M Dezawa

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
  2. ncbi request reprint Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neurons
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Expert Opin Biol Ther 5:427-35. 2005
  3. ncbi request reprint Marrow stromal cells: implications in health and disease in the nervous system
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Curr Mol Med 5:723-32. 2005
  4. ncbi request reprint Insights into autotransplantation: the unexpected discovery of specific induction systems in bone marrow stromal cells
    M Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cell Mol Life Sci 63:2764-72. 2006
  5. ncbi request reprint [Insights into auto-transplantation: the unexpected discovery of transdifferentiation systems in bone marrow stromal cells]
    Mari Dezawa
    Tanpakushitsu Kakusan Koso 52:158-65. 2007
  6. doi request reprint Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseases
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Med Mol Morphol 41:14-9. 2008
  7. ncbi request reprint Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
  8. ncbi request reprint Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Neurol 187:266-78. 2004
  9. ncbi request reprint Effects of bone marrow stromal cell injection in an experimental glaucoma model
    Saiyuu Yu
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 344:1071-9. 2006
  10. ncbi request reprint [Specific induction of neurons and Schwann cells from bone marrow stromal cells and application to neurodegenerative diseases]
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    No Shinkei Geka 33:645-9. 2005

Collaborators

Detail Information

Publications42

  1. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
    ..This study shows that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach...
  2. ncbi request reprint Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neurons
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Expert Opin Biol Ther 5:427-35. 2005
    ..This review summarises the respective potentials, benefits and drawbacks of MSC-derived neurons, and discusses the possibility of their clinical application in neurodegenerative diseases...
  3. ncbi request reprint Marrow stromal cells: implications in health and disease in the nervous system
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Curr Mol Med 5:723-32. 2005
    ..Here we focus on the respective potentials of MSC-derived cells and discuss the possibility of clinical application in neurodegenerative and neurotraumatic diseases...
  4. ncbi request reprint Insights into autotransplantation: the unexpected discovery of specific induction systems in bone marrow stromal cells
    M Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cell Mol Life Sci 63:2764-72. 2006
    ..Here I describe the discovery of these induction systems and focus on the potential use of MSC-derived cells for 'auto-cell transplantation therapy' in neuro- and muscle-degenerative diseases...
  5. ncbi request reprint [Insights into auto-transplantation: the unexpected discovery of transdifferentiation systems in bone marrow stromal cells]
    Mari Dezawa
    Tanpakushitsu Kakusan Koso 52:158-65. 2007
  6. doi request reprint Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseases
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Med Mol Morphol 41:14-9. 2008
    ..In this review, their differentiation into functional neural and muscle cell lineages is the focus, and their potential to the application for tissue reconstruction in neurodegenerative and muscle degenerative diseases is discussed...
  7. ncbi request reprint Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
    ..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
  8. ncbi request reprint Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Neurol 187:266-78. 2004
    ....
  9. ncbi request reprint Effects of bone marrow stromal cell injection in an experimental glaucoma model
    Saiyuu Yu
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 344:1071-9. 2006
    ..This study suggests that BMSC transplantation may be worthy as a neuroprotective tool to treat glaucoma...
  10. ncbi request reprint [Specific induction of neurons and Schwann cells from bone marrow stromal cells and application to neurodegenerative diseases]
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    No Shinkei Geka 33:645-9. 2005
  11. ncbi request reprint [Future views and challenges to the peripheral nerve regeneration by cell based therapy]
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine
    Rinsho Shinkeigaku 45:877-9. 2005
    ..Here we focus on the respective potentials of MSC-derived cells and discuss the possibility of clinical application in neurodegenerative and muscle degenerative diseases...
  12. ncbi request reprint Increase in bFGF-responsive neural progenitor population following contusion injury of the adult rodent spinal cord
    Yi Xu
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 397:174-9. 2006
    ..Thus, the activation of bFGF-responsive progenitor cells and the concomitant increase in the population of bFGF+ cells following SCI might be beneficial for spinal cord repair if these progenitor cells are properly manipulated...
  13. doi request reprint Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke
    Makoto Hayase
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Cereb Blood Flow Metab 29:1409-20. 2009
