Osamu Handa

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. pmc Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Med Gas Res 2:23. 2012
  2. doi request reprint Redox biology and gastric carcinogenesis: the role of Helicobacter pylori
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 16:1-7. 2011
  3. doi request reprint Helicobacter pylori: a ROS-inducing bacterial species in the stomach
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kajiicho, Kawaramachidori Hirokouji Agaru, Kamigyou ku, Kyoto, 602 8566, Japan
    Inflamm Res 59:997-1003. 2010
  4. ncbi request reprint CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling
    Osamu Handa
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Pharmacol 73:1697-702. 2007
  5. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Japan
    Int J Mol Med 17:997-1004. 2006
  6. doi request reprint Role of metallothionein in murine experimental colitis
    Toshifumi Tsuji
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 31:1037-46. 2013
  7. doi request reprint Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 45:692-702. 2010
  8. doi request reprint Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells
    Tomohisa Takagi
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 25:1259-65. 2010
  9. doi request reprint Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice
    Tetsuya Okayama
    Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 25:141-9. 2009
  10. doi request reprint Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Dig Dis Sci 55:2797-804. 2010

Collaborators

Detail Information

Publications91

  1. pmc Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Med Gas Res 2:23. 2012
    ..abstract:..
  2. doi request reprint Redox biology and gastric carcinogenesis: the role of Helicobacter pylori
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 16:1-7. 2011
    ..Understanding the molecular mechanism of H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer...
  3. doi request reprint Helicobacter pylori: a ROS-inducing bacterial species in the stomach
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kajiicho, Kawaramachidori Hirokouji Agaru, Kamigyou ku, Kyoto, 602 8566, Japan
    Inflamm Res 59:997-1003. 2010
    ..However, the precise mechanism by which Helicobacter pylori induces gastric carcinogenesis is presently unclear...
  4. ncbi request reprint CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling
    Osamu Handa
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Pharmacol 73:1697-702. 2007
    ..Understanding the molecular mechanism by which H. pylori-induced carcinogenesis is important for developing new strategies against gastric cancer...
  5. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Japan
    Int J Mol Med 17:997-1004. 2006
    ..These results suggest that rosuvastatin prevents the development of DSS-induced colitis in mice via the inhibition of mucosal inflammatory responses associated with the preservation of eNOS transcription...
  6. doi request reprint Role of metallothionein in murine experimental colitis
    Toshifumi Tsuji
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 31:1037-46. 2013
    ..These data indicate that MTs play an important role in the prevention of colonic mucosal inflammation in a mouse model of DSS-induced colitis, thus suggesting that endogenous MTs play a protective role against intestinal inflammation...
  7. doi request reprint Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 45:692-702. 2010
    ..In addition, the protective role of PZ and the possible mechanism of its effect on indomethacin-induced small intestinal injury were investigated...
  8. doi request reprint Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells
    Tomohisa Takagi
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 25:1259-65. 2010
    ..In this study, we investigated the therapeutic efficacy of ES in an experimental rat model of colitis, and evaluated the restitution of intestinal epithelial cells treated with ES in vitro...
  9. doi request reprint Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice
    Tetsuya Okayama
    Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 25:141-9. 2009
    ..We examined whether hyperthermia attenuated the metastatic potential of colon cancer through the induction of heat shock protein 70 (Hsp70)...
  10. doi request reprint Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Dig Dis Sci 55:2797-804. 2010
    ..The aim of this study was to investigate whether the inhalation of CO ameliorated 2,4,6-trinitrobenzine sulfonic acid (TNBS)-induced colitis in mice...
  11. ncbi request reprint Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats
    Yutaka Isozaki
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Int J Mol Med 17:497-502. 2006
    ..These results suggest that TMG is effective for the treatment of colitis in rats induced by TNBS. In the future, TMG could be a new therapeutic agent for IBD...
  12. ncbi request reprint Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis
    Yutaka Isozaki
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Scand J Gastroenterol 41:944-53. 2006
    ..The aim of this study was to investigate the anti-inflammatory effects of NM on experimental colitis in rats...
  13. ncbi request reprint Role of the thrombin/protease-activated receptor 1 pathway in intestinal ischemia-reperfusion injury in rats
    Hisato Tsuboi
    Department of Inflammation and Immunology, Kyoto Prefectural Univ of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G678-83. 2007
    ....
