Mikio Furuse

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 26:9003-15. 2006
  2. pmc Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 29:2372-89. 2009
  3. ncbi request reprint ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Kyoto 606 8501, Japan
    Cell 126:741-54. 2006
  4. ncbi request reprint Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:44785-94. 2004
  5. ncbi request reprint Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues
    Akihito Inoko
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 8:837-45. 2003
  6. pmc Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 171:939-45. 2005
  7. ncbi request reprint Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential
    Shin ichiro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8501, Japan
    J Cell Sci 117:5087-96. 2004
  8. ncbi request reprint Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
  9. doi request reprint abLIM3 is a novel component of adherens junctions with actin-binding activity
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Eur J Cell Biol 89:807-16. 2010
  10. ncbi request reprint A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 117:1247-57. 2004

Collaborators

Detail Information

Publications30

  1. pmc Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 26:9003-15. 2006
    ..These findings indicate that ZO-3 is dispensable in vivo in terms of individual viability, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment...
  2. pmc Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 29:2372-89. 2009
    ....
  3. ncbi request reprint ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Kyoto 606 8501, Japan
    Cell 126:741-54. 2006
    ..When NZO-1 was forcibly recruited to lateral membranes and dimerized, claudins were dramatically polymerized. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized...
  4. ncbi request reprint Establishment and characterization of cultured epithelial cells lacking expression of ZO-1
    Kazuaki Umeda
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:44785-94. 2004
    ..Finally, we discussed advantageous aspects of the gene knock-out system with cultured epithelial cells in epithelial cell biology...
  5. ncbi request reprint Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues
    Akihito Inoko
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 8:837-45. 2003
    ..However, in contrast to ZO-1/ZO-2, our knowledge of the expression and distribution of ZO-3 is still fragmentary, partly due to a lack of antibodies that specifically distinguish ZO-3 from ZO-1 and ZO-2...
  6. pmc Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 171:939-45. 2005
    ..These findings indicate the critical function of tricellulin for formation of the epithelial barrier...
  7. ncbi request reprint Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential
    Shin ichiro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, 606 8501, Japan
    J Cell Sci 117:5087-96. 2004
    ....
  8. ncbi request reprint Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
    Yuko Sugihara-Mizuno
    Department of Cell Biology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 12:473-86. 2007
    ....
  9. doi request reprint abLIM3 is a novel component of adherens junctions with actin-binding activity
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Eur J Cell Biol 89:807-16. 2010
    ..These results suggest that abLIM3 is involved in anchoring LIM domain-binding components of AJs to circumferential actin bundles in specific cell types...
  10. ncbi request reprint A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells
    Miho Matsuda
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 117:1247-57. 2004
    ....
  11. ncbi request reprint Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
    Shin iciro Kitajiri
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    Hear Res 187:25-34. 2004
    ..These findings, i.e., very complex expression patterns of claudin species in the inner ear, would reflect the importance and the complexity of the barrier function of TJs in the inner ear...
  12. pmc Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization
    Junichi Ikenouchi
    Department of Cell Biology, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 176:779-86. 2007
    ..The requirement for ZO-1 differs between belt-like AJ and TJ formation. We propose that ZO-1 is directly involved in the establishment of two distinct junctional domains, belt-like AJs and TJs, during epithelial polarization...
  13. pmc Loss of occludin affects tricellular localization of tricellulin
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Mol Biol Cell 19:4687-93. 2008
    ....
  14. ncbi request reprint Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Invest Dermatol 118:1073-9. 2002
    ....
  15. doi request reprint The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells
    Senye Takahashi
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Sci 122:985-94. 2009
    ..These findings suggest that LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and that the turnover of TJs is regulated by ubiquitylation...
  16. ncbi request reprint Claudin-based barrier in simple and stratified cellular sheets
    Shoichiro Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto, Japan
    Curr Opin Cell Biol 14:531-6. 2002
    ..Recent advances reveal that claudins - major cell adhesion molecules in tight junctions - are directly involved in this intercellular sealing, not only in simple but also in stratified cellular sheets in vertebrates...
  17. ncbi request reprint Expression of claudin-5 in dermal vascular endothelia
    Kazumasa Morita
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Dermatol 12:289-95. 2003
    ..These findings confirmed that TJs in dermal vascular endothelial cells are composed of claudin-5...
  18. pmc Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    Takehiro Nitta
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 161:653-60. 2003
    ..e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of BBB but also opens a new way to deliver potential drugs across the BBB into the central nervous system...
  19. ncbi request reprint Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
    Yoko Hamazaki
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 277:455-61. 2002
    ....
  20. doi request reprint Generation of transgenic medaka expressing claudin7-EGFP for imaging of tight junctions in living medaka embryos
    Tatsuo Miyamoto
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cell Tissue Res 335:465-71. 2009
    ..This transgenic medaka line will thus be useful for imaging of TJs in living embryos and hence in screening for mutations affecting cell-cell adhesion...
  21. pmc Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 156:1099-111. 2002
    ..These findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin...
  22. ncbi request reprint Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos
    Kazumasa Moriwaki
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Dev Biol 312:509-22. 2007
    ..These results clearly demonstrate that the barrier function of TJs in the TE is required for normal blastocyst formation...
  23. doi request reprint Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning
    Miho Matsuda
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Exp Cell Res 314:939-49. 2008
    ..These data suggest that FL-REX is a powerful tool to identify novel proteins localized at TJs and AJs...
  24. ncbi request reprint JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
    Hiroe Ohnishi
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:46014-22. 2004
    ..These findings suggest that JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons...
  25. ncbi request reprint Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:1959-67. 2003
    ..e. the expression of adherens and tight junction adhesion molecules, respectively)...
  26. pmc Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase
    Tomohito Higashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 285:16231-8. 2010
    ..Furthermore, Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs...
  27. ncbi request reprint Claudins in occluding junctions of humans and flies
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Trends Cell Biol 16:181-8. 2006
    ..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies...
  28. pmc Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice
    Tatsuo Miyamoto
    Department of Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    J Cell Biol 169:527-38. 2005
    ....
  29. pmc Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency
    Yohei Kawai
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:4075-80. 2011
    ..These results suggest that Cld4 is induced by E-protein activity in the later stages of DP cells to increase the efficiency of positive selection, uncovering a hitherto unrecognized function of a Cld family protein...
  30. ncbi request reprint Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
    Yumiko Kiuchi-Saishin
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yonoe Koshida, Sakyo ku, Kyoto 606, Japan
    J Am Soc Nephrol 13:875-86. 2002
    ..These segment-specific expression patterns of claudins are discussed, with special reference to the physiologic functions of tight junctions in nephrons...