Hiroshi Date

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Protective effect of surfactant inhalation against warm ischemic injury in an isolated rat lung ventilation model
    Akihiro Ohsumi
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e72574. 2013
  2. ncbi request reprint Outcome of living-donor lobar lung transplantation using a single donor
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Thorac Cardiovasc Surg 144:710-5. 2012
  3. doi request reprint The impact of complete lymph node dissection for lung cancer on the postoperative course
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Thorac Surg Clin 22:239-42. 2012
  4. doi request reprint Diagnostic strategies for mediastinal tumors and cysts
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Thorac Surg Clin 19:29-35, vi. 2009
  5. doi request reprint Update on living-donor lobar lung transplantation
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Curr Opin Organ Transplant 16:453-7. 2011
  6. doi request reprint Less maintenance immunosuppression in lung transplantation following hematopoietic stem cell transplantation from the same living donor
    F Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Transplant 11:1509-16. 2011
  7. doi request reprint Impact of KRAS and EGFR gene mutations on recurrence and survival in patients with surgically resected lung adenocarcinomas
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan
    Ann Surg Oncol 19:S347-54. 2012
  8. doi request reprint Reconditioning lungs donated after cardiac death using short-term hypothermic machine perfusion
    Daisuke Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Transplantation 94:999-1004. 2012
  9. pmc Induction chemoradiotherapy is superior to induction chemotherapy for the survival of non-small-cell lung cancer patients with pathological mediastinal lymph node metastasis
    Shinichi Toyooka
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Interact Cardiovasc Thorac Surg 15:954-60. 2012
  10. doi request reprint Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene
    Tsuyoshi Takahashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 17:889-97. 2010

Detail Information

Publications118 found, 100 shown here

  1. pmc Protective effect of surfactant inhalation against warm ischemic injury in an isolated rat lung ventilation model
    Akihiro Ohsumi
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e72574. 2013
    ..The reduction in oxidative damage and the inhibition of apoptosis might contribute to the protection of the warm ischemic lungs. ..
  2. ncbi request reprint Outcome of living-donor lobar lung transplantation using a single donor
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Thorac Cardiovasc Surg 144:710-5. 2012
    ..Several case reports have been published on successful living-donor lobar lung transplantation using a single donor; however, little is known about its outcome...
  3. doi request reprint The impact of complete lymph node dissection for lung cancer on the postoperative course
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Thorac Surg Clin 22:239-42. 2012
    ..It is recommended that all patients with resectable NSCLC undergo LND because the procedure provides patients with the most accurate staging and the opportunity for effective adjuvant therapy...
  4. doi request reprint Diagnostic strategies for mediastinal tumors and cysts
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Thorac Surg Clin 19:29-35, vi. 2009
    ..The choice of biopsy technique depends on the localization of the lesion, clinical factors such as the age and the condition of the patient, and the availability of special techniques with the required expert and the equipment...
  5. doi request reprint Update on living-donor lobar lung transplantation
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Curr Opin Organ Transplant 16:453-7. 2011
    ..Living-donor lobar lung transplantation (LDLLT) has been performed as a life-saving procedure for critically ill patients who are unlikely to survive the long wait for cadaveric lungs. This article will review the current status of LDLLT...
  6. doi request reprint Less maintenance immunosuppression in lung transplantation following hematopoietic stem cell transplantation from the same living donor
    F Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Transplant 11:1509-16. 2011
    ..In our study, LDLLT involving the same donor as for HSCT appeared to have advantages related to lower immunosuppression compared to LDLLT from relatives who were not the HSCT donors...
  7. doi request reprint Impact of KRAS and EGFR gene mutations on recurrence and survival in patients with surgically resected lung adenocarcinomas
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan
    Ann Surg Oncol 19:S347-54. 2012
    ..However, the influence of these gene alterations on patients' prognosis remains controversial...
  8. doi request reprint Reconditioning lungs donated after cardiac death using short-term hypothermic machine perfusion
    Daisuke Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Transplantation 94:999-1004. 2012
    ..Hypothermic machine perfusion (HMP) is widely used to preserve kidneys and livers for transplantation. This study investigated whether short-term HMP could improve the quality of lungs donated after cardiac death (DCD)...
  9. pmc Induction chemoradiotherapy is superior to induction chemotherapy for the survival of non-small-cell lung cancer patients with pathological mediastinal lymph node metastasis
    Shinichi Toyooka
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Interact Cardiovasc Thorac Surg 15:954-60. 2012
    ....