  14. doi request reprint Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1
    Hiroyuki Yoriki
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 28:632-8. 2013
    ..Heme oxygenase-1 (HO-1) has recently gained attention for anti-inflammatory and cytoprotective effects. This study aimed to investigate the effects of hemin, an HO-1 inducer, on indomethacin-induced enteritis in mice...
  15. doi request reprint Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Gastroenterol Hepatol 27:70-5. 2012
    ..However, the precise pathogenesis and therapeutic strategy have not been fully revealed. The aim of the present study was to determine the upregulated proteins in the small intestine exposed to indomethacin...
  16. doi request reprint Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa
    Yuji Naito
    Medical Proteomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 23:S250-7. 2008
    ..In the present study, we investigated the correlation between endoscopic findings and iNOS mRNA expression/NO-modified proteins in the gastric mucosa...
  17. doi request reprint Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Dig Dis Sci 56:1663-71. 2011
    ..The purpose of this investigation was to determine whether exogenous CO could modulate intestinal inflammation...
  18. ncbi request reprint Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-gamma ligand, pioglitazone, in rats
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Redox Rep 7:294-9. 2002
    ..In conclusion, activation of PPAR-gamma may represent a novel approach to the treatment of intestinal inflammation induced by ischemia-reperfusion...
  19. pmc Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution
    Tomohisa Takagi
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine 602 8566 Kyoto, Japan
    World J Gastroenterol 17:3802-9. 2011
    ..To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in vitro...
  20. doi request reprint Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: a randomized controlled trial
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 27:1377-83. 2012
    ..The objective of this study is to determine the efficacy of 0.13% hyaluronic acid (HA) solution for high and sustained mucosal elevation during colorectal EMR...
  21. doi request reprint Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 25:S144-8. 2010
    ..The aim of this study was to identify new intestinal proteins potentially associated with acute inflammation using proteomic profiling of an in vivo mice model of ulcerative colitis...
  22. doi request reprint Helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2
    Hirokazu Kajikawa
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Digestion 76:248-55. 2007
    ..We investigated the involvement of PAR2 in the interleukin (IL)-8 production by Helicobacter pylori-infected gastric epithelial cells...
  23. doi request reprint Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 44:30-4. 2009
    ..In the present study, we investigated the mechanism by which indomethacin induced mucosal injury by using an in vitro model of small intestine...
  24. doi request reprint Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis
    Satoshi Kokura
    Kyoto Prefectural University of Medicine, Japan
    Int J Hyperthermia 26:101-7. 2010
    ....
  25. ncbi request reprint Inhibitory effects of catechins on neutrophil-dependent gastric inflammation
    Osamu Handa
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachidori Hirokouji Agaru, Kyoto, Japan
    Redox Rep 7:324-8. 2002
    ..These results suggest that tea may inhibit carcinogenesis partly through the anti-inflammatory effects of tea catechins on PMN-dependent gastric mucosal inflammation...
  26. ncbi request reprint Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade
    Tomohisa Takagi
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 7:283-9. 2002
    ..These data suggest that peroxisome proliferator-activated receptor-gamma may be a novel therapeutic target for the therapy of inflammatory bowel disease...
  27. ncbi request reprint MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid
    Munehiro Kugai
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cell Physiol Biochem 32:942-50. 2013
    ..We assessed the involvement of Multi Drug Resistance (MDR) 1 in intestinal epithelial cell injury caused by aspirin using MDR1 gene-transfected Caco2 cells...
  28. doi request reprint Anoxia/reoxygenation induces epithelial-mesenchymal transition in human colon cancer cell lines
    Manabu Okajima
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Oncol Rep 29:2311-7. 2013
    ..These results indicate that A/R induces EMT in human colon cancer cells through an NF-κB-dependent transcriptional pathway...
  29. doi request reprint BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1
    Akihito Harusato
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Inflamm Bowel Dis 19:740-53. 2013
    ..HO-1 supports the suppression of experimental colitis and localizes mainly in macrophages in colonic mucosa. This study was undertaken to elucidate the Bach1/HO-1 system's effects on the pathogenesis of experimental colitis...
  30. ncbi request reprint Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model
    Ken Inoue
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Biol Pharm Bull 34:1659-65. 2011
    ..These findings suggest that DKT reduces intestinal fibrosis associated with decreasing expression of HSP47 and collagen content in the intestine...
  31. doi request reprint Role of tumor necrosis factor-α in the pathogenesis of indomethacin-induced small intestinal injury in mice
    Kohei Fukumoto
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Int J Mol Med 27:353-9. 2011
    ..TNF-α plays an important role in the pathogenesis of indomethacin-induced small intestinal damage. These results suggest that TNF-α could become a new therapeutic target for NSAID-induced small intestinal damage...
