Haruhiko Akiyama

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
  2. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
  3. ncbi [Sox family regulate chondrogenesis]
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University
    Clin Calcium 16:368- 72. 2006
  4. ncbi Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Matrix Biol 26:224-33. 2007
  5. doi Control of chondrogenesis by the transcription factor Sox9
    Haruhiko Akiyama
    Department of Orthopaedics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Mod Rheumatol 18:213-9. 2008
  6. doi In-vitro characteristics of cemented titanium femoral stems with a smooth surface finish
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Sakyo, Kyoto, Kyoto 606 8507, Japan
    J Orthop Sci 18:29-37. 2013
  7. doi A novel technique for impaction bone grafting in acetabular reconstruction of revision total hip arthroplasty using an ex vivo compaction device
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Shogoin Kawahara cho, Sakyo, Kyoto, 606 8507, Japan
    J Orthop Sci 16:26-37. 2011
  8. doi Cemented total hip arthroplasty with subtrochanteric femoral shortening transverse osteotomy for severely dislocated hips: outcome with a 3- to 10-year follow-up period
    Haruhiko Akiyama
    Department of Orthopedic Surgery, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Orthop Sci 16:270-7. 2011
  9. pmc Unraveling the transcriptional regulatory machinery in chondrogenesis
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Bone Miner Metab 29:390-5. 2011
  10. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005

Detail Information

Publications60

  1. ncbi The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
    ..Our in vitro studies indicate that the ubiquitin-proteasome proteolytic system degrades Sox9 and regulates its transcriptional activity...
  2. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway...
  3. ncbi [Sox family regulate chondrogenesis]
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University
    Clin Calcium 16:368- 72. 2006
    ..Indeed, mouse genetics approaches clearly indicate that these Sox family transcription factors are essential for chondrogenesis...
  4. ncbi Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Matrix Biol 26:224-33. 2007
    ..These results provide evidence that Sox9 induces ectopic chondrogenesis in mesenchymal cells and strongly suggest that its expression may be regulated by Hox genes during limb bud development...
  5. doi Control of chondrogenesis by the transcription factor Sox9
    Haruhiko Akiyama
    Department of Orthopaedics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Mod Rheumatol 18:213-9. 2008
    ..This review discusses the molecular properties and mechanisms of Sry-related high-mobility-group box (Sox) transcription factor, Sox9, in chondrogenesis...
  6. doi In-vitro characteristics of cemented titanium femoral stems with a smooth surface finish
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Sakyo, Kyoto, Kyoto 606 8507, Japan
    J Orthop Sci 18:29-37. 2013
    ..However, we have reported excellent clinical and radiological outcomes for cemented titanium stems made using the composite-beam concept. This study examines the characteristics of cemented titanium femoral stems with a smooth surface...
  7. doi A novel technique for impaction bone grafting in acetabular reconstruction of revision total hip arthroplasty using an ex vivo compaction device
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Shogoin Kawahara cho, Sakyo, Kyoto, 606 8507, Japan
    J Orthop Sci 16:26-37. 2011
    ....
  8. doi Cemented total hip arthroplasty with subtrochanteric femoral shortening transverse osteotomy for severely dislocated hips: outcome with a 3- to 10-year follow-up period
    Haruhiko Akiyama
    Department of Orthopedic Surgery, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Orthop Sci 16:270-7. 2011
    ..The purpose of this study was to evaluate the outcomes of a cemented THA with a simultaneous subtrochanteric femoral shortening transverse osteotomy in patients with Crowe type III or IV developmental dysplasia of the hip...
  9. pmc Unraveling the transcriptional regulatory machinery in chondrogenesis
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Bone Miner Metab 29:390-5. 2011
    ....
  10. pmc Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:14665-70. 2005
    ..Thus, our results strongly suggest that all osteo-chondroprogenitor cells, as well as progenitors in a variety of tissues, are derived from Sox9-expressing precursors during mouse embryogenesis...
