Haruhisa Inoue

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease
    Naoki Yahata
    Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e25788. 2011
  2. pmc P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    PLoS ONE 6:e21050. 2011
  3. doi request reprint Neurodegenerative disease-specific induced pluripotent stem cell research
    Haruhisa Inoue
    Center for iPS Cell Research and Application, Kyoto University, 53, Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Cell Res 316:2560-4. 2010
  4. doi request reprint Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness
    Takayuki Kondo
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 12:487-96. 2013
  5. doi request reprint A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish
    Hideaki Matsui
    Department of Neurology, Kyoto University, Graduate School of Medicine, Kyoto 606 8507, Japan
    Neurosci Res 65:263-71. 2009
  6. doi request reprint Proteasome inhibition in medaka brain induces the features of Parkinson's disease
    Hideaki Matsui
    Department of Neurology, Kyoto University, Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 115:178-87. 2010
  7. doi request reprint Response to Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"
    Naohiro Egawa
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Sci Transl Med 5:188lr2. 2013
  8. doi request reprint Drug screening for ALS using patient-specific induced pluripotent stem cells
    Naohiro Egawa
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Sci Transl Med 4:145ra104. 2012
  9. pmc Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1
    Tamaki Wada
    Stem Cell and Drug Discovery Institute, Kyoto, Japan
    Stem Cells Transl Med 1:396-402. 2012
  10. pmc N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease
    Koichi Ando
    School of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Biol Chem 286:7619-28. 2011

Collaborators

Detail Information

Publications21

  1. pmc Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease
    Naoki Yahata
    Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e25788. 2011
    ..Induced pluripotent stem (iPS) cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease...
  2. pmc P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    PLoS ONE 6:e21050. 2011
    ..Therefore, assessment of sensorimotor gating could be used to detect the earliest manifestations of tauopathies exemplified by prodromal AD, in which abnormal tau protein may play critical roles in the onset of neuronal dysfunctions...
  3. doi request reprint Neurodegenerative disease-specific induced pluripotent stem cell research
    Haruhisa Inoue
    Center for iPS Cell Research and Application, Kyoto University, 53, Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Cell Res 316:2560-4. 2010
    ..Further progress in these areas of research can be made for currently incurable neurodegenerative diseases...
  4. doi request reprint Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness
    Takayuki Kondo
    Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 12:487-96. 2013
    ..It also illustrates how patient-specific iPSCs can be useful for analyzing AD pathogenesis and evaluating drugs...
  5. doi request reprint A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish
    Hideaki Matsui
    Department of Neurology, Kyoto University, Graduate School of Medicine, Kyoto 606 8507, Japan
    Neurosci Res 65:263-71. 2009
    ..Moreover, the amounts of dopamine persistently decreased in the brain of these MPTP-treated fish. MPTP-treated medaka is valuable for modeling human PD...
  6. doi request reprint Proteasome inhibition in medaka brain induces the features of Parkinson's disease
    Hideaki Matsui
    Department of Neurology, Kyoto University, Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 115:178-87. 2010
    ....
  7. doi request reprint Response to Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells"
    Naohiro Egawa
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Sci Transl Med 5:188lr2. 2013
    ..Our work and the study of Bilican et al. highlight the need for complementary assays to detect subtle phenotypic differences between control and mutant induced pluripotent stem cell lines...
  8. doi request reprint Drug screening for ALS using patient-specific induced pluripotent stem cells
    Naohiro Egawa
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Sci Transl Med 4:145ra104. 2012
    ..These findings suggest that motor neurons generated from ALS patient-derived iPSCs may provide a useful tool for elucidating ALS disease pathogenesis and for screening drug candidates...
  9. pmc Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1
    Tamaki Wada
    Stem Cell and Drug Discovery Institute, Kyoto, Japan
    Stem Cells Transl Med 1:396-402. 2012
    ..Thus, this model is expected to help unravel the disease mechanisms involved in the development of FALS and also lead to potential drug discoveries based on the prevention of neurodegeneration...
  10. pmc N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease
    Koichi Ando
    School of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Biol Chem 286:7619-28. 2011
    ..The dissociation of N-cadherin-mediated synaptic contact by Aβ may underlie the pathological basis of neurodegeneration such as neuronal death, synaptic loss, and Tau phosphorylation in Alzheimer disease brain...
  11. doi request reprint Research on neurodegenerative diseases using induced pluripotent stem cells
    Keiko Imamura
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Psychogeriatrics 12:115-9. 2012
    ..In this review, we discuss the recent advances in iPSC technology as well as its potential applications...
  12. pmc Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis
    Yoshitaka Tashiro
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan
    J Biol Chem 287:42984-94. 2012
    ..Enhancement of proteasome activity may be a promising strategy for the treatment of ALS...
  13. doi request reprint Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease
    Tomoyuki Fumuro
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Clin Neurophysiol 124:1398-405. 2013
    ..We examined whether PD patients could increase BP amplitude by means of neuro-feedback (NFB) training for their slow cortical potentials (SCPs)...
  14. doi request reprint Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement
    Hideaki Matsui
    Department of Neurology, Kyoto University, Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Neurosci Res 66:151-61. 2010
    ..Thus, PINK1 contributes to the maintenance of dopamine metabolism, even before the selective death of dopaminergic neurons. Our animal model is therefore a valuable tool to detect pathogenesis in Parkinson's patients in the early stages...
  15. doi request reprint α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion
    Hodaka Yamakado
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Neurosci Res 73:173-7. 2012
    ..Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo...
  16. pmc The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death
    Naohiro Egawa
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 286:7947-57. 2011
    ....
  17. doi request reprint Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis
    Gaku Murakami
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Biomol Screen 16:405-14. 2011
    ..The assay developed here provides a powerful strategy for discovering novel lead molecules for treating familial SOD1-mediated ALS...
  18. pmc Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
    Masatoshi Kajiwara
    Center for Induced Pluripotent Stem Cell Research and Application, Department of Surgery, Graduate School of Medicine, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 109:12538-43. 2012
    ..These data underscore the importance of donor differences when comparing the differentiation propensities of hiPSC clones...
  19. ncbi request reprint [ALS disease modeling and drug screening using patient-specific iPS cells]
    Naohiro Egawa
    Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
    Rinsho Shinkeigaku 53:1020-2. 2013
    ..Anacardic acid treatment reverted those phenotypes. Disease-specific iPSCs might provide a first step for drug-screening platform for ALS using patient-specific iPSCs. ..
  20. doi request reprint Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..These results suggest that the rotenone mouse model may be useful for assessing candidate antiparkinson agents, and that nAChR (nicotinic acetylcholine receptor) stimulation can protect DA neurons against degeneration...
  21. ncbi request reprint A chemical probe that labels human pluripotent stem cells
    Nao Hirata
    Institute for Integrated Cell Material Sciences WPI iCeMS, Kyoto University, Kyoto 606 8501, Japan Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Cell Rep 6:1165-74. 2014
    ..Although KP-1, like other pluripotent markers, is not absolutely specific for pluripotent stem cells, the identified chemical probe may be used in conjunction with other reagents. ..