  10. doi request reprint Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene
    Tsuyoshi Takahashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 17:889-97. 2010
    ..We screened for EML4-ALK fusion genes and examined the clinicopathological and genetic characteristics of fusion-harboring NSCLC tumors...
  11. doi request reprint Hyperfractionated irradiation with 3 cycles of induction chemotherapy in stage IIIA-N2 lung cancer
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    World J Surg 36:2858-64. 2012
    ..The purpose of the present study was to improve the prognosis of patients with stage IIIA-N2 non-small cell lung cancer (NSCLC). To achieve that goal, we performed induction chemoradiotherapy followed by surgery...
  12. doi request reprint Survival and relapse pattern after trimodality therapy for malignant pleural mesothelioma
    Kenichi Okubo
    Department of Thoracic Surgery, Kyoto University Hospital, Kawahara cho, Shogoin, Sakyo ku, Japan
    Gen Thorac Cardiovasc Surg 57:585-90. 2009
    ..We reviewed our experience of trimodality therapy as a single-institution study in Japan...
  13. pmc Induction chemoradiotherapy followed by surgical resection for clinical T3 or T4 locally advanced non-small cell lung cancer
    Kazuhiko Shien
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Ann Surg Oncol 19:2685-92. 2012
    ..To examine the usefulness of trimodality therapy in patients with clinical T3 or T4 (cT3-4) locally advanced non-small cell lung cancer (LA-NSCLC)...
  14. doi request reprint Therapeutic effect of surfactant inhalation during warm ischemia in an isolated rat lung perfusion model
    Akihiro Ohsumi
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transpl Int 25:1096-105. 2012
    ..Our results indicated that surfactant inhalation in the last phase of warm ischemia maintained lung tissue energy levels and prevented cytokine production, resulting in the alleviation of warm ischemia-reperfusion injury...
  15. doi request reprint Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model
    Hideki Motoyama
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Heart Lung Transplant 32:505-10. 2013
    ..This study was designed to evaluate the effect of the fibrinolytic agent plasmin on lungs damaged by thrombi in an ex vivo lung perfusion (EVLP) system...
  16. doi request reprint Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment
    Masaru Jida
    Departments of Cancer and Thoracic Surgery, Graduate School of Medicine, Okayama University, Kita ku, Okayama, Japan
    Cancer Sci 100:1931-4. 2009
    ..Thus, patients who have smoked less than 13 PY might be candidates for gefitinib treatment when EGFR mutation status cannot be determined...
  17. ncbi request reprint The effect of β-2 adrenoreceptor agonist inhalation on lungs donated after cardiac death in a canine lung transplantation model
    Jin Sakamoto
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 31:773-9. 2012
    ..It is a matter of great importance in a donation after cardiac death to attenuate ischemia-reperfusion injury (IRI) related to the inevitable warm ischemic time...
  18. doi request reprint Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion
    Daisuke Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Heart Lung Transplant 31:187-93. 2012
    ..In this study we investigated whether DCD lungs can be resuscitated after warm ischemia with normothermic ex vivo lung perfusion (EVLP)...
  19. doi request reprint Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model
    Jin Sakamoto
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Transplantation 92:864-70. 2011
    ..However, it can rarely be initiated from the onset of cardiac arrest, particularly in uncontrolled DCD donors. We investigated the protective effect of the last 60 min of ventilation during a 240-min warm ischemic time...
  20. doi request reprint Perioperative assessment of oversized lobar graft downsizing in living-donor lobar lung transplantation using three-dimensional computed tomographic volumetry
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transpl Int 23:e41-4. 2010
    ..In LDLLT, segmentectomy of the superior segment of the lower lobe is a useful option for downsizing an oversized graft and three-dimensional CT volumetry can provide meaningful data for size matching...
  21. doi request reprint Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model
    Akihiro Ohsumi
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 31:1136-42. 2012
    ..Because surfactant function deteriorates in lungs during warm ischemia, we hypothesized pre-recovery surfactant inhalation would mitigate warm ischemia-reperfusion injury...
  22. doi request reprint Sacrificing the pulmonary arterial branch to the spared lobe is a risk factor of bronchopleural fistula in sleeve lobectomy after chemoradiotherapy
    Shinichi Toyooka
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Eur J Cardiothorac Surg 43:568-72. 2013
    ..In this study, we describe our experience performing sleeve lobectomies and the associated anastomotic complications after induction CRT...
