    Maki Goto
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
    Pharmacogenetics 14:471-8. 2004
    ..We have previously reported that an intestinal P-glycoprotein (MDR1) contributes to this variation as an absorptive barrier, but the role of hepatic metabolism is not clear...
  14. ncbi request reprint Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney
    Yumiko Urakami
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Pharm Res 21:976-81. 2004
    ..Creatinine is excreted into urine by tubular secretion in addition to glomerular filtration. The purpose of this study was to clarify molecular mechanisms underlying the tubular secretion of creatinine in the human kidney...
  15. ncbi request reprint Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells
    Kayoko Ashida
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G617-23. 2002
    ..These findings indicate that T(3) treatment inhibits the uptake of [(14)C]glycylsarcosine by decreasing the transcription and/or stability of PEPT1 mRNA...
  16. doi request reprint Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto, Japan
    Pharmacogenet Genomics 18:413-23. 2008
    ..Furthermore, the development of renal dysfunction was analyzed in relation to the CYP3A5 genotype...
  17. ncbi request reprint Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats
    Yuriko Shimizu
    Dept of Pharmacy, Kyoto Univ Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G664-70. 2005
    ....
  18. ncbi request reprint Absence of influence of concomitant administration of rabeprazole on the pharmacokinetics of tacrolimus in adult living-donor liver transplant patients: a case-control study
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Drug Metab Pharmacokinet 24:458-63. 2009
    ..These findings suggest a safer dosing and monitoring of tacrolimus coadministered with rabeprazole early on after liver transplantation regardless of the CYP2C19 and CYP3A5 genotypes of transplant patients and their donors...
  19. doi request reprint Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer
    Yosuke Togashi
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Thorac Oncol 5:950-5. 2010
    ..We investigated CSF concentrations of erlotinib and its active metabolite OSI-420...
  20. ncbi request reprint Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1
    Yumiko Urakami
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Drug Metab Pharmacokinet 20:200-5. 2005
    ..Creatinine is excreted into urine via tubular secretion in addition to glomerular filtration. In the present study, characteristics of the creatinine transport in renal epithelial cells were investigated...
  21. ncbi request reprint Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
    Naoko Kimura
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan
    Drug Metab Pharmacokinet 20:379-86. 2005
    ..These findings suggest that metformin is a superior substrate for renal OCT2 rather than hepatic OCT1, and renal OCT2 plays a dominant role for metformin pharmacokinetics...
  22. ncbi request reprint Decreased expression of glucose and peptide transporters in rat remnant kidney
    Nobuhiko Nakamura
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan
    Drug Metab Pharmacokinet 19:41-7. 2004
    ..These findings suggested that loss of SGLT2 during chronic renal failure implies a high risk of renal glucosuria...
  23. ncbi request reprint Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers
    Mari Jiko
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    Int J Clin Oncol 12:284-90. 2007
    ..We investigated the pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine in patients with urogenital cancer to clarify the significance of monitoring of the serum concentration of paclitaxel...
  24. ncbi request reprint Pharmacodynamic analysis of tacrolimus and cyclosporine in living-donor liver transplant patients
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Japan
    Clin Pharmacol Ther 78:168-81. 2005
    ..We investigated pharmacodynamic properties of the 2 drugs and their clinical relevance in liver transplantation...
  25. ncbi request reprint Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats
    Hiroaki Yamaguchi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 21:330-8. 2004
    ..The aim of this study was to clarify the effects of renal failure on intestinal secretion of quinolone antibacterial drugs...
  26. ncbi request reprint Lansoprazole-tacrolimus interaction in Japanese transplant recipient with CYP2C19 polymorphism
    Kazushige Takahashi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Pharmacother 38:791-4. 2004
    ..To report a patient with a high tacrolimus blood concentration after lansoprazole administration and assess the potential interaction between tacrolimus and lansoprazole...
  27. ncbi request reprint Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients
    Yuichi Uwai
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Hum Genet 49:40-5. 2004
    ..These findings suggest that the common SNPs in the MDR1 gene have no influence on the expression of its transcript in RCC segments as well as in the normal kidney cortex...
