Akinori Akaike

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Preclinical evidence of neuroprotection by cholinesterase inhibitors
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Alzheimer Dis Assoc Disord 20:S8-11. 2006
  2. ncbi request reprint [Endogenous factors regulating neuronal apoptosis]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:245-50. 2005
  3. doi request reprint Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Mol Neurosci 40:211-6. 2010
  4. ncbi request reprint Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Life Sci 74:263-9. 2003
  5. ncbi request reprint [Role of nitric oxide in survival and death of neurons]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nihon Yakurigaku Zasshi 119:15-20. 2002
  6. doi request reprint Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil
    Yuki Takada-Takatori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women s College, Kyoto, Japan
    J Neurosci Res 86:3575-83. 2008
  7. ncbi request reprint p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 79:849-60. 2005
  8. ncbi request reprint Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 549:19-26. 2006
  9. ncbi request reprint Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 82:126-37. 2005
  10. ncbi request reprint Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Kyoto 606 8501, Japan
    Neurosci Lett 383:199-202. 2005

Detail Information

Publications96

  1. ncbi request reprint Preclinical evidence of neuroprotection by cholinesterase inhibitors
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Alzheimer Dis Assoc Disord 20:S8-11. 2006
    ..This review summarizes data that suggest donepezil possesses neuroprotective actions in addition to amelioration of cognitive deficits by inhibition of acetylcholinesterase...
  2. ncbi request reprint [Endogenous factors regulating neuronal apoptosis]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:245-50. 2005
    ..These findings suggest that serofendic acid is a low-molecular-weight bioactive factor that promotes survival of CNS neurons, probably through the attenuation of free radical-mediated insults...
  3. doi request reprint Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Mol Neurosci 40:211-6. 2010
    ..These results suggest that nicotine as well as AChE inhibitors, donepezil and galantamine, prevent glutamate neurotoxicity through alpha4 and alpha7 nAChRs and the PI3K-Akt pathway...
  4. ncbi request reprint Pharmacological and physiological properties of serofendic acid, a novel neuroprotective substance isolated from fetal calf serum
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Life Sci 74:263-9. 2003
    ..These findings suggest that serofendic acid is a low-molecular-weight neuroprotective factor that attenuates free radical-mediated damage triggered by excessive stimulation of neuronal glutamate receptors...
  5. ncbi request reprint [Role of nitric oxide in survival and death of neurons]
    Akinori Akaike
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nihon Yakurigaku Zasshi 119:15-20. 2002
    ..Those findings suggest that regulation of intracellular ROS levels plays a critical role in protecting neurons against NO-mediated radical stress in neurodegenerative disorders...
  6. doi request reprint Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil
    Yuki Takada-Takatori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women s College, Kyoto, Japan
    J Neurosci Res 86:3575-83. 2008
    ..This study provides novel insight into the mechanism of donepezil-induced neuroprotection that involves nAChR up-regulation...
  7. ncbi request reprint p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 79:849-60. 2005
    ....
  8. ncbi request reprint Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 549:19-26. 2006
    ..These results suggest that galanthamine and tacrine protect cortical neurons from glutamate neurotoxicity via different mechanisms...
  9. ncbi request reprint Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 82:126-37. 2005
    ..Also, addition of iron inhibited dopamine-induced cytotoxicity. These results suggest that iron can provide protection when it accelerates the conversion of dopamine oxidation intermediates...
  10. ncbi request reprint Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Kyoto 606 8501, Japan
    Neurosci Lett 383:199-202. 2005
    ..Serofendic acid (5 microM) also prevented SNOC-induced neurotoxicity. These results indicate that serofendic acid protects cultured motor neurons from glutamate neurotoxicity by reducing the cytotoxic action of NO...
  11. doi request reprint Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 443:199-203. 2008
    ..These results suggest that dbcAMP induces differentiation into the noradrenergic phenotype through both PKA activation and butyrate...
  12. ncbi request reprint Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation
    Yuki Takada-Takatori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women s College, Kyoto, Japan
    Biol Pharm Bull 32:318-24. 2009
    ..This review summarizes recent findings on the roles of the nicotinic receptor in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation...