  23. doi request reprint Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma
    Ryutaro Kikuchi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 19:S412-20. 2012
    ..The insulin-like growth factor 1 receptor (IGF1R) is widely expressed in normal tissues and many malignancies in humans. We investigated the clinical significance of the expression of the IGF1R gene in human lung adenocarcinoma...
  24. ncbi request reprint Pulmonary resection for metastatic head and neck cancer
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    World J Surg 32:1657-62. 2008
    ..To confirm a role for resection of pulmonary metastases for such tumors, we reviewed our institutional experience...
  25. doi request reprint Repeat resection of pulmonary metastasis is beneficial for patients with osteosarcoma of the extremities
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Interact Cardiovasc Thorac Surg 9:649-53. 2009
    ..Our data imply that repeat pulmonary metastasectomy might be beneficial because it can salvage a subset of patients with osteosarcoma who retain favorable prognostic determinants...
  26. doi request reprint Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer
    Tsuyoshi Takahashi
    Faculty of Medicine, Department of Thoracic Surgery, Kyoto University, Sakyo ku, Kyoto, Japan
    J Surg Oncol 101:500-6. 2010
    ..However, their prognostic significance in nonsmall cell lung cancer (NSCLC) is still unclear. In this study, we examined the effect of Keap1 gene mutations on survival and disease-free interval using resected primary NSCLC tissue...
  27. doi request reprint Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients
    Akihiko Yoshizawa
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    J Thorac Oncol 8:52-61. 2013
    ....
  28. ncbi request reprint Short-term outcome in living donors for lung transplantation: the role of preoperative computer tomographic evaluations of fissures and vascular anatomy
    Fengshi Chen
    Department of Thoracic Surgery and Radiology, Kyoto University, Kyoto, Japan
    Transpl Int 25:732-8. 2012
    ..Living donor lobectomies were safely performed with low morbidities in our institution. Preoperative computer tomographic evaluations might be useful in donor lobectomies...
  29. ncbi request reprint Lung metastasectomy for colorectal carcinoma in patients with a history of hepatic metastasis
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Ann Thorac Cardiovasc Surg 17:13-8. 2011
    ....
  30. ncbi request reprint Incidence and pattern of hemolytic anemia after minor ABO-mismatched living-donor lobar lung transplantation
    Akihiro Ohsumi
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Surg Today 43:1250-3. 2013
    ..Solid organ transplants from donors with minor ABO-mismatches can be complicated by hemolysis. We investigated the incidence of de novo anti-ABO antibody production and hemolysis in patients receiving LDLLT across minor ABO-mismatches...
  31. ncbi request reprint Successful sub-zero non-freezing preservation of rat lungs at -2 degrees C utilizing a new supercooling technology
    Toshihiro Okamoto
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 27:1150-7. 2008
    ....
  32. doi request reprint Pulmonary adenocarcinomas with micropapillary component significantly correlate with recurrence, but can be well controlled with EGFR tyrosine kinase inhibitors in the early stages
    Shinji Sumiyoshi
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Lung Cancer 81:53-9. 2013
    ..Moreover, PA-MPCs with recurrence were associated with relatively better survival. These findings indicate that PA-MPCs were biologically aggressive but could be controlled with EGFR-TKIs...
  33. ncbi request reprint Recurrent lung cancer in the mediastinum noticed after a living-donor lobar lung transplantation
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, and Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Ann Thorac Cardiovasc Surg 15:119-22. 2009
    ..Recurrent disease appeared in her transplanted lungs 10 months after resection of the LNs, and she died of pneumonia with chronic rejection 2 years and 7 months after transplantation...
  34. doi request reprint Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer
    Shotaro Iwakiri
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Cancer 115:2580-93. 2009
    ..The authors elucidated particular chemokine receptors that are expressed on lung cancer cells, as well as the clinical significance of the expression of these chemokine receptors in completely resected nonsmall cell lung cancer (NSCLC)...
  35. doi request reprint Living-donor, single-lobe lung transplantation and simultaneous contralateral pneumonectomy in a child
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    J Heart Lung Transplant 30:471-4. 2011
    ..At 18 months after transplantation, the patient returned to school life and is currently able to carry out daily activities without supplemental oxygen...
  36. doi request reprint Comparison of pulmonary function test and computed tomography volumetry in living lung donors
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 30:572-5. 2011
    ..Our second goal was to compare the data of pulmonary function tests with CT volumetry in living lung donors...
