Research Topics
| M DezawaSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantationMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Clin Invest 113:1701-10. 2004..This study shows that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach...- Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neuronsMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Expert Opin Biol Ther 5:427-35. 2005..This review summarises the respective potentials, benefits and drawbacks of MSC-derived neurons, and discusses the possibility of their clinical application in neurodegenerative diseases... - Marrow stromal cells: implications in health and disease in the nervous systemMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Curr Mol Med 5:723-32. 2005..Here we focus on the respective potentials of MSC-derived cells and discuss the possibility of clinical application in neurodegenerative and neurotraumatic diseases... - Insights into autotransplantation: the unexpected discovery of specific induction systems in bone marrow stromal cellsM Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Cell Mol Life Sci 63:2764-72. 2006..Here I describe the discovery of these induction systems and focus on the potential use of MSC-derived cells for 'auto-cell transplantation therapy' in neuro- and muscle-degenerative diseases... - [Insights into auto-transplantation: the unexpected discovery of transdifferentiation systems in bone marrow stromal cells]Mari Dezawa
Tanpakushitsu Kakusan Koso 52:158-65. 2007 - Systematic neuronal and muscle induction systems in bone marrow stromal cells: the potential for tissue reconstruction in neurodegenerative and muscle degenerative diseasesMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Med Mol Morphol 41:14-9. 2008..In this review, their differentiation into functional neural and muscle cell lineages is the focus, and their potential to the application for tissue reconstruction in neurodegenerative and muscle degenerative diseases is discussed... - Bone marrow stromal cells generate muscle cells and repair muscle degenerationMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
Science 309:314-7. 2005..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow... - Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formationMasayoshi Ohta
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Exp Neurol 187:266-78. 2004.... - Effects of bone marrow stromal cell injection in an experimental glaucoma modelSaiyuu Yu
Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Biochem Biophys Res Commun 344:1071-9. 2006..This study suggests that BMSC transplantation may be worthy as a neuroprotective tool to treat glaucoma... - [Specific induction of neurons and Schwann cells from bone marrow stromal cells and application to neurodegenerative diseases]Mari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
No Shinkei Geka 33:645-9. 2005 - [Future views and challenges to the peripheral nerve regeneration by cell based therapy]Mari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine
Rinsho Shinkeigaku 45:877-9. 2005..Here we focus on the respective potentials of MSC-derived cells and discuss the possibility of clinical application in neurodegenerative and muscle degenerative diseases... - Increase in bFGF-responsive neural progenitor population following contusion injury of the adult rodent spinal cordYi Xu
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
Neurosci Lett 397:174-9. 2006..Thus, the activation of bFGF-responsive progenitor cells and the concomitant increase in the population of bFGF+ cells following SCI might be beneficial for spinal cord repair if these progenitor cells are properly manipulated... - Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of strokeMakoto Hayase
Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
J Cereb Blood Flow Metab 29:1409-20. 2009..These suggest a high potential for this MSC approach in the replenishment of neural cells for stroke and for a wide range of neurodegenerative conditions that require various types of neural cells... - Practical induction system for dopamine-producing cells from bone marrow stromal cells using spermine-pullulan-mediated reverse transfection methodKentaro Nagane
Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
Tissue Eng Part A 15:1655-65. 2009..Our study indicates the availability of the reverse transfection method for the induction of dopamine-producing neuronal cells from BMSCs, which is expected to apply to cell-based therapy in Parkinson's disease... - Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injuryTomoyuki Yoshihara