  13. ncbi request reprint Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons
    Rie Kanki
    Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyoku, Kyoto 606 8507, Japan
    Brain Res 1015:73-81. 2004
    ..A sub-lethal concentration of malonate exacerbated both NMDA- and AMPA-induced motor neuron death. These data suggest that mitochondrial dysfunction predisposes motor neurons to ionotropic glutamate receptor-mediated excitotoxicity...
  14. ncbi request reprint Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons
    Ryota Taguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, 606 8501, Kyoto, Japan
    Eur J Pharmacol 477:195-203. 2003
    ..These results indicate that serofendic acid protects cultured cortical neurons from acute Glu neurotoxicity by reducing the cytotoxic action of NO and de novo protein synthesis is not required for this neuroprotection...
  15. ncbi request reprint Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
    Yuki Takada-Takatori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Neuropharmacology 51:474-86. 2006
    ..These results suggest that donepezil and galanthamine prevent glutamate neurotoxicity through alpha4- and alpha7-nAChRs, followed by the PI3K-Akt pathway, and that tacrine protects neuronal cells through a different pathway...
  16. ncbi request reprint Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 542:69-76. 2006
    ..These results indicate that serofendic acid prevents glutamate-induced apoptosis in cultured cortical neurons by the prevention of loss of mitochondrial membrane potential and the reduction of the process of caspase-3 activation...
  17. ncbi request reprint Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Neurochem 97:1232-42. 2006
    ..Hence, NO production resulting from MAPK-dependent microglial iNOS induction is a crucial event in thrombin-induced dopaminergic neurodegeneration, whereas damage of other midbrain cells is MAPK-dependent but is NO-independent...
  18. doi request reprint Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity
    Tetsuhiro Niidome
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 386:734-8. 2009
    ..Our results suggest that non-fibrillar Abeta42 protects hippocampal neurons from glutamate-induced neurotoxicity through regulation of the NMDA receptor...
  19. doi request reprint Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..These results suggest that the rotenone mouse model may be useful for assessing candidate antiparkinson agents, and that nAChR (nicotinic acetylcholine receptor) stimulation can protect DA neurons against degeneration...
  20. ncbi request reprint Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    Mitsugi Okawara
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Pharmacol 73:550-60. 2007
    ..Either antioxidative activity or sirtuin-activating potential may play an important role in the neuroprotectice actions of resveratrol against different kinds of insults...
  21. doi request reprint Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice
    Tetsuhiro Niidome
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Neuroreport 19:1361-4. 2008
    ..These results suggest that neurogenesis, probably reflecting the survival of neural progenitor cells, differs between the subgranular zone and the subventricular zone...
  22. ncbi request reprint Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons
    Yuki Takada-Takatori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women s College, Kyoto, Japan
    J Pharmacol Sci 112:265-72. 2010
    ..In contrast to chronic donepezil treatment that enhanced the level of nicotine-induced Ca(2+) influx, chronic nicotine treatment did not significantly alter the level of Ca(2+) influx...
  23. ncbi request reprint Stimulation of nicotinic acetylcholine receptors protects motor neurons
    Tomoki Nakamizo
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyoku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 330:1285-9. 2005
    ..These results suggest that stimulation of nAChR may be used as a treatment for ALS...
  24. ncbi request reprint Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Neurol 206:43-52. 2007
    ..These results suggest that thrombin and the activation of MAP kinases are involved in ICH-induced neuronal injury, and that neuroprotective effects of MAP kinases are in part mediated by arrestment of microglial activities...
  25. doi request reprint Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures
    Seiko Wakita
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Neurosci Methods 192:83-9. 2010
    ..By contrast, spinal cells did not increase dopaminergic neurite outgrowth. These results indicate that the present method is valuable for evaluating nigrostriatal projections in vitro...
  26. ncbi request reprint Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Eur J Pharmacol 527:77-85. 2005
    ....
  27. ncbi request reprint Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
    Shinji Fujimoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 50:179-87. 2004
    ..These results suggest that vesicular release of neuronal origin constitutes a crucial component of extracellular glutamate increase during ischemic insults, which triggers neuronal injury...
  28. ncbi request reprint Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 455:91-100. 2002
    ..These results suggest that direct interaction with NMDA receptors but not sigma receptors is crucial to the neuroprotective effects of sigma receptor ligands with affinity for NMDA receptors...