  37. ncbi request reprint Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Cardiothorac Surg 41:1037-42. 2012
    ..For a better understanding of the patients undergoing resection of pulmonary pleomorphic carcinoma, we reviewed our experience with these patients...
  38. doi request reprint Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury
    Jitian Zhang
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    J Heart Lung Transplant 28:79-84. 2009
    ..We hypothesized that nebulized milrinone would mitigate warm ischemia-reperfusion injury of lung...
  39. doi request reprint Hypothermic machine perfusion ameliorates ischemia-reperfusion injury in rat lungs from non-heart-beating donors
    Daisuke Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 92:858-63. 2011
    ..The use of non-heart-beating donors (NHBD) has come into practice to resolve the shortage of donor lungs. This study investigated whether hypothermic machine perfusion (HMP) can improve the quality of NHBD lungs...
  40. doi request reprint Pulmonary resection for metastases from hepatocellular carcinoma
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    World J Surg 32:2213-7. 2008
    ..To confirm the role for resection of pulmonary metastases for such tumors, we reviewed our institutional experience...
  41. ncbi request reprint Use of virtual assisted lung mapping (VAL-MAP), a bronchoscopic multispot dye-marking technique using virtual images, for precise navigation of thoracoscopic sublobar lung resection
    Masaaki Sato
    Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan Electronic address
    J Thorac Cardiovasc Surg 147:1813-9. 2014
    ..The safety and efficacy of VAL-MAP were evaluated...
  42. doi request reprint Virtual endobronchial ultrasound for transbronchial needle aspiration
    Masaaki Sato
    Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan Electronic address
    J Thorac Cardiovasc Surg 146:1204-12. 2013
    ..Endobronchial ultrasound-guided transbronchial needle aspiration could be performed better with computer-based preparation...
  43. ncbi request reprint Pharmacokinetic study of weekly (days 1-5) low-dose S-1 in patients with non-small-cell lung cancer
    Tsuyoshi Shoji
    Department of Thoracic Surgery, Kyoto University Hospital, Shogoin kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Rev Recent Clin Trials 7:167-72. 2012
    ..To reduce adverse effects and improve compliance, we studied a "5-day on/2-day off" low-dose regimen of S-1 and evaluated pharmacokinetics in patients with non-small-cell lung cancer (NSCLC)...
  44. ncbi request reprint Outcomes and pulmonary function in living lobar lung transplant donors
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Transpl Int 25:153-7. 2012
    ..6 ± 8.9% and 89.3 ± 8.7% of the preoperative value 3, 6, and 12 months postoperatively. Living-donor lobectomy was performed with low morbidity. Pulmonary function even after lobectomy was better preserved than expected...
  45. doi request reprint Management of patients with coronary stents in elective thoracic surgery
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Hospital, 54 Shogoin Kawara cho, Sakyo ku, Kyoto, 606 8507 Kyoto, Japan
    Gen Thorac Cardiovasc Surg 59:477-82. 2011
    ..We investigated retrospectively perioperative management for patients with coronary stents undergoing thoracic surgery...
  46. doi request reprint Stent angioplasty for a kink in the pulmonary artery anastomosis soon after living-donor lobar lung transplantation
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Ann Thorac Surg 92:e105-6. 2011
    ..Approximately 24 hours after reperfusion, stent angioplasty was performed, resulting in the patient being successfully weaned from extracorporeal membrane oxygenation on postoperative day 4...
  47. doi request reprint Tumor extension along chest wall tract after diagnostic intervention in malignant pleural mesothelioma
    Fengshi Chen
    Department of Thoracic Surgery and Diagnostic Pathology, Kyoto University, Kyoto, Japan
    Interact Cardiovasc Thorac Surg 12:1060-2. 2011
    ..Despite the small number of cases, the importance of resection of the chest wall tract for the diagnostic intervention might be implied at EPP...
  48. doi request reprint Forced oscillation technique as a non-invasive assessment for lung transplant recipients
    Hiroshi Hamakawa
    Departments of Organ Preservation Technology, Department of Thoracic Surgery, Graduate School of Medicine, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Adv Exp Med Biol 662:293-8. 2010
    ..Thus, postoperative pulmonary function follow-up using forced oscillation technique was useful in assessing peripheral airway condition in critically ill patients, and may be able to detect acute rejection...
  49. doi request reprint Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis
    Toshiaki Ohara
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Ann Thorac Surg 86:e7-8. 2008
    ..However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions...