  32. ncbi request reprint Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis
    Kazuhiro Katada
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    Digestion 73:89-100. 2006
    ....
  33. doi request reprint FGF19 protects colonic epithelial cells against hydrogen peroxide
    Kazuhiko Uchiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Digestion 83:180-3. 2011
    ..In the present study, we investigate the anti-apoptosis effect of FGF19 in colonic epithelial cells treated with H₂O₂...
  34. doi request reprint Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells
    Etsuko Kishimoto
    Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G230-8. 2011
    ..We concluded that TRPV1 functions in chemokine production in esophageal epithelial cells, and this function may be regulated by ROS via posttranslational modification of TRPV1...
  35. ncbi request reprint CV-11974, angiotensin II type I receptor antagonist, reduces the severity of indomethacin-induced rat enteritis
    Toshimitsu Okuda
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Dig Dis Sci 53:657-63. 2008
    ....
  36. ncbi request reprint Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells
    Nami Nakabe
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 23:217-24. 2007
    ..In this study, we investigated the effects of hyperthermia on the activation of NF-kappaB and the up regulation of E-selectin and VCAM-1 in human endothelial cells stimulated by TNF-alpha...
  37. doi request reprint Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity
    Shinya Yamada
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Doshisha University, Kyoto, Japan
    J Gastroenterol Hepatol 27:1816-24. 2012
    ..The aim of this study was to characterize specific gene expression profiles of intestinal mucosa in indomethacin-induced small intestinal injury, and to investigate the effects of rebamipide on the expression of these genes...
  38. doi request reprint Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis
    Kazuhiko Uchiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G1163-70. 2012
    ..These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease...
  39. doi request reprint Efficacy of magnifying endoscopy with flexible spectral imaging color enhancement in the diagnosis of colorectal tumors
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Gastroenterol 46:65-72. 2011
    ..We evaluated and compared FICE magnification to narrow-band imaging (NBI) magnification...
  40. doi request reprint Role of nociceptors/neuropeptides in the pathogenesis of visceral hypersensitivity of nonerosive reflux disease
    Norimasa Yoshida
    Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital, 15 749 Honmachi Higashiyama ku, Kyoto, 605 0981, Japan
    Dig Dis Sci 58:2237-43. 2013
    ....
  41. doi request reprint Possibility of ex vivo animal training model for colorectal endoscopic submucosal dissection
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Colorectal Dis 28:49-56. 2013
    ....
  42. doi request reprint Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts
    Kazuhiko Uchiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho Hirokoji Kawaramachi Kamigyo ku, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 391:1122-6. 2010
    ..Our findings demonstrate that CO treatment to MF increased FGF15 expression via inhibition of miR-710 and FGF15 enhanced colonic epithelial cell restitution...
  43. doi request reprint Protective effect of serotonin derivatives on glucose-induced damage in PC12 rat pheochromocytoma cells
    Rosaria Piga
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Br J Nutr 103:25-31. 2010
    ....
  44. doi request reprint Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1
    Tomohisa Takagi
    Kyoto Prefectural University of Medicine, Japan
    J Pharmacol Exp Ther 331:255-64. 2009
    ..Phosphorylation of ERK and Nrf2, activation and nuclear translocation of Nrf2, and oxidation of Keap1 are all involved in the lansoprazole-induced HO-1 up-regulation...
  45. ncbi request reprint Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1
    Tomohisa Takagi
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Sience, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Inflammation 32:83-8. 2009
    ..In conclusion, the inhalation of CO protected mice from the synovial inflammation of CIA. Based on these data, the beneficial effects of CO in murine RA model may be attributed to its anti-inflammatory properties...
  46. ncbi request reprint Antitumor effect of whole body hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer
    Takeshi Hattori
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hyperthermia 23:591-8. 2007
    ..This study investigated the antitumor effects of WBH combined with alpha-GalCer in a mouse subcutaneous tumor model of colon cancer...
  47. ncbi request reprint Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis
    Yuji Naito
    Department of Medical Proteomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 18:821-8. 2006
    ..This transcriptome approach provided insight into genes and putative genetic pathways thought to be affected by stimulation with gastroduodenal refluxates...
