Shinsaku Imashuku

Summary

Affiliation: Kyoto City Hospital
Country: Japan

Publications

  1. ncbi request reprint Epstein-Barr virus-associated T-lymphoproliferative disease with hemophagocytic syndrome, followed by fatal intestinal B lymphoma in a young adult female with WHIM syndrome. Warts, hypogammaglobulinemia, infections, and myelokathexis
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, 1 2 Higashi Takada cho, Mibu, Nakagyo ku, Kyoto 604 8845, Japan
    Ann Hematol 81:470-3. 2002
  2. ncbi request reprint Systemic type Epstein-Barr virus-related lymphoproliferative diseases in children and young adults: challenges for pediatric hemato-oncologists and infectious disease specialists
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, Hyogo Prefecture, Japan
    Pediatr Hematol Oncol 24:563-8. 2007
  3. pmc Severe hypernatremia and hyperchloremia in an elderly patient with IgG-kappa-type multiple myeloma
    Shinsaku Imashuku
    Division of Hematology, Takasago seibu Hospital, Takasago, Japan
    J Blood Med 4:43-7. 2013
  4. pmc Effectiveness of a combination of cyclosporine A, suplatast tosilate and prednisolone on periodic oscillating hypereosinophilia
    Shinsaku Imashuku
    Divisions of Pediatrics and Hematology, Takasago seibu Hospital, Takasago, Japan
    Int Med Case Rep J 4:79-82. 2011
  5. pmc Rituximab for managing acquired hemophilia A in a case of chronic neutrophilic leukemia with the JAK2 kinase V617F mutation
    Shinsaku Imashuku
    Division of Hematology, Takasagoseibu Hospital, Takasago, Japan
    J Blood Med 3:157-61. 2012
  6. pmc Concurrence of thyrotoxicosis and Gitelman's syndrome-associated hypokalemia-induced periodic paralysis
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, Takasago
    Pediatr Rep 4:e18. 2012
  7. pmc Spontaneous resolution of macrocytic anemia: old disease revisited
    Shinsaku Imashuku
    Division of Hematology, Takasagoseibu Hospital, Takasago, Japan
    J Blood Med 3:45-7. 2012
  8. pmc Anti-Factor V inhibitor in patients with autoimmune diseases: case report and literature review
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, Takasago, Hyogo
    Int Med Case Rep J 4:31-4. 2011
  9. doi request reprint Persistent thrombocytosis in elderly patients with rare hyposplenias that mimic essential thrombocythemia
    Shinsaku Imashuku
    Division of Hematology, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago 676 0812, Japan
    Int J Hematol 95:702-5. 2012
  10. ncbi request reprint High dose immunoglobulin (IVIG) may reduce the incidence of Langerhans cell histiocytosis (LCH)-associated central nervous system involvement
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo Prefecture, Japan
    CNS Neurol Disord Drug Targets 8:380-6. 2009

Detail Information

Publications76

  1. ncbi request reprint Epstein-Barr virus-associated T-lymphoproliferative disease with hemophagocytic syndrome, followed by fatal intestinal B lymphoma in a young adult female with WHIM syndrome. Warts, hypogammaglobulinemia, infections, and myelokathexis
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, 1 2 Higashi Takada cho, Mibu, Nakagyo ku, Kyoto 604 8845, Japan
    Ann Hematol 81:470-3. 2002
    ..However, 6 weeks later, fatal EBV(+) B lymphoma unresponsive to chemotherapy occurred in the intestine and other organs. Caution must be exercised that the patient with WHIM syndrome may be at risk for EBV-LPD...
  2. ncbi request reprint Systemic type Epstein-Barr virus-related lymphoproliferative diseases in children and young adults: challenges for pediatric hemato-oncologists and infectious disease specialists
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, Hyogo Prefecture, Japan
    Pediatr Hematol Oncol 24:563-8. 2007
    ....