  11. doi Revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device with bone allograft: minimum 4.5-year follow-up results and mechanical analysis
    H Akiyama
    Kobe City Medical Center General Hospital, Department of Orthopaedics, 4 6, Minatojimanakamachi, Chuo Ku, Kobe City, Hyogo 650 0046, Japan
    J Bone Joint Surg Br 93:1194-200. 2011
    ..This clinical study indicates that revision total hip replacement using the Kerboull-type acetabular reinforcement device with bone allografts yielded satisfactory mid-term results...
  12. doi Clinical outcomes of cemented double-tapered titanium femoral stems: a minimum 5-year follow-up
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto, 606 8507, Japan
    J Orthop Sci 16:689-97. 2011
    ..In 2004, we produced a straight-collared double-tapered stem made from a titanium alloy with a smooth surface for cemented total hip arthroplasty. In this study, we retrospectively examined the mid-term outcomes of this stem...
  13. pmc Cthrc1 is a positive regulator of osteoblastic bone formation
    Hiroaki Kimura
    Department of Orthopaedics, Kyoto University, Kyoto, Japan
    PLoS ONE 3:e3174. 2008
    ..Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors...
  14. doi Osteoconduction of porous Ti metal enhanced by acid and heat treatments
    Toshiyuki Kawai
    Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shougoin Sakyou ku, Kyoto, 606 8507, Japan
    J Mater Sci Mater Med 24:1707-15. 2013
    ..Their apatite-forming abilities did not depend upon their surface roughness nor type of crystalline phase, but upon the positive surface charge. ..
  15. doi Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation
    Tatsuya Sueyoshi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Matrix Biol 31:352-9. 2012
    ....
  16. ncbi Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass
    Rika Nakanishi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Bone Miner Res 23:271-7. 2008
    ..Transgenic mice overexpressing Sfrp4 in osteoblasts were established. These mice exhibited low bone mass caused by a decrease in bone formation...
  17. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation...
  18. doi Long-term results of cemented total hip arthroplasty for dysplasia, with structural autograft fixed with poly-L-lactic acid screws
    Koji Goto
    Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    J Arthroplasty 24:1146-51. 2009
    ..2%, and 56.1% at 15 years, respectively. The results of this study indicated that poly-L-lactic acid screws are safe and useful for the fixation of acetabular bone graft concomitant to cemented THA with a careful rehabilitation program...
  19. doi Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons
    Tsunemitsu Soeda
    Department of Orthopedics, Kyoto University, Kyoto, Japan
    Genesis 48:635-44. 2010
    ..This mouse line is a valuable tool for the temporal genetic tracing of the progeny of, and inducible gene modification in Sox9-expressing cells...
  20. doi Revision total hip replacement with a cemented long femoral component: minimum 9-year follow-up results
    Kazutaka So
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto, 606 8507, Japan
    Arch Orthop Trauma Surg 133:869-74. 2013
    ..The aim of this study was to analyze the long-term results of revision total hip replacement using a cemented long femoral component and identify factors that influence the results...
  21. pmc Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
    Yuko Mori-Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9360-5. 2003
    ..We hypothesize that these cells change their cell fate and acquire the ability to differentiate into osteoblasts. We conclude that Sox9 is required for the determination of the chondrogenic lineage in CNC cells...
  22. doi Long-term results of cemented total hip arthroplasty in developmental dysplasia with acetabular bulk bone grafts after improving operative techniques
    Haruhiko Akiyama
    Department of Orthopedic Surgery, Kyoto University, Sakyo, Kyoto, Japan
    J Arthroplasty 25:716-20. 2010
    ..Our results indicate excellent long-term clinical and radiographic survivorship of a cemented acetabular component with bulk autograft for acetabular dysplasia...
  23. doi Generation of transgenic mice for conditional overexpression of Sox9
    Youngwoo Kim
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto, Japan
    J Bone Miner Metab 29:123-9. 2011
    ..This Sox9 conditional transgenic mouse line will be a valuable tool to uncover tissue-specific and developmental stage-specific functions of Sox9...
