Hiroshi Keino

Summary

Affiliation: Kyorin University School of Medicine
Country: Japan

Publications

  1. doi request reprint Effect of infliximab on gene expression profiling in Behcet's disease
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:7681-6. 2011
  2. doi request reprint Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 94:802-7. 2010
  3. doi request reprint Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:1548-56. 2011
  4. ncbi request reprint [Therapeutic effect of the low molecular weight inhibitor of the NF-kappaB signaling pathway on experimental autoimmune uveoretinitis]
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Nihon Ganka Gakkai Zasshi 114:944-54. 2010
  5. pmc Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611 Japan
    Arthritis Res Ther 10:R122. 2008
  6. pmc Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506)
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
    Br J Ophthalmol 91:1537-40. 2007
  7. doi request reprint Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2529-36. 2010
  8. doi request reprint High mobility group box protein-1 in experimental autoimmune uveoretinitis
    Takayo Watanabe
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2283-90. 2009
  9. pmc Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Br J Ophthalmol 91:237-42. 2007
  10. ncbi request reprint Functional expression of B7H1 on retinal pigment epithelial cells
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Exp Eye Res 86:52-9. 2008

Collaborators

Detail Information

Publications22

  1. doi request reprint Effect of infliximab on gene expression profiling in Behcet's disease
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:7681-6. 2011
    ..In this study, the effect of infliximab on gene expression patterns in peripheral blood mononuclear cells of Behçet's disease patients was investigated before and after initiation of infliximab treatment...
  2. doi request reprint Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 94:802-7. 2010
    ..To determine whether an active metabolite of vitamin A, all-trans retinoic acid (ATRA), reduces inflammation in experimental autoimmune uveoretinitis (EAU)...
  3. doi request reprint Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:1548-56. 2011
    ..To determine whether synthetic retinoic acid receptor (RAR)-α/β-specific agonist Am80 reduces inflammation in experimental autoimmune uveoretinitis (EAU)...
  4. ncbi request reprint [Therapeutic effect of the low molecular weight inhibitor of the NF-kappaB signaling pathway on experimental autoimmune uveoretinitis]
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Nihon Ganka Gakkai Zasshi 114:944-54. 2010
    ..These results indicate that oral administration of STA-5326 is effective in suppressing inflammation in the EAU model. The new NF-kappaB inhibitor, STA-5326 represents a promising therapeutic modality for refractory uveitis in humans...
  5. pmc Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, 181 8611 Japan
    Arthritis Res Ther 10:R122. 2008
    ..The purpose of this study was to determine if oral administration of the interleukin (IL) 12/IL-23 inhibitor, STA-5326, is effective in experimental autoimmune uveoretinitis (EAU)...
  6. pmc Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506)
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
    Br J Ophthalmol 91:1537-40. 2007
    ....
  7. doi request reprint Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2529-36. 2010
    ..To determine whether iris pigment epithelium (IPE)-induced T regulatory (Treg) cells can suppress the activation of bystander T cells with cell contact via costimulatory interactions...
  8. doi request reprint High mobility group box protein-1 in experimental autoimmune uveoretinitis
    Takayo Watanabe
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2283-90. 2009
    ..To investigate whether high mobility group box protein (HMGB)-1, acting as a novel proinflammatory cytokine, is involved in experimental autoimmune uveoretinitis (EAU)...
  9. pmc Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Br J Ophthalmol 91:237-42. 2007
    ..To determine whether intravitreal injection of tacrolimus suppresses ongoing experimental autoimmune uveoretinitis (EAU) in rats...
  10. ncbi request reprint Functional expression of B7H1 on retinal pigment epithelial cells
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Exp Eye Res 86:52-9. 2008
    ..These data suggest that B7H1 expressed on RPE cells plays an immunosuppressive role in ocular inflammation, which may contribute to immune privilege in the posterior segment of the eye...
  11. ncbi request reprint Circulating neutrophils in Behçet disease is resistant for apoptotic cell death in the remission phase of uveitis
    Keita Fujimori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Graefes Arch Clin Exp Ophthalmol 246:285-90. 2008
    ..Hypopyon consists of inflammatory cells infiltrating the eye, with polymorphonuclear cells (PMNs) as the main component. The present study was conducted to investigate the apoptosis property of PMNs in BD patients with uveitis...
  12. ncbi request reprint Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Tokyo 160 0023, Japan
    Exp Eye Res 83:981-8. 2006
    ..These results suggest a possibility that adherent monocytes isolated from BD patients may acquire a property to induce ACAID by treatment with TGF-beta2...
  13. ncbi request reprint Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide
    Hiroshi Keino
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Arch Ophthalmol 122:1179-84. 2004
    ..Vasoactive intestinal peptide (VIP), a neuropeptide that is known to be present in lymphoid tissue microenvironments, shows prominent anti-inflammatory actions...
  14. doi request reprint Decreased ocular inflammatory attacks and background retinal and disc vascular leakage in patients with Behcet's disease on infliximab therapy
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 95:1245-50. 2011
    ..To evaluate the efficacy of infliximab treatment in patients with refractory uveoretinitis associated with Behçet's disease...
  15. doi request reprint Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease
    Makiko Nakayama
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Retina 32:2061-9. 2012
    ..Our objective was to analyze subfoveal choroidal thickness by EDI-OCT before and after the initiation of high-dose corticosteroid treatment in 8 patients (16 eyes) with new-onset acute Vogt-Koyanagi-Harada (VKH) disease...
  16. doi request reprint Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells
    Ayano Imai
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:7299-309. 2012
    ..To determine whether supernatants of human retinal pigment epithelium (RPE) cells can convert CD4⁺ T cells into regulatory T cells (Tregs) under Treg-induction conditions in vitro and in vivo...
  17. ncbi request reprint Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10
    Takeshi Kezuka
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    J Immunol 173:1454-62. 2004
    ..The present results indicate that PEC treated with CGRP suppress murine EAU in an Ag-specific manner, even in the efferent phase, and IL-10 secreted from PEC might play an important role in the CGRP-mediated suppression of murine EAU...
  18. ncbi request reprint Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 45:1879-86. 2004
    ....
  19. ncbi request reprint Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 181:7525-36. 2008
    ..The results are compatible with the hypothesis that the eye-derived Treg cells acquire functions that participate in the establishment of immune tolerance in the posterior segment of the eye...
  20. doi request reprint Frequency and clinical features of intraocular inflammation in Tokyo
    Hiroshi Keino
    Department of Ophthalmology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Clin Experiment Ophthalmol 37:595-601. 2009
    ..To investigate frequencies and clinical features of intraocular inflammation (uveitis) in Tokyo, Japan...
  21. doi request reprint Vitreous surgery for macular hole in patients with Vogt-Koyanagi-Harada disease
    Izumi Kobayashi
    Kyorin Eye Center, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, Japan
    Clin Experiment Ophthalmol 36:861-4. 2008
    ..Macular holes have also been reported previously in patients during the convalescent stage of VKH and this communication describes the outcome of two patients who underwent vitreo-retinal surgery for this problem...
  22. ncbi request reprint Association between severity of inflammation in CNS and development of sunset glow fundus in Vogt-Koyanagi-Harada disease
    Hiroshi Keino
    Department of Ophthalmology, Tokyo Medical University, Japan
    Am J Ophthalmol 141:1140-1142. 2006
    ..To investigate the association between central nervous system (CNS) inflammation at disease onset and the appearance of sunset glow fundus (SGF) in Vogt-Koyanagi-Harada (VKH) disease...