  28. ncbi request reprint Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
    Satohiro Masuda
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Am Soc Nephrol 17:2127-35. 2006
    ..These results indicate that hMATE2-K is a new human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes...
  29. ncbi request reprint Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases
    Yuji Sakurai
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 21:61-7. 2004
    ..The aim of present study was to clarify the alteration in the levels of renal drug transporters and their correlation with the urinary drug excretion in renal diseases patients...
  30. doi request reprint Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity
    Moto Kajiwara
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    J Hum Genet 54:40-6. 2009
    ..This is the first demonstration of functional impairment of the MATE family induced by cSNPs...
  31. doi request reprint Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    Clin Pharmacokinet 52:593-609. 2013
    ..The secondary objective was to identify genetic determinant(s) for the cerebrospinal fluid (CSF) permeability of erlotinib and its active metabolite OSI-420...
  32. ncbi request reprint Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo
    Hiroaki Yamaguchi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Pharmacol Exp Ther 300:1063-9. 2002
    ..In conclusion, our results indicated that P-glycoprotein mediated the intestinal secretion of grepafloxacin and limited the bioavailability of this drug in vivo...
  33. ncbi request reprint Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1
    Moto Kajiwara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Renal Physiol 293:F1564-70. 2007
    ..7%, and Sp1-binding and promoter activity were significantly decreased. This is the first study to clarify the transcriptional mechanisms of the MATE1 gene and to identify a SNP affecting the promoter activity of hMATE1...
  34. ncbi request reprint Hepatocyte nuclear factor-4{alpha} regulates the human organic anion transporter 1 gene in the kidney
    Ken Ogasawara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Am J Physiol Renal Physiol 292:F1819-26. 2007
    ..This paper reports the first characterization of the human OAT1 promoter and the first gene in the kidney whose promoter activity is regulated by HNF-4alpha...
  35. ncbi request reprint Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
    Hideyuki Motohashi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Pharmacol 503:25-30. 2004
    ..Present findings should be useful information to understand the renal handling of famotidine and cimetidine...
  36. ncbi request reprint Forecasting of blood tacrolimus concentrations based on the Bayesian method in adult patients receiving living-donor liver transplantation
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Clin Pharmacokinet 42:1161-78. 2003
    ..To evaluate Bayesian prediction of blood tacrolimus concentrations in adult patients receiving living-donor liver transplantation (LDLT) using previously obtained population pharmacokinetic parameters...
  37. ncbi request reprint Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2
    Miyako Okamura
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Pharm Res 20:1389-93. 2003
    ..The aim of this study was to examine the effects of zinc on the intestinal peptide transporters (PEPT1 and basolateral peptide transporter) and to elucidate the mechanism of the interactions...
  38. ncbi request reprint Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo
    Kayoko Ashida
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 21:969-75. 2004
    ..To examine the effect of thyroid hormone status on PEPT1 in vivo, the activity and expression of PEPT1 in the small intestine were examined in euthyroid and hyperthyroid rats...
  39. doi request reprint Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation
    Maki Goto
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 325:610-6. 2008
    ....
  40. ncbi request reprint Gene expression levels and immunolocalization of organic ion transporters in the human kidney
    Hideyuki Motohashi
    Department of Pharmacy, Division of Artificial Kidneys, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Am Soc Nephrol 13:866-74. 2002
    ..These results suggest that hOAT1, hOAT3, and hOCT2 play predominant roles in the transport of organic ions across the basolateral membrane of human proximal tubules...
  41. ncbi request reprint Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus
    Masahiro Shimomura
    Department of Pharmacy, Kyoto University Hospital, Graduate School of Medicine, Sakyo ku, Kyoto, 606 8507, Japan
    J Surg Res 103:215-22. 2002
    ..In the present study, we investigated the respective contribution of the jejunum and ileum to the first-pass effect of tacrolimus in rats...
