Tadashi Kasahara

Summary

Affiliation: Kyoritsu College of Pharmacy
Country: Japan

Publications

  1. ncbi request reprint Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha
    T Kasahara
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    Eur Cytokine Netw 9:47-55. 1998
  2. ncbi request reprint Macrophage signaling, apoptosis, lectins and leukocyte trafficking
    T Kasahara
    Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Trends Immunol 22:593-4. 2001
  3. ncbi request reprint Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation
    Tadashi Kasahara
    Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo, 105 8512, Japan
    Antioxid Redox Signal 4:491-9. 2002
  4. pmc The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan
    J Biol Chem 284:12680-90. 2009
  5. ncbi request reprint Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    Yoshihito X Fujii
    Department of Pharmacology, Kyoritsu College of Pharmacy, Minato ku, Tokyo 105 8512, Japan
    J Neuroimmunol 189:69-74. 2007
  6. ncbi request reprint Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic cell line, HT93
    Naomi Yoshida
    Department of Biochemistry, Kyoritsu University of Pharmacy, Minato ku, Tokyo, Japan
    Biol Pharm Bull 30:1826-32. 2007
  7. ncbi request reprint Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276
    Jun ichi Furusawa
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 21:778-85. 2009
  8. doi request reprint Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis
    Tomonori Kaneda
    Faculty of Pharmacy, Keio University, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Cancer Lett 270:354-61. 2008
  9. ncbi request reprint Indirubin, a Chinese anti-leukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells
    Kazuhiro Suzuki
    National Institute of Health Sciences, Tokyo, Japan
    Br J Haematol 130:681-90. 2005
  10. doi request reprint TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cytokine 45:72-9. 2009

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha
    T Kasahara
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    Eur Cytokine Netw 9:47-55. 1998
    ..e., juxtacrine interaction in unfixed conditions...
  2. ncbi request reprint Macrophage signaling, apoptosis, lectins and leukocyte trafficking
    T Kasahara
    Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Trends Immunol 22:593-4. 2001
    ..The 10th International Symposium of the Molecular Cell Biology of Macrophages (Macrophages 2001) was held in Tokyo, Japan from 21-22 June 2001...
  3. ncbi request reprint Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation
    Tadashi Kasahara
    Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo, 105 8512, Japan
    Antioxid Redox Signal 4:491-9. 2002
    ..These results indicated that mitochondria pathway is required for IR-induced apoptosis, and FAK overexpression prevents this pathway, thus rendering antiapoptotic states...
  4. pmc The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan
    J Biol Chem 284:12680-90. 2009
    ..Thus, our results both in vitro and in vivo strongly suggest that L611S mutant of JAK2 harbors potent oncogenic activity, and this probably requires the antiapoptotic signaling pathway...
  5. ncbi request reprint Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    Yoshihito X Fujii
    Department of Pharmacology, Kyoritsu College of Pharmacy, Minato ku, Tokyo 105 8512, Japan
    J Neuroimmunol 189:69-74. 2007
    ....
  6. ncbi request reprint Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic cell line, HT93
    Naomi Yoshida
    Department of Biochemistry, Kyoritsu University of Pharmacy, Minato ku, Tokyo, Japan
    Biol Pharm Bull 30:1826-32. 2007
    ..These results indicate that the ability to produce eotaxin-2/CCL24 is acquired during the differentiation into eosinophilic lineage which is dependent on GATA-1 expression...
  7. ncbi request reprint Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276
    Jun ichi Furusawa
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 21:778-85. 2009
    ..Taken together, Licochalcone A might contribute to the potent anti-inflammatory effect of G. inflata through the unique mechanism of NF-kappaB inhibition...
  8. doi request reprint Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis
    Tomonori Kaneda
    Faculty of Pharmacy, Keio University, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Cancer Lett 270:354-61. 2008
    ..The results provide clear evidence that 925Y of FAK is critical for melanoma metastasis and this phosphorylation site will be an anti-metastatic target...