  3. pmc Severe hypernatremia and hyperchloremia in an elderly patient with IgG-kappa-type multiple myeloma
    Shinsaku Imashuku
    Division of Hematology, Takasago seibu Hospital, Takasago, Japan
    J Blood Med 4:43-7. 2013
    ..In this patient, we successfully managed the severe hypernatremia/hyperchloremia, caused by the combined effects of intravenous saline burden in a state of poor oral fluid intake, during the treatment for IgG-kappa type multiple myeloma...
  4. pmc Effectiveness of a combination of cyclosporine A, suplatast tosilate and prednisolone on periodic oscillating hypereosinophilia
    Shinsaku Imashuku
    Divisions of Pediatrics and Hematology, Takasago seibu Hospital, Takasago, Japan
    Int Med Case Rep J 4:79-82. 2011
    ....
  5. pmc Rituximab for managing acquired hemophilia A in a case of chronic neutrophilic leukemia with the JAK2 kinase V617F mutation
    Shinsaku Imashuku
    Division of Hematology, Takasagoseibu Hospital, Takasago, Japan
    J Blood Med 3:157-61. 2012
    ..Acquired hemophilia A is rarely found in association with myeloproliferative neoplasms, such as the JAK2 kinase V617F mutation-positive chronic neutrophilic leukemia (CNL)...
  6. pmc Concurrence of thyrotoxicosis and Gitelman's syndrome-associated hypokalemia-induced periodic paralysis
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, Takasago
    Pediatr Rep 4:e18. 2012
    ..This case underscores the importance of careful examinations of adolescents with complaints of truancy as well as of precise determinations of the causes of hypokalemia-associated paralysis...
  7. pmc Spontaneous resolution of macrocytic anemia: old disease revisited
    Shinsaku Imashuku
    Division of Hematology, Takasagoseibu Hospital, Takasago, Japan
    J Blood Med 3:45-7. 2012
    ..It is well recognized that marrow abnormalities in alcoholic patients are reversible. Physicians should be aware that there is a subset of patients with macrocytic anemia that could be improved without medication...
  8. pmc Anti-Factor V inhibitor in patients with autoimmune diseases: case report and literature review
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, Takasago, Hyogo
    Int Med Case Rep J 4:31-4. 2011
    ..Clinical features of autoimmune disease-related Factor V deficiency are discussed, along with eight previously reported cases over the past 20 years...
  9. doi request reprint Persistent thrombocytosis in elderly patients with rare hyposplenias that mimic essential thrombocythemia
    Shinsaku Imashuku
    Division of Hematology, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago 676 0812, Japan
    Int J Hematol 95:702-5. 2012
    ..A correct diagnosis is essential for the management of persistent thrombocytosis...
  10. ncbi request reprint High dose immunoglobulin (IVIG) may reduce the incidence of Langerhans cell histiocytosis (LCH)-associated central nervous system involvement
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo Prefecture, Japan
    CNS Neurol Disord Drug Targets 8:380-6. 2009
    ....
  11. doi request reprint Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo 676 0812, Japan
    Int J Hematol 90:506-12. 2009
    ..001). Novel measures are required in preventing the development of DI in MSB-type LCH patients with "risk" bone lesions...
  12. doi request reprint M-protein-positive chronic active Epstein-Barr virus infection: features mimicking HIV-1 infection
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, 1 10 41 Nakasuji Takasago, Hyogo, Japan
    Int J Hematol 90:235-8. 2009
    ..In addition, such clinical features mimic HIV-1 infection. We report here a case of CAEBV with M-protein detected which may shed a new light on the pathogenesis of this disease...
  13. ncbi request reprint Treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in young adults: a report from the HLH study center
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Med Pediatr Oncol 41:103-9. 2003
    ..Early etoposide treatment has been confirmed to be effective in children. However, it is unclear whether the same treatment is useful in adults...
