Wataru Aoi

Summary

Affiliation: Kyoto Prefectural University of Medicine
Country: Japan

Publications

  1. ncbi request reprint Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice
    Wataru Aoi
    Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602 0841, Japan
    Antioxid Redox Signal 5:139-44. 2003
  2. pmc Exercise and functional foods
    Wataru Aoi
    Research Center for Sports Medicine, Doshisha University, Kyoto 602 8580, Japan
    Nutr J 5:15. 2006
  3. ncbi request reprint Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:892-7. 2008
  4. doi request reprint A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1 5 Hangi cho Shimogamo, Sakyo ku, Kyoto 606 8522, Japan
    Gut 62:882-9. 2013
  5. doi request reprint Regular exercise reduces colon tumorigenesis associated with suppression of iNOS
    Wataru Aoi
    Kyoto Prefectural University, Japan
    Biochem Biophys Res Commun 399:14-9. 2010
  6. ncbi request reprint Inhibitory effect of fermented milk on delayed-onset muscle damage after exercise
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Nutr Biochem 18:140-5. 2007
  7. ncbi request reprint Effect of exercise on hepatic gene expression in rats: a microarray analysis
    Wataru Aoi
    Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Life Sci 75:3117-28. 2004
  8. ncbi request reprint Oxidative stress and delayed-onset muscle damage after exercise
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Free Radic Biol Med 37:480-7. 2004
  9. doi request reprint Relaxant effect of microtitan via regulation of autonomic nerve activity in mice
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo Hangi cho 1 5, Sakyo ku, Kyoto 606 8522, Japan
    Life Sci 85:408-11. 2009
  10. doi request reprint The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity
    Wataru Aoi
    Kyoto Prefectural University, Japan
    Am J Physiol Endocrinol Metab 298:E799-806. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice
    Wataru Aoi
    Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602 0841, Japan
    Antioxid Redox Signal 5:139-44. 2003
    ..Astaxanthin can attenuate exercise-induced damage in mouse skeletal muscle and heart, including an associated neutrophil infiltration that induces further damage...
  2. pmc Exercise and functional foods
    Wataru Aoi
    Research Center for Sports Medicine, Doshisha University, Kyoto 602 8580, Japan
    Nutr J 5:15. 2006
    ..This article describes various "functional foods" that have been reported to be effective for improving exercise performance or health promotion, along with the relevant physiological changes that occur during exercise...
  3. ncbi request reprint Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:892-7. 2008
    ..Our results suggested that astaxanthin promoted lipid metabolism rather than glucose utilization during exercise via CPT I activation, which led to improvement of endurance and efficient reduction of adipose tissue with training...
  4. doi request reprint A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1 5 Hangi cho Shimogamo, Sakyo ku, Kyoto 606 8522, Japan
    Gut 62:882-9. 2013
    ..The purpose of this study was to identify new myokines that contribute to the prevention of colon tumorigenesis...
  5. doi request reprint Regular exercise reduces colon tumorigenesis associated with suppression of iNOS
    Wataru Aoi
    Kyoto Prefectural University, Japan
    Biochem Biophys Res Commun 399:14-9. 2010
    ..Our results suggest that regular exercise prevents colon tumorigenesis, at least partly via the suppression of iNOS expression associated with anti-inflammation...
  6. ncbi request reprint Inhibitory effect of fermented milk on delayed-onset muscle damage after exercise
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Nutr Biochem 18:140-5. 2007
    ..These results indicate that fermented milk can ameliorate delayed-onset muscle damage after prolonged exercise, which is associated with an increased antioxidant capacity of muscles...
  7. ncbi request reprint Effect of exercise on hepatic gene expression in rats: a microarray analysis
    Wataru Aoi
    Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Life Sci 75:3117-28. 2004
    ..These results indicate that long-term exercise can alter liver function via changes of gene expression, especially the genes encoding signal transduction proteins such as p38 and stat3...
  8. ncbi request reprint Oxidative stress and delayed-onset muscle damage after exercise
    Wataru Aoi
    Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Free Radic Biol Med 37:480-7. 2004
    ....
