Research Topics
Species | Tomohide HoriSummaryAffiliation: Kyoto University Graduate School of Medicine Location: Kyoto, Japan Summary: Hepatobiliary and pancreatic suregry Liver transplantation Transplant immunology Liver regeneration Grants: 2008 Grants-in-Aid for Scientific Research 2009 The Uehara Memorial Foundation Publications
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Detail Information
Publications
Living-donor liver transplantation for moderate or severe porto-pulmonary hypertension accompanied by pulmonary arterial hypertension: a single-centre experience over 2 decades in JapanEri Ogawa
Divisions of Hepato Pancreato Biliary and Transplant Surgery, Department of Surgery, Kyoto University Hospital, 54 Shogoinkawara cho Sakyo ku, Kyoto, 606 8507, Japan
J Hepatobiliary Pancreat Sci 19:638-49. 2012..Poor outcomes of PPHTN contraindicate OLT. There are no guidelines for living-donor liver transplantation (LDLT) in PPHTN patients...- Muromonab-CD3 therapy for refractory rejections after liver transplantation: a single-center experience during two decades in JapanDaisuke Ueda
Divisions of Hepato Pancreato Biliary and Transplant Surgery, Department of Surgery, Kyoto University Hospital, 54 Shogoinkawara cho, Sakyo ku, Kyoto, 606 8507, Japan
J Hepatobiliary Pancreat Sci 17:885-91. 2010..Refractory rejections still occur in the liver transplantation (LT) field. The aim of this study was to investigate significant factors for the introduction of therapy with muromonab-CD3 (MCD3) after LT... - Hashimoto's encephalopathy after interferon therapy for hepatitis C virus in adult liver transplant recipient accompanied by post-transplant lymphoproliferative disorder related to Epstein-Barr virus infectionT Hori
Department of Transplant Surgery, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
Transpl Infect Dis 12:347-52. 2010..Molecular-targeted therapy was given for recurrent PTLD, based on analysis of sampling specimens. This therapy was effective, but tumor lysis syndrome occurred, and the patient died at 5.3 years after LDLT... - Pediatric orthotopic living-donor liver transplantation cures pulmonary hypertension caused by Abernethy malformation type IbTomohide Hori
Department of Hepato Pancreato Biliary, Transplant and Pediatric Surgery, Kyoto University Hospital, Kyoto, Japan
Pediatr Transplant 15:e47-52. 2011..Although the mPAP temporarily increased above the mean arterial pressure, mPAP was stable during OLDLT. FNH and steatosis were confirmed histopathologically. In summary, pediatric OLDLT was performed successfully in PH caused by PSS... - Does a positive lymphocyte cross-match contraindicate living-donor liver transplantation?Tomohide Hori
Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan
Surgery 147:840-4. 2010..There is still no consensus on the importance of lymphocyte cross-matching (LCM) in the field of living-donor liver transplantation (LDLT)... - Herpes simplex virus hepatitis after pediatric liver transplantationT Hori
Department of Hepato Pancreato Biliary, Transplant and Pediatric Surgery, Kyoto University Hospital, Kyoto, Japan
Transpl Infect Dis 12:353-7. 2010..We conclude that well considered therapy based on the real-time detection of HSV hepatitis is indispensable for the further improvements of outcome in HSV hepatitis after LRLT... - Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulationMie Torii
Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, Tsu, Japan
Eur J Immunol 40:787-96. 2010..Our data suggest that TRX suppresses airway inflammation by inhibiting MIF production thereby limiting the downstream recruitment of eosinophils to the lung independently of modulating systemic Th1/Th2 immunity... 