  42. ncbi request reprint Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients
    Miwa Uesugi
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Shogoin, Kyoto, Japan
    Pharmacogenet Genomics 16:119-27. 2006
    ..These results indicate that intestinal CYP3A5, as well as hepatic CYP3A5, plays an important role in the first-pass effect of orally administered tacrolimus...
  43. ncbi request reprint Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
    Lin Ji
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto, Japan
    Kidney Int 62:514-24. 2002
    ..However, their changes in chronic renal failure (CRF) are poorly understood. The present study examined the renal handling of organic ions and the expression of these transporters under CRF...
  44. pmc Computational modelling of H+-coupled peptide transport via human PEPT1
    Megumi Irie
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Physiol 565:429-39. 2005
    ..These findings indicated that the inferred mechanisms are able to sufficiently interpret the transport of both neutral and charged substrates by PEPT1...
  45. ncbi request reprint Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction
    Hiromi Okabe
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan
    J Pharm Pharmacol 54:65-70. 2002
    ....
  46. ncbi request reprint A transient increase of calcineurin phosphatase activity in living-donor kidney transplant recipients with acute rejection
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Drug Metab Pharmacokinet 25:411-7. 2010
    ....
  47. ncbi request reprint Modulation of P-glycoprotein expression in hyperthyroid rat tissues
    Naoki Nishio
    Department of Pharmacy, Kyoto University Hospital, Kyoto 606 8507, Japan
    Drug Metab Dispos 33:1584-7. 2005
    ..Taken together, these findings suggest that thyroid hormone induces Pgp expression in a tissue-selective manner, and that the modulation of mdr1a/1b mRNA expression in the hyperthyroid state varies among tissues...
  48. ncbi request reprint Transient up-regulation of P-glycoprotein reduces tacrolimus absorption after ischemia-reperfusion injury in rat ileum
    Takanori Omae
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 69:561-8. 2005
    ..Therefore, the monitoring of the enterocyte P-glycoprotein level would provide useful information for determining the dosage of tacrolimus immediately after small bowl transplantation...
  49. ncbi request reprint Distinct effects of omeprazole and rabeprazole on the tacrolimus blood concentration in a kidney transplant recipient
    Kazushige Takahashi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Drug Metab Pharmacokinet 22:441-4. 2007
    ..The present case indicates that rabeprazole can be used safely in place of omeprazole in kidney transplant recipients receiving tacrolimus...
  50. doi request reprint Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney
    Ken Ogasawara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    J Hum Genet 53:607-14. 2008
    ..This is the first study to investigate the influences of rSNPs on mRNA expression of SLC22A in the kidney and to identify a regulatory polymorphism affecting OCT2 promoter activity...
  51. ncbi request reprint Evaluation of Calvert's formula for dosage adjustment of carboplatin in Japanese patients with hormone refractory prostate cancer
    Eriko Sato
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Japan
    Biol Pharm Bull 29:1441-4. 2006
    ..min/ml of carboplatin was comparatively safe for Japanese patients with prostate cancer...
  52. ncbi request reprint Diurnal rhythm of H+-peptide cotransporter in rat small intestine
    Xiaoyue Pan
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 283:G57-64. 2002
    ..These findings indicate that the intestinal PEPT1 undergoes diurnal regulation in its activity and expression, and this could affect the intestinal absorption of dietary protein...
  53. ncbi request reprint Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney
    Naoshi Horiba
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 278:14669-76. 2003
    ..These findings suggest that rNaGLT1 is a novel Na(+)-dependent glucose transporter with low substrate affinity that mediates tubular reabsorption of glucose...
  54. ncbi request reprint Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1
    Tomohiro Terada
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 23:1696-701. 2006
    ..Transport characteristics and tissue distribution of the rat H+/organic cation antiporter MATE1 (multidrug and toxin extrusion 1) were examined...
  55. ncbi request reprint Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity
    Sachiko Yokoo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto 606 8507, Japan
    Biochem Pharmacol 74:477-87. 2007
    ..In conclusion, the nephrotoxicity of platinum agents was closely associated with their renal accumulation, which is determined by the substrate specificity of the OCT and MATE families...