  48. ncbi request reprint Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution
    Takahiro Suzuki
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
    J Pharmacol Sci 106:469-77. 2008
    ..These results suggest that rebamipide protects against aspirin-induced gastric mucosal lesions by preserving gastric epithelial cell-to cell integrity in addition to the anti-inflammatory effects...
  49. doi request reprint Effect of hyperthermia combined with gemcitabine on apoptotic cell death in cultured human pancreatic cancer cell lines
    Satoko Adachi
    Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Hyperthermia 25:210-9. 2009
    ..Therefore, we speculated that activated NF-kappaB in a pancreatic cell line might be inhibited by heat treatment, resulting in the enhancement of gemcitabine-induced cytotoxicity...
  50. doi request reprint Heat-shock protein 70-overexpressing gastric epithelial cells are resistant to indomethacin-induced apoptosis
    Ikuhiro Hirata
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Digestion 79:243-50. 2009
    ..In this study, we revealed the effect of overexpressed heat-shock protein 70 (HSP70) in indomethacin-induced apoptosis and oxidative stress...
  51. doi request reprint Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1
    Akifumi Fukui
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G927-36. 2012
    ..Our findings indicate that ASA-induced ROS production can specifically modify the expression of ZO-1 protein and induce increased cell permeability, which may ultimately cause small intestinal mucosal injury...
  52. doi request reprint Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells
    Rosaria Piga
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Br J Nutr 102:264-72. 2009
    ..These results identify a mechanism of action of serotonin derivatives against endothelial damage at a cellular level, and underline their benefits against the disorders and complications related to reactive oxygen species...
  53. ncbi request reprint Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling
    Emiko Manabe
    School of Nursing, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Cell Biochem 103:1925-37. 2008
    ..ASX may prevent the progression of diabetic nephropathy mainly through ROS scavenging effect in mitochondria of mesangial cells and thus is expected to be very useful for the prevention of diabetic nephropathy...
  54. doi request reprint Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice
    Shinya Yamada
    Department of Molecular Gastroenterology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 26:398-404. 2011
    ..To define the role of IL-17A in small intestinal injury and inflammation, we studied the effects of indomethacin administration in mice with targeted deletions of the IL-17A gene...
  55. ncbi request reprint Methylparaben potentiates UV-induced damage of skin keratinocytes
    Osamu Handa
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Toxicology 227:62-72. 2006
    ..These results indicate that MP, which has been considered a safe preservative in cosmetics, may have harmful effects on human skin when exposed to sunlight...
  56. ncbi request reprint Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    World J Gastroenterol 12:2024-30. 2006
    ....
  57. ncbi request reprint Blocking of NF-kappaB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line
    Miho Ueda
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Lett 193:177-82. 2003
    ..Therefore, this study suggests the possibility that blocking of NF-kappaB activity renders gastric cancer cells susceptible to the apoptosis induced by TNF-alpha...
  58. ncbi request reprint The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB
    Satoshi Kokura
    Department of Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Lett 229:223-33. 2005
    ..These results demonstrate that the combination of edaravone with CPT-11 may constitute a new strategy for treating primary and metastatic colon cancer...
  59. doi request reprint Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis
    Tomohisa Takagi
    Biomedical Safety Science, Graduate School of Medical Science, Kyoto Prefectual University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 23:S229-33. 2008
    ..The aim of the present study was to determine the intestinal levels and localization of ho-1 mRNA and HO-1 protein in patients with UC...
  60. doi request reprint Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection
    Takashi Ando
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cancer 125:2595-602. 2009
    ..0464, OR = 2.43, 95% CI = 1.21-4.48). Our results suggest that the HLA class II and IL-10-592A/C polymorphisms synergistically affect the susceptibility to GC development of H. pylori-infected individuals in the Japanese population...
  61. ncbi request reprint Whole body hyperthermia improves obesity-induced insulin resistance in diabetic mice
    Satoshi Kokura
    Biomedical Safety Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Hyperthermia 23:259-65. 2007
    ..In this study, we examined the efficacy of whole body hyperthermia (WBH) on obesity-induced insulin resistance in diabetic mice...
  62. doi request reprint Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer
    Takeshi Ishikawa
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cancer 133:1119-25. 2013
    ..The findings of this study indicate that the assay of whole blood IFN-γ production offers promise for evaluating the clinical response of patients to cancer immunotherapy. ..