Fatal impact of lymphocyte cross-matching upon humoral rejection after adult living related liver transplantationTomohide Hori
Transpl Int 23:338-40. 2010- Intentional portal pressure control is key to improving the outcome of living donor liver transplantation: the Kyoto University Hospital experienceYasuhiro Ogura
Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University Hospital
Clin Transpl . 2008..Intentional portal pressure control can be applied in many liver transplantation situations to overcome small-for-size problems... - UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10Linan Wang
Department of Cellular and Molecular Immunology, Mie Graduate School of Medicine, Tsu, Mie, Japan
Immunobiology 215:124-32. 2010.... - Significance of portal venous VEGF during liver regeneration after hepatectomyChiduru Yamamoto
Department of Hepatobiliary and Pancreatic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
J Surg Res 159:e37-43. 2010.... - Portal pressure <15 mm Hg is a key for successful adult living donor liver transplantation utilizing smaller grafts than beforeYasuhiro Ogura
Division of Hepatobiliary Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Liver Transpl 16:718-28. 2010..In conclusion, our strategy for A-LDLT has changed from larger graft-based A-LDLT to controlled portal pressure-based A-LDLT with smaller grafts. A portal pressure <15 mm Hg seems to be a key for successful A-LDLT... 
Comprehensive and innovative techniques for liver transplantation in rats: a surgical guideTomohide Hori
Department of Neuroscience, Mayo Clinic, Birdsall Research Building, Room 323, 4500 San Pablo Road, Jacksonville, Florida, FL 32224, United States
World J Gastroenterol 16:3120-32. 2010..To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery...- Left-sided grafts for living-donor liver transplantation and split grafts for deceased-donor liver transplantation: their impact on long-term survivalTomohide Hori
Divisions of Hepato Biliary Pancreatic, Transplant and Pediatric Surgery, Department of Surgery, Kyoto University Hospital, Kyoto, 606 8507, Japan
Clin Res Hepatol Gastroenterol 36:47-52. 2012..A small-for-size graft is important in living-donor liver transplantation (LDLT) and deceased-donor liver transplantation (DDLT)... - Thrombotic microangiopathy-like disorder after living-donor liver transplantation: a single-center experience in JapanTomohide Hori
Department of Hepato Pancreato Biliary, Kyoto University Hospital, Kyoto 606 8507, Japan
World J Gastroenterol 17:1848-57. 2011..To investigate thrombotic microangiopathy (TMA) in liver transplantion, because TMA is an infrequent but life-threatening complication in the transplantation field... - Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failureFeng Chen
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
Hepatology 53:1294-305. 2011..CONCLUSION: EGFR activation with p38 MAPK/NFκB signaling contributes to the regulation of tight junction integrity in ALF. EGFR activation may thus play an important role in vasogenic brain edema in ALF... - Muromonab-CD3 for the successful treatment of early chronic rejection after pediatric liver transplantation: report of a caseTomohide Hori
Department of Hepato Pancreato Biliary, Transplant, and Pediatric Surgery, Kyoto University Hospital, 54 Shogoinkawara cho, Sakyo ku, Kyoto, 606 8507, Japan
Surg Today 41:585-90. 2011..The ascites and jaundice also disappeared, and the patient's general condition improved. Liver needle biopsies on POD 47 and 61 confirmed dramatic recovery from severe graft damage... - Progressive familial intrahepatic cholestasis: a single-center experience of living-donor liver transplantation during two decades in JapanTomohide Hori
Division of Hepato Biliary Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
Clin Transplant 25:776-85. 2011..Therefore, some PFIC patients require liver transplantation (LT). Although three types of PFIC have been identified, their etiologies include unknown mechanisms... - Progressive familial intrahepatic cholestasisTomohide Hori
Department of Neuroscience, Mayo Clinic in Florida, Jacksonville, FL 32224, USA
