Akaike A. Preclinical evidence of neuroprotection by cholinesterase inhibitors. Alzheimer Dis Assoc Disord. 2006;20:S8-11 pubmed
..This review summarizes data that suggest donepezil possesses neuroprotective actions in addition to amelioration of cognitive deficits by inhibition of acetylcholinesterase. ..
Akaike A, Takada Takatori Y, Kume T, Izumi Y. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci. 2010;40:211-6 pubmed publisher
..These results suggest that nicotine as well as AChE inhibitors, donepezil and galantamine, prevent glutamate neurotoxicity through alpha4 and alpha7 nAChRs and the PI3K-Akt pathway. ..
Masaki Y, Izumi Y, Matsumura A, Akaike A, Kume T. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. Eur J Pharmacol. 2017;798:26-34 pubmed publisher
..These results suggest that DDC prevents dopaminergic neurons from oxidative stress by upregulation of glial expression of HO-1. ..