  63. doi request reprint Impact of Helicobacter pylori eradication on circulating adiponectin in humans
    Takashi Ando
    Department of Gastroenterology, Social Insurance Kyoto Hospital, Koyamashimofusa cho 27, Kita ku, Kyoto, 603 8151, Japan
    Helicobacter 18:158-64. 2013
    ..Adiponectin is an adipose-derived protein considered to play a significant role in the development of metabolic syndrome. The aim of this study was to clarify the influence of H. pylori infection on circulating adiponectin in humans...
  64. doi request reprint The detection of surface patterns by flexible spectral imaging color enhancement without magnification for diagnosis of colorectal polyps
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Colorectal Dis 27:605-11. 2012
    ..Resolution of FICE has recently been improved. We evaluated diagnostic accuracy for neoplastic and non-neoplastic colorectal polyp differentiation with detection of surface patterns by FICE without magnification...
  65. ncbi request reprint Decrease of the regulatory T-cell population by adoptive T-cell transfer in a mouse colorectal cancer transplant model
    Tsuguhiro Matsumoto
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Oncol Res 19:543-54. 2011
    ..Moreover, Tregs were increased by addition of IFN-gamma mAb. ACT may decrease Tregs in tumor-bearing hosts. One of the mechanisms is considered to be IFN-gamma inhibiting the induction of Tregs...
  66. ncbi request reprint Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori
    Osamu Handa
    Department of Intrernal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Can J Gastroenterol 16:785-9. 2002
    ..These results suggest that polaprezinc, mainly the zinc component, may inhibit H pylori-induced PMN-mediated gastric inflammation by attenuating CD11b/CD18 expression on PMN and IL-8 production from gastric epithelial cells...
  67. ncbi request reprint Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 18:560-9. 2003
    ..To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene...
  68. doi request reprint Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice
    Ikuhiro Hirata
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    Dig Dis Sci 56:1379-86. 2011
    ..Accumulating evidence shows the functions of H(2)S in various models of disease, but rarely in colitis. In this study, we investigated the role of endogenous H(2)S in a dextran sodium sulfate (DSS)-induced colitis model...
  69. ncbi request reprint Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: a nutrigenomic approach
    Yuji Naito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Int J Mol Med 18:685-95. 2006
    ..In addition, the present approach may help us gain a better understanding of the genes and pathways involved in the anti-diabetic mechanism of astaxanthin...
  70. doi request reprint Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency
    Akihito Harusato
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Free Radic Res 45:717-27. 2011
    ..In conclusion, deficiency of the Bach1 gene inhibited apoptosis and thus suppressed mucosal injury, indicating that Bach1 is a novel therapeutic target for indomethacin-induced intestinal injury...
  71. pmc Gastric peroxisome proliferator activator receptor-γ expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats
    Yuji Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:170-7. 2011
    ..In conclusion, activation of gastric epithelial PPAR-γ receptor by its ligands may represent a novel therapeutic approach for gastric inflammation via up-regulation of heat shock proteins and endoplasmic reticulum-related proteins...
  72. ncbi request reprint Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice
    Takeshi Ishikawa
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Clin Exp Metastasis 20:445-50. 2003
    ..These results suggest that the activities of NOS and HO could influence experimental metastasis in an organ-specific manner...
  73. doi request reprint Silver nanoparticles as a safe preservative for use in cosmetics
    Satoshi Kokura
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Nanomedicine 6:570-4. 2010
    ..Ag nanoparticles appear to be suitable for use as a preservative in cosmetics...
  74. pmc Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells
    Hitomi Okada
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 50:47-52. 2012
    ..These data indicate that N(ε)-(hexanoyl)lysine modification of tropomyosin 1 may be related to neoplastic transformation by N-methyl-N'-nitro-N-nitrosoguanidine in gastric epithelial cells...
  75. pmc Transcriptome Analysis for Cytoprotective Actions of Rebamipide against Indomethacin-Induced Gastric Mucosal Injury in Rats
    Yuji Naito
    Medical Proteomics, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 41:202-10. 2007
    ....
  76. doi request reprint Efficacy of hyaluronic acid in endoscopic mucosal resection of colorectal tumors
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto, Japan
    J Gastroenterol Hepatol 26:286-91. 2011
    ..In the present study, we assessed the appropriate concentration of HA for EMR...
  77. pmc Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice
    Satomi Akagiri
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 42:158-66. 2008
    ..These results suggest that BOF decreases the weight and size gains of WAT along with up-regulating UCP1 mRNA in WAT in high-fat diet-fed mice...