    ..These suggest a high potential for this MSC approach in the replenishment of neural cells for stroke and for a wide range of neurodegenerative conditions that require various types of neural cells...
  14. doi request reprint Practical induction system for dopamine-producing cells from bone marrow stromal cells using spermine-pullulan-mediated reverse transfection method
    Kentaro Nagane
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:1655-65. 2009
    ..Our study indicates the availability of the reverse transfection method for the induction of dopamine-producing neuronal cells from BMSCs, which is expected to apply to cell-based therapy in Parkinson's disease...
  15. ncbi request reprint Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury
    Tomoyuki Yoshihara
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurotrauma 24:1026-36. 2007
    ..Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans...
  16. ncbi request reprint Implantation of neural stem cells via cerebrospinal fluid into the injured root
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Neuroreport 15:1249-53. 2004
    ..These findings suggest that neural stem cells integrated by infusion through CSF might have a beneficial effect on nerve regeneration by inducing a continuity of Schwann cells and astrocytes at the transition zone...
  17. ncbi request reprint Peripheral nerve regeneration through the space formed by a chitosan gel sponge
    N Ishikawa
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biomed Mater Res A 83:33-40. 2007
    ..45 and 2.75 microm in diameter at 2 and 4 months, respectively, after surgery. These results indicate that the chitosan gel sponge sandwich might be suitable as a graft for peripheral nerve regeneration...
  18. doi request reprint Peripheral nerve regeneration by transplantation of BMSC-derived Schwann cells as chitosan gel sponge scaffolds
    Namiko Ishikawa
    Department of Plastic and Reconstructive Surgery, Johoku Hospital, Kyoto, Japan
    J Biomed Mater Res A 89:1118-24. 2009
    ..58 mum at 2 months to 2.84 mum at 4 months postsurgery. This study indicates that chitosan gel sponges containing BMSC-derived Schwann cells have strong potentiality as a graft that can be used for peripheral nerve regeneration...
  19. ncbi request reprint Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res A 71:661-8. 2004
    ..These findings suggested that H/A gel with bFGF could serve not only as an efficient cellular scaffold, but also as a stabilizing matrix for bFGF for peripheral nerve regeneration...
  20. ncbi request reprint Neurogenesis in the ependymal layer of the adult rat 3rd ventricle
    Yi Xu
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Neurol 192:251-64. 2005
    ..These results indicate that neural progenitor cells exist in the ependymal layer of the adult rat 3rd ventricle and that they may differentiate into neurons functioning in the hypothalamus...
  21. ncbi request reprint Choroid plexus ependymal cells host neural progenitor cells in the rat
    Yutaka Itokazu
    Department of Anatomy and Neurobiology, Kyoto University, Graduate School of Medicine, Kyoto, Japan
    Glia 53:32-42. 2006
    ..03% (untreated) to 1.14% (38-fold, EGF) and 1.03% (35-fold, FGF2), respectively. These findings indicate that neural progenitor cells exist among CPECs in the rat...
  22. ncbi request reprint Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina
    Takaya Miyawaki
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Neurosci 24:8124-34. 2004
    ....
  23. ncbi request reprint Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons
    Yumi Watanabe
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe chou, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 379:158-63. 2005
    ..The results of the present study indicate that CPECs can support the survival and function of neurons in vitro by secreting factors that are likely to be of peptide/protein nature rather than small chemicals...
  24. ncbi request reprint [Insights into auto-transplantation--the unexpected discovery of transdifferentiation systems in bone marrow stromal cells and its application]
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Brain Nerve 59:503-8. 2007
    ..Here I describe the discovery of these induction systems and focus on the potential use of MSC-derived cells for "auto-cell transplantation therapy" in muscle-degenerative diseases...
  25. ncbi request reprint Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell property
    Satoshi Shimizu
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 359:915-20. 2007
    ..These results suggest that human MSCs can be induced to be a substitute for Schwann cells that may be applied for nerve regeneration...
  26. ncbi request reprint Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode
    H Ishikawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Gene Ther 12:289-98. 2005
    ..These results suggest that this method may be useful for the delivery of genes into RGCs with simplicity and minimal tissue damage...
  27. ncbi request reprint Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord
    Takahito Kamada
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Neuropathol Exp Neurol 64:37-45. 2005
    ..Transplantation of BMSC-SCs is a potentially useful treatment for spinal cord injury...
  28. ncbi request reprint Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse
    Yoshiko Takano
    Department of Ophthalmology, Hirosaki University School of Medicine, Japan