  50. doi request reprint Pulmonary resection for metastasis from renal cell carcinoma
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Interact Cardiovasc Thorac Surg 7:825-8. 2008
    ..3% and 41.7%, respectively, while 3-year and 5-year disease-free survival rate was 35.0% and 17.5%, respectively. Our study suggested that pulmonary metastasectomy for renal cell carcinoma might be well justified...
  51. doi request reprint Prognostic factors of pulmonary metastasectomy for colorectal carcinomas
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Sakyo ku, Kyoto University, 54 Shogoin Kawahara cho, Kyoto 606 8507, Japan
    World J Surg 33:505-11. 2009
    ..This study was designed to clarify a role for resection of pulmonary metastases for such tumors and to define the patients who benefit from pulmonary metastasectomy...
  52. doi request reprint Living-donor lobar lung transplantation for pulmonary complications after hematopoietic stem cell transplantation
    Masaomi Yamane
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama, Japan
    Transplantation 86:1767-70. 2008
    ..We reviewed our experiences regarding living-donor lobar lung transplantation (LDLLT) in patients with pulmonary complications of HSCT...
  53. doi request reprint Pulmonary resection for metastasis from esophageal carcinoma
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Interact Cardiovasc Thorac Surg 7:809-12. 2008
    ..Pulmonary metastasectomy for esophageal carcinoma with postoperative chemotherapy was seemingly justified. Solitary pulmonary metastasis might be a good candidate for favorable prognostic factor...
  54. doi request reprint Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma
    Masashi Ishikawa
    Faculty of Medicine, Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto, 606 8507, Japan
    Lung Cancer 76:431-8. 2012
    ..We retrospectively evaluated the expression levels of EphA2 and ephrin-A1 in surgically treated pathological (p-) stage I NSCLC tumor samples, and their relation to clinicopathologic features or postoperative prognoses...
  55. ncbi request reprint Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation: preliminary results of a Japanese series
    Yoshinori Okada
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryomachi, Aoba ku, Sendai, 980 8575, Japan
    Surg Today 42:152-6. 2012
    ..We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation...
  56. ncbi request reprint The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas
    Kentaro Kimura
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata cho, Okayama, Japan
    Oncol Rep 20:1265-8. 2008
    ..0004). Our study indicated that BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese MPMs, suggesting its pathogenic role and the ethnic difference in MPMs...
  57. ncbi request reprint Surgical management of bronchopulmonary typical carcinoid tumors: an institutional experience
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Interact Cardiovasc Thorac Surg 11:737-9. 2010
    ....
  58. doi request reprint Use of totally implantable central venous access port via the basilic vein in patients with thoracic malignancies
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Hospital, 54 Shogoin Kawaracho, Sakyo ku, Kyoto, 606 8507, Japan
    Int J Clin Oncol 14:208-12. 2009
    ....
  59. ncbi request reprint Repeat resection of pulmonary metastasis is beneficial for patients with colorectal carcinoma
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    World J Surg 34:2373-8. 2010
    ..To identify the class of patients who benefit from pulmonary resection of recurrent pulmonary metastases, we herein reviewed our institutional experience...
  60. ncbi request reprint Bronchial healing after living-donor lobar lung transplantation
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Surg Today 39:938-43. 2009
    ..To review the outcome of bronchial healing after living-donor lobar lung transplantation (LDLLT)...
  61. doi request reprint Prognostic factors for patients in postoperative brain metastases from surgically resected non-small cell lung cancer
    Jin Sakamoto
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University Hospital, 54 Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Int J Clin Oncol 19:50-6. 2014
    ..In this retrospective study, we investigated the prognostic factors in patients with postoperative brain metastases from surgical resected non-small cell lung cancer (NSCLC)...
  62. pmc Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients
    Masashi Kobayashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto
    Exp Ther Med 3:952-958. 2012
    ..0042). Intratumoral Wnt2B expression was associated with the expression of survivin and c-Myc, tumor proliferation and patient survival in MPM. Wnt2B is a potential molecular target for the treatment of Wnt2B-overexpressing MPMs...
  63. doi request reprint Registry of the Japanese society of lung and heart-lung transplantation: the official Japanese lung transplantation report 2012
    Takahiro Oto
    Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmacological Sciences, 2 5 1, Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Gen Thorac Cardiovasc Surg 61:208-11. 2013
    ..However, donor shortage remains a limitation of lung transplantation in Japan. The lung transplant centers in Japan should continue to make a special effort to save critically ill patients waiting for lung transplantation...