  29. pmc Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42
    Naotaka Izuo
    Department of Pharmacology, Graduate School of Pharmaceutical Science, Kyoto University, Kyoto 606 8501, Japan
    ACS Chem Neurosci 3:674-81. 2012
    ..These results suggest that Aβ42-mediated toxicity is caused by the turn that favors toxic oligomers, which increase generation of ROS...
  30. doi request reprint Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease
    Yasuaki Goto
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, 606 8501, Japan
    Eur J Pharmacol 583:84-91. 2008
    ....
  31. ncbi request reprint Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures
    Ryota Taguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 535:86-94. 2006
    ....
  32. pmc Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Br J Pharmacol 147:729-36. 2006
    ..Development of aminoglutethimide analogs possessing neuroprotective properties may be of therapeutic value...
  33. ncbi request reprint Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Life Sci 81:740-9. 2007
    ..The present findings are important for the interpretation of the mechanisms of NMDA and OGD cytotoxicity...
  34. ncbi request reprint Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Sci 109:110-8. 2009
    ....
  35. ncbi request reprint c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production
    Haruki Shibata
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 83:102-9. 2006
    ....
  36. doi request reprint Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors
    Jun Takahashi
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem Lett 20:1721-3. 2010
    ..In vitro evaluation showed that cyclohexylmethylcarbamate derivative 3u potently and selectively inhibits butyrylcholinesterase...
  37. ncbi request reprint Serofendic acid, a sulfur-containing diterpenoid derived from fetal calf serum, attenuates reactive oxygen species-induced oxidative stress in cultured striatal neurons
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Pharmacol Exp Ther 311:51-9. 2004
    ....
  38. doi request reprint Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells
    Yasuhiro Hama
    Department of Pharmacology, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuropharmacology 55:677-86. 2008
    ..On the other hand, niflumic acid, a Cl(-) channel blocker, markedly inhibited RGC death induced by kainate as well as by NMDA. These results underscore the important role of Cl(-) in acute excitotoxicity in adult rat RGCs...
  39. doi request reprint Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport
    Takaaki Matsuo
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, and Department of Neurology and Clinical Research Center, Utano National Hospital, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 640:68-74. 2010
    ..These results suggest that the inhibition of vesicular dopamine transport by haloperidol, spiperone, pimozide and aripiprazole results in a reduction in vesicular dopamine content...
  40. doi request reprint Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 88:2155-64. 2010
    ....
  41. doi request reprint Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment
    Yuki Takada-Takatori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women s College, Kyoto 610 0395, Japan
    Eur J Pharmacol 590:150-6. 2008
    ..This study increases understanding of the less-studied mechanism of chronic donepezil treatment-induced nicotinic receptor up-regulation and increased sensitivity to donepezil...
  42. ncbi request reprint Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation
    Tetsuhiro Niidome
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 548:1-8. 2006
    ..Our results suggest that oxidative stress triggers caspase-mediated apoptosis of neural progenitor cells by trophic support deprivation...
  43. ncbi request reprint Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin
    Haruki Shibata
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Neurochem 86:1201-12. 2003
    ....
  44. ncbi request reprint Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats
    Shinji Fujimoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Cereb Blood Flow Metab 28:506-15. 2008
    ..These results suggest that plasminogen/plasmin system augmenting thrombin neurotoxicity participates in hemorrhagic cortical injury...
  45. ncbi request reprint Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Neurosci 21:2329-35. 2005
    ..Thus, with strict structural specificity, PS but not pregnenolone or PHS attenuates AMPA cytotoxicity, probably by inhibiting activities of AMPA receptor-associated channels...
  46. ncbi request reprint alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta
    Takaaki Nishimoto
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 86:1096-105. 2008
    ..These findings suggest that AMPA activates PI3K-Akt and subsequently inhibits GSK3beta and that inactivated GSK3beta attenuates glutamate-induced caspase-3 cleavage and neurotoxicity...
  47. ncbi request reprint Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture
    Qand Agha Nazari
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachicho, Sakyo ku, Kyoto 606 8501, Japan
    Biol Pharm Bull 36:1356-62. 2013
    ..These results suggest that curcumin and THERACURMIN exert potent protective effects against SNP-induced cytotoxicity by free radical-scavenging and iron-chelating activities. ..