    Biochem Biophys Res Commun 313:1015-22. 2004
    ..It is suggested that some types of Ca(2+) channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients...
  29. ncbi request reprint [Neural repair]
    Masaaki Kitada
    Department of Anatomy and Neurobiology, Kyoto University Postgraduate School of Medicine
    Nihon Rinsho 66:921-5. 2008
    ..In this review, we introduce the differentiation potential of MSCs and finally discuss about their benefits and drawbacks of these induction systems for cell-based therapy in neuro-traumatic and neuro-degenerative diseases...
  30. ncbi request reprint Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats
    Toshiro Mimura
    Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    J Neurosurg 101:806-12. 2004
    ....
  31. ncbi request reprint Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats
    Xiaofen Mo
    Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Invest Ophthalmol Vis Sci 43:2401-5. 2002
    ..To determine whether the brain-derived neurotrophic factor (BDNF) gene can be transfected into retinal ganglion cells (RGCs) by electroporation and whether axotomized RGCs can be rescued after transfection by BDNF in adult rats...
  32. ncbi request reprint The role of c-fos in cell death and regeneration of retinal ganglion cells
    Toshiyuki Oshitari
    Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan
    Invest Ophthalmol Vis Sci 43:2442-9. 2002
    ..To investigate the effect of c-fos on apoptotic cell death and regeneration of damaged retinal ganglion cells (RGCs) in tissue culture of retinal explants...
  33. ncbi request reprint Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector
    Ming Zhu Zhao
    Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan
    J Cereb Blood Flow Metab 26:1176-88. 2006
    ..The present study shows that combined therapy is more therapeutically efficient than MSC cell therapy alone, and it may extend the therapeutic time window from superacute to acute phase...
  34. ncbi request reprint The role of von Hippel-Lindau protein in the differentiation of neural progenitor cells under normoxic and anoxic conditions
    Yoshihide Tanaka
    Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Kanazawa Ku, Kanagawa, Japan
    Neurosci Lett 383:28-32. 2005
    ..Differentiation of neuronal progenitor cells may thus depend on oxygen density...
  35. ncbi request reprint Bone marrow stromal cells that enhanced fibroblast growth factor-2 secretion by herpes simplex virus vector improve neurological outcome after transient focal cerebral ischemia in rats
    Naokado Ikeda
    Department of Neurosurgery, Osaka Medical College, Japan
    Stroke 36:2725-30. 2005
    ....
  36. ncbi request reprint Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease
    Hitoshi Yamada
    Yokohama Neurology Clinic and School of Medicine, Yokohama City University, 1 211 1 Mutsukawa, Minami Ku, Yokohama 232 0066, Japan
    Ann Neurol 54:352-9. 2003
    ..VHL gene transduction provides a new therapeutic approach for treatment of PD...
  37. ncbi request reprint Behavioral and histological evaluation of a focal cerebral infarction rat model transplanted with neurons induced from bone marrow stromal cells
    Toshiro Mimura
    Department of Neurosurgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Yokohama, Japan
    J Neuropathol Exp Neurol 64:1108-17. 2005
    ..0% +/- 0.23%). The survival rates of MSDNCs and MSCs 1 month after transplantation were approximately 45% and 10%, respectively. These results suggest that use of MSDNCs may be a promising therapeutic strategy for cerebral infarction...
  38. ncbi request reprint Central and peripheral nerve regeneration by transplantation of Schwann cells and transdifferentiated bone marrow stromal cells
    Mari Dezawa
    Department of Anatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Anat Sci Int 77:12-25. 2002
    ..The strategy to transdifferentiate MSCs into the cells with a Schwann cell phenotype and the induction of sciatic and optic nerve regeneration are described...
  39. ncbi request reprint Increment of murine spermatogonial cell number by gonadotropin-releasing hormone analogue is independent of stem cell factor c-kit signal
    Masako Ohmura
    Department of Anatomy, Yokohama City University of Medicine, Yokohoma, Japan
    Biol Reprod 68:2304-13. 2003
    ....
  40. ncbi request reprint Brain-derived neurotrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitro
    Masahiko Takano
    Exp Eye Res 74:319-23. 2002
    ..In conclusion, an aged human retina can regenerate neurites from RGCs in vitro and brain-derived neurotrophic factor significantly promotes the regeneration...
  41. ncbi request reprint Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist
    Hitoshi Yamazaki
    Department of Ophthalmology, Hirosaki University School of Medicine, Hirosaki, Japan
    Invest Ophthalmol Vis Sci 43:919-26. 2002
    ..The purpose of the present study was to evaluate the pharmacologic effects of several Ca(2+) antagonists on the retinal degeneration of RCS rats...
  42. ncbi request reprint Effects of vibration and hyaluronic acid on activation of three-dimensional cultured chondrocytes
    Ryohei Takeuchi
    Yokohama City University School of Medicine, Yokohama, Japan
    Arthritis Rheum 54:1897-905. 2006
    ..To investigate the effects of vibration (Vib) and hyaluronic acid (HA) on 3-dimensional cultured cartilage...