  9. ncbi request reprint Indirubin, a Chinese anti-leukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells
    Kazuhiro Suzuki
    National Institute of Health Sciences, Tokyo, Japan
    Br J Haematol 130:681-90. 2005
    ..These results suggest that indirubin augments the neutrophilic differentiation of human myelocytic leukaemia HL-60 cells through inhibition of CDK2 and activation of PU.1...
  10. doi request reprint TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cytokine 45:72-9. 2009
    ..Thus, these data suggest that TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation through its ubiquitin ligase activity...
  11. doi request reprint Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo, Japan
    Mol Pharmacol 76:745-53. 2009
    ..Taken together, licochalcone A might contribute to the potent anti-inflammatory effect of G. inflata through the inhibition of IKK activation...
  12. ncbi request reprint Cofilin plays a critical role in IL-8-dependent chemotaxis of neutrophilic HL-60 cells through changes in phosphorylation
    Akiko Hirayama
    Division of Biosignaling, National Institute of Health Sciences, 18 1 Kamiyoga 1 Chome, Tokyo, Japan
    J Leukoc Biol 81:720-8. 2007
    ..These results suggested that unphosphorylated cofilin plays a critical role in leukocyte chemotaxis and that PI-3K is involved in the control of the phosphorylation/dephosphorylation cycle of cofilin...
  13. doi request reprint Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation
    Jun Kamishimoto
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 23:849-56. 2011
    ..Taken together, it was clarified that PI3K-Akt activation through the phosphorylation of EpoR at Y479 is required for oncogenic signaling of JAK2 V617F mutant and that targeted disruption of this pathway has therapeutic utility...
  14. ncbi request reprint Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    J Biol Chem 278:29359-65. 2003
    ..Thus, we propose a novel role for FAK in the NF-kappaB activation pathway leading to the production of cytokines...
  15. pmc Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan
    PLoS ONE 8:e52844. 2013
    ....
  16. doi request reprint The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice
    Miyuki Abe
    Department of Biochemistry, Faculty of Pharmacology, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Int Immunopharmacol 9:870-7. 2009
    ..Thus, our results both in vitro and in vivo suggest that Jak2 harboring V617F mutation is a potent oncogene able to promote cell transformation and tumorigenesis...
  17. ncbi request reprint A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation
    Yoshiko Sonoda
    Department of Biochemistry and Pharmacognosy, Kyoritsu University of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 31:1279-83. 2008
    ..Glycosphingolipid 7 might be a candidate for an inhibitor of cell proliferation in melanomas...
  18. ncbi request reprint Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1
    Daiju Ichikawa
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biol Pharm Bull 27:1353-8. 2004
    ....
  19. ncbi request reprint Proteolipid protein 2 is associated with melanoma metastasis
    Yoshiko Sonoda
    Faculty of Pharmacy, Keio University, Tokyo, Japan
    Oncol Rep 23:371-6. 2010
    ..These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt...
  20. doi request reprint The fixed structure of Licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Int Immunopharmacol 10:562-71. 2010
    ..Taken together, it is suggested that Licochalcone A is a promising anti-inflammatory drug in vivo and its fixed structure is critical for anti-inflammatory activity...
  21. ncbi request reprint Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin
    Megumi Funakoshi-Tago
    Department of Biochemistry, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Int Immunopharmacol 11:1150-9. 2011
    ....
  22. doi request reprint TRAF6 is a critical signal transducer in IL-33 signaling pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 20:1679-86. 2008
    ..Thus, these data demonstrate that TRAF6 plays a pivotal role in IL-33 signaling pathway through its ubiquitin ligase activity...
  23. ncbi request reprint Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3
    Yoko Makuta
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 26:1076-81. 2003
    ..These results first indicate that Erk1/2 and STAT-3 regulate CCR5 expression, and that Erk-mediated phosphorylation of Ser is required for full stimulation of STAT-3 in CCR5 expression...
