Kouji Hirota

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs
    Kouji Hirota
    Cellular and Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama 351 0198, Japan
    Nature 456:130-4. 2008
  2. ncbi Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling
    Kouji Hirota
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Japan
    Epigenetics 4:5-7. 2009
  3. ncbi Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses
    Kouji Hirota
    Genetic Dynamics Research Unit Laboratory, RIKEN Institute of Physical and Chemical Research, Wako Shi, Saitama 351 0198, Japan
    Nucleic Acids Res 32:855-62. 2004
  4. ncbi The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination
    Yong Qing
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS Genet 7:e1002148. 2011
  5. ncbi Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling
    Kouji Hirota
    Genetic System Regulation Laboratory, RIKEN The Institute of Physical and Chemical Research, Discovery Research Institute, Wako Shi, Saitama 351 0198, Japan
    Eukaryot Cell 5:1980-9. 2006
  6. ncbi Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26
    Kouji Hirota
    Shibata Distinguished Senior Scientist Laboratory, RIKEN Discovery Research Institute, Wako Shi, Saitama 351 0198, Japan
    Mol Biol Cell 19:1162-73. 2008
  7. ncbi Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
    Kimiyo N Yamamoto
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:6492-6. 2011
  8. ncbi Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot
    Kouji Hirota
    Genetic Dynamics Research Unit Laboratory, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 0198, Japan
    Genetics 165:505-15. 2003
  9. ncbi KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents
    Kazunori Yoshikiyo
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:21553-7. 2010
  10. ncbi The USP1/UAF1 complex promotes double-strand break repair through homologous recombination
    Junko Murai
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 31:2462-9. 2011

Collaborators

Detail Information

Publications15

  1. ncbi Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs
    Kouji Hirota
    Cellular and Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama 351 0198, Japan
    Nature 456:130-4. 2008
    ..Our results demonstrate that transcription through the promoter region is required to make DNA sequences accessible to transcriptional activators and to RNAPII...
  2. ncbi Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling
    Kouji Hirota
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Japan
    Epigenetics 4:5-7. 2009
    ..Here, we hypothesize that RNAPII transcription of mlonRNAs disrupts chromatin array. This idea may provide a new clue to understand why so many species of ncRNAs are expressed in eukaryotic cells...
  3. ncbi Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses
    Kouji Hirota
    Genetic Dynamics Research Unit Laboratory, RIKEN Institute of Physical and Chemical Research, Wako Shi, Saitama 351 0198, Japan
    Nucleic Acids Res 32:855-62. 2004
    ..Such a role for these proteins may serve as a paradigm for the regulation of stress response in higher eukaryotes...
  4. ncbi The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination
    Yong Qing
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS Genet 7:e1002148. 2011
    ..We suggest that BRCA2 might thus serve as a platform to recruit various RAD51 mediators at the appropriate position at the DNA-damage site...
  5. ncbi Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling
    Kouji Hirota
    Genetic System Regulation Laboratory, RIKEN The Institute of Physical and Chemical Research, Discovery Research Institute, Wako Shi, Saitama 351 0198, Japan
    Eukaryot Cell 5:1980-9. 2006
    ..This notion provides new insights into the molecular mechanisms of the Tup family corepressors in gene regulation...
  6. ncbi Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26
    Kouji Hirota
    Shibata Distinguished Senior Scientist Laboratory, RIKEN Discovery Research Institute, Wako Shi, Saitama 351 0198, Japan
    Mol Biol Cell 19:1162-73. 2008
    ..Thus, we propose that multiple chromatin modulators regulate chromatin structure reversibly and participate in the regulation of both meiotic recombination and stress-induced transcription around CRE-like sequences...
  7. ncbi Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
    Kimiyo N Yamamoto
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:6492-6. 2011
    ..Our findings thus suggest that ubiquitylated FANCD2 recruits SLX4 to DNA damage sites, where it mediates the resolution of recombination intermediates generated during the processing of ICLs...
  8. ncbi Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot
    Kouji Hirota
    Genetic Dynamics Research Unit Laboratory, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 0198, Japan
    Genetics 165:505-15. 2003
    ..These observations suggest that these fission yeast Tup1-like corepressors repress chromatin remodeling at CRE-related sequences and that Rst2 antagonizes this function...
  9. ncbi KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents
    Kazunori Yoshikiyo
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:21553-7. 2010
    ....
  10. ncbi The USP1/UAF1 complex promotes double-strand break repair through homologous recombination
    Junko Murai
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 31:2462-9. 2011
    ..Disruption of NHEJ in UAF1-deficient cells restored cellular resistance to camptothecin and the PARP inhibitor. Our results indicate that the USP1/UAF1 complex promotes HR, at least in part by suppressing NHEJ...
  11. ncbi Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity
    Terry John Evans
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo ku, Kyoto 606 8501, Japan
    DNA Repair (Amst) 9:1292-8. 2010
    ..Our panel of mutants is likely to be useful in screening large compound libraries for an emerging class of chemotherapeutic drugs, which includes inhibitors of DNA repair enzymes such as PARP and DNA polymerases...
  12. ncbi DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken
    Masaoki Kohzaki
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 189:1117-27. 2010
    ..Together, these data define a role for Polnu and Pol in recombination and suggest that the DNA synthesis associated with Ig gene conversion is accounted for by three specialized DNA polymerases...
  13. ncbi Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks
    Mari Fujita
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo ku, Kyoto, Japan
    PLoS ONE 8:e60043. 2013
    ....
  14. ncbi Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands
    Takeo Narita
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 15:1228-39. 2010
    ..This unexpected enzymatic property of Polδ in the bypass of UV photoproducts challenges the received notion that the accuracy of Polδ prevents bypassing damaged templates...
  15. ncbi Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences
    Koji Kikuchi
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Kyoto 606 8501, Japan
    J Biol Chem 284:26360-7. 2009
    ..Conversely, the overexpression of Blm, even an ATPase-defective mutant, strongly stimulated gene targeting. In summary, Blm promotes HR between diverged sequences through a novel ATPase-independent mechanism...