  56. doi request reprint Population analysis of myelosuppression profiles using routine clinical data after the ICE (ifosfamide/carboplatin/etoposide) regimen for malignant gliomas
    Yoshitaka Yano
    Center for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachi cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    J Pharm Sci 98:4402-12. 2009
    ....
  57. doi request reprint Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells
    Masahiro Tsuda
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 329:185-91. 2009
    ..These results suggest that apical hMATE1 is involved in drug interactions between cimetidine and cationic compounds in the proximal tubular epithelial cells...
  58. ncbi request reprint Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Drug Metab Pharmacokinet 23:134-8. 2008
    ..A drug-drug interaction between rabeprazole and tacrolimus was not observed in this case study presented, suggesting that this combination could be safely used in tacrolimus therapy after liver transplantation...
  59. doi request reprint Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Drug Metab Dispos 37:821-6. 2009
    ....
  60. ncbi request reprint Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha
    Jin Shimakura
    Department of Pharmacy, Kyoto University Hospital, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G851-6. 2006
    ..In addition to the well-established roles of PPARalpha, we propose a novel function of PPARalpha in the small intestine, that is, the regulation of nitrogen absorption through PEPT1 during fasting...
  61. ncbi request reprint cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney
    Yumiko Urakami
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Am Soc Nephrol 13:1703-10. 2002
    ..These findings suggested that hOCT2-A contributes to the renal clearance of endogenous and exogenous organic cations...
  62. ncbi request reprint Prediction of glycylsarcosine transport in Caco-2 cell lines expressing PEPT1 at different levels
    Megumi Irie
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8507, Kyoto, Japan
    Pflugers Arch 452:64-70. 2006
    ..With this improved model, Gly-Sar transport in clones 1 and 9 was well-predicted, suggesting that our model can simulate Gly-Sar transport in cells expressing PEPT1 at different levels...
  63. ncbi request reprint Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten
    Xiaoyue Pan
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 307:626-32. 2003
    ....
  64. ncbi request reprint Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1
    Masahiro Tsuda
    Dept of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Renal Physiol 292:F593-8. 2007
    ..The present experimental strategy is very useful in identifying the driving force of cloned transporters whose driving force has not been evaluated...
  65. ncbi request reprint Distinct inhibitory effects of tacrolimus and cyclosporin a on calcineurin phosphatase activity
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 312:816-25. 2005
    ..Distinct pharmacodynamics may partly contribute to the therapeutic drug monitoring strategy in transplant patients receiving calcineurin inhibitors...
  66. pmc Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity
    Kumiko Nishihara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 85:570-82. 2013
    ....
  67. ncbi request reprint Required transient dose escalation of tacrolimus in living-donor liver transplant recipients with high concentrations of a minor metabolite M-II in bile
    Masahiro Shimomura
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Drug Metab Pharmacokinet 23:313-7. 2008
    ..In conclusion, a minor metabolite M-II was first found in the human bile, suggesting that the appearance of M-II in bile could associate with the extensive metabolism of tacrolimus and/or the requirement of larger oral dosage...
  68. doi request reprint Effect of itraconazole on the pharmacokinetics of everolimus administered by different routes in rats
    Akira Yokomasu
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biopharm Drug Dispos 30:517-23. 2009
    ..871 to 0.923 or 0.867, respectively. In conclusion, intraintestinally administered itraconazole dramatically increased the AUC of everolimus delivered intraintestinally by inhibiting the intestinal first-pass extraction of this drug...
  69. doi request reprint MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 26:1590-5. 2009
    ....
  70. ncbi request reprint Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2
    Yasushi Habu
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 66:1107-14. 2003
    ..These phenomena partly contribute to the changed renal disposition of organic anions and cations in hyperuricemia...
  71. ncbi request reprint Gene expression variance based on random sequencing in rat remnant kidney
    Naoshi Horiba
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 66:29-45. 2004
    ..In this study, digital expression profiling was carried out to construct a subtractive mRNA expression database for the 5/6 nephrectomized kidney...