  24. doi request reprint Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells
    Chiho Nishizawa
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan
    Free Radic Res 43:1240-7. 2009
    ..The apoptotic cell death induced by the pyrrolidinium fullerene derivative was suggested to be mediated by ROS generated by the pyrrolidinium fullerene derivative...
  25. ncbi request reprint TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species
    Daiju Ichikawa
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biochem Biophys Res Commun 351:93-8. 2006
    ..Thus, we concluded that resistance against TNF-alpha-induced cell death is rendered by TRAF6, which regulates ROS accumulation...
  26. ncbi request reprint Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NF-kappaB
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biochem Pharmacol 76:662-71. 2008
    ..This negative regulation of NF-kappaB activation by Celecoxib might be an important mechanism leading to its anti-inflammatory activity...
  27. doi request reprint Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacology, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biochem Pharmacol 76:1681-93. 2008
    ..These data suggest that Licochalcone A is a specific inhibitor for Stat3 and would be employed for the treatment of various diseases caused by disorders of the Jak/Stat pathway...
  28. ncbi request reprint Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis
    Yuji Tamagiku
    Department of Biochemistry, Kyoritsu University of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Biochem Biophys Res Commun 323:445-52. 2004
    ....
  29. ncbi request reprint Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
    Megumi Funakoshi-Tago
    Department of Biochemistry and Immunology, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512
    J Biochem 137:189-97. 2005
    ..Taken together, our results suggest that c-Src plays a critical role in IL-1-induced NF-kappa B activation through the IKK complex...
  30. ncbi request reprint Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan
    Cell Signal 24:2024-34. 2012
    ..Taking these findings together, JAK2 V617F mutant-induced JNK signaling pathway is an attractive target for MPN therapy, and pyrrolidinium fullerene derivative is now considered a candidate potent drug for MPNs...
  31. pmc STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, USA
    J Biol Chem 285:5296-307. 2010
    ..Although it remains unclear why the presence of EpoR is required to activate oncogenic signaling via the JAK2 mutant and STAT5, its interacting ability is a target for the treatment of these hematopoietic diseases...
  32. ncbi request reprint Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway
    Jun ichi Furusawa
    Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan
    Int Immunopharmacol 9:499-507. 2009
    ..These findings suggest that the anti-inflammatory effect of Glycyrrhiza inflata is ascribable to the potent inhibition of NF-kappaB by Licochalcone A, Licochalcone B and Licochalcone D...
  33. doi request reprint Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells
    Shota Tanifuji
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Int Immunopharmacol 10:769-76. 2010
    ..These results suggest that Lico D inhibits mast cell degranulation via the inhibition of both extracellular Ca2+ influx and activation of the MEK-ERK pathway...
  34. ncbi request reprint TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Eur J Biochem 270:1257-68. 2003
    ..Taken together, our results demonstrate that c-Src and TRAF6 are key mediators of IL-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways...
  35. ncbi request reprint FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways
    Daisuke Yamamoto
    Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 15:575-83. 2003
    ..We assumed that FAK activates PKC and PI3-kinase-Akt pathway, which resulted in marked induction of cyclin D3 expression and CDK activity...
  36. ncbi request reprint C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation
    Ken ichiro Hashimoto
    Department of Biochemistry, Kyoritsu University of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo, 105 8512, Japan
    Cell Signal 18:955-63. 2006
    ....
  37. ncbi request reprint Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line
    Sachiko Matsui
    International Department, Minophagen Pharmaceutical Co, Ltd, 8 10 22, Akasaka, Minato ku, Tokyo 107 0052, Japan
    Int Immunopharmacol 4:1633-44. 2004
    ....
  38. ncbi request reprint Sulfatides inhibit adhesion, migration, and invasion of murine melanoma B16F10 cell line in vitro
    Hiroki Ozawa
    Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Tokyo 105 8512, Japan
    Biol Pharm Bull 35:2054-8. 2012
    ..Therefore, these sulfatides may serve as promising drug candidates for the treatment of cancer metastasis...