  64. pmc Pulmonary function of individual lung lobes after complex living-donor lobar lung transplantation using inspiratory and expiratory three-dimensional computed tomographic volumetry
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Interact Cardiovasc Thorac Surg 15:1077-9. 2012
    ....
  65. pmc Long-term outcome of induction chemoradiotherapy with docetaxel and cisplatin followed by surgery for non-small-cell lung cancer with mediastinal lymph node metastasis
    Shinichi Toyooka
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Interact Cardiovasc Thorac Surg 14:565-9. 2012
    ..7 years, the 3-year and 7-year overall survival (OS) rates for the entire population were 72.7 and 63.6%, respectively. Our results suggest that tri-modality therapy is promising for NSCLC patients with mediastinal nodal metastasis...
  66. doi request reprint Posterior reversible encephalopathy syndrome due to immunosuppressant after living-donor lobar lung transplantation: report of a case
    Tsuyoshi Shoji
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, Japan
    Gen Thorac Cardiovasc Surg 60:514-7. 2012
    ..PRES should be considered one of the important morbidity after lung transplantation...
  67. pmc Oxidative stress induced interleukin-32 mRNA expression in human bronchial epithelial cells
    Megumi Kudo
    Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Respir Res 13:19. 2012
    ..We further investigated transcriptional regulation responsible for IFNγ induced IL-32 expression in human airway epithelial cells...
  68. pmc Usefulness of endobronchial ultrasound in patients with previously treated thoracic malignancy
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Interact Cardiovasc Thorac Surg 14:34-7. 2012
    ..Despite the small number of cases, our results can reveal the usefulness of EBUS-TBNA particularly in patients with previously treated thoracic malignancy...
  69. ncbi request reprint Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer
    Masashi Kobayashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Anticancer Res 31:4619-23. 2011
    ..V-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations are attractive molecular targets for cancer treatment. Detection of BRAF gene mutation and analyses in non-small cell lung cancer (NSCLC) are of great scientific interest...
  70. doi request reprint Living-donor lobar lung transplantation with sparing of bilateral native upper lobes: a novel strategy
    Takuji Fujinaga
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Heart Lung Transplant 30:351-3. 2011
    ..Ten months after the transplantation, the patient has returned to a normal lifestyle without supplemental oxygen...
  71. doi request reprint Postoperative pleural effusion in living lobar lung transplant donors
    Toshiya Toyazaki
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Gen Thorac Cardiovasc Surg 59:440-2. 2011
    ..The mechanism of this complication was not clearly elucidated, but surgeons should not ignore the possibility of pleural effusion necessitating readmission in living-donor lobar lung transplant donors...
  72. doi request reprint Salvage lung resection for non-small cell lung cancer after stereotactic body radiotherapy in initially operable patients
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    J Thorac Oncol 5:1999-2002. 2010
    ..To further understand the indications for salvage surgery and the pathogenesis of tumor recurrence in these patients, we retrospectively reviewed cases treated at our institution...
  73. doi request reprint D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung
    Shotaro Iwakiri
    Department of Thoracic Surgery, Kyoto University, Sakyo ku, Japan
    Ann Surg Oncol 16:1678-85. 2009
    ..The purpose of this study is to assess the clinical significance of D2-40 status in completely resected non-small cell lung cancer...
  74. doi request reprint Multi-frequency forced oscillation technique using impulse oscillations: can it give mechanical information about the lung periphery?
    Hiroshi Hamakawa
    Department of Thoracic Surgery, Kobe City Medical Center General Hospital, Kobe City, Hyogo, Japan
    Adv Exp Med Biol 765:73-9. 2013
    ..This result might relate to the uncertainty of IOS for detecting mechanical properties of the lung periphery...
  75. doi request reprint Delayed chest closure assessed by transesophageal echocardiogram in single-lobe lung transplantation
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ann Thorac Surg 92:2254-7. 2011
    ..The following day, her chest could be completely closed. The pulmonary vein anastomosis, confirmed by transesophageal echocardiogram, was now patent. Currently, 7 months after the transplantation, she is well without limitations...
  76. doi request reprint Single-lobe lung transplantation for rapidly deteriorating pulmonary venoocclusive disease
    Koji Takahashi
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ann Thorac Surg 95:689-91. 2013
    ..Preoperatively, the recipient was intubated under deep sedation because of repeated episodes of pulmonary edema due to rapidly deteriorating pulmonary venoocclusive disease...