  48. ncbi request reprint Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Neurochem 95:950-61. 2005
    ..These results suggest that serofendic acid protects against 6-OHDA-induced SNpc dopaminergic neurodegeneration in a rat model of Parkinson's disease...
  49. doi request reprint A molecular pathway involved in the generation of microtubule-associated protein 2-positive cells from microglia
    Tetsuhiro Niidome
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 370:184-8. 2008
    ..These results indicate that activation of BMP signaling through Smad and Id2 proteins is one of the molecular pathways involved in the generation of microglia-derived MAP2-positive and GFAP-positive cells...
  50. doi request reprint Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures
    Takaaki Matsuo
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Lett 481:78-81. 2010
    ..These results suggest that aripiprazole protects dopaminergic neurons against glutamate cytotoxicity partly by reducing intracellular dopamine content...
  51. doi request reprint Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation
    Yoshiari Shimmyo
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Neuroreport 19:1329-33. 2008
    ..These two compounds have novel pharmacological effects that may be beneficial for Alzheimer's disease treatment...
  52. ncbi request reprint Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease
    Noriyuki Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 282:4364-72. 2007
    ..These data suggest that proteasome inhibition afforded cytoprotection against oxidative stress by the elevation of glutathione content, and its elevation was mediated by p38 MAPK phosphorylation...
  53. doi request reprint Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection
    Noriyuki Yamamoto
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 88:1934-42. 2010
    ..These results suggest that mesencephalic HO-1 protein level is regulated by proteasome activity and the elevation by proteasome inhibition affords neuroprotection...
  54. doi request reprint Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway
    Keita Takahashi
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurochem 109:1324-37. 2009
    ..In conclusion, ER stress-induced APP undergoes alpha- and gamma-secretase cleavage and subsequently induces CHOP-mediated cell death...
  55. doi request reprint Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene
    Pi Lin Wang
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Neurosci Res 87:2105-14. 2009
    ..Taken together, our results suggest that Rac1 regulates transcription of the APP gene in primary hippocampal neurons...
  56. ncbi request reprint Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuropharmacology 47:904-15. 2004
    ..Among the vitamin E analogs examined, alpha-tocotrienol exhibited the most potent neuroprotective actions in rat striatal cultures...
  57. doi request reprint AMPA reduces surface expression of NR1 through regulation of GSK3beta
    Takaaki Nishimoto
    Department of Neuroscience for Drug Discovery, Kyoto University, Kyoto, Japan
    Neuroreport 20:161-5. 2009
    ..Our data suggest that AMPA reduces the cell surface expression of NMDA receptors through the regulation of GSK3beta and, consequently, reduces the amount of intracellular Ca2+...
  58. ncbi request reprint Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 557:132-40. 2007
    ..These results suggest that pramipexole protects dopaminergic neurons from glutamate neurotoxicity by the reduction of intracellular dopamine content, independently of dopamine D2-like receptor activation...
  59. ncbi request reprint Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 508:85-91. 2005
    ....
  60. ncbi request reprint Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons
    Tomofusa Yamauchi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neurosci Lett 347:155-8. 2003
    ..These results suggest that dopamine inhibits glutamate induced-NOS activation via D1 receptor, resulting in the protection of retinal neurons...
  61. doi request reprint Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons
    Satoru Matsuda
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 368:971-6. 2008
    ..These results suggest that microglia-derived MAP2-positive cells possess properties of functional neurons...
  62. ncbi request reprint Protective effect of luteolin on an oxidative-stress model induced by microinjection of sodium nitroprusside in mice
    Qand Agha Nazari
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Sci 122:109-17. 2013
    ..These results suggest that intrastriatal or oral administration of luteolin protected mice brain from SNP-induced oxidative damage by scavenging and chelating effects...
  63. doi request reprint Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features
    Yoshiari Shimmyo
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606 8501, Japan
    Biochim Biophys Acta 1780:819-25. 2008
    ..We firstly revealed novel pharmacophore features of flavonoids by using cell-free, cell-based and in silico docking studies. These results contribute to the development of new BACE-1 inhibitors for the treatment of AD...