  39. doi request reprint JAK2 is an important signal transducer in IL-33-induced NF-κB activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 23:363-70. 2011
    ..On the other hand, the activation of ERK, JNK and p38 was unaffected by JAK2 inhibition and JAK2 deficiency. Thus, these data demonstrate that JAK2 plays an important role in regulating IL-33-induced NF-κB activation...
  40. ncbi request reprint Inhibition by (+/-)-indenestrol A of interferon gamma-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells
    Taiko Oda
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    Mutat Res 534:187-95. 2003
    ..These results suggest a novel mechanism for the carcinogenic promoting activity of DES via its metabolite, (+/-)-IA...
  41. doi request reprint Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs
    Fumihito Ueda
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Tokyo 105 8512, Japan
    Cell Signal 25:2115-24. 2013
    ..Taken together, FANCC is most likely to be critical for resistance to DNA cross-linking drug-induced DNA damage in cells transformed by JAK2 V617F mutant. ..
  42. ncbi request reprint Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice
    Yoshihito X Fujii
    Department of Pharmacology, Kyoritsu College of Pharmacy, Shibakoen, Minato ku, Tokyo, Japan
    J Neuroimmunol 188:80-5. 2007
    ..They also support the notion that a non-neuronal cholinergic system is involved in regulating immune cell function...
  43. doi request reprint Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells
    Kazuya Sumi
    Department of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan
    FEBS Lett 585:1884-90. 2011
    ..Conversely, knockdown and inhibition of Aurka in cells expressing mutant JAK2 abolished the resistance to CDDP. Taken together, Aurka is most likely critical for resistance to DNA damage in cells transformed by JAK2 V617F mutant...
  44. doi request reprint Dermatophagoides farinae extract induces severe atopic dermatitis in NC/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment
    Tomoyuki Oshio
    Department of Biochemistry, Keio University Faculty of Pharmacy, Tokyo, Japan
    Int Immunopharmacol 9:403-11. 2009
    ..These data indicate that severe atopic dermatitis induced by DfE accompanies elevated chemokine levels, and it was proposed that tacrolimus ointment is beneficial for the treatment of severe AD...
  45. doi request reprint Synthetic studies on glycosphingolipids from Protostomia phyla: syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi
    Noriyasu Hada
    Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Carbohydr Res 343:2221-8. 2008
    ..Compounds 1 and 2 were found to be potent enhancers of IL-8 production...
  46. ncbi request reprint Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2
    Yayoi Murakami
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Tokyo 105 8512, Japan
    J Biochem 141:401-10. 2007
    ..Thus, our results suggest that protective effects of Bcl-x(L) and Bcl-2 against brefeldin A-induced cell death appear to be dependent on the regulation of JNK activation...
  47. ncbi request reprint Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan Electronic address
    Int Immunopharmacol 20:258-63. 2014
    ..These observations clearly indicate that the modification of pyrrolidinium fullerene with a suitable length of alkyl group such as butyl group enhances its apoptotic effect through inhibition of the ASK1-MKK4/7-JNK pathway. ..
  48. ncbi request reprint Proteome analysis of focal adhesion kinase (FAK)-overexpressing cells
    Ryoko Utsubo
    Department of Biochemistry, Kyoritsu University of Pharmacy, Tokyo, Japan
    Biol Pharm Bull 27:1735-41. 2004
    ..Increased proteins included stress proteins such as hsp90, ribosomal proteins, and antioxidant enzymes such as peroxyredoxin 2. Some of these proteins are assumed to contribute to the antiapoptotic action of FAK...
  49. ncbi request reprint Induction of antioxidant enzymes by FAK in a human leukemic cell line, HL-60
    Yoshiko Sonoda
    Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato, Tokyo 105 8512, Japan
    Biochim Biophys Acta 1683:22-32. 2004
    ..These results suggest that FAK upregulates antioxidant enzymes and suppresses lipid peroxidation, resulting in the anti-apoptotic state for oxidative stress...
  50. doi request reprint Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 20:1995-2001. 2008
    ..Accordingly, our results suggest that this tyrosine phosphorylation in JH1 domain may be involved in common negative regulation mechanism for Jak family...