  14. ncbi request reprint Chronic myeloid leukemia in a patient with chronic idiopathic thrombocytopenic purpura: rapid response to imatinib mesylate (STI571)
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Med Pediatr Oncol 41:159-60. 2003
  15. doi request reprint Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH Study Group
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo Prefecture, Japan 676 0812
    Haematologica 93:615-8. 2008
    ....
  16. ncbi request reprint Sensorineural hearing loss in a case of familial hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Division of Pediatrics, Kyoto City Hospital, Kyoto, Japan
    Pediatr Blood Cancer 49:856-8. 2007
    ....
  17. ncbi request reprint Fatal hemophagocytic lymphohistiocytosis with clonal and granular T cell proliferation in an infant
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Mibu, Kyoto, Japan
    Acta Haematol 110:217-9. 2003
  18. ncbi request reprint Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, Takasago, Japan
    Pediatr Blood Cancer 50:308-11. 2008
    ..In rare cases, patients with Langerhans cell histiocytosis (LCH) develop neurodegenerative CNS disease (ND-CNS-LCH). Management of ND-CNS-LCH has not been established...
  19. ncbi request reprint Etoposide-related secondary acute myeloid leukemia (t-AML) in hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo Prefecture, Japan
    Pediatr Blood Cancer 48:121-3. 2007
  20. ncbi request reprint Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: analysis of 96 patients
    Shinsaku Imashuku
    Division of Paediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago City, Hyogo Prefecture, Japan
    Eur J Pediatr 164:315-9. 2005
    ..Future novel diagnostic measures are required to define the precise nature of HLH in group 5...
  21. ncbi request reprint Response to imatinib mesylate in a patient with idiopathic hypereosinophilic syndrome associated with cyclic eosinophil oscillations
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, Takasago 676 0812, Japan
    Int J Hematol 81:310-4. 2005
    ..Although imatinib mesylate is a choice of treatment for patients with HES, its precise molecular mechanism in individual cases remains to be clarified...
  22. ncbi request reprint Pineal dysfunction (low melatonin production) as a cause of sudden death in a long-term survivor of Langerhans cell histiocytosis?
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Med Pediatr Oncol 41:151-3. 2003
  23. doi request reprint Treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH); update 2010
    Shinsaku Imashuku
    Division of Pediatrics and Hematology, Takasago seibu Hospital, Tagasago, Japan
    J Pediatr Hematol Oncol 33:35-9. 2011
    ....
  24. ncbi request reprint Management of severe neutropenia with cyclosporin during initial treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis
    S Imashuku
    Division of Pediatrics, Children s Research Hospital, Kyoto Prefectural University of Medicine Japan
    Leuk Lymphoma 36:339-46. 2000
    ..Improved neutrophil recovery as a result of CSA treatment makes it possible to continue immunochemotherapy safely and obtain improved patient outcomes...
  25. ncbi request reprint Splenectomy in haemophagocytic lymphohistiocytosis: report of histopathological changes with CD19+ B-cell depletion and therapeutic results
    S Imashuku
    Division of Paediatrics, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Br J Haematol 108:505-10. 2000
    ..Further study is needed to establish the therapeutic value of splenectomy in this disease...
  26. ncbi request reprint Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH)
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Leuk Lymphoma 39:37-49. 2000
    ....
  27. ncbi request reprint Advances in the management of hemophagocytic lymphohistiocytosis
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Japan
    Int J Hematol 72:1-11. 2000
    ..Currently, 30% to 40% of HLH cases have a poor outcome. It is necessary for hematologists to cooperate with specialists in other fields so that early diagnosis, which is critical for improvements in outcome, can be made...
  28. ncbi request reprint Bone marrow changes mimicking myelodysplasia in patients with hemophagocytic lymphohistiocytosis
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Japan
    Int J Hematol 72:353-7. 2000
    ..The impact of these findings on pathophysiology and prognosis in HLH patients remains to be determined...