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Neurotrauma 24:1026-36. 2007..Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans... - Implantation of neural stem cells via cerebrospinal fluid into the injured rootMasayoshi Ohta
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Neuroreport 15:1249-53. 2004..These findings suggest that neural stem cells integrated by infusion through CSF might have a beneficial effect on nerve regeneration by inducing a continuity of Schwann cells and astrocytes at the transition zone... - Peripheral nerve regeneration through the space formed by a chitosan gel spongeN Ishikawa
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Biomed Mater Res A 83:33-40. 2007..45 and 2.75 microm in diameter at 2 and 4 months, respectively, after surgery. These results indicate that the chitosan gel sponge sandwich might be suitable as a graft for peripheral nerve regeneration... - Peripheral nerve regeneration by transplantation of BMSC-derived Schwann cells as chitosan gel sponge scaffoldsNamiko Ishikawa
Department of Plastic and Reconstructive Surgery, Johoku Hospital, Kyoto, Japan
J Biomed Mater Res A 89:1118-24. 2009..58 mum at 2 months to 2.84 mum at 4 months postsurgery. This study indicates that chitosan gel sponges containing BMSC-derived Schwann cells have strong potentiality as a graft that can be used for peripheral nerve regeneration... - Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerveMasayoshi Ohta
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
J Biomed Mater Res A 71:661-8. 2004..These findings suggested that H/A gel with bFGF could serve not only as an efficient cellular scaffold, but also as a stabilizing matrix for bFGF for peripheral nerve regeneration... - Neurogenesis in the ependymal layer of the adult rat 3rd ventricleYi Xu
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
Exp Neurol 192:251-64. 2005..These results indicate that neural progenitor cells exist in the ependymal layer of the adult rat 3rd ventricle and that they may differentiate into neurons functioning in the hypothalamus... - Choroid plexus ependymal cells host neural progenitor cells in the ratYutaka Itokazu
Department of Anatomy and Neurobiology, Kyoto University, Graduate School of Medicine, Kyoto, Japan
Glia 53:32-42. 2006..03% (untreated) to 1.14% (38-fold, EGF) and 1.03% (35-fold, FGF2), respectively. These findings indicate that neural progenitor cells exist among CPECs in the rat... - Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retinaTakaya Miyawaki
Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
J Neurosci 24:8124-34. 2004.... - Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neuronsYumi Watanabe
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe chou, Sakyo ku, Kyoto 606 8501, Japan
Neurosci Lett 379:158-63. 2005..The results of the present study indicate that CPECs can support the survival and function of neurons in vitro by secreting factors that are likely to be of peptide/protein nature rather than small chemicals... - [Insights into auto-transplantation--the unexpected discovery of transdifferentiation systems in bone marrow stromal cells and its application]Mari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Brain Nerve 59:503-8. 2007..Here I describe the discovery of these induction systems and focus on the potential use of MSC-derived cells for "auto-cell transplantation therapy" in muscle-degenerative diseases... - Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell propertySatoshi Shimizu
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
Biochem Biophys Res Commun 359:915-20. 2007..These results suggest that human MSCs can be induced to be a substitute for Schwann cells that may be applied for nerve regeneration... - Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrodeH Ishikawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Gene Ther 12:289-98. 2005..These results suggest that this method may be useful for the delivery of genes into RGCs with simplicity and minimal tissue damage... - Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cordTakahito Kamada
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan
J Neuropathol Exp Neurol 64:37-45. 2005..Transplantation of BMSC-SCs is a potentially useful treatment for spinal cord injury... - Study of drug effects of calcium channel blockers on retinal degeneration of rd mouseYoshiko Takano
Department of Ophthalmology, Hirosaki University School of Medicine, Japan
Biochem Biophys Res Commun 313:1015-22. 2004..It is suggested that some types of Ca(2+) channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients... - [Neural repair]Masaaki Kitada
Department of Anatomy and Neurobiology, Kyoto University Postgraduate School of Medicine
