Takashi Akamizu

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. doi request reprint Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect
    Takashi Akamizu
    The First Department of Medicine, Wakayama Medical University, Wakayama 641 8509, Japan
    Peptides 32:2295-300. 2011
  2. doi request reprint The physiological significance and potential clinical applications of ghrelin
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto 606 8507, Japan
    Eur J Intern Med 23:197-202. 2012
  3. ncbi request reprint Emerging results of anticatabolic therapy with ghrelin
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Opin Clin Nutr Metab Care 10:278-83. 2007
  4. doi request reprint Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
    Takashi Akamizu
    Ghrelin Research Project, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Eur J Endocrinol 158:491-8. 2008
  5. ncbi request reprint Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure
    T Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Kyoto University Hospital, Japan
    J Endocrinol 188:333-44. 2006
  6. doi request reprint A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth
    Hiroyuki Ariyasu
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, 54 Shogin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 151:1743-50. 2010
  7. ncbi request reprint Transgenic mice overexpressing des-acyl ghrelin show small phenotype
    Hiroyuki Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 146:355-64. 2005
  8. doi request reprint A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School ofMedicine, Kyoto 606 8507, Japan
    Am J Physiol Endocrinol Metab 297:E802-11. 2009
  9. doi request reprint Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo
    Mika Bando
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Physiol Endocrinol Metab 302:E403-8. 2012
  10. ncbi request reprint Effects of ghrelin administration on decreased growth hormone status in obese animals
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Endocrinol Metab 293:E819-25. 2007

Detail Information

Publications51

  1. doi request reprint Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect
    Takashi Akamizu
    The First Department of Medicine, Wakayama Medical University, Wakayama 641 8509, Japan
    Peptides 32:2295-300. 2011
    ..These studies will hopefully lead to the development of novel therapeutic applications for ghrelin in the future. This review summarizes the recent advances in this area of research...
  2. doi request reprint The physiological significance and potential clinical applications of ghrelin
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto 606 8507, Japan
    Eur J Intern Med 23:197-202. 2012
    ..This review summarizes the recent advances in this area of research...
  3. ncbi request reprint Emerging results of anticatabolic therapy with ghrelin
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Curr Opin Clin Nutr Metab Care 10:278-83. 2007
    ..Potential conditions in which ghrelin treatment may be useful include cachexia, anorexia and ageing. We highlight a number of intriguing basic topics related to the anticatabolic effects of ghrelin...
  4. doi request reprint Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
    Takashi Akamizu
    Ghrelin Research Project, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Eur J Endocrinol 158:491-8. 2008
    ..Ghrelin plays a major role in the regulation of food intake (FI), which makes it a strong candidate for the treatment of anorexia...
  5. ncbi request reprint Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure
    T Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Kyoto University Hospital, Japan
    J Endocrinol 188:333-44. 2006
    ..These observational associations warrant further experimental studies to clarify the physiologic significance of these effects...
  6. doi request reprint A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth
    Hiroyuki Ariyasu
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, 54 Shogin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 151:1743-50. 2010
    ..However, GPDTR-Tg mice did not display any decreases in IGF-I levels or any growth retardation. Our results strongly suggest that circulating ghrelin does not play a crucial role in somatic growth...
  7. ncbi request reprint Transgenic mice overexpressing des-acyl ghrelin show small phenotype
    Hiroyuki Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 146:355-64. 2005
    ..These data suggest that overexpressed des-acyl ghrelin may modulate the GH-IGF-I axis and result in small phenotype in transgenic mice...
  8. doi request reprint A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School ofMedicine, Kyoto 606 8507, Japan
    Am J Physiol Endocrinol Metab 297:E802-11. 2009
    ..Thus, we successfully generated a Tg model of ghrelinoma, which is a good tool to investigate chronic effects of ghrelin excess. Moreover, their characteristic features could be a hint on ghrelinoma...
  9. doi request reprint Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo
    Mika Bando
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Physiol Endocrinol Metab 302:E403-8. 2012
    ..These results indicate that intraislet ghrelin does not play a major role in the regulation of insulin secretion in vivo...
  10. ncbi request reprint Effects of ghrelin administration on decreased growth hormone status in obese animals
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Endocrinol Metab 293:E819-25. 2007
    ..HFD mice injected with low-dose ghrelin and GHRH for 10 days did not show weight gain. These results indicate that low-dose ghrelin and GHRH treatment may restore decreased GH secretion in obesity without worsening obesity...
  11. ncbi request reprint Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome
    Yuji Hataya
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 144:5365-71. 2003
    ..In conclusion, plasma ghrelin levels are altered in LPS-injected rats, and ghrelin treatment may provide a new therapeutic approach to the wasting syndrome and critical illness...
  12. doi request reprint Establishment of a novel ghrelin-producing cell line
    Hiroshi Iwakura
    54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 151:2940-5. 2010
    ..This cell line will be a useful tool for both studying the production and secretion of ghrelin and screening of ghrelin-modulating drugs...
  13. doi request reprint Overexpression of intraislet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice
    Mika Bando
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Physiol Endocrinol Metab 305:E140-8. 2013
    ....