  24. pmc Is the bone-bonding ability of a cementless total hip prosthesis enhanced by alkaline and heat treatments?
    Kazutaka So
    Department of Orthopaedic Surgery, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto, 606 8507, Japan
    Clin Orthop Relat Res 471:3847-55. 2013
    ..Although bone-bonding ability of the alkali- and heat-treated titanium surface has been demonstrated in animal studies, it remains unknown whether it enhances or provides durable bone bonding in humans...
  25. doi Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament
    Yuki Sugimoto
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Development 140:2280-8. 2013
    ..Thus, the Scx(+)/Sox9(+) progenitor pool is a unique multipotent cell population that gives rise to tenocytes, ligamentocytes and chondrocytes for the establishment of the chondro-tendinous/ligamentous junction...
  26. doi Pelvic instability and trunk and hip muscle recruitment patterns in patients with total hip arthroplasty
    Hiroshige Tateuchi
    Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Electromyogr Kinesiol 23:151-8. 2013
    ..47, p < 0.05) in patients with THA. These results suggest that patients with THA have dysfunction of the stabilizer muscles of the lumbopelvic region along with increased pelvic motion...
  27. pmc Good short-term outcome of primary total hip arthroplasty with cementless bioactive glass ceramic bottom-coated implants: 109 hips followed for 3–9 years
    Kazutaka So
    Department of Orthopaedics, Kyoto University, Kyoto, Japan
    Acta Orthop 83:599-603. 2012
    ..We examined the clinical and radiographic outcome of the cementless titanium hip implant with a bottom coating of apatite-wollastonite containing bioactive glass ceramic...
  28. doi Long-term survivorship analysis of hip arthroplasty with vitallium mold cup
    Hai le Pan
    Department of Orthopaedics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    J Orthop Sci 15:459-62. 2010
    ..Cup arthroplasty was used in the initial attempts to preserve the bone stock of the femoral head and neck for hip reconstruction. However, little conclusive data are available regarding its long-term survivorship...
  29. pmc Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation
    Hiroaki Kimura
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 356:935-41. 2007
    ..Our results indicate that TN-W is a novel marker of preosteoblasts in early stage of osteogenesis, and that TN-W inhibits cell proliferation and differentiation of preosteoblasts mediated by canonical Wnt signaling...
  30. doi Bone-bonding properties of Ti metal subjected to acid and heat treatments
    Toshiyuki Kawai
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shougoin, Kyoto, Japan
    J Mater Sci Mater Med 23:2981-92. 2012
    ..The present study has demonstrated that acid and subsequent heat treatments are effective for conferring stable fixation properties on Ti metal implants...
  31. doi A new cementless total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4.8-year results
    Keiichi Kawanabe
    Department of Orthopaedic Surgery, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res B Appl Biomater 90:476-81. 2009
    ..Although this was a relatively short-term study, treatment that creates a bioactive surface on titanium and titanium alloy implants has considerable promise for clinical application...
  32. doi Load dispersion effects of acetabular reinforcement devices used in revision total hip arthroplasty: a simulation study using finite element analysis
    Keiichi Kawanabe
    Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, Chuo Ku, Kobe, Japan
    J Arthroplasty 26:1061-6. 2011
    ..For all 4 reinforcement devices, the stress was reduced to less than one-half of that in the control. All the devices were useful for preventing the collapse of bulk bone grafts applied to load-bearing defects...
  33. doi Computed tomography-based navigation to determine the femoral neck osteotomy and location of the acetabular socket of an arthrodesed hip
    Haruhiko Akiyama
    Department of Orthopedics, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan
    J Arthroplasty 24:1292.e1-4. 2009
    ..In this report, we introduce a technical solution, using a computed tomography-based navigation system to determine the site and direction of the femoral neck osteotomy and the positioning of the acetabular socket...