  78. ncbi request reprint A novel vitamin E derivative (TMG) protects against gastric mucosal damage induced by ischemia and reperfusion in rats
    Hiroshi Ichikawa
    First Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Dig Dis Sci 48:54-8. 2003
    ..It is concluded that TMG inhibited lipid peroxidation and reduced development of the gastric mucosal inflammation induced by I/R in rats...
  79. pmc A Mouse Model of Metabolic Syndrome; Increase in Visceral Adipose Tissue Precedes the Development of Fatty Liver and Insulin Resistance in High-Fat Diet-Fed Male KK/Ta Mice
    Satomi Akagiri
    Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 42:150-7. 2008
    ..These data indicate that our mouse model would be useful for future studies that investigate the role of visceral WAT and its products in the development of metabolic syndrome...
  80. ncbi request reprint A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice
    Tatsuya Yuba
    Department of Respiratory Molecular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Respir Med 101:793-9. 2007
    ..Overproduction of nitric oxide by nitric oxide synthase (NOS) is thought to promote hyperoxic lung injury. The present study was conducted to examine the role of inducible nitric oxide synthase (iNOS) in hyperoxic lung injury in mice...
  81. ncbi request reprint Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Dig Dis Sci 50:S104-12. 2005
    ..Inhibition of apoptosis-related genes is possibly important for the cytoprotective effect of rebamipide against indomethacin-induced gastric mucosal cell injury...
  82. ncbi request reprint Long fish tapeworm in the intestine: an in situ observation by capsule endoscopy
    Koichi Soga
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
    Intern Med 50:325-7. 2011
    ..The stretching of the strobila by strong peristalsis in the ileum may have resulted in the separation of the caudal portion of the strobila, which descended into the colon and was eventually passed per rectum...
  83. pmc Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin
    Tomohisa Takagi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 48:178-82. 2011
    ..Enolase-1 and albumin were found to be DiBrY modified. These proteins may be responsible for the development of neutrophil-associated intestinal injury induced by indomethacin...
  84. pmc Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells
    Ying Qin
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Biochem Nutr 49:174-81. 2011
    ....
  85. ncbi request reprint alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Antioxid Redox Signal 4:195-206. 2002
    ..NF-kappaB is essential to DSS-induced colitis, suggesting molecular approach targeting of NF-kappaB for treatment of inflammatory bowel disease...
  86. ncbi request reprint Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells
    Rosaria Piga
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Atherosclerosis 193:328-34. 2007
    ..Taken together, these results suggest that either acute hyperglycemic spikes could exert an influence on the onset of diabetic complications and on the development of the atherogenic profile on diabetic and non-diabetic subjects...
  87. doi request reprint Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer
    Tomoko Oya-Ito
    Department of Medical Proteomics, Kyoto Prefectural University of Medicine, 465 Kaji i, Kyoto 602 8566, Japan
    Biochim Biophys Acta 1812:769-81. 2011
    ..Our results suggest that posttranslational modification of heat-shock protein 27 by methylglyoxal may have important implications for epithelial cell injury in gastrointestinal cancer...
  88. ncbi request reprint Tumor necrosis factor-alpha-induced cytokine-induced neutrophil chemoattractant-1 (CINC-1) production by rat gastric epithelial cells: role of reactive oxygen species and nuclear factor-kappaB
    Osamu Handa
    Vascular Cell Biology Inflammation Program, Lawson Health Research Institute, London, Ontario, Canada
    J Pharmacol Exp Ther 309:670-6. 2004
    ..Taken together, these findings indicate that CINC-1, a counterpart of the human GRO, production by rat gastric epithelial cells in response to TNF-alpha stimulation is an oxidant stress-mediated and NF-kappaB-dependent event...
  89. ncbi request reprint Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of platelet-activating factor and the chemokines LIX and KC
    W Sean Madorin
    Vascular Cell Biology Laboratory, Lawson Health Research Institute and the Department of Physiology, University of Western Ontario, London, Ontario, Canada
    Circ Res 94:944-51. 2004
    ..The activated myocytes promote PMN transendothelial migration, an effect attributable to LIX and KC, and possibly, PAF...
  90. ncbi request reprint Points of control exerted along the macrophage-endothelial cell-polymorphonuclear neutrophil axis by PECAM-1 in the innate immune response of acute colonic inflammation
    Naohito Sugimoto
    Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada
    J Immunol 181:2145-54. 2008
    ..Collectively, our findings indicate that PECAM-1 modulation of PMN function (at a step before diapedesis) most likely contributes to the inflammation in a colitis model with a strong innate immune component...