Kikuko Hotta

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Replication study of 15 recently published Loci for body fat distribution in the Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 20:336-50. 2013
  2. doi request reprint Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:647-51. 2011
  3. doi request reprint Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:716-9. 2011
  4. ncbi request reprint Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto, Japan
    J Hum Genet 57:46-51. 2012
  5. doi request reprint Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto, Japan
    J Hum Genet 57:305-10. 2012
  6. pmc Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Japan
    BMC Med Genet 11:172. 2010
  7. doi request reprint Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
    Takuya Kitamoto
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Hum Genet 132:783-92. 2013
  8. ncbi request reprint NUDT3 rs206936 is associated with body mass index in obese Japanese women
    Aya Kitamoto
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Endocr J 60:991-1000. 2013
  9. ncbi request reprint Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits
    Aya Kitamoto
    Medical Research Support Center, Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Endocr J 61:683-9. 2014
  10. ncbi request reprint Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease
    Takuya Kitamoto
    Medical Research Support Center, Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 59:241-6. 2014

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Replication study of 15 recently published Loci for body fat distribution in the Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 20:336-50. 2013
    ..This study used CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to fat distribution are associated with visceral fat area (VFA) and subcutaneous fat area (SFA) in the Japanese population...
  2. doi request reprint Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:647-51. 2011
    ..SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome...
  3. doi request reprint Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 56:716-9. 2011
    ..022 in women). None of the other SNPs were significantly associated with SFA. Our results suggest that there is a VFA-specific genetic factor and that a polymorphism in the SH2B1 gene influences the risk of visceral fat accumulation...
  4. ncbi request reprint Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto, Japan
    J Hum Genet 57:46-51. 2012
    ..00039 and 0.00059, respectively) were observed in women, but not in men. Our results suggest that polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women...
  5. doi request reprint Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto, Japan
    J Hum Genet 57:305-10. 2012
    ..Our results suggest that two SNPs in the FTO gene are associated with subcutaneous fat accumulation. The contributions of other SNPs are inconclusive because of a limitation of the sample power...
  6. pmc Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Japan
    BMC Med Genet 11:172. 2010
    ..We investigated whether this SNP is associated with the occurrence and progression of nonalcoholic fatty liver disease (NAFLD) in the Japanese population...
  7. doi request reprint Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
    Takuya Kitamoto
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Hum Genet 132:783-92. 2013
    ..Polymorphisms in the SAMM50 and PARVB genes in addition to those in the PNPLA3 gene were observed to be associated with the development and progression of NAFLD...
  8. ncbi request reprint NUDT3 rs206936 is associated with body mass index in obese Japanese women
    Aya Kitamoto
    EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Endocr J 60:991-1000. 2013
    ..This significant association was not observed in the men. The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio. Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women. ..
  9. ncbi request reprint Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits
    Aya Kitamoto
    Medical Research Support Center, Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Endocr J 61:683-9. 2014
    ..Our data suggest variations in GCKR and TRIB1 are involved in the development of nonalcoholic fatty liver disease. ..
  10. ncbi request reprint Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease
    Takuya Kitamoto
    Medical Research Support Center, Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Hum Genet 59:241-6. 2014
    ..1 × 10(-6)) and NAS (P=3.4 × 10(-6)). Our results suggested that variations, including insertion/deletions, in PARVB, as well as those in PNPLA3, are important in the progression of NAFLD...
  11. ncbi request reprint [New insight of genome-wide association study (GWAS)]
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine
    Nihon Rinsho 71:231-6. 2013
    ..GWAS will highlight a better understanding of the underlying molecular mechanisms in the regulation of obesity and distribution of body fat...