  29. ncbi request reprint Requirement for etoposide in the treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    S Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Japan
    J Clin Oncol 19:2665-73. 2001
    ..We sought to identify the clinical variables most critical to successful treatment of Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH)...
  30. doi request reprint Treatment of patients with hypothalamic-pituitary lesions as adult-onset Langerhans cell histiocytosis
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago 676 0812, Japan
    Int J Hematol 94:556-60. 2011
    ..Early diagnosis and initiation of treatment are required to improve the outcome of CNS-LCH in adult patients...
  31. ncbi request reprint Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, 1 2 Higashi Takada cho, Mibu, Nakagyo ku, Kyoto 604 8854, Japan
    Crit Rev Oncol Hematol 44:259-72. 2002
    ....
  32. ncbi request reprint Low natural killer activity and central nervous system disease as a high-risk prognostic indicator in young patients with hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Cancer 94:3023-31. 2002
    ..To the authors' knowledge, it remains to be determined whether persistently low natural killer cell (NK) activity and a high incidence of central nervous system (CNS) disease increase the probability of FHL...
  33. ncbi request reprint Biomarker and morphological characteristics of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis
    S Imashuku
    Division of Pediatrics, Children s Research Hospital, Kyoto Prefectural University of Medicine, Japan
    Med Pediatr Oncol 31:131-7. 1998
    ..Although the immunological characteristics of EB-VAHS were previously reported, data on non-EB-VAHS were sporadic and fragmentary. This study has compared the clearly distinguishable groups of EBV-positive vs. EBV-negative HLH cases...
  34. ncbi request reprint Longitudinal follow-up of patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Haematologica 89:183-8. 2004
    ..The main purpose of this study was to determine the outcome of the EBV-HLH patients treated between 1992 and 2001...
  35. ncbi request reprint Early blastic transformation following complete cytogenetic response in a pediatric chronic myeloid leukemia patient treated with imatinib mesylate
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:320-2. 2004
    ..CML patients who respond slowly to imatinib may still be candidates for allo-SCT, even when a major cytogenetic response is obtained...
  36. ncbi request reprint Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child
    Aya Ogami
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:427-30. 2004
    ..Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare...
  37. ncbi request reprint Characteristic perforin gene mutations of haemophagocytic lymphohistiocytosis patients in Japan
    Ikuyo Ueda
    Department of Paediatrics, and Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Br J Haematol 121:503-10. 2003
    ..Examination of the geographical origins of the ancestors in the perforin-mutant HLH patients revealed that they mostly came from the Western part of Japan, suggesting that the present-day cases may largely derive from a common ancestor...
  38. ncbi request reprint A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 83:51-4. 2006
    ....
  39. ncbi request reprint [Chronic Epstein-Barr virus infection]
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital
    Nihon Rinsho 63:503-7. 2005
  40. ncbi request reprint Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kajiicho 465 Hirokoji, Kamigyoku, Kyoto 602 8566, Japan
    Br J Haematol 117:525-30. 2002
    ..Only one case of T lineage ALL expressed a small-sized isoform of Helios (designated as He6). It was also found that the expression of Ai1 and He1 was low in Ik6-positive patients (Fisher's exact test; Ai1 P = 0.005, Hel P = 0.035)...
  41. ncbi request reprint Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis: Results from the Japan Langerhans Cell Histiocytosis Study Group-96 protocol study
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Cancer 107:613-9. 2006
    ..To overcome these issues, the Japan LCH Study Group-96 (JLSG-96) protocol was conducted prospectively from 1996 to 2001 in Japan...
  42. ncbi request reprint Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis
    Tomoko Teramura
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Leuk Lymphoma 43:173-9. 2002
    ..These results suggest that the quantitative analysis of cell-free EBV genome copy number is useful for evaluating disease activity and for predicting the response to therapy in EBV-HLH...
  43. ncbi request reprint Association of transforming growth factor-beta1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases
    Kanako Hatta
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamigyo ku, Kyoto, Japan
    Haematologica 92:1470-4. 2007
    ..In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases...