  34. doi Clinical results of the wear performance of cross-linked polyethylene in total hip arthroplasty: prospective randomized trial
    Kentaro Ise
    Department of Orthopedic Surgery, Kyoto University, Sakyo ku, Kyoto, Japan
    J Arthroplasty 24:1216-20. 2009
    ..Furthermore, long-term investigations will be necessary for understanding CLPE wear in vivo...
  35. pmc Developing a novel custom cutting guide for curved peri-acetabular osteotomy
    Bungo Otsuki
    Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan
    Int Orthop 37:1033-8. 2013
    ..We have designed and made a custom cutting guide for individual patients. The purpose of the study was to evaluate the efficacy of this new method and cutting guide...
  36. doi Preoperative prediction of ambulatory status at 6 months after total hip arthroplasty
    Manabu Nankaku
    Rehabilitation Unit, Kyoto University Hospital, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Phys Ther 93:88-93. 2013
    ..Preoperative instruction about the functional outcomes and optimum goal of rehabilitation is helpful for patients undergoing THA...
  37. doi [Transcriptional regulation in chondrogenesis by Sox9]
    Haruhiko Akiyama
    Deaprtment of Orthopaedics, Kyoto University, Kyoto, Japan
    Clin Calcium 21:845-51. 2011
    ..Recent studies showed that p300÷CBP, Trap230 (med12) , Wwp2, and Med25 are components of transcriptional machinery of Sox9 in chondrogenesis...
  38. pmc Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77005, USA
    Biol Reprod 84:342-50. 2011
    ..This revealed the physical relationship between Sertoli and germ cells in developing testis cords and provided a novel perspective on Sertoli cell development...
  39. pmc SOX9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy
    Seiji Kishi
    Department of Nephrology, Graduate School of Medicine, Health Bioscience Institute, University of Tokushima, Tokushima 770 8503, Japan
    J Biol Chem 286:32162-9. 2011
    ..The results suggested that the transdifferentiation of MCs into chondrocyte-like cells in chronic hypoxic stress may result in irreversible structural change in DN...
  40. pmc The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2813-28. 2002
    ..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
  41. ncbi Computer-assisted fluoroscopic navigation system for removal of distal femoral bone cement in revision total hip arthroplasty
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, Kyoto, Japan
    J Arthroplasty 22:445-8. 2007
    ..Thus, a computer-assisted fluoroscopic navigation system is a useful tool for the improvement of the surgical technique in revision total hip arthroplasty...
  42. pmc Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones
    Kenta Saito
    Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 8:e54853. 2013
    ..Taken together, these data suggest that TACE-EGFR signaling in chondrocytes is involved in the turnover of the growth plate during postnatal development via the transcriptional regulation of osteoprotegerin, Rankl, and Mmp-13...
  43. doi Effects of vertical motion of the centre of mass on walking efficiency in the early stages after total hip arthroplasty
    Manabu Nankaku
    Rehabilitation Unit, Kyoto University Hospital, 54 Kawahara cho, Shogoin, Sakyo ku Kyoto, Japan
    Hip Int 22:521-6. 2012
    ..The purpose of this study was to identify factors related to walking efficiency in the early postoperative period of total hip arthroplasty (THA)...
  44. ncbi Transforming growth factor-beta1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes
    Shogo Mukai
    Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan
    Ultrasound Med Biol 31:1713-21. 2005
    ..These results indicate that LIPUS promotes the proliferation and retains the differentiation state of chondrocytes in the aggregate culture and that TGF-beta1 plays an important role in mediating the LIPUS effects in chondrocytes...
  45. pmc SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells
    Eriko Sumi
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Am J Pathol 170:1854-64. 2007
    ..These results indicate that SOX9 is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis...
  46. pmc Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 23:1900-13. 2009
    ..Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells...
  47. doi Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres
    Yutaka Kuroda
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kawahara cho 54, Sakyo ku, Kyoto, Japan
    J Bone Miner Metab 28:608-16. 2010
    ..rhFGF-2 may be a promising strategy for the treatment of ONFH...