  64. doi request reprint Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation
    Yasuhiko Izumi
    Department of Pharmacology, Kyoto University, Shimoadachi cho, Sakyo ku, Japan
    J Neurochem 110:745-55. 2009
    ..These data suggest that endogenous dopamine is responsible for the vulnerability to glutamate toxicity of dopaminergic neurons and one of the mechanisms may be an enhancement of dopamine synthesis mediated by ERK...
  65. doi request reprint Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures
    Masatoshi Ohnishi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Eur J Pharmacol 602:288-93. 2009
    ..Besides adding further evidence that nicotinic receptor stimulation exerts neuroprotective functions, these results reveal a novel mode of action of nicotine on neural tissues that appears after long-term treatment...
  66. doi request reprint Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells
    Toru Oda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto 606 8501, Japan
    Eur J Pharmacol 598:27-31. 2008
    ..Taken together, bromocriptine-induced neurite outgrowth via src and the MEK/extracellular signal-regulated kinase 1/2 signaling pathway in PC12 cells...
  67. ncbi request reprint Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuroreport 16:1157-61. 2005
    ..Norepinephrine and serotonin do not provide a neuroprotective effect. Thus, GABAergic inhibitory control may be a decisive factor regulating survival of orexin neurons under excitotoxic insults...
  68. doi request reprint Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture
    Hiroshi Katsuki
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Peptides 31:1131-8. 2010
    ..Overall, these characteristics of orexin neurons may be taken into consideration to understand the behaviors of these neurons under physiological and pathophysiological conditions...
  69. ncbi request reprint Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells
    Toru Oda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Sci 104:349-54. 2007
    ..Moreover, donepezil potentiated the NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK). These results suggest that donepezil potentiated neuronal differentiation by enhancing the activation of ERK...
  70. ncbi request reprint Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade
    Takeshi Kihara
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 70:274-82. 2002
    ....
  71. doi request reprint Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
    Yasuhiko Izumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Free Radic Biol Med 53:669-79. 2012
    ..Thus, this study demonstrated that DDC contained in green perilla enhanced cellular resistance to oxidative damage through activation of the Nrf2-ARE pathway...
  72. ncbi request reprint Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity
    Tetsuhiro Niidome
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Neuroreport 18:813-6. 2007
    ....
  73. ncbi request reprint N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, 606 8501, Kyoto, Japan
    Neurosci Lett 341:123-6. 2003
    ..Thus, tonic activation of N-methyl-D-aspartate receptors driven by neuronal activity may play an important role in the maintenance of dopaminergic neurons...
  74. ncbi request reprint Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    Yuki Takada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Pharmacol Exp Ther 306:772-7. 2003
    ..These results suggest that donepezil not only protects cortical neurons against glutamate neurotoxicity via alpha4beta2- and alpha7-nAChRs but also prevents apoptotic neuronal death...
  75. ncbi request reprint Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection
    Tomofusa Yamauchi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Invest Ophthalmol Vis Sci 44:2750-6. 2003
    ....
  76. ncbi request reprint Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone
    Noriko Sakka
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Neuroreport 14:2425-8. 2003
    ..These data suggest that superoxide and endogenous dopamine play an important role in dopaminergic neuronal loss...
  77. ncbi request reprint New insight into the functional role of acetylcholine in developing embryonic rat retinal neurons
    Hiroki Yasuyoshi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Invest Ophthalmol Vis Sci 43:446-51. 2002
    ..To examine the effects of acetylcholine (ACh) on glutamate-induced neurotoxicity in embryonic rat retinal neurons...
  78. ncbi request reprint Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice
    Nobuhiko Taniuchi
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Neuroreport 18:1801-5. 2007
    ..These results indicate that neurogenesis is decreased with degrees of Abeta pathology, and that there is no gender difference in their proliferation in APPswe/PS1dE9 transgenic mice...
  79. ncbi request reprint Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes
    Toshihiro Takeda
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 47:1882-90. 2006
    ..We examined whether serofendic acid (SFA) has protective effects against oxidative stress in cardiac myocytes...
  80. pmc Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum
    Toshiaki Kume
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:3288-93. 2002
    ..These findings suggest that serofendic acid is a low-molecular-weight bioactive factor that promotes survival of CNS neurons, probably through the attenuation of free radical-mediated insults...