Hepatobiliary Pancreat Dis Int 9:570-8. 2010..Three types of progressive familial intrahepatic cholestasis (PFIC) have been identified, but their etiologies include unknown mechanisms... - Living-donor liver transplantation for progressive familial intrahepatic cholestasisTomohide Hori
Division of Hepato Biliary Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Hospital, 54 Shogoinkawara cho, Sakyo ku, Kyoto, 606 8507, Japan
World J Surg 35:393-402. 2011..Progressive familial intrahepatic cholestasis (PFIC) results in liver cirrhosis during the disease course, although the etiology includes unknown mechanisms. Some PFIC patients require liver transplantation (LT)... - Liver transplantation for congenital biliary dilatation: a single-center experienceTomohide Hori
Divisions of Hepato Pancreato Biliary, Transplant and Pediatric Surgery, Department of Surgery, Kyoto University Hospital, Kyoto, Japan
Dig Surg 27:492-501. 2010..There are no definitive guidelines on liver transplantation for congenital biliary dilatation... - Graft loss and poor outcomes after living-donor liver transplantation owing to arterioportal shunts caused by liver needle biopsiesT Hori
Department of Surgery, Kyoto University Hospital, Japan
Transplant Proc 42:2642-4. 2010..Arterioportal shunts (APS) are well-known critical complications after liver transplantation (OLT). The aims of this study were to assess the frequency and causes of APS after OLT and to analyze APS patients with poor outcomes... - Long-term outcomes after living-donor liver transplantation for Alagille syndrome: a single center 20-year experience in JapanT Hori
Am J Transplant 10:1951-2. 2010 - Transperitoneal laparoscopic surgery using endostaplers for adult unilateral diaphragmatic eventrationTomohide Hori
Department of Hepato pancreato biliary and Transplantation Surgery, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
Surg Laparosc Endosc Percutan Tech 19:e46-50. 2009..The postoperative course was uneventful with normalization of the diaphragm. In this paper, we present our modified techniques of transperitoneal minimally invasive surgery for diaphragmatic eventration... - Assessment of liver graft function and regeneration by galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy in adult living-donor liver transplantationTaku Iida
Division of Hepato Biliary Pancreatic Surgery, Mie University, Tsu City, Mie, Japan
Clin Transplant 23:271-7. 2009..We evaluated the graft functional reserve by technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) liver scintigraphy... - Impact of lymph node micrometastasis in hilar bile duct carcinoma patientsKentaro Taniguchi
First Department of Surgery, Mie University School of Medicine, Tsu City, Mie Prefecture, Japan
World J Gastroenterol 12:2549-55. 2006..To immunohistochemically examine micrometastasis and VEGF-C expression in hilar bile duct carcinoma (HBDC) and to evaluate the clinical significance of the results... - K(ICG) value, a reliable real-time estimator of graft function, accurately predicts outcomes in adult living-donor liver transplantationTomohide Hori
First Department of Surgery, School of Medicine, Mie University, Tsu City, Mie Prefecture, Japan
Liver Transpl 12:605-13. 2006..In conclusion, we suggested that K(ICG) values can predict clinical outcomes at the early postoperative period after LDLT by sharply reflecting the influence of systemic dynamics on splanchnic circulation... - Optimal portal venous circulation for liver graft function after living-donor liver transplantationShintaro Yagi
First Department of Surgery, Mie University School of Medicine, Tsu City, Japan
Transplantation 81:373-8. 2006..We investigated optimal portal venous circulation for liver graft function after LDLT in adult recipients retrospectively... - Significance of lymph node micrometastasis in pN0 hilar bile duct carcinomaK Taniguchi
First Department of Surgery, Mie University School of Medicine, 2 174, Edobashi, Tsu City, Mie Prefecture 514 8507, Japan
Eur J Surg Oncol 32:208-12. 2006..To examine micrometastasis in node-negative hilar bile duct carcinoma (HBDC) using an immunohistochemical method and evaluated the clinical significance... - Significance of CT attenuation value in liver grafts following right lobe living-donor liver transplantationTaku Iida
First Department of Surgery, Mie University, Tsu, Mie, Japan