  51. ncbi request reprint Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G
    Shinya Sakurai
    Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1 5 30, Minato ku, Tokyo 105 8512, Japan
    Biochem Biophys Res Commun 293:174-81. 2002
    ..These results indicated that 397FAK induces apoptosis in T98G cells, by interrupting signals of FAK leading to the survival pathway in T98G glioma cells...
  52. ncbi request reprint Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library
    Kaoru Kusui
    National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    Mol Cell Biochem 262:187-93. 2004
    ..These results suggest that some cofilin molecules bind the ribosomal S18 protein under physiological conditions...
  53. pmc Role of bone marrow-derived monocytes/macrophages in the repair of mucosal damage caused by irradiation and/or anticancer drugs in colitis model
    Junji Takaba
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Keio University, 1 5 30, Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Mediators Inflamm 2010:634145. 2010
    ..Our results suggest that monocytes/macrophages contribute to the mucosal recovery and regeneration following mucosal damage by anticancer drug therapy...
  54. ncbi request reprint Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells
    Hidemi Watanabe
    National Institute of Health Sciences, 18 1 Kamiyoga 1 Chome, Setagaya Ku, 158 8501, Tokyo, Japan
    Biochem Biophys Res Commun 306:26-31. 2003
    ..These findings suggest that TPT may have an enhancing effect on the neutrophilic maturation of leukocytes...
  55. doi request reprint Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
    Yasuo Harada
    Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences, Tokyo 105 8512, Japan
    Cancer Lett 319:83-8. 2012
    ..1.7-ρ(0) cells. Moreover, PP acted synergistically with dexamethasone to inhibit PCM6 cell proliferation. In conclusion, we identified PP as a potential anticancer drug directed against mitochondrial respiratory complex I/STAT3...
  56. ncbi request reprint Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region
    Taiko Oda
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    J Immunol 169:3329-35. 2002
    ..In conclusion, a new action of alprazolam was elucidated, as shown in the inhibition of c-Rel/p65- and c-Rel/p50-regulated transcription...
  57. pmc Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration
    Isao Ishii
    Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences Tokyo, Japan
    Front Oncol 2:137. 2012
    ..Here, we review accumulating knowledge on its working mechanisms and evaluate PP as a novel anti-cancer drug that targets mitochondrial respiration...
  58. ncbi request reprint Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Reprod Immunol 51:220-5. 2004
    ..We investigated whether cervical shortening and high interleukin (IL)-8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre-labor rupture of membranes (pPROM)...
  59. ncbi request reprint MEK-ERK is involved in SUMO-1 foci formation on apoptosis
    Ryoko Utsubo-Kuniyoshi
    Division of Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Cancer Sci 98:569-76. 2007
    ..These results suggest that the formation of SUMO-1 foci is regulated by the MEK-ERK pathway and may induce apoptosis...
  60. ncbi request reprint Improved gene expression in resting macrophages using an oligopeptide derived from Vpr of human immunodeficiency virus type-1
    Izuru Mizoguchi
    Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Biochem Biophys Res Commun 338:1499-506. 2005
    ..The data suggest that C45D18 contributes to improving the ability of a non-viral vector to transduce macrophages with exogenous genes and we discuss its further application...
  61. ncbi request reprint Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system
    Hongyan Dong
    Department of Molecular Preventive Medicine and CREST, School of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 298:675-86. 2002
    ..Taken together this study has shown the systemic and comprehensive gene expression profile during FHF and may contribute to better understanding of the mechanism of FHF...
  62. ncbi request reprint Bisphenol A significantly enhances the neutrophilic differentiation of promyelocytic HL-60 cells
    Hidemi Watanabe
    National Institute of Health Sciences, 18 1 Kamiyoga 1 Chome, Setagaya, Tokyo 158 8501, Japan
    Int Immunopharmacol 3:1601-8. 2003
    ..Long-term exposure to BPA might significantly affect the innate immunity of mammals, even at low doses...