  9. doi request reprint Relaxant effect of microtitan via regulation of autonomic nerve activity in mice
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo Hangi cho 1 5, Sakyo ku, Kyoto 606 8522, Japan
    Life Sci 85:408-11. 2009
    ..It has been shown that microtitan may possibly affect the nervous system. In the present study, we examined the effect of microtitan on spontaneous activity during the sleeping period and on autonomic nervous activity in mice...
  10. doi request reprint The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity
    Wataru Aoi
    Kyoto Prefectural University, Japan
    Am J Physiol Endocrinol Metab 298:E799-806. 2010
    ..These observations demonstrate that miR-696 is a physical activity-dependent miRNA involved in the translational regulation of PGC-1alpha and skeletal muscle metabolism in mice...
  11. doi request reprint Dietary whey hydrolysate with exercise alters the plasma protein profile: a comprehensive protein analysis
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Nutrition 27:687-92. 2011
    ..In the present study, we investigated the effect of dietary whey protein on endurance and glycogen resynthesis and attempted to identify plasma proteins that reflected the physical condition by a comprehensive proteomics approach...
  12. ncbi request reprint Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 341:376-81. 2006
    ....
  13. ncbi request reprint Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 31:1288-91. 2007
    ....
  14. ncbi request reprint Laser capture microdissection/GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice
    Yuji Naito
    Departments of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Redox Rep 9:307-12. 2004
    ..In the present study we report larger groups of transcripts displaying significant expression modulation in glomerular cells obtained from the early phase of diabetic nephropathy...
  15. doi request reprint Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606 8522, Japan
    Biochem Biophys Res Commun 432:650-3. 2013
    ..These data suggests that dietary propolis improves insulin sensitivity and blood pressures in the early stage of the process in development of insulin resistance, which may be mediated by suppression of metabolic acidosis...
  16. doi request reprint Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Biochem Biophys Res Commun 413:330-5. 2011
    ..Furthermore, regular exercise decreased the expression of heat shock protein 47, a marker of hepatic fibrosis, in the liver. Our results suggest that regular exercise prevents fatty liver via improvement of hepatic lipid metabolism...
  17. ncbi request reprint Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes
    Hiromu Ohnogi
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
    Biosci Biotechnol Biochem 76:961-6. 2012
    ..keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome...
  18. ncbi request reprint Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Biofactors 20:49-59. 2004
    ..In conclusion, administration of astaxanthin might be a novel approach for the prevention of diabetes nephropathy...
  19. doi request reprint Titanium-treated surroundings attenuate psychological stress associated with autonomic nerve regulation in office workers with daily emotional stress
    Wataru Aoi
    Laboratory of Health Science, Kyoto Prefectural University, Hangi cho Shimogamo, Sakyo ku, Kyoto, Japan
    Physiol Behav 108:13-8. 2012
    ..3%, 95% CI=4.7-21.9; days 3-4, 26.8%, 95% CI=4.9-38.7; and days 5-6, 24.1%, 95% CI=5.8-34.0 vs. before trial). These results suggest that sleeping in a room containing titanium lowers physiological and psychological stress...
  20. ncbi request reprint Oxidative stress and skeletal muscle dysfunction with aging
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Curr Aging Sci 4:101-9. 2011
    ..This article describes the influence of oxidative stress on the progress of age-related muscle dysfunction and reviews the effect of countermeasures such as exercise and diet...
  21. pmc Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men
    Wataru Aoi
    Laboratory of Health Science, Kyoto Prefectural University Kyoto, Japan
    Front Physiol 4:80. 2013
    ..58, P = 0.038). Conclusion: The reduction in circulating miR-486 may be associated with metabolic changes during exercise and adaptation induced by training...
  22. ncbi request reprint Cyclosporin A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration
    Kunihiro Sakuma
    Department of Legal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, 602 8566 Kyoto, Japan
    Acta Neuropathol 110:269-80. 2005
    ..Our results demonstrated that CsA treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration in vivo...