  81. ncbi request reprint Excitotoxic degeneration of hypothalamic orexin neurons in slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Neurobiol Dis 15:61-9. 2004
    ....
  82. ncbi request reprint Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons
    Hisashi Shirakawa
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Pharmacol 454:165-75. 2002
    ..These results indicate that neuroactive steroids affect NMDA cytotoxicity by modulation of Ca(2+) influx through NMDA receptor-associated channels...
  83. ncbi request reprint Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor
    Yasuaki Goto
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimodachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 351:259-65. 2006
    ..Our results support the notion of an association between Alzheimer's disease and cerebrovascular disease, and suggest a new mechanism for neuroprotection by promoting endocytosis of NMDA receptor...
  84. ncbi request reprint Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    J Pharmacol Exp Ther 311:836-44. 2004
    ..The present results suggest that endogenous supply of D-serine as a glycine site agonist is important for neuronal injury involving NMDA receptor overactivation in the cerebral cortex...
  85. doi request reprint Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2
    Takeshi Kihara
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 393:728-33. 2010
    ..Exposure of neurons to PGE2 led to cell death, and Abeta production was enhanced by PGE2 (1 ng/mL, 48 h). Collectively, these results suggest that Abeta might cause neuroinflammation that aggravates Alzheimer's disease pathogenesis...
  86. ncbi request reprint A critical role of TRPM2 in neuronal cell death by hydrogen peroxide
    Shuji Kaneko
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Pharmacol Sci 101:66-76. 2006
    ..These results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons...
  87. doi request reprint A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia
    Hideki Nonaka
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 380:60-4. 2009
    ..These results indicate that SOX2 upregulation is involved in the generation of microglia-derived MAP2-positive and GFAP-positive cells through SMAD4...
  88. ncbi request reprint Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site
    Shuji Kaneko
    Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurosci 22:82-92. 2002
    ..These results suggest that the structure of the II-III linker region is an important determinant of N-type channel function and pharmacology. The lack of syntaxin binding hints at a unique physiological function of these channels...
  89. ncbi request reprint Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells
    Masaya Nakanishi
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Eur J Neurosci 25:649-58. 2007
    ....
  90. doi request reprint Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine
    Shigeru Akasofu
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba shi, Ibaraki 300 2635, Japan
    Eur J Pharmacol 588:189-97. 2008
    ....
  91. ncbi request reprint Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures
    Fumitaka Osakada
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Kyoto Sakyo 606 8501, Japan
    Eur J Pharmacol 465:15-22. 2003
    ..These results suggest that alpha-tocopherol protects striatal neurons by the reduction of oxidative stress, presumably by decreasing intracellular O(2)(-) levels, and at least partly by the inhibition of apoptosis...
  92. ncbi request reprint Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions
    Hideyuki Sawada
    Department of Neurology, Graduate School of Medicine, Sakyoku, Kyoto 606 8507, Japan
    J Biol Chem 279:10710-9. 2004
    ..Thus, the proteasome plays an important role in both inclusion body formation and dopaminergic neuronal death but these processes form opposite sides on the proteasome regulation in this model...
  93. ncbi request reprint Synthesis and pharmacological profile of serofendic acids A and B
    Taro Terauchi
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tsukuba shi 300 2635, Japan
    Bioorg Med Chem 15:7098-107. 2007
    ..A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders...
  94. ncbi request reprint Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection
    Masaharu Akao
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cardiovasc Drug Rev 25:333-41. 2007
    ..Our findings suggest that serofendic acid may represent a novel candidate for cardioprotective therapy in ischemia/reperfusion injury...
  95. ncbi request reprint Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons
    Yusuke Nakatsu
    Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Toxicol Sci 89:235-42. 2006
    ..We propose two independent neuronal death pathways by tributyltin; one is glutamate receptor-dependent cell death via ERK phosphorylation, and the other may be glutamate receptor-independent cell death via p38 activation...
  96. doi request reprint Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: involvement of direct inhibition of caspase-3
    Yoshiari Shimmyo
    Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Neurosci Res 86:1836-45. 2008
    ..These results show that myricetin is a potent antineurodegenerative compound and may contribute to the discovery of a drug with which to combat neurodegeneration...