  72. doi request reprint Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion
    Katsuhiro Masago
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
    Clin Lung Cancer 12:307-12. 2011
    ..Thus, we investigated the pharmacokinetics (PK) of erlotinib and its active metabolite OSI-420 in non-small-cell lung cancer (NSCLC) of malignant pleural effusion (MPE)...
  73. ncbi request reprint Impact of genetic variation in breast cancer resistance protein (BCRP/ABCG2) on sunitinib pharmacokinetics
    Tomoyuki Mizuno
    Department of Pharmacy, Kyoto University Hospital, Kyoto, Japan
    Drug Metab Pharmacokinet 27:631-9. 2012
    ..These results suggest that the loss of protein expression of ABCG2 by genetic polymorphism is associated with an increase in the systemic exposure to sunitinib and sunitinib-induced toxicity...
  74. doi request reprint Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1
    Atsushi Yonezawa
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Sakyo ku, Kyoto, Japan
    Am J Physiol Cell Physiol 295:C632-41. 2008
    ..1 and 63.7 nM, respectively. We propose that hRFT1 and rRFT1 are novel mammalian riboflavin transporters, which belong to a new mammalian riboflavin transporter family...
  75. doi request reprint Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
    Masayo Aoki
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto, Japan
    Am J Physiol Renal Physiol 295:F165-70. 2008
    ..These results indicate that kidney-specific expression of human OCT2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1...
  76. doi request reprint Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients
    Kana Toyama
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Pharmacogenet Genomics 20:135-8. 2010
    ..In conclusion, heterozygous MATE variants could not influence the disposition of metformin in diabetic patients...
  77. ncbi request reprint Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function
    Tomohiro Terada
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 316:416-20. 2004
    ..This is the first demonstration of a functional impairment of the SLC15A family induced by a single nucleotide polymorphism...
  78. ncbi request reprint Characterization of the Basal promoter element of human organic cation transporter 2 gene
    Jun ichi Asaka
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 321:684-9. 2007
    ..This article reports the first characterization of the hOCT2 promoter and shows that USF-1 functions as a basal transcriptional regulator of the hOCT2 gene via the E-box...
  79. ncbi request reprint Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3
    Jun ichi Asaka
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    Pharm Res 23:697-704. 2006
    ..We previously reported that rat (r)OCT2 expression in the kidney was regulated by testosterone. In this study, we examined the transcriptional mechanisms underlying the testosterone-dependent regulation of rOCT2 expression...
  80. doi request reprint Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation
    Ikuko Yano
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, Japan
    Eur J Clin Pharmacol 68:259-66. 2012
    ....
  81. ncbi request reprint Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1
    Jin Shimakura
    Dept of Pharmacy, Kyoto Univ Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G471-7. 2005
    ..This study reports the first characterization of the hPEPT1 promoter and shows the significant role of Sp1 in the basal transcriptional regulation of hPEPT1...
  82. ncbi request reprint Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2)
    Yuichi Uwai
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Kyoto, Japan
    Pharm Res 24:811-5. 2007
    ..The aim of the present study was to investigate whether the other renal organic anion transporter hOAT3 (SLC22A8) and organic cation transporter hOCT2 (SLC22A2) transport the antivirals...
  83. ncbi request reprint Na(+)-dependent fructose transport via rNaGLT1 in rat kidney
    Naoshi Horiba
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    FEBS Lett 546:276-80. 2003
    ..These results indicated that rNaGLT1 is a primary fructose transporter in rat renal brush-border membranes...
  84. ncbi request reprint Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3
    Yuichi Uwai
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 74:161-8. 2007
    ..These findings propose the possibility that the administration of MMF decreases the renal clearance of drugs which are substrates of hOAT1 and hOAT3. Present data suggest that hOAT3 contributes to the renal tubular secretion of MPAG...