  23. ncbi request reprint Low birth weight is associated with high waist-to-height ratio in Japanese elementary school girls
    Kiyomi Harada
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
    Tohoku J Exp Med 231:85-91. 2013
    ..001). The waist-to-height ratio was significantly higher in the < 3,000 g group in girls (P = 0.004), but not in the boys. Our results suggest that intrauterine environmental insults might have an effect on children, depending on sex. ..
  24. doi request reprint Combined light exercise after meal intake suppresses postprandial serum triglyceride
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Med Sci Sports Exerc 45:245-52. 2013
    ..The present study investigated the effects of combined low-intensity exercise before and after a high-fat meal on serum triglyceride concentrations...
  25. ncbi request reprint Angelica keiskei extract improves insulin resistance and hypertriglyceridemia in rats fed a high-fructose drink
    Hiromu Ohnogi
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
    Biosci Biotechnol Biochem 76:928-32. 2012
    ..These results suggest that AE improved the insulin resistance and hypertriglyceridemia of the fructose-drinking rats...
  26. doi request reprint Dietary intervention with cooking instructions and self-monitoring of the diet in free-living hypertensive men
    Kaori Kitaoka
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Clin Exp Hypertens 35:120-7. 2013
    ..0-143.0, P = .231; 84.9-85.3, P = .381). In the intervention group, the urinary sodium-to-potassium excretion ratio was significantly improved by focusing on cooking instructions and self-monitoring of the diet...
  27. doi request reprint Exercise and food factors
    Wataru Aoi
    Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
    Forum Nutr 61:147-55. 2009
    ..This article describes various food factors that have been reported to be effective for improving health promotion, along with the relevant physiological changes that occur during exercise...
  28. doi request reprint Potential role of oxidative protein modification in energy metabolism in exercise
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1 5 Hangi cho Shimogamo, Sakyo ku, Kyoto, 606 8522, Japan
    Subcell Biochem 77:175-87. 2014
    ..This oxidative protein modification may be useful as a potential biomarker to examine the oxidative stress levels, antioxidant compounds, and their possible benefits in exercise. ..
  29. doi request reprint Ingestion of low dose pyroglutamyl leucine improves dextran sulfate sodium-induced colitis and intestinal microbiota in mice
    Sayori Wada
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo, Kyoto, 606 8522, Japan
    J Agric Food Chem 61:8807-13. 2013
    ..Administration of pyroGlu-Leu normalized population of Bacteroidetes and Firmicutes in the colon. These results indicate that pyroGlu-Leu has a potential therapeutic effect against IBD at a practical dose. ..
  30. doi request reprint Role of oxidative stress in impaired insulin signaling associated with exercise-induced muscle damage
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606 8522, Japan Electronic address
    Free Radic Biol Med 65:1265-72. 2013
    ..Muscle-damaging exercise may thus lead to decreased endurance capacity and muscle fatigue in exercise, and it may decrease the efficiency of exercise therapy for metabolic improvement. ..
  31. pmc Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function
    Wataru Aoi
    Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606 8522, Japan
    J Nutr Metab 2011:676208. 2011
    ..Furthermore, it has been suggested that several phytochemicals contained in natural foods can improve nutrient metabolism and prevent protein degradation in the muscle...
  32. ncbi request reprint Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 315:892-6. 2004
    ....
  33. ncbi request reprint Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion
    Diego Colombo
    Dipartimento di Chimica e Biochimica Medica, Universita di Milano, Via Saldini 50, 20133 Milan, Italy
    Cancer Lett 186:37-41. 2002
    ..Two of these, devoid of any functionality on the lipophilic chain, when tested in an in vivo two-stage carcinogenesis test, exhibited marked inhibitory effects on mouse skin tumor promotion...
  34. ncbi request reprint Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 65:179-83. 2002
    ..2-0.6 mg per ear. In addition, all of the compounds tested except for compound 5 showed potent inhibitory effects on EBV-EA induction (100% inhibition at 1 x 10(3) mol ratio/TPA)...