  44. ncbi request reprint Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Hematol 82:427-32. 2007
    ..None had homozygous nonsense mutations. Our data suggest that nonsense perforin gene mutations yield early onset and missense mutations late onset in FHL2 cases...
  45. doi request reprint Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
    Gen Kano
    Department of Paediatrics, Kyoto Prefectural University of Medicine, Japan
    Leuk Lymphoma 49:965-73. 2008
    ....
  46. ncbi request reprint Impact of glutathione S-transferase gene deletion on early relapse in childhood B-precursor acute lymphoblastic leukemia
    Mami Takanashi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    Haematologica 88:1238-44. 2003
    ..However, results of previous reports have been controversial. This study was undertaken to clarify the influence of GST polymorphism on the outcome of childhood B-precursor acute lymphoblastic leukemia (ALL)...
  47. ncbi request reprint Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL)
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pediatr Blood Cancer 46:482-8. 2006
    ..Classification of familial hemophagocytic lymphohistiocytosis (FHL) into FHL2, FHL3, and other subtypes based on genetic abnormalities has recently become possible. We studied the phenotypic differences among these subtypes in Japan...
  48. ncbi request reprint Risk of etoposide-related acute myeloid leukemia in the treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Int J Hematol 75:174-7. 2002
    ..An appropriate dosage of etoposide for the treatment of EBV-HLH would be in the range of 1,000 to 3,000 mg/m2. However, even at these doses, care must be taken to prevent the rare risk of t-AML...
  49. ncbi request reprint Successful non-T-cell-depleted HLA-haploidentical 3-loci mismatched bone marrow transplantation
    Shigeki Yagyu
    Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan
    Eur J Haematol 74:529-32. 2005
    ..Our case suggests that non-TCD HLA-haploidentical 3-loci mismatched BMT can be safely performed from mother to offspring even when feto-maternal microchimerism is barely detectable with the current detection procedure...
  50. ncbi request reprint Use of rituximab to treat refractory Diamond-Blackfan anemia
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Eur J Haematol 74:442-4. 2005
    ..Rituximab may be a successful therapy for refractory DBA where B cells play a crucial role in the pathogenesis of the severe anemia...
  51. ncbi request reprint Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11)
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kaiji cho, Hirokoji, Kamigyo ku, Kyoto, Japan
    Genes Chromosomes Cancer 36:413-9. 2003
    ..Through a similar mechanism, we believe that MOZ, fused to an unidentified partner gene at 2p23, may have caused an alteration in histone acetylation, resulting in the development of tMDS in this patient...
  52. ncbi request reprint Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement
    Toshihiko Imamura
    Department of Paediatrics, Kyoto Prefectural University of Medicine, Japan
    Br J Haematol 119:119-21. 2002
    ..001). These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL gene rearrangement in the development of infant ALL, which represents a distinct entity of childhood ALL...
  53. ncbi request reprint High serum values of soluble CD154, IL-2 receptor, RANKL and osteoprotegerin in Langerhans cell histiocytosis
    Rumiko Ishii
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Pediatr Blood Cancer 47:194-9. 2006
    ..To determine useful biochemical markers in Langerhans cell histiocytosis (LCH), we analyzed the serum levels of soluble CD154 (sCD154), IL2 receptor (sIL2-R), receptor activator of NF-kappaB ligand (sRANKL), and osteoprotegerin (OPG)...
  54. ncbi request reprint Cerebellar ataxia in pediatric patients with Langerhans cell histiocytosis
    Shinsaku Imashuku
    Division of Pediatrics, Kyoto City Hospital and Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    J Pediatr Hematol Oncol 26:735-9. 2004
    ..Brain magnetic resonance imaging is strongly recommended for early detection of cerebellar lesions, but it remains to be determined whether there are any therapeutic measures to prevent exacerbation of CNS disease...