  48. doi Illuminating testis morphogenesis in the mouse
    Liesl Nel-Themaat
    Department of Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Androl 31:5-10. 2010
    ..Transgenic mice that express fluorescent protein reporters offer new opportunities for time-lapse imaging to visualize live cells and their behaviors during testis differentiation and morphogenesis...
  49. doi Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    Kenichiro Furuyama
    Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Nat Genet 43:34-41. 2011
    ..These results suggest interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status...
  50. pmc Lung epithelial branching program antagonizes alveolar differentiation
    Daniel R Chang
    Department of Pulmonary Medicine and Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 110:18042-51. 2013
    ..The resulting temporal delay of differentiation by the branching program may provide new insights to lung immaturity in preterm neonates and the increase in organ complexity during evolution. ..
  51. doi Periosteal cells are a major source of soft callus in bone fracture
    Hiroki Murao
    Department of Orthopaedics, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo, Kyoto, Japan
    J Bone Miner Metab 31:390-8. 2013
    ..Our findings show that the periosteal cells in which Sox9 expression is induced just after fracture are the major source of the chondrocytes and osteoblasts in the fracture callus. ..
  52. pmc Morphometric analysis of testis cord formation in Sox9-EGFP mice
    Liesl Nel-Themaat
    Department of Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Dyn 238:1100-10. 2009
    ..These results suggest that cord formation is a highly dynamic process that subsequently becomes refined to establish the final number of seminiferous tubule precursors...
  53. doi Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix metalloproteinase-13 induced by interleukin-1β in chondrocytes in an intensity-dependent manner
    Akira Ito
    Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Ultrasound Med Biol 38:1726-33. 2012
    ..Our results indicate that LIPUS may potentially protect articular cartilage by inhibiting MMP mRNA expression in an intensity-dependent manner and should thus be considered a useful candidate for daily treatment of OA...
  54. pmc Conditional inactivation of Blimp1 in adult mice promotes increased bone mass
    Yoshiteru Miyauchi
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Biol Chem 287:28508-17. 2012
    ..These data suggest that Blimp1 is a potential target to promote increased bone mass and prevent osteoclastogenesis...
  55. doi Muscle mass and composition of the hip, thigh and abdominal muscles in women with and without hip osteoarthritis
    Yoshihiro Fukumoto
    Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Ultrasound Med Biol 38:1540-5. 2012
    ..Thus, actual contractile tissue of gluteus medius and rectus abdominis substantially decreased, although muscle mass was similar, whereas both quantitative and qualitative changes occurred in quadriceps femoris in patients with hip OA...
  56. doi Prediction of ambulation ability following total hip arthroplasty
    Manabu Nankaku
    Rehabilitation Unit, Kyoto University Hospital, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    J Orthop Sci 16:359-63. 2011
    ..The aim of this study was to examine whether it is possible to predict ambulation ability for patients with THA at 6 months postoperatively...
  57. ncbi Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice
    Rika Nakanishi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Bone Miner Res 21:1713-21. 2006
    ..We segregated a QTL for peak BMD on Chr 13 by generating congenic sublines of the senescence-accelerated mouse SAMP6. Sfrp 4 within this locus was responsible for lower BMD of SAMP6...
  58. doi Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: a postmortem study
    Youta Torii
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Schizophr Res 134:137-42. 2012
    ..These findings indicate that the impact of aging has a greater effect on the WM in the STG in schizophrenic subjects than in normal individuals, although the pathological basis is still unclear...
  59. doi A pilot project for the Japan arthroplasty register
    Haruhiko Akiyama
    Department of Orthopedic Surgery, Kyoto University, Kyoto, Kyoto, Japan
    J Orthop Sci 17:358-69. 2012
    ..More than ten registers have been launched globally, but no national register has been reported in Asia...
  60. doi Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
    Patrick P Lin
    Department of Orthopaedic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Carcinogenesis 30:1789-95. 2009
    ..Deletion of Rb does not initiate sarcoma formation in mice, but it accelerates formation of both soft tissue sarcomas and OS...