  85. doi request reprint Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study
    Keiko Shinsako
    Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    Int J Clin Oncol 15:512-4. 2010
    ..Our results suggest that sorafenib administered at a dose of 400 mg twice per day was well tolerated, at least for 6 months, for a patient undergoing hemodialysis...
  86. ncbi request reprint Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters
    Ken Ogasawara
    Department of Pharmacy, Kyoto University Hospital, Japan
    Drug Metab Pharmacokinet 25:190-9. 2010
    ..These findings indicate that HCV-related cirrhosis is a crucial factor affecting the expression of hepatic drug transporters, especially MRP4...
  87. ncbi request reprint Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters
    Yuko Tanihara
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 74:359-71. 2007
    ..These results suggest that hMATE1 and hMATE2-K function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney...
  88. doi request reprint Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats
    Kumiko Nishihara
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Am J Physiol Renal Physiol 298:F923-34. 2010
    ....
  89. ncbi request reprint The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats
    Xiaoyue Pan
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Nutr 134:2211-5. 2004
    ..These findings suggest that food intake, rather than the light cycle, greatly affects the diurnal rhythm of SGLT1 and PEPT1 expressions...
  90. ncbi request reprint Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats
    Kumiko Nishihara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 73:1482-90. 2007
    ....
  91. ncbi request reprint The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1
    Jin Shimakura
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 71:1581-8. 2006
    ..Taken together, the present study suggests that Cdx2 plays a key role in the transcriptional regulation of the intestine-specific expression of PEPT1, possibly through interaction with Sp1...
  92. ncbi request reprint Thyroid hormone regulates the expression and function of P-glycoprotein in Caco-2 cells
    Naoki Nishio
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Pharm Res 25:1037-42. 2008
    ..In this study, we examined the effect of 3,5,3'-L-triiodothyronine (T(3)) on the function and expression of Pgp using the human intestinal epithelial cell line Caco-2...
  93. ncbi request reprint Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2
    Maki Goto
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 66:163-70. 2003
    ..Therefore, the temporal induction and subsequent down-regulation of the enterocyte Pgp could affect bioavailability of several drugs during the regeneration of the intestinal wall...
  94. ncbi request reprint Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2
    Atsuko Fukada
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 302:532-8. 2002
    ..These findings could provide useful information for the design of effective nicotine delivery...
  95. ncbi request reprint Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2
    Masahiro Okuda
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Drug Metab Pharmacokinet 21:432-6. 2006
    ..Fluoroquinolone antibacterials have the ability to inhibit the transport of creatinine by hOCT2, with DX-619 being much more effective than LVFX...
  96. ncbi request reprint Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes
    Shuichi Ohnishi
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biochim Biophys Acta 1609:218-24. 2003
    ....
  97. doi request reprint Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1
    Tomoko Sato
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Sakyo ku, Kyoto 606 507, Japan
    Biochem Pharmacol 76:894-903. 2008
    ..These cells could be useful for examining the routes by which compounds are eliminated, or predicting transporter-mediated drug interaction...
  98. ncbi request reprint Prospective evaluation of the bayesian method for individualizing tacrolimus dose early after living-donor liver transplantation
    Masahide Fukudo
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Pharmacol 49:789-97. 2009
    ..These findings suggest that the Bayesian method can be used to calculate maintenance doses of tacrolimus in adult patients early after living-donor liver transplantation...
  99. doi request reprint Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
    Naoko Kimura
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Pharmacol 77:1429-36. 2009
    ..49+/-0.14mM. These results indicated that the specificity of hOCT1 and hOCT2 was not determined simply by guanidino group. Among guanidine compounds, aminoguanidine was identified as a new superior substrate for hOCT2...
  100. ncbi request reprint An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients
    Satohiro Masuda
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Pharmacol Ther 112:184-98. 2006
    ....
  101. doi request reprint Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice
    Shingo Watanabe
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    J Pharmacol Exp Ther 334:651-6. 2010
    ..In this study, we demonstrated that MATE1 is responsible for renal tubular secretion of a zwitterionic substrate cephalexin in vivo...