  55. ncbi request reprint Non-T-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation from a family donor based on fetomaternal microchimerism in pediatric hematologic malignancies
    Hiroyuki Ishida
    Division of Pediatrics, Matsushita Memorial Hospital, Osaka, Japan
    J Pediatr Hematol Oncol 26:68-71. 2004
    ..Both of these patients have maintained complete remission for more than 8 months post-SCT. Non-T-cell-depleted SCT from haploidentical HLA 2 loci-mismatched family donors seems feasible if microchimerism is detectable...
  56. ncbi request reprint Hb Bristol-Alesha presenting thalassemia-type hyperunstable hemoglobinopathy
    Gen Kano
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 80:410-5. 2004
    ....
  57. ncbi request reprint Detection of myelodysplastic syndrome/ acute myeloid leukemia evolving from aplastic anemia in children, treated with recombinant human G-CSF
    Shinsaku Imashuku
    Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan
    Haematologica 88:ECR31. 2003
    ..125). There were no cases of overt AML in either cohort. Interpretation and Conclusions: G-CSF therapy did not increase the risk of t-MDS/AML development in children with aplastic anemia over a median follow-up of 3.7 years..
  58. ncbi request reprint Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy
    Toshihiko Imamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kajii cho Hirokoji Kamigyo ku, Kyoto, Japan
    Leuk Lymphoma 46:729-35. 2005
    ..Careful management is required to prevent such episodes in patients with markedly decreased coagulation factors and increased D-dimer levels following L-asparaginase administration...
  59. ncbi request reprint Hemophagocytic syndrome associated with severe adenoviral pneumonia: usefulness of real-time polymerase chain reaction for diagnosis
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 77:295-8. 2003
    ..This approach may provide important clues for improving outcomes and clarifying the exact etiology in cases of often fatal, infection-associated HPS...
  60. ncbi request reprint High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis
    Tomohito Yagi
    Department of Pediatrics, Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Blood 99:1350-5. 2002
    ..Thus, the pathogenesis of myelomonocytic/monocytic AML may involve aberrant regulation of apoptosis due to unscheduled expression of the Ik6 isoform...
  61. ncbi request reprint A novel missense mutation (1060G --> C) in the phosphoglycerate kinase gene in a Japanese boy with chronic haemolytic anaemia, developmental delay and rhabdomyolysis
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Br J Haematol 122:1009-13. 2003
    ..The patient developed the full clinical symptoms of PGK1 deficiency including haemolytic anaemia, myopathy, central nervous system disorder and growth retardation, which is unusual...
  62. ncbi request reprint Successful treatment of congenital systemic juvenile xanthogranuloma with Langerhans cell histiocytosis-based chemotherapy
    Takuya Nakatani
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Pediatr Hematol Oncol 26:371-4. 2004
    ..The LCH-based multiagent chemotherapy including cytarabine, vincristine, methotrexate, and prednisolone ameliorated the symptoms rapidly. She was treated for 12 months and is currently doing well as a normally developing 2-year-old...
  63. doi request reprint The central nervous system complications of bone marrow transplantation in children
    Shoko Yoshida
    Department of Radiology, Kyoto City Hospital, 1 2 Higashi Takada cho, Mibu, Nakagyo ku, Kyoto, 604 8845, Japan
    Eur Radiol 18:2048-59. 2008
    ..CNS complications can be life-threatening for immunosuppressed children, so accurate diagnosis is important for prompt and appropriate treatment...
  64. pmc Deferasirox reduces oxidative stress in patients with transfusion dependency
    Katsuyasu Saigo
    Faculty of Pharmacological Sciences, Himeji Dokkyo University, 7 Kami ohno, Himeji, Hyogo, Japan
    J Clin Med Res 5:57-60. 2013
    ..We monitored oxidative status and serum ferritin levels after in vivo administration of deferasirox (DFS) and studied the in vitro effects of iron chelators on neutrophil function...