  14. ncbi request reprint Short-term secretory regulation of the active form of ghrelin and total ghrelin during an oral glucose tolerance test in patients with anorexia nervosa
    Yoshikatsu Nakai
    School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Eur J Endocrinol 150:913-4. 2004
  15. doi request reprint Efficacy of ghrelin as a therapeutic approach for age-related physiological changes
    Hiroyuki Ariyasu
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Endocrinology 149:3722-8. 2008
    ..Long-term administration of ghrelin kept aged mice with low body weight and low adiposity. These results suggest that ghrelin might be a novel approach for the therapy of age-related metabolic and physiological changes...
  16. ncbi request reprint Establishment of a novel neuroblastoma mouse model
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Int J Oncol 33:1195-9. 2008
    ..These findings indicated that the adrenal tumor was a neuroblastoma. This mouse model would be a useful tool for development of chemotherapeutic drugs and understanding the etiology of neuroblastoma...
  17. doi request reprint Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro
    Hiroshi Iwakura
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital, Kyoto, Japan
    Endocrinology 152:2619-25. 2011
    ..These findings will provide new direction for further studies seeking to further understand the regulation of ghrelin secretion, which will in turn lead to greater understanding of the physiological role of ghrelin...
  18. ncbi request reprint Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimnetal Therapeutics, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto 606 8507, Japan
    Eur J Endocrinol 150:447-55. 2004
    ..In this study, we have conducted a double-blind, randomized, placebo-controlled trial to investigate the pharmacokinetics, safety, and endocrine and appetite effects of ghrelin in young healthy volunteers...
  19. ncbi request reprint [Translational research of ghrelin in endocrine and metabolic diseases]
    Takashi Akamizu
    Ghrelin Research Project, Translational Research Center, Kyoto University Hospital
    Nihon Rinsho 62:424-9. 2004
  20. ncbi request reprint Elevated serum immunoglobulin g4 levels in patients with graves' disease and their clinical implications
    Ken Takeshima
    The First Department of Medicine, Wakayama Medical University, Wakayama, Japan
    Thyroid 24:736-43. 2014
    ..Thus, the present study suggests the presence of a novel subtype of GD. Measuring serum IgG4 levels may help to distinguish this new entity and provide potential therapeutic options for GD. ..
  21. ncbi request reprint Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent autoimmune thyroid diseases
    Yu Shu Li
    Translational Research Center, Kyoto University School of Medicine, 54 Shogoin Kawaharacho Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 145:2524-30. 2004
    ....
  22. ncbi request reprint Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa
    Yoshikatsu Nakai
    College of Medical Technology, Kyoto University, Kyoto University Hospital, 53 Kawaharacho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Eur J Endocrinol 149:R1-3. 2003
    ..Therefore, we studied plasma levels of active ghrelin during oral glucose tolerance test (OGTT) in anorectic patients, using a radioimmunoassay (RIA) specific for active ghrelin...
  23. ncbi request reprint [Investigation of pathophysiology of Graves' disease by animal models]
    Takashi Akamizu
    Translational Research Center, Kyoto University Hospital
    Nihon Rinsho Meneki Gakkai Kaishi 26:329-35. 2003
  24. ncbi request reprint Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin
    Hiroyuki Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 143:3341-50. 2002
    ..These data suggest that the short-term secretory regulation of total ghrelin and the active form of ghrelin is delayed in obese animals and that blood glucose levels may be involved in the delayed regulation...
  25. ncbi request reprint Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway
    Takeshi Shimada
    The First Department of Medicine, Wakayama Medical University, Wakayama, Japan
    Metabolism 63:469-74. 2014
    ..On the other hand, the function of des-acyl ghrelin (Des-G) has not been fully elucidated. The aim of the present study is to examine the anti-apoptotic effect of Des-G on endothelial cells...
  26. ncbi request reprint A case of subclinical hypothyroidism developing marked pleural effusions and peripheral edema with elevated vascular endothelial growth factor
    Yuji Hataya
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocr J 54:577-84. 2007
    ..Furthermore, elevated VEGF may be a contributing factor in the pathogenesis of extravascular volume overload in hypothyroid patients...
  27. ncbi request reprint Translational research on the clinical applications of ghrelin
    Takashi Akamizu
    Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto, Japan
    Endocr J 53:585-91. 2006
  28. ncbi request reprint Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I
    Hiroshi Iwakura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 87:4885-8. 2002
    ..This is the first case of tumor in which ghrelin gene expression was detected by Northern blot analysis using total RNA...
  29. ncbi request reprint Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease
    Hitomi Hiratani
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 90:2898-903. 2005
    ..0058). These findings suggest that alleles of intron 7 of the TSHR gene contribute to GD susceptibility...
  30. pmc Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Biol Chem 287:19985-96. 2012
    ..AFF4 may therefore help to maintain activation of AMPK downstream signaling under conditions of prolonged stimulation with ghrelin, such as during fasting...