  77. doi request reprint Pulmonary lymphoepithelioma-like carcinoma with rapid progression
    Satona Tanaka
    Department of Thoracic Surgery, Kyoto University, Sakyo ku, Kyoto, Japan
    Gen Thorac Cardiovasc Surg 60:164-7. 2012
    ..At admission, the EBV deoxyribonucleic acid (DNA) blood level was 40 copies/μg. The EBV DNA was undetectable after the second surgery...
  78. doi request reprint Giant primary liposarcoma of the chest
    Tsuyoshi Shoji
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Gen Thorac Cardiovasc Surg 57:159-61. 2009
    ..Histological examination of both patients' tumors revealed a well-differentiated liposarcoma, with no pathological relation to the previous lipoma resected in either case...
  79. doi request reprint Clinical outcomes of short hook wire and suture marking system in thoracoscopic resection for pulmonary nodules
    Kentaroh Miyoshi
    Department of Cancer and Thoracic Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Cardiothorac Surg 36:378-82. 2009
    ..In this study, we reviewed our recent experience to examine the problems for resecting procedure using the device and determine if the system negatively impacts the survival rates for lung cancers...
  80. doi request reprint ABO-incompatible living-donor lobar lung transplantation
    Tsuyoshi Shoji
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara cho, Kyoto, Japan
    J Heart Lung Transplant 30:479-80. 2011
    ..To our knowledge, this case represents the first successful living-donor lobar lung transplantation from ABO-incompatible donors...
  81. ncbi request reprint Value of FOXP3 expression in peripheral blood as rejection marker after miniature swine lung transplantation
    Naoki Satoda
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 27:1293-301. 2008
    ..There is emerging clinical evidence that, paradoxically, expression of forkhead box P3 (FOXP3, a specific marker for the regulatory T cells) is upregulated within rejecting grafts...
  82. doi request reprint Characteristic endobronchial ultrasound image of hemangiopericytoma/solitary fibrous tumor
    Fengshi Chen
    Department of Thoracic Surgery and Diagnostic Pathology, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Interact Cardiovasc Thorac Surg 11:331-2. 2010
    ..Preoperative EBUS revealed a tumor with abundant thin-walled vessel-like structures, which was consistent with HPC/SFT. The tumor was completely resected and was finally diagnosed as low-grade malignant HPC/SFT...
  83. doi request reprint Post-transplant lymphoproliferative disorder following cytomegalovirus reactivation in a lung recipient
    Akihiro Aoyama
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Gen Thorac Cardiovasc Surg 58:251-4. 2010
    ....
  84. doi request reprint Non-specific interstitial pneumonia as a manifestation of graft-versus-host disease following pediatric allogeneic hematopoietic stem cell transplantation
    Aya Miyagawa-Hayashino
    Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Pathol Int 60:137-42. 2010
    ..Because the patient had chronic GVHD of the skin and the liver preceeded by the development of pulmonary involvement, NSIP may represent one of the facets of pulmonary GVHD...
  85. doi request reprint Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities
    Fengshi Chen
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Cardiothorac Surg 34:1235-9. 2008
    ..Factors affecting recurrence and survival after pulmonary resection for metastatic osteosarcomas are controversial. To confirm a role for resection of pulmonary metastases for such tumors, we herein reviewed our institutional experience...
  86. doi request reprint Peripheral primitive neuroectodermal tumour of the chest wall invading lung with regional lymph node metastasis
    Makoto Sonobe
    Department of Thoracic Surgery, Kyoto University Hospital, Japan
    Eur J Cardiothorac Surg 35:185-7. 2009
    ..After surgery, combination chemotherapy with cyclophosphamide, vincristine, doxorubicin, ifosphamide, and etoposide was given. Five years after resection, the patient remains alive and well, with no signs of recurrence...
  87. ncbi request reprint Accuracy of epidermal growth factor receptor gene mutation analysis by direct sequencing method based on small biopsy specimens from patients with non-small cell lung cancer: analysis of results in 19 patients
    Katsuhiro Masago
    Department of Respiratory Medicine, Kyoto University Hospital, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Int J Clin Oncol 13:442-6. 2008
    ....
  88. pmc Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma
    Toshi Menju
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e25301. 2011
    ..Since the GEP100 PH domain interacts with both Her2 and EGFR, targeting this domain may provide novel cancer therapeutics...