  65. ncbi request reprint Prognostic value of early response to treatment combined with conventional risk factors in pediatric acute lymphoblastic leukemia
    Akira Morimoto
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
    Int J Hematol 81:228-34. 2005
    ..Our new prognostic definition (R1, R2, R3) incorporating day 14 marrow findings is useful to tailor early-phase treatments for better therapeutic results in childhood ALL...
  66. ncbi request reprint Molecular diagnosis and recent therapeutic results of fatal infectious mononucleosis
    Shinsaku Imashuku
    Am J Clin Pathol 118:805-6. 2002
  67. ncbi request reprint A preparatory regimen of total body irradiation, busulphan and melphalan for allogeneic bone marrow transplantation in childhood high-risk leukemia and lymphoma
    Takao Yoshihara
    Department of Pediatrics, Matsushita Memorial Hospital, 5 55, Sotojima cho, Moriguchi Shi, Osaka, 570 8540, Japan
    Anticancer Res 23:1739-42. 2003
    ....
  68. ncbi request reprint Evolution of myelodysplastic syndrome and acute myelogenous leukaemia in children with hepatitis-associated aplastic anaemia
    Akira Ohara
    First Department of Pediatrics, Toho University School of Medicine, Tokyo, Japan
    Br J Haematol 116:151-4. 2002
    ..The incidence of MDS/AML in severe HAA patients who did not receive BMT (n = 30, 27.0 +/- 10.8%) appeared to be similar to that of severe idiopathic AA patients (n = 155, 14.7 +/- 3.7%) treated in the same period...
  69. ncbi request reprint Treatment responses of childhood aplastic anaemia with chromosomal aberrations at diagnosis
    Shouichi Ohga
    Aplastic Anaemia Committee of the Japanese Society of Paediatric Haematology, Tokyo, Japan
    Br J Haematol 118:313-9. 2002
    ..These results suggest that IST can be applied as the initial therapy for AA with cytogenetic abnormalities in the absence of completely matched donors...
  70. ncbi request reprint Risk-directed treatment of infant acute lymphoblastic leukaemia based on early assessment of MLL gene status: results of the Japan Infant Leukaemia Study (MLL96)
    Keiichi Isoyama
    Department of Paediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan
    Br J Haematol 118:999-1010. 2002
    ..Novel therapeutic initiatives are warranted for infants with MLL+ disease, particularly those with initial CNS leukaemic involvement or age less than 6 months, or both...
  71. ncbi request reprint Constitutional pericentric inversion of chromosome 9 and haemopoietic stem cell transplantation: delayed engraftment
    Shinsaku Imashuku
    Br J Haematol 118:1195-6. 2002
  72. ncbi request reprint [A woman complicated with immune thrombocytopenic purpura, subclinical Graves disease and peripheral neuropathy 5 years after allogeneic bone marrow transplantation]
    Hiroyuki Ishida
    Division of Pediatrics, Matsushita Memorial Hospital
    Rinsho Ketsueki 46:1123-8. 2005
    ..The level of thyroglobulin in the donor, who had not developed Graves disease, was also elevated, indicating that late onset-subclinical Graves disease was caused by donor lymphocytes that were autoreactive to the thyroid glands...
  73. doi request reprint Increased incidence of adamantane-resistant influenza A(H1N1) and A(H3N2) viruses during the 2006-2007 influenza season in Japan
    Reiko Saito
    J Infect Dis 197:630-2; author reply 632-3. 2008
  74. ncbi request reprint Identification of a gene expression signature associated with pediatric AML prognosis
    Tomohito Yagi
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Blood 102:1849-56. 2003
    ....
  75. ncbi request reprint Serial morphologic observation of bone marrow in aplastic anemia in children
    Fumio Bessho
    Department of Pediatrics, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Int J Hematol 81:400-4. 2005
    ..An elucidation of the role of mast cells may provide information about the differences between aplastic anemia and MDS or about the transition of aplastic anemia to MDS...