Hidenori Arai

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Management of type IIb dyslipidemia
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 19:105-14. 2012
  2. doi request reprint Toward the realization of a better aged society: messages from gerontology and geriatrics
    Hidenori Arai
    Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 12:16-22. 2012
  3. ncbi request reprint More intensive lipid lowering is associated with regression of coronary atherosclerosis in diabetic patients with acute coronary syndrome--sub-analysis of JAPAN-ACS study
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 17:1096-107. 2010
  4. doi request reprint Geriatrics in the most aged country, Japan
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Arch Gerontol Geriatr 49:S1-2. 2009
  5. ncbi request reprint Polymorphisms of apolipoprotein e and methylenetetrahydrofolate reductase in the Japanese population
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Japan
    J Atheroscler Thromb 14:167-71. 2007
  6. ncbi request reprint Serum lipid survey and its recent trend in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Atheroscler Thromb 12:98-106. 2005
  7. ncbi request reprint Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara cho, Shogoin, Sakuo ku, Kyoto 606 8507, Japan
    J Atheroscler Thromb 12:240-50. 2005
  8. ncbi request reprint Prevalence of metabolic syndrome in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 13:202-8. 2006
  9. doi request reprint Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:2195-201. 2008
  10. ncbi request reprint C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 17:219-28. 2010

Detail Information

Publications44

  1. ncbi request reprint Management of type IIb dyslipidemia
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 19:105-14. 2012
    ..Thus, the management of type IIb dyslipidemia is very important for the prevention of cardiovascular disease, so we have attempted to provide a guideline for the management of type IIb dyslipidemia...
  2. doi request reprint Toward the realization of a better aged society: messages from gerontology and geriatrics
    Hidenori Arai
    Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 12:16-22. 2012
    ..1...
  3. ncbi request reprint More intensive lipid lowering is associated with regression of coronary atherosclerosis in diabetic patients with acute coronary syndrome--sub-analysis of JAPAN-ACS study
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 17:1096-107. 2010
    ..The purpose of this study was to address the association of lipid levels after statin therapy with regression of atherosclerotic coronary lesions and major cardiovascular events in patients after ACS...
  4. doi request reprint Geriatrics in the most aged country, Japan
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Arch Gerontol Geriatr 49:S1-2. 2009
    ..Additionally, there is a need for improvement of our insurance systems to support such care. Our approach to the aging society will pave the way for other countries in Asia and the west...
  5. ncbi request reprint Polymorphisms of apolipoprotein e and methylenetetrahydrofolate reductase in the Japanese population
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Japan
    J Atheroscler Thromb 14:167-71. 2007
    ..The aim of this study is to analyze the effect of apolipoprotein E (apo E) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on serum lipid and homocysteine levels in the general Japanese population...
  6. ncbi request reprint Serum lipid survey and its recent trend in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Atheroscler Thromb 12:98-106. 2005
    ..The present results will become the standard serum lipid level data for the Japanese people, and succeeding 10-year surveys will clarify the trends of lipid levels in this country...
  7. ncbi request reprint Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara cho, Shogoin, Sakuo ku, Kyoto 606 8507, Japan
    J Atheroscler Thromb 12:240-50. 2005
    ..Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events...
  8. ncbi request reprint Prevalence of metabolic syndrome in the general Japanese population in 2000
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 13:202-8. 2006
    ..Intervention to reduce the incidence of metabolic syndrome in Japan is necessary to reduce the risk of cardiovascular disease...
  9. doi request reprint Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:2195-201. 2008
    ..In the present study, to further examine the role of CCR2 in the development of obesity and type 2 diabetes, we studied the effect of pharmacological inhibition of CCR2 from the early stage of obesity in db/db mice...
  10. ncbi request reprint C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 17:219-28. 2010
    ..In the present study, therefore, we examined whether pharmacological inhibition of CCR2 is effective against the development of diet-induced metabolic disorders...
  11. ncbi request reprint Ezetimibe ameliorates early diabetic nephropathy in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Atheroscler Thromb 19:608-18. 2012
    ..In the present study, therefore, we examined the protective effect of ezetimibe on diabetic nephropathy in db/db mice...
  12. doi request reprint Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice
    Masayuki Sugimoto
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Japan
    Atherosclerosis 204:388-94. 2009
    ....
  13. doi request reprint Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy
    Akira Mima
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabetes 57:1712-22. 2008
    ....
  14. ncbi request reprint Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury
    Yang Xu
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 363:782-7. 2007
    ..Adventitial small vessels were positive both for CD31 and GFP. Our data indicate that BM-derived cells can contribute to the development of atherosclerosis in the presence of hypercholesterolemia...