  89. ncbi request reprint Octreotide, a somatostatin analogue, in the treatment of chylothorax associated with idiopathic fibrosing mediastinitis
    Yosuke Togashi
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
    Tohoku J Exp Med 222:51-3. 2010
    ..After discharge, the patient has received octreotide treatment for 6 months without serious adverse events. We suggest octreotide as a treatment option for FM...
  90. doi request reprint Large solitary fibrous tumor with overexpression of insulin-like growth factor-2
    Ryo Okabe
    Department of Thoracic Surgery, Kyoto University Hospital, Shogoin Kawara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Interact Cardiovasc Thorac Surg 11:688-90. 2010
    ..Two years after surgery, the patient remains alive and well, with no signs of recurrence or hypoglycemia...
  91. doi request reprint The allelic distribution of a single nucleotide polymorphism in the PDCD5 gene locus of Japanese non-small cell lung cancer patients
    Kei Nanba
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Mol Med Report 1:667-71. 2008
    ..This suggests the presence of an ethnicity-related difference in the role of PDCD5 in the pathogenesis of lung cancer...
  92. doi request reprint Safety of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan
    Hiroki Nagai
    Outpatient Oncology Unit, Kyoto University Hospital, Kyoto, 606 8507, Japan
    Int J Clin Oncol 16:560-7. 2011
    ..Therefore, we aimed to clarify the safety profile of erlotinib...
  93. doi request reprint First registry report: lung transplantation in Japan: The Japanese Society of Lung and Heart-Lung Transplantation
    Toru Bando
    The Japanese Society of Lung and Heart Lung Transplantation, Utsunomiya, Japan
    Gen Thorac Cardiovasc Surg 56:17-21. 2008
    ..The current transplant laws need to be reconsidered...
  94. doi request reprint Age-related changes in the trachea in healthy adults
    Hiroaki Sakai
    Departments of Thoracic Surgery, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Adv Exp Med Biol 662:115-20. 2010
    ..32; p = 0.00364). There were measurable age related changes of the trachea both in the area and the shape. Aging results in the increased tracheal area and a distortion of the roundness...
  95. ncbi request reprint Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung
    Hiroshi Suehisa
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama, Japan
    J Clin Oncol 25:3952-7. 2007
    ..The present study evaluated whether the EGFR status could be used as a biologic predictor of the outcome of adjuvant chemotherapy with uracil-tegafur...
  96. ncbi request reprint Induction chemoradiotherapy prior to surgery for non-small cell lung cancer invading the left atrium
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Cardiothorac Surg 33:315-6. 2008
    ..Our case suggests that induction chemoradiotherapy prior to surgery can be an appropriate strategy among carefully selected patients with non-small cell lung cancer invading the left atrium...
  97. ncbi request reprint ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer
    Tetsuya Fujii
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Lung Cancer 59:377-84. 2008
    ..Further study is needed to clarify the value of molecular predictors for customizing therapy for patients with NSCLC...
  98. doi request reprint Current status of postoperative follow-up for lung cancer in Japan: questionnaire survey by the Setouchi Lung Cancer Study Group-A0901
    Shigeki Sawada
    Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, 160 Kou, Minamiumemoto cho, Matsuyama, Ehime 791 0280, Japan
    Gen Thorac Cardiovasc Surg 60:104-11. 2012
    ..Under these circumstances, each doctor establishes his or her own follow-up protocol. This questionnaire survey was conducted to grasp the current status of postoperative follow-up in Japan...
  99. ncbi request reprint [Living-donor lobar lung transplantation for pediatric patients]
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nihon Geka Gakkai Zasshi 111:284-7. 2010
    ..A new organ transplantation law, which takes effect from July 2010, will give hope to sick children who do not have suitable living donors in their families...
  100. ncbi request reprint Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation
    Ryujiro Sugimoto
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    J Heart Lung Transplant 27:921-4. 2008
    ..Although a beneficial effect of sirolimus in the treatment of LAM has not been definitively determined, this report may provide useful information for management of recurrent LAM after lung transplantation...
  101. ncbi request reprint [Current status of lung transplantation in Japan]
    Hiroshi Date
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine
    Nihon Rinsho 68:2266-70. 2010
    ..The 5-year survival rate was 81.4% in LDLLT and 68.6% in CLT (p = 0.104), which were much better than world average...