Am J Transplant 5:1076-84. 2005..014). Histological findings revealed that the parenchymal damage was severe in the grafts with low CT-AVs. The CT-AVs in the grafts may be a useful parameter for assessing the allograft functional reserve... - [A case report of advanced gastric remnant cancer treated with extended resection accompanied with reconstructions of the portal vein and the hepatic artery with resultant disease free survival for one year and eight months]Tomohide Hori
First Department of Surgery, Mie University, School of Medicine
Nippon Shokakibyo Gakkai Zasshi 102:190-5. 2005 - Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantationShintaro Yagi
First Department of Surgery, Mie University School of Medicine, 2 174, Edobashi, Tsu City, Mie Prefecture, 514 8507, Japan
Liver Transpl 11:68-75. 2005..Adequate liver regeneration requires an adequate increase in portal venous pressure and flow reflected by clearance of HGF and elevated VEGF levels... - Intrahepatic hepatic vein stenosis after living-related liver transplantation treated by insertion of an expandable metallic stentKentaro Yamagiwa
First Department of Surgery, Mie University School of Medicine, Tsu City, Mie Prefecture, Japan
Am J Transplant 4:1006-9. 2004..The results of an analysis of the venogram and CT volumetric data suggested that the pathogenesis of the stenosis was twisting of the venous trunk during hypertrophy of the liver parenchyma... - [A case of gastric gastrointestinal autonomic nerve tumor of fornix prolapsed into bulbus of the duodenum with ball valve syndrome]Tomohide Hori
Department of Surgery, Yamamoto General Hospital
Nippon Shokakibyo Gakkai Zasshi 100:673-9. 2003 - A rare case of huge gastrointestinal stromal tumor (GIST) of the stomach extending into the posterior mediastinumHideki Machishi
Department of Surgery, Yamamoto General Hospital, Mie, Japan
Dig Dis Sci 47:1492-7. 2002 - Noradrenalin-secreting retroperitoneal schwannoma resected by hand-assisted laparoscopic surgery: report of a caseTomohide Hori
First Department of Surgery, Mie University Graduate School of Medicine, 2-17-4 Edobashi, Tsu, Mie 514-8507, Japan
Surg Today 36:1108-13. 2006..Immunohistologically, the tumor cells were stained with S-100 protein and neuron-specific enolase. Her noradrenalin level normalized immediately after the operation and she remains in good health 3 years 2 months later... - Use of an interpositional venous graft posterior to the pancreas for LDLT patients with portal vein thrombosisShugo Mizuno
First Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
Hepatogastroenterology 54:541-4. 2007..This method provided a shorter rout between the donor and recipient portal vein than a jump graft. Our experience suggests that this solution can be helpful in treating portal vein thrombosis... - Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosisTomohide Hori
Department of Hepatobiliary Pancreatic Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu City, Mie Prefecture, 514 8507, Japan
World J Gastroenterol 13:5918-25. 2007.... - Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammationKanako Saito
Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, Tsu, Japan
J Immunol 181:6889-97. 2008.... - Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunctionTomohide Hori
Department of Hepato pancreato biliary and Transplant Surgery, Kyoto University Hospital, Kyoto, 606 8507, Japan
World J Gastroenterol 14:5933-7. 2008..The patient was finally staged as T2, N0, H0, P0, M(-), stage II. We present the first case of spontaneous necrosis of solid gallbladder adenocarcinoma, with a review of previous studies... - Assessment of cardiac output in liver transplantation recipientsTomohide Hori
Department of Hepato Pancreato Biliary Surgery and Transplantation, Kyoto University Hospital, Sakyo ku, Kyoto, 606 8507, Japan
Hepatobiliary Pancreat Dis Int 7:362-6. 2008..We investigated the clinical advantages of a novel non-invasive method for measuring systemic hemodynamic parameters using indocyanine green (ICG)... - Optimal systemic hemodynamic stability for successful clinical outcomes after adult living-donor liver transplantation: prospective observational studyTomohide Hori
Department of Hepato Pancreato Biliary Surgery and Transplantation, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