  15. doi request reprint Differential effect of statins on diabetic nephropathy in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Int J Mol Med 28:683-7. 2011
    ..In conclusion, our data suggest that pitavastatin and rosuvastatin can improve diabetic nephropathy through the suppression of glomerular hypertrophy, independent of lipid-lowering or anti-oxidative effects...
  16. doi request reprint Chronic kidney disease (CKD) is an independent risk factor for long-term care insurance (LTCI) need certification among older Japanese adults: a two-year prospective cohort study
    Minoru Yamada
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Arch Gerontol Geriatr 57:328-32. 2013
    ..44 [95% CI 1.12-1.86]). Our results indicate that CKD is independently associated with new LTCI service need certification and is an important marker of frailty in older adults...
  17. pmc Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells
    Kazuo Torikoshi
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 7:e41186. 2012
    ..These results suggest that TGF-β up-regulates PIASy expression in MCs to down-regulateα-SMA gene transcription by the interaction with E12...
  18. doi request reprint Community-based exercise program is cost-effective by preventing care and disability in Japanese frail older adults
    Minoru Yamada
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Med Dir Assoc 13:507-11. 2012
    ..In Japan, older adults are assessed by frailty checklist for care prevention. However, the effect of care prevention programs in community-dwelling frail older adults is still unclear...
  19. doi request reprint Complex obstacle negotiation exercise can prevent falls in community-dwelling elderly Japanese aged 75 years and older
    Minoru Yamada
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 12:461-7. 2012
    ....
  20. ncbi request reprint Gender difference in ICER Igamma transgenic diabetic mouse
    Akari Inada
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biosci Biotechnol Biochem 71:1920-6. 2007
    ..Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions...
  21. doi request reprint Prevalence of sarcopenia in community-dwelling Japanese older adults
    Minoru Yamada
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Electronic address
    J Am Med Dir Assoc 14:911-5. 2013
    ..Sarcopenia, the age-dependent loss of skeletal muscle mass, is highly prevalent among older adults in many countries; however, the prevalence of sarcopenia in healthy Japanese community-dwelling older adults is not well characterized...
  22. doi request reprint Global brain atrophy is associated with physical performance and the risk of falls in older adults with cognitive impairment
    Minoru Yamada
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 13:437-42. 2013
    ..The purpose of this study was to determine whether global brain atrophy is associated with cognitive function, physical performance and fall incidents in older adults with mild cognitive disorder...
  23. doi request reprint Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and non-elderly using a visual analogue scale: the importance of appetite and depressive mood
    Hiroshi Kanamori
    Department of Nephrology, Kyoto University Hospital, Kyoto, Japan
    Geriatr Gerontol Int 12:65-71. 2012
    ..The assessment of their psychosocial status and quality of life (QOL) is therefore becoming more and more important along with laboratory data or comorbidities...
  24. doi request reprint Role of growth arrest-specific gene 6 in diabetic nephropathy
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Vitam Horm 78:375-92. 2008
    ..Inhibition of the Gas6/Axl pathway in diabetic patients might be beneficial to slow down the progression of diabetic nephropathy...
  25. ncbi request reprint Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy
    Hiroshi Kanamori
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 360:772-7. 2007
    ..Thus blocking the MCP-1/CCR2 pathway ameliorated glomerulosclerosis, indicating that the MCP-1/CCR2 pathway plays a crucial role in the progression of diabetic nephropathy...
  26. doi request reprint Priorities of health care outcomes for the elderly
    Masahiro Akishita
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Am Med Dir Assoc 14:479-84. 2013
    ..For this purpose, surveys were conducted on priorities of health care outcomes for the elderly...
  27. doi request reprint Both conventional indices of cognitive function and frailty predict levels of care required in a long-term care insurance program for memory clinic patients in Japan
    Hajime Takechi
    Departments of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Faculty of Social Studies, Doshisha University, Kyoto, Japan
    Geriatr Gerontol Int 12:630-6. 2012
    ..To delineate relationships among cognitive function, frailty and level of care required in the Japanese long-term care insurance program (LTCIP) in outpatient memory clinic patients...
  28. ncbi request reprint Acute renal failure after exercise in a Japanese sumo wrestler with renal hypouricemia
    Akira Mima
    Department of Nephrology, Kyoto University Graduate School of Medicine, and Department of Internal Medicine, Ijinkai Takeda General Hospital, Kyoto, Japan
    Am J Med Sci 336:512-4. 2008
    ..Thus, we describe a Japanese sumo wrestler of familial renal hypouricemia complicated with anaerobic exercise-induced ARF, with definite demonstration of genetic abnormality in the responsible gene, URAT1...