Nihon Rinsho 66:921-5. 2008..In this review, we introduce the differentiation potential of MSCs and finally discuss about their benefits and drawbacks of these induction systems for cell-based therapy in neuro-traumatic and neuro-degenerative diseases... - Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult ratsToshiro Mimura
Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
J Neurosurg 101:806-12. 2004.... - Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult ratsXiaofen Mo
Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
Invest Ophthalmol Vis Sci 43:2401-5. 2002..To determine whether the brain-derived neurotrophic factor (BDNF) gene can be transfected into retinal ganglion cells (RGCs) by electroporation and whether axotomized RGCs can be rescued after transfection by BDNF in adult rats... - The role of c-fos in cell death and regeneration of retinal ganglion cellsToshiyuki Oshitari
Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan
Invest Ophthalmol Vis Sci 43:2442-9. 2002..To investigate the effect of c-fos on apoptotic cell death and regeneration of damaged retinal ganglion cells (RGCs) in tissue culture of retinal explants... - Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vectorMing-Zhu Zhao
Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan
J Cereb Blood Flow Metab 26:1176-88. 2006..The present study shows that combined therapy is more therapeutically efficient than MSC cell therapy alone, and it may extend the therapeutic time window from superacute to acute phase... - The role of von Hippel-Lindau protein in the differentiation of neural progenitor cells under normoxic and anoxic conditionsYoshihide Tanaka
Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Kanagawa, Japan
Neurosci Lett 383:28-32. 2005..Differentiation of neuronal progenitor cells may thus depend on oxygen density... - Bone marrow stromal cells that enhanced fibroblast growth factor-2 secretion by herpes simplex virus vector improve neurological outcome after transient focal cerebral ischemia in ratsNaokado Ikeda
Department of Neurosurgery, Osaka Medical College, Japan
Stroke 36:2725-30. 2005..CONCLUSIONS: Our data suggest that the FGF-2 gene-modified MSCs with the HSV-1 vector can contribute to remarkable functional recovery after stroke compared with MSCs transplantation alone... - Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's diseaseHitoshi Yamada
Yokohama Neurology Clinic and School of Medicine, Yokohama City University, 1 211 1 Mutsukawa, Minami Ku, Yokohama 232 0066, Japan
Ann Neurol 54:352-9. 2003..VHL gene transduction provides a new therapeutic approach for treatment of PD... - Behavioral and histological evaluation of a focal cerebral infarction rat model transplanted with neurons induced from bone marrow stromal cellsToshiro Mimura
Department of Neurosurgery, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Yokohama, Japan
J Neuropathol Exp Neurol 64:1108-17. 2005..0% +/- 0.23%). The survival rates of MSDNCs and MSCs 1 month after transplantation were approximately 45% and 10%, respectively. These results suggest that use of MSDNCs may be a promising therapeutic strategy for cerebral infarction... - Central and peripheral nerve regeneration by transplantation of Schwann cells and transdifferentiated bone marrow stromal cellsMari Dezawa
Department of Anatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Anat Sci Int 77:12-25. 2002..The strategy to transdifferentiate MSCs into the cells with a Schwann cell phenotype and the induction of sciatic and optic nerve regeneration are described... - Increment of murine spermatogonial cell number by gonadotropin-releasing hormone analogue is independent of stem cell factor c-kit signalMasako Ohmura
Department of Anatomy, Yokohama City University of Medicine, Yokohoma, Japan
Biol Reprod 68:2304-13. 2003.... - Brain-derived neurotrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitroMasahiko Takano
Exp Eye Res 74:319-23. 2002..In conclusion, an aged human retina can regenerate neurites from RGCs in vitro and brain-derived neurotrophic factor significantly promotes the regeneration... - Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonistHitoshi Yamazaki
Department of Ophthalmology, Hirosaki University School of Medicine, Hirosaki, Japan
Invest Ophthalmol Vis Sci 43:919-26. 2002..The purpose of the present study was to evaluate the pharmacologic effects of several Ca(2+) antagonists on the retinal degeneration of RCS rats... - Effects of vibration and hyaluronic acid on activation of three-dimensional cultured chondrocytesRyohei Takeuchi
Yokohama City University School of Medicine, Yokohama, Japan
Arthritis Rheum 54:1897-905. 2006..To investigate the effects of vibration (Vib) and hyaluronic acid (HA) on 3-dimensional cultured cartilage...