J Gastroenterol Hepatol 23:e170-8. 2008..However, identities of optimal systemic hemodynamics for excellent outcomes and precise parameters for clinical strategy remain unclear... - Alloantigen-specific prolongation of allograft survival in recipient mice treated by alloantigen immunization following ultraviolet-B irradiationTomohide Hori
Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu City, Mie Prefecture, 514 8507, Japan
Transpl Immunol 19:45-54. 2008.... - Maximizing venous outflow after right hepatic living donor liver transplantation with a venous graft patchShugo Mizuno
Department of Surgery, Mie University School of Medicine, Tsu, Japan
Dig Surg 25:67-73. 2008..Thus, modified venoplasty with a graft patch in the right hepatic LDLT not only improved hepatic vein hemodynamics (based on the ultrasound findings), but also improved liver function and decreased daily ascitic fluid volume... - Survival rates according to the Cancer of the Liver Italian Program scores of 345 hepatocellular carcinoma patients after multimodality treatments during a 10-year period in a retrospective studyKentaro Yamagiwa
Department of Surgery, Mie Prefectural Shima Hospital, Mie, Japan
J Gastroenterol Hepatol 23:482-90. 2008..This retrospective cohort study of HCC patients was conducted to assess the efficacy of treatment modalities according to the CLIP score... - Improvement of morphological changes after 70% hepatectomy with portocaval shunt: preclinical study in porcine modelTaku Iida
First Department of Surgery, Mie University, Tsu, Japan
J Surg Res 143:238-46. 2007..We have evaluated the use of portocaval shunt (PCS) to control PVF and PVP following partial hepatectomy (PH) to reduce the postoperative liver damage... - Carcinoembryonic antigen-producing adrenal adenoma resected using combined lateral and anterior transperitoneal laparoscopic surgeryTomohide Hori
Department of Hepatobiliary Pancreatic Surgery and Breast Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu City, Mie Prefecture, 514 8507, Japan
World J Gastroenterol 13:6094-7. 2007..We present, to the best of our knowledge, the first case of CEA-producing adrenal adenoma, along with a review of the relevant literature, and discuss our laparoscopic surgery techniques... - Post-immune UV irradiation induces Tr1-like regulatory T cells that suppress humoral immune responsesLinan Wang
Department of Bioregulation, Mie University Graduate School of Medicine, Tsu, Mie, 514 8507, Japan
Int Immunol 20:57-70. 2008..Possible detrimental effects of UV irradiation after vaccination are also discussed... - Liver graft pretreated in vivo or ex vivo by γ-aminobutyric acid receptor regulationTomohide Hori
Division of Transplant and Pediatric Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Neuroscience, Mayo Clinic, Jacksonville, Florida Electronic address
J Surg Res 182:166-75. 2013..Here, the strategic potential of graft pretreatment in vivo and ex vivo by GABAR regulation was investigated... - Liver Transplantation for Primary Hyperoxaluria Type 1: A Single-center Experience during Two Decades in JapanTomohide Hori
Divisions of Hepato Pancreato Biliary, Transplant and Pediatric Surgery, Department of Surgery, Kyoto University, 54 Shogoinkawara cho, Sakyo ku, Kyoto, 606 8507, Japan
World J Surg 37:688-93. 2013..A definitive diagnosis is often delayed until ESRD appears. Based on the etiology, liver transplantation (LT) seems to be the definitive treatment... - Hepatic arterial reconstruction for orthotopic liver transplantation in the ratTomohide Hori
Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida 32224, USA
J Surg Res 178:907-14. 2012..Orthotopic liver transplantation (OLT) models in rats have been investigated in many studies. The reconstruction of hepatic artery is required for reliable OLT and also requires advanced skills... - How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living-donor liver transplantation: strategy for donor safety with a smaller-size graft and excellent recipient resultsTomohide Hori
Division of Hepato Biliary Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Hospital, Kyoto, Japan
Clin Transplant 26:E324-34. 2012..The kICG/graft weight value may have potential as a parameter for optimal PVF and a predictor for LDLT results...