  29. doi request reprint [Erratum] Differential effect of statins on diabetic nephropathy in db/db mice
    Yukinori Tamura
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Int J Mol Med 33:1371. 2014
    ..4B. Shown below is the new version of Fig. 4B with the correct values. [the original article was published in the International Journal of Molecular Medicine 28: 683-687, 2011 DOI: 10.3892/ijmm.2011.769]. ..
  30. ncbi request reprint Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
    Akiko Harauma
    Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 358:751-6. 2007
    ..Aqueous extract of ML had a strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl and inhibited lipoprotein oxidation. These results confirm that ML contains anti-oxidative substances that might help prevent atherosclerosis...
  31. ncbi request reprint Coexpression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolism
    Hidenori Komori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Arterioscler Thromb Vasc Biol 28:1298-303. 2008
    ..This study was aimed to clarify the role of the human SR-BI/CD36 and LIMP-II Analogues-1 (CLA-1) as a molecular target of selective uptake of cholesteryl ester from HDL in vivo...
  32. pmc AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions
    Dat Nguyen Tien
    1 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan 2 Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan 3 Department of Biomolecular Engineering, Kyoto Institute of Technology, Kyoto, Japan
    Sci Rep 4:5094. 2014
    ..These results demonstrated a novel role of AMAP1 as a negative feedback regulator of NF-κB, and presented it as a possible target for anti-inflammatory treatments. ..
  33. ncbi request reprint Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study
    Hidenori Arai
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine
    J Atheroscler Thromb 20:195-203. 2013
    ..We therefore examined the association between sd-LDL cholesterol (sd-LDL-C) and CVD in a Japanese cohort...
  34. doi request reprint Indications and practice for tube feeding in Japanese geriatricians: implications of multidisciplinary team approach
    Mihoko Ogita
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Tokyo, Japan
    Geriatr Gerontol Int 12:643-51. 2012
    ....
  35. ncbi request reprint Roles of coagulation pathway and factor Xa in rat mesangioproliferative glomerulonephritis
    Keiko Nomura
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Lab Invest 87:150-60. 2007
    ....
  36. doi request reprint Arterial stiffness is associated with low skeletal muscle mass in Japanese community-dwelling older adults
    Ricardo Aurélio Carvalho Sampaio
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 14:109-14. 2014
    ..To examine whether arterial stiffness, measured by the cardio-ankle vascular index (CAVI), is associated with skeletal muscle mass index (SMI) in Japanese community-dwelling older adults...
  37. doi request reprint Age-dependent changes in skeletal muscle mass and visceral fat area in Japanese adults from 40 to 79 years-of-age
    Minoru Yamada
    Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 14:8-14. 2014
    ..The aim of the present study was to evaluate the age-dependent changes in skeletal muscle mass and the visceral fat area in Japanese adults from 40 to 79 years-of-age...
  38. pmc SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells
    Eriko Sumi
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Am J Pathol 170:1854-64. 2007
    ..These results indicate that SOX9 is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis...
  39. pmc Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis
    Yoshihisa Tsuji
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Immunity 37:326-38. 2012
    ..These studies indicate that gut commensals enable noninfectious pancreatic inflammation via NOD1 signaling in pancreatic acinar cells...
  40. doi request reprint Faster decline of physical performance in older adults with higher levels of baseline locomotive function
    Minoru Yamada
    Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Geriatr Gerontol Int 12:238-46. 2012
    ..The purpose of this longitudinal study was to determine whether the rate of decline in community-dwelling older adults varies according to baseline locomotive function levels...
  41. ncbi request reprint Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells
    Xin Zhuge
    Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 351:865-71. 2006
    ..These results indicate that the protection of atherogenesis in TP(-/-) mice is not associated with TP in BM-derived cells...
  42. ncbi request reprint [Current trend of hyperlipidemia in Japan--comparison with the trend in United States and Europe]
    Hidenori Arai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine
    Nihon Rinsho 65:241-7. 2007
  43. doi request reprint Survey on geriatricians’ experiences of adverse drug reactions caused by potentially inappropriate medications: commission report of the Japan Geriatrics Society
    Masahiro Akishita
    Department of Geriatric Medicine, The University of Tokyo, and Tokyoo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 11:3-7. 2011
    ..The JGS working group in collaboration with the Japan Broadcasting Corporation conducted the survey to geriatricians to investigate their experiences of adverse drug reactions (ADR) caused by potentially inappropriate medications...
  44. ncbi request reprint Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy
    Kojiro Nagai
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Kidney Int 68:552-61. 2005
    ..We have already reported Gas6 is involved in glomerular hypertrophy observed in diabetic nephropathy. However, the molecular mechanisms involved in glomerular hypertrophy are still unknown, especially in vivo...