  31. doi request reprint Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II
    Takashi Akamizu
    The First Department of Medicine, Wakayama Medical University, 811 1 Kimi idera, Wakayama 641 8509, Japan
    Eur J Endocrinol 166:235-40. 2012
    ..We hypothesized that acyl-CoA is the fatty acid substrate for ghrelin acylation. Because serum octanoyl-CoA levels are altered by fatty acid oxidation disorders, we examined circulating ghrelin levels in affected patients...
  32. ncbi request reprint Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay
    Takashi Akamizu
    Department of Medicine and Clinical Science, 54 Shogoin Kawaharacho, Kyoto 606 8507 Japan
    J Clin Endocrinol Metab 90:6-9. 2005
    ..These findings indicate that separate measurements of the two ghrelin form levels may provide valuable information on their structure, gender differences, and physiological implications...
  33. ncbi request reprint Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients
    Takashi Akamizu
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Hum Genet 48:236-42. 2003
    ..These findings suggest the presence of susceptible genes of AITD, especially distinct subgroups of GD, in or near 5q23-q33...
  34. ncbi request reprint Monoclonal antibodies to thyroid specific autoantigens
    Takashi Akamizu
    Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Autoimmunity 36:361-6. 2003
    ..In this manuscript, I primarily focus on studies concerning MAbs to three major thyroid specific autoantigens, Tg, TPO and TSHR, and summarize studies using the mAbs...
  35. ncbi request reprint Thyroid hormone action is disrupted by bisphenol A as an antagonist
    Kenji Moriyama
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 87:5185-90. 2002
    ..This is the first report that BPA can antagonize T(3) action at the transcriptional level. BPA may disrupt the function of various types of nuclear hormone receptors and their cofactors to disturb our internal hormonal environment...
  36. ncbi request reprint Prevalence and clinico-epidemiology of familial Graves' disease in Japan based on nationwide epidemiologic survey in 2001
    Takashi Akamizu
    Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto 606 8507, Japan
    Endocr J 50:429-36. 2003
    ..These findings confirm the familial clustering of GD in the Japanese population, indicating the importance of environmental factors, genetic factors or both in the development of the disease...
  37. ncbi request reprint IgG4-related ocular adnexal disease mimicking thyroid-associated orbitopathy
    Hidefumi Inaba
    The First Department of Medicine, Wakayama Medical University, Japan
    Intern Med 52:2545-51. 2013
    ..This report provides a novel description of this unusual disease entity among HT, TAO and IgG4-RD...
  38. ncbi request reprint Generation of a transgenic animal model of hyperthyroid Graves' disease
    Misa Kim-Saijo
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Immunol 33:2531-8. 2003
    ..Thus, our transgenic mouse may provide a novel and useful animal model for elucidating the pathogenesis and pathophysiology of GD...
  39. ncbi request reprint [Hashitoxicosis]
    Takashi Akamizu
    Translational Research Center, Kyoto University School of Medicine
    Nihon Rinsho . 2006
  40. ncbi request reprint [Thyrotropin receptor and signal transduction]
    Takashi Akamizu
    Translational Research Center, Kyoto University School of Medicine
    Nihon Rinsho 63:57-61. 2005
  41. ncbi request reprint Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice
    Hiroshi Iwakura
    Department of Medicine and Clinical Science, Endocrinology and Metabolism, Kyoto University Graduate School of Medicine, Japan
    J Biol Chem 280:15247-56. 2005
    ..The present study raises the possibility that desacyl ghrelin may have influence on glucose metabolism...
  42. ncbi request reprint Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients
    Toshiaki Shinomiya
    Department of Psychosomatic Internal Medicine, Kansai Medical University, Osaka, Japan
    Scand J Gastroenterol 40:648-53. 2005
    ..In addition, some patients also suffer from anorexia and body-weight loss. To investigate the role of ghrelin in the pathophysiology of FD, circulating ghrelin levels in affected patients were measured...
  43. ncbi request reprint Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese
    Koichi Furugaki
    Department of Pathology, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    J Hum Genet 49:166-8. 2004
    ..0051, odds ratio (OR)=1.7] and AITD ( P=0.016, OR=1.5) in a dominant model. These results suggested that the CTLA4 gene is involved in the susceptibility for GD and AITD in the Japanese...
  44. ncbi request reprint Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  45. doi request reprint The -590CC genotype in the IL4 gene as a strong predictive factor for the development of hypothyroidism in Hashimoto disease
    Takashi Nanba
    Clin Chem 54:621-3. 2008
  46. ncbi request reprint [Mechanism of ghrelin gene expression]
    Naotetsu Kanamoto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:340-3. 2004
  47. ncbi request reprint Comment on "thyrotropin receptor expression in cardiac muscle tissue"
    Donald F Sellitti
    J Clin Endocrinol Metab 87:946. 2002
  48. ncbi request reprint SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease
    Senji Shirasawa
    Department of Pathology, Research Institute, International Medical Center of Japan, Toyama 1 21 1, Shinjuku ku, Tokyo 162 8655, Japan
    Hum Mol Genet 13:2221-31. 2004
    ....
  49. ncbi request reprint Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene
    Naotetsu Kanamoto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Endocrinology 145:4144-53. 2004
    ..These results suggest a potential role for upstream stimulatory factor transcription factors